Full Text Journal Articles by
Author Krista Brown

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A Prospective Clinical Trial Comparing Surgical Fixation Versus Nonoperative Management of Minimally Displaced Complete Lateral Compression Pelvis Fractures.

Gerard P Slobogean, Greg E Gaski, Jason Nascone, Marcus F Sciadini, Roman M Natoli, Theodore T Manson, Christopher Lebrun, Todd McKinley, Walter W Virkus, Anthony T Sorkin, Krista Brown, Andrea Howe, Joshua Rudnicki, Blessing Enobun, Nathan N O'Hara, Jeff Gill, Robert V O'Toole,

<h4>Objective</h4>To compare the early pain and functional outcomes of operative fixation versus nonoperative management for minimally displaced complete lateral compression (LC; OTA/AO 61-B1/B2) pelvic fractures.<h4>Design</h4>Prospective clinical trial.<h4>Setting</h4>Two academic trauma centers.<h4>Patients</h4>Forty-eight adult patients with LC pelvic ring injuries with <10 mm of displacement were treated nonoperatively and 47 with surgical fixation. ... Read more >>

J Orthop Trauma (Journal of orthopaedic trauma)
[2021, 35(11):592-598]

Cited: 0 times

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Single-cell RNA sequencing of intramedullary canal tissue to improve methods for studying fracture repair biology.

James M Dominguez, Sharon M Moe, Neal X Chen, Todd O McKinley, Krista M Brown, Yunlong Liu, Hongyu Gao, Roman M Natoli,

The ability to study the bone microenvironment of failed fracture healing may lead to biomarkers for fracture nonunion. Herein the authors describe a technique for isolating individual cells suitable for single-cell RNA sequencing analyses from intramedullary canal tissue collected by reaming during surgery. The purpose was to detail challenges and ... Read more >>

Biotechniques (BioTechniques)
[2021, 71(2):431-438]

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Exploring the prognostic and therapeutic utility of expanded mutation profiling in appendix peritoneal metastasis managed with CRS/HIPEC.

Chunmeng Zhang, Benjamin D Plambeck, Margaret E Craig, Alexander Tu, Ryan J Mikus, Valerie Shostrom, Sean P McDermott, Ikponmwosa Igbinigie, Krista Brown, Allison Cushman-Vokoun, Jason M Foster,

<h4>Introduction</h4>Interrogation of cancers with next-generation sequencing (NGS) mutation panels has become widely utilized, identifying prognostic and actionable mutations. This study explored the value of expanded mutation analysis in appendix peritoneal metastases (APM).<h4>Methods</h4>Forty-eight APM patients treated 2013-2018 were retrospectively collected from a registry. Fifty-gene NGS analysis was performed in CLIA approved ... Read more >>

J Surg Oncol (Journal of surgical oncology)
[2021, 123(7):1599-1609]

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Fixation using Alternative Implants for the Treatment of Hip Fractures (FAITH-2): The Exploratory Health-Related Quality of Life and Patient-Reported Functional Outcomes of a Multi-Centre 2 × 2 Factorial Randomized Controlled Pilot Trial in Young Femoral Neck Fracture Patients.

Gerard P Slobogean, Sheila Sprague, Sofia Bzovsky, Taryn Scott, Lehana Thabane, Diane Heels-Ansdell, Robert V O'Toole, Andrea Howe, Greg E Gaski, Lauren C Hill, Krista M Brown, Darius Viskontas, Mauri Zomar, Gregory J Della Rocca, Nathan N O'Hara, Mohit Bhandari, ,

<h4>Purpose</h4>Femoral neck fractures in young patients are typically managed with internal fixation using either cancellous screws or a sliding hip screw (SHS). Although fixation preserves the hip joint, patients are still at risk of complications and poor clinical outcomes which lead to diminished function and health related quality of life ... Read more >>

Injury (Injury)
[2021, 52(10):3051-3059]

Cited: 1 time

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Predictors of Improved Early Clinical Outcomes After Elective Implant Removal.

Laurence B Kempton, Greg E Gaski, Krista Brown, Todd O McKinley, Walter W Virkus,

<h4>Objectives</h4>To determine preoperative factors predictive of improvement in pain and function after elective implant removal. We hypothesized that patients undergoing orthopaedic implant removal to relieve pain would have significant improvements in both pain and function.<h4>Design</h4>Prospective cohort study.<h4>Setting</h4>Level I Trauma Center.<h4>Patients/participants</h4>One hundred eighty-nine patients were enrolled after consenting for orthopaedic implant ... Read more >>

J Orthop Trauma (Journal of orthopaedic trauma)
[2021, 35(3):e103-e107]

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Fixation Using Alternative Implants for the Treatment of Hip Fractures (FAITH-2): The Clinical Outcomes of a Multicenter 2 × 2 Factorial Randomized Controlled Pilot Trial in Young Femoral Neck Fracture Patients.

Gerard P Slobogean, Sheila Sprague, Sofia Bzovsky, Taryn Scott, Lehana Thabane, Diane Heels-Ansdell, Robert V O'Toole, Andrea Howe, Greg E Gaski, Lauren C Hill, Krista M Brown, Darius Viskontas, Mauri Zomar, Gregory J Della Rocca, Nathan N O'Hara, Mohit Bhandari, ,

<h4>Objective</h4>To assess whether the fixation method and vitamin D supplementation affect the risk of patient-important outcomes within 12 months of injury in nongeriatric femoral neck fracture patients.<h4>Design</h4>A pilot factorial randomized controlled trial.<h4>Setting</h4>Fifteen North American clinical sites.<h4>Participants</h4>Ninety-one adults 18-60 years of age with a femoral neck fracture requiring surgical fixation.<h4>Intervention</h4>Participants were ... Read more >>

J Orthop Trauma (Journal of orthopaedic trauma)
[2020, 34(10):524-532]

Cited: 2 times

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Significant Improvement in the Value of Surgical Treatment of Tibial Plateau Fractures Through Surgeon Practice Standardization.

Laurence B Kempton, Christopher A Schneble, Krista Brown, Anthony T Sorkin, Walter W Virkus,

<h4>Introduction</h4>It is unclear whether cost-based decisions to improve the value of surgical care (quality:cost ratio) affect patient outcomes. Our hypothesis was that surgeon-directed reductions in surgical costs for tibial plateau fracture fixation would result in similar patient outcomes, thus improving treatment value.<h4>Methods</h4>This was a prospective observational study with retrospective control ... Read more >>

J Am Acad Orthop Surg (The Journal of the American Academy of Orthopaedic Surgeons)
[2020, 28(18):772-779]

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Investigating the utility of extended mutation analysis in gastrointestinal peritoneal metastasis.

Jason M Foster, Asish Patel, Chunmeng Zhang, Valerie Shostrom, Krista Brown, Allison M Cushman-Vokoun,

<h4>Background and objectives</h4>Outcomes for gastrointestinal peritoneal metastases (GI-PM) are worse compared to systemic metastases, with a paucity of data exploring extended mutation profiling. An exploratory mutation analysis in GI-PMs was performed as a "proof of concept" of potential predictive values of profiling in GI-PM and rates of actionable mutations.<h4>Methods</h4>The study ... Read more >>

J Surg Oncol (Journal of surgical oncology)
[2020, 122(6):1106-1113]

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Fixation Using Alternative Implants for the Treatment of Hip Fractures: The feasibility of a multicenter 2 × 2 factorial randomized controlled trial evaluating surgical treatment and vitamin D supplementation in young femoral neck fracture patients.

Sheila Sprague, Mohit Bhandari, Sofia Bzovsky, Taryn Scott, Lehana Thabane, Diane Heels-Ansdell, Robert V O'Toole, Andrea Howe, Greg E Gaski, Lauren C Hill, Krista M Brown, Darius Viskontas, Mauri Zomar, Gregory J Della Rocca, Gerard P Slobogean,

<h4>Objectives</h4>To conduct a pilot trial for the Fixation using Alternative Implants for the Treatment of Hip Fractures (FAITH-2) protocol to assess feasibility of a definitive trial.<h4>Design</h4>Pilot trial.<h4>Setting</h4>Twenty-five clinical sites across North America and Australia were initiated, but enrolment occurred in only 15 North American sites.<h4>Patients/participants</h4>Ninety-one randomized adults aged 18 to ... Read more >>

OTA Int (OTA international : the open access journal of orthopaedic trauma)
[2020, 3(2):e066]

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Does Operative Intervention Provide Early Pain Relief for Patients With Unilateral Sacral Fractures and Minimal or No Displacement?

Paul Tornetta, Jason A Lowe, Julie Agel, Brian H Mullis, Clifford B Jones, David Teague, Laurence Kempton, Krista Brown, Darin Friess, Anna N Miller, Clay A Spitler, Erik Kubiak, Joshua L Gary, Ross Leighton, Saam Morshed, Heather A Vallier,

<h4>Objectives</h4>To compare pain after operative versus nonoperative pelvic ring injuries with unilateral sacral fractures.<h4>Design</h4>Prospective, multicenter, observational.<h4>Setting</h4>Sixteen trauma centers.<h4>Patients/participants</h4>Skeletally mature patients with pelvic ring injury and minimally displaced unilateral zone 1 or 2 sacral fractures and without anteroposterior compression injuries.<h4>Main outcome measurements</h4>Pelvic displacement was documented on injury plain radiographs and computed ... Read more >>

J Orthop Trauma (Journal of orthopaedic trauma)
[2019, 33(12):614-618]

Cited: 3 times

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Fixation using alternative implants for the treatment of hip fractures (FAITH-2): design and rationale for a pilot multi-centre 2 × 2 factorial randomized controlled trial in young femoral neck fracture patients.

, Gerard P Slobogean, Sheila Sprague, Sofia Bzovsky, Diane Heels-Ansdell, Lehana Thabane, Taryn Scott, Mohit Bhandari,

<h4>Background</h4>Femoral neck fractures in patients ≤ 60 years of age are often very different injuries compared to low-energy, hip fractures in elderly patients and are difficult to manage because of inherent problems associated with high-energy trauma mechanisms and increased functional demands for recovery. Internal fixation, with multiple cancellous screws or a sliding ... Read more >>

Pilot Feasibility Stud (Pilot and feasibility studies)
[2019, 5:70]

Cited: 3 times

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Early Immunologic Response in Multiply Injured Patients With Orthopaedic Injuries Is Associated With Organ Dysfunction.

Greg E Gaski, Cameron Metzger, Tyler McCarroll, Robert Wessel, Jeremy Adler, Andrew Cutshall, Krista Brown, Yoram Vodovotz, Timothy R Billiar, Todd O McKinley,

<h4>Objectives</h4>To quantify the acute immunologic biomarker response in multiply injured patients with axial and lower extremity fractures and to explore associations with adverse short-term outcomes including organ dysfunction and nosocomial infection (NI).<h4>Design</h4>Prospective cohort study.<h4>Setting</h4>Level 1 academic trauma center.<h4>Patients</h4>Consecutive multiply injured patients, 18-55 years of age, with major pelvic and lower ... Read more >>

J Orthop Trauma (Journal of orthopaedic trauma)
[2019, 33(5):220-228]

Cited: 3 times

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Correction: Type V Collagen Induced Tolerance Suppresses Collagen Deposition, TGF-β and Associated Transcripts in Pulmonary Fibrosis.

Ragini Vittal, Elizabeth A Mickler, Amanda J Fisher, Chen Zhang, Katia Rothhaar, Hongmei Gu, Krista M Brown, Amir Emtiazjoo, Jeremy M Lott, Sarah B Frye, Gerald N Smith, George E Sandusky, Oscar W Cummings, David S Wilkes,

[This corrects the article DOI: 10.1371/journal.pone.0076451.]. ... Read more >>

PLoS One (PloS one)
[2018, 13(12):e0209107]

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Support stance in carers of adults with eating disorders: Factors associated with collaborative versus directive approaches.

Josie Geller, Suja Srikameswaran, Megumi Iyar, Joanna Zelichowska, Michel Thibodeau, Krista E Brown, Erin C Dunn,

The support provided by family and friends is integral to patient motivation and clinical outcomes across health care populations. However, little is known about factors that promote or interfere with the type of support offered.<h4>Objective</h4>This research examined factors associated with collaborative versus directive support among carers of adults with eating ... Read more >>

Int J Eat Disord (The International journal of eating disorders)
[2017, 50(5):498-505]

Cited: 2 times

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Developing and Pilot Testing the Readiness and Motivation Interview for Families in Pediatric Weight Management.

Josie Geller, Jillian Avis, Suja Srikameswaran, Joanna Zelichowska, Katie Dartnell, Bailey Scheuerman, Arnaldo Perez, Allison Rasquinha, Krista E Brown, Jean-Pierre Chanoine, Geoff Ball,

Clinical acumen is often used to assess families' motivation prior to initiating pediatric obesity management due to a lack of available tools. The purpose of this pilot study was to (i) develop and (ii) pilot test the "Readiness and Motivation Interview for Families" (RMI-Family) in pediatric weight management. We conducted ... Read more >>

Can J Diet Pract Res (Canadian journal of dietetic practice and research : a publication of Dietitians of Canada = Revue canadienne de la pratique et de la recherche en dietetique : une publication des Dietetistes du Canada)
[2015, 76(4):190-193]

Cited: 1 time

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Effectiveness of a peer-delivered dissonance-based program in reducing eating disorder risk factors in high school girls.

Anna C Ciao, Janet D Latner, Krista E Brown, Daria S Ebneter, Carolyn B Becker,

<h4>Objective</h4>This pilot study investigated the feasibility, acceptability, and effectiveness of a peer-led dissonance-based eating disorders (ED) prevention/risk factor reduction program with high school girls.<h4>Method</h4>Ninth grade girls (n = 50) received the peer-led program within the school curriculum. A quasi-experimental design was used to assess changes in ED risk factors preintervention ... Read more >>

Int J Eat Disord (The International journal of eating disorders)
[2015, 48(6):779-784]

Cited: 5 times

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Role of complement activation in obliterative bronchiolitis post-lung transplantation.

Hidemi Suzuki, Mark E Lasbury, Lin Fan, Ragini Vittal, Elizabeth A Mickler, Heather L Benson, Rebecca Shilling, Qiang Wu, Daniel J Weber, Sarah R Wagner, Melissa Lasaro, Denise Devore, Yi Wang, George E Sandusky, Kelsey Lipking, Pankita Pandya, John Reynolds, Robert Love, Thomas Wozniak, Hongmei Gu, Krista M Brown, David S Wilkes,

Obliterative bronchiolitis (OB) post-lung transplantation involves IL-17-regulated autoimmunity to type V collagen and alloimmunity, which could be enhanced by complement activation. However, the specific role of complement activation in lung allograft pathology, IL-17 production, and OB is unknown. The current study examines the role of complement activation in OB. Complement-regulatory ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2013, 191(8):4431-4439]

Cited: 39 times

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The psychometric properties of the Readiness and Motivation Questionnaire: a symptom-specific measure of readiness for change in the eating disorders.

Josie Geller, Krista E Brown, Suja Srikameswaran, William Piper, Erin C Dunn,

Readiness for change, as assessed by the readiness and motivation interview (RMI), predicts a number of clinical outcome variables in eating disorders including enrollment in intensive treatment, symptom change, dropout, and relapse. Although clinically useful, the training and administration of the RMI is time consuming. The purpose of this research ... Read more >>

Psychol Assess (Psychological assessment)
[2013, 25(3):759-768]

Cited: 9 times

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Gorlin syndrome presenting with a unilateral ovarian fibroma in a 22-year-old woman: a case report.

Terence Finch, Chitra Pushpanathan, Krista Brown, Yasser El-Gohary,

<h4>Introduction</h4>Nevoid basal cell carcinoma syndrome, or Gorlin syndrome, is an inherited disorder characterized by malignancies of the skin and other organs, skeletal abnormalities, and congenital malformations. The syndrome follows an autosomal dominant inheritance pattern with a gene mutation localized to 9q22.3.<h4>Case presentation</h4>We present the case of a 22-year-old Caucasian woman ... Read more >>

J Med Case Rep (Journal of medical case reports)
[2012, 6:148]

Cited: 4 times

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The efficacy of a brief motivational intervention for individuals with eating disorders: a randomized control trial.

Josie Geller, Krista E Brown, Suja Srikameswaran,

<h4>Objective</h4>Individuals with eating disorders are often ambivalent about recovery, and previous research has shown that readiness for change predicts enrollment in intensive treatment, symptom change, dropout, and relapse. Given the demonstrated importance of readiness for change, researchers and clinicians have turned to investigating interventions designed to enhance motivation. The purpose ... Read more >>

Int J Eat Disord (The International journal of eating disorders)
[2011, 44(6):497-505]

Cited: 12 times

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Addressing the EDNOS issue and improving upon the utility of DSM-IV: classifying eating disorders using symptom profiles.

Erin C Dunn, Josie Geller, Krista E Brown, Mollie E Bates,

<h4>Objective</h4>To compare the descriptive and clinical utility of two classification systems: DSM-IV eating disorder diagnoses and proposed symptom profiles. The symptom profiles are based on the presence of overvalued ideas about shape/weight, as well as combinations of three key eating disorder symptoms (e.g. body mass index (BMI) above or below ... Read more >>

Eur Eat Disord Rev (European eating disorders review : the journal of the Eating Disorders Association)
[2010, 18(4):271-280]

Cited: 4 times

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Responsiveness of the Eating Disorders Quality of Life Scale (EDQLS) in a longitudinal multi-site sample.

Carol E Adair, Gisele C Marcoux, Theanna F Bischoff, Brian S Cram, Carol J Ewashen, Jorge Pinzon, Joanne L Gusella, Josie Geller, Yvette Scattolon, Patricia Fergusson, Lisa Styles, Krista E Brown,

<h4>Background</h4>In eating disorders (EDs), treatment outcome measurement has traditionally focused on symptom reduction rather than functioning or quality of life (QoL). The Eating Disorders Quality of Life Scale (EDQLS) was recently developed to allow for measurement of broader outcomes. We examined responsiveness of the EDQLS in a longitudinal multi-site study.<h4>Methods</h4>The ... Read more >>

Health Qual Life Outcomes (Health and quality of life outcomes)
[2010, 8:83]

Cited: 7 times

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Factors associated with improvements in readiness for change: low vs. normal BMI eating disorders.

Josie Geller, Stephanie E Cassin, Krista E Brown, Suja Srikameswaran,

<h4>Objective</h4>To examine factors associated with improvements in readiness for change as a function of body mass index (BMI) in individuals assessed for eating disorders treatment.<h4>Method</h4>Participants (n = 128) completed the Readiness and Motivation Interview (RMI) and measures of psychiatric and eating disorder symptoms, quality of life, and self-esteem at baseline ... Read more >>

Int J Eat Disord (The International journal of eating disorders)
[2009, 42(1):40-46]

Cited: 9 times

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Supporting friends and family members with eating disorders: discrepancies between intentions and reality.

Krista E Brown, Josie Geller,

This study examined how female undergraduate students anticipated they would approach a friend or family member with disordered eating and what kinds of support they believed to be helpful. The relationship between eating disorder symptomatology and anticipated approaches also was examined. Participants read vignettes depicting scenarios involving a friend or ... Read more >>

Eat Disord (Eating disorders)
[2006, 14(3):215-228]

Cited: 5 times

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Assessing readiness for change in adolescents with eating disorders.

Josie Geller, Krista E Brown, Shannon L Zaitsoff, Rosanne Menna, Mollie E Bates, Erin C Dunn,

The Readiness and Motivation Interview (RMI) is a semistructured interview measure of readiness and motivation to change that can be used for all eating disorder diagnoses. The RMI has demonstrated excellent psychometric properties and has both clinical and predictive utility in adult samples. This study examined the psychometric properties of ... Read more >>

Psychol Assess (Psychological assessment)
[2008, 20(1):63-69]

Cited: 17 times

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