Full Text Journal Articles by
Author Krishna J Rocha Singh

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Directional atherectomy before paclitaxel coated balloon angioplasty in complex femoropopliteal disease: The VIVA REALITY study.

Krishna J Rocha-Singh, Ravish Sachar, Brian G DeRubertis, Claus C A Nolte-Ernsting, John G Winscott, Prakash Krishnan, Eric C Scott, Lawrence A Garcia, Jean-Luc Baeriswyl, Gary Ansel, Kenneth Rosenfield, Thomas Zeller, ,

<h4>Background</h4>Drug coated balloon (DCB) angioplasty significantly reduces reintervention rates in patients with symptomatic femoropopliteal peripheral artery disease (PAD). However, stand-alone DCB use in long, severely calcified lesions is frequently associated with vessel recoil and/or high-grade dissections necessitating provisional stent implantation.<h4>Objectives</h4>Assess the safety and effectiveness of a vessel preparation strategy with ... Read more >>

Catheter Cardiovasc Interv (Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions)
[2021, :]

Cited: 0 times

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The Ranger "Low-Dose" Paclitaxel Drug-Coated Balloon: Is Less Really More?

Krishna J Rocha-Singh,

JACC Cardiovasc Interv (JACC. Cardiovascular interventions)
[2021, 14(10):1134-1136]

Cited: 0 times

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Retrospective Real-World Studies of Paclitaxel and Mortality: Defining the Many Faces of Bias.

Krishna J Rocha-Singh,

JACC Cardiovasc Interv (JACC. Cardiovascular interventions)
[2020, 13(17):2062-2064]

Cited: 1 time

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Statistical Alchemy and the Road Ahead.

Krishna J Rocha-Singh, Sue Duval,

JACC Cardiovasc Interv (JACC. Cardiovascular interventions)
[2019, 12(24):2525-2527]

Cited: 0 times

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Drug-Coated Balloon Treatment of Femoropopliteal Lesions for Patients With Intermittent Claudication and Ischemic Rest Pain.

Thomas Zeller, Marianne Brodmann, Antonio Micari, Koen Keirse, Patrick Peeters, Gunnar Tepe, Dierk Scheinert, Michael R Jaff, Krishna J Rocha-Singh, Pei Li, Randy Schmahl, Gary M Ansel, ,

Circ Cardiovasc Interv (Circulation. Cardiovascular interventions)
[2019, 12(1):e007730]

Cited: 1 time

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One-Year Outcomes Following Directional Atherectomy of Popliteal Artery Lesions: Subgroup Analysis of the Prospective, Multicenter DEFINITIVE LE Trial.

Aljoscha Rastan, James F McKinsey, Lawrence A Garcia, Krishna J Rocha-Singh, Michael R Jaff, Stuart Harlin, Suraj Kamat, Sean Janzer, Thomas Zeller,

PURPOSE:To report the effectiveness of directional atherectomy for the treatment of popliteal artery occlusive disease. METHODS:This subset of the prospective, multicenter, single-arm DEFINITIVE LE trial included 158 patients (mean age 72.0±10.9 years; 82 men) who underwent directional atherectomy in 162 popliteal artery lesions between 2009 and 2011. Forty-eight (30.4%) patients ... Read more >>

J Endovasc Ther (Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists)
[2018, 25(1):100-108]

Cited: 4 times

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Directional Atherectomy Followed by a Paclitaxel-Coated Balloon to Inhibit Restenosis and Maintain Vessel Patency: Twelve-Month Results of the DEFINITIVE AR Study.

Thomas Zeller, Ralf Langhoff, Krishna J Rocha-Singh, Michael R Jaff, Erwin Blessing, Beatrice Amann-Vesti, Marek Krzanowski, Patrick Peeters, Dierk Scheinert, Giovanni Torsello, Sebastian Sixt, Gunnar Tepe, ,

<h4>Background</h4>Studies assessing drug-coated balloons (DCB) for the treatment of femoropopliteal artery disease are encouraging. However, challenging lesions, such as severely calcified, remain difficult to treat with DCB alone. Vessel preparation with directional atherectomy (DA) potentially improves outcomes of DCB.<h4>Methods and results</h4>DEFINITIVE AR study (Directional Atherectomy Followed by a Paclitaxel-Coated Balloon ... Read more >>

Circ Cardiovasc Interv (Circulation. Cardiovascular interventions)
[2017, 10(9):]

Cited: 23 times

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Angiographic classification of patterns of restenosis following femoropopliteal artery intervention: A proposed scoring system.

Lawrence A Garcia, Krishna J Rocha-Singh, Prakash Krishnan, Thomas Zeller, Gunnar Tepe, Mark Fleming, Juan F Granada, Mark A Turco, Christopher Tieché, Michael R Jaff,

<h4>Objectives</h4>To propose a classification system for characterizing angiographic femoropopliteal artery restenosis patterns associated with common endovascular modalities.<h4>Background</h4>Peripheral artery disease is a worldwide issue affecting millions of people. Despite a myriad of endovascular technologies available to treat peripheral artery disease of the femoropopliteal arteries, restenosis remains a common failure mode. Characterizing ... Read more >>

Catheter Cardiovasc Interv (Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions)
[2017, 90(4):639-646]

Cited: 2 times

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Analysis of IN.PACT DEEP trial on the association between changes in perfusion from pre- to postrevascularization and clinical outcomes in critical limb ischemia.

Tarek A Hammad, Thomas Zeller, Iris Baumgartner, Dierk Scheinert, Krishna J Rocha-Singh, Mehdi H Shishehbor,

<h4>Objectives</h4>To quantify changes in ankle and toe pressure from pre- to post-endovascular revascularization for critical limb ischemia (CLI) and examine their association with major adverse limb events (MALE).<h4>Background</h4>Despite societal guidelines recommendation of routine hemodynamic surveillance following revascularization, little is known about hemodynamic assessment in CLI.<h4>Methods</h4>Among the 358 patients with CLI ... Read more >>

Catheter Cardiovasc Interv (Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions)
[2017, 90(6):986-993]

Cited: 2 times

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Patient-level meta-analysis of 999 claudicants undergoing primary femoropopliteal nitinol stent implantation.

Krishna J Rocha-Singh, Joshua A Beckman, Gary Ansel, Sean P Lyden, Peter Schneider, Manish Mehta, Michael Dake, Christopher M Mullin, Michael R Jaff, ,

<h4>Condensed abstract</h4>The factors that impact the clinical effectiveness of bare nitinol stents in claudicants with symptomatic femoropopliteal atherosclerosis are incompletely known. The authors analyzed variables that may influence stent durability and provide a benchmark for their effectiveness. Data analyzed from six studies (999 patients) included baseline noninvasive hemodynamic tests, angiographic ... Read more >>

Catheter Cardiovasc Interv (Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions)
[2017, 89(7):1250-1256]

Cited: 2 times

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An analysis of IN.PACT DEEP randomized trial on the limitations of the societal guidelines-recommended hemodynamic parameters to diagnose critical limb ischemia.

Mehdi H Shishehbor, Tarek A Hammad, Thomas Zeller, Iris Baumgartner, Dierk Scheinert, Krishna J Rocha-Singh,

<h4>Objective</h4>Recent small single-center data indicate that the current hemodynamic parameters used to diagnose critical limb ischemia are insensitive. We investigated the validity of the societal guidelines-recommended hemodynamic parameters against core laboratory-adjudicated angiographic data from the multicenter IN.PACT DEEP (RandomIzed AmPhirion DEEP DEB vs StAndard PTA for the treatment of below ... Read more >>

J Vasc Surg (Journal of vascular surgery)
[2016, 63(5):1311-1317]

Cited: 14 times

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One-Year Outcomes Following Directional Atherectomy of Infrapopliteal Artery Lesions: Subgroup Results of the Prospective, Multicenter DEFINITIVE LE Trial.

Aljoscha Rastan, James F McKinsey, Lawrence A Garcia, Krishna J Rocha-Singh, Michael R Jaff, Elias Noory, Thomas Zeller, ,

<h4>Purpose</h4>To report a subgroup analysis of the prospective, multicenter, single-arm DEFINITIVE LE trial to assess the effectiveness of directional atherectomy for the treatment of infrapopliteal artery lesions at 1 year.<h4>Methods</h4>In the DEFINITIVE LE trial, follow-up assessments occurred up to 1 year postprocedure. Of the 800 patients enrolled, 145 subjects with ... Read more >>

J Endovasc Ther (Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists)
[2015, 22(6):839-846]

Cited: 14 times

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A Comparison of Clinical Outcomes for Diabetic and Nondiabetic Patients Following Directional Atherectomy in the DEFINITIVE LE Claudicant Cohort.

Lawrence A Garcia, Michael R Jaff, Krishna J Rocha-Singh, Thomas Zeller, Christopher Bosarge, Suraj Kamat, James F McKinsey,

<h4>Purpose</h4>To report a subset analysis that evaluated the hypothesis that directional atherectomy for peripheral artery disease in diabetic claudicants has noninferior primary patency at 12 months compared with nondiabetic claudicants.<h4>Methods</h4>DEFINITIVE LE, a US/European multicenter study, assessed the effectiveness of directional atherectomy using SilverHawk/TurboHawk systems for treatment of peripheral artery disease ... Read more >>

J Endovasc Ther (Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists)
[2015, 22(5):701-711]

Cited: 9 times

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A single stent strategy in patients with lifestyle limiting claudication: 3-year results from the Durability II trial.

Krishna J Rocha-Singh, Marc Bosiers, Greg Schultz, Michael R Jaff, Manish Mehta, Jon S Matsumura, ,

<h4>Objectives</h4>To evaluate longer-term safety and efficacy of a single self-expanding stent up to 20 cm in length in patients with atherosclerotic disease of the superficial femoral (SFA) and proximal popliteal arteries.<h4>Background</h4>Angioplasty and stenting are options for revascularization of symptomatic peripheral artery disease. While angioplasty alone is effective in short lesions, ... Read more >>

Catheter Cardiovasc Interv (Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions)
[2015, 86(1):164-170]

Cited: 19 times

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Lower extremity revascularization using directional atherectomy: 12-month prospective results of the DEFINITIVE LE study.

James F McKinsey, Thomas Zeller, Krishna J Rocha-Singh, Michael R Jaff, Lawrence A Garcia, ,

<h4>Objectives</h4>The aim of this study was to assess the safety and effectiveness of directional atherectomy (DA) for endovascular treatment of peripheral arterial disease (PAD) in infrainguinal arteries in patients with claudication or critical limb ischemia.<h4>Background</h4>To date, no prospective, multicenter, independently-adjudicated study has evaluated the effectiveness and durability of DA in ... Read more >>

JACC Cardiovasc Interv (JACC. Cardiovascular interventions)
[2014, 7(8):923-933]

Cited: 75 times

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The ROX coupler: creation of a fixed iliac arteriovenous anastomosis for the treatment of uncontrolled systemic arterial hypertension, exploiting the physical properties of the arterial vasculature.

John P Foran, Ajay K Jain, Ivan P Casserly, David E Kandzari, Krishna J Rocha-Singh, Adam Witkowski, Barry T Katzen, David Deaton, Peter Balmforth, Paul A Sobotka,

Uncontrolled hypertension, whether due to drug resistance or poor adherence and persistence, remains a problem in many patients. The ROX coupler is a novel technology designed to reduce arterial blood pressure consequent to the predicted physical effects of reducing vascular resistance and improving arterial compliance. This article describes the technical ... Read more >>

Catheter Cardiovasc Interv (Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions)
[2015, 85(5):880-886]

Cited: 17 times

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Drug-eluting balloon versus standard balloon angioplasty for infrapopliteal arterial revascularization in critical limb ischemia: 12-month results from the IN.PACT DEEP randomized trial.

Thomas Zeller, Iris Baumgartner, Dierk Scheinert, Marianne Brodmann, Marc Bosiers, Antonio Micari, Patrick Peeters, Frank Vermassen, Mario Landini, David B Snead, K Craig Kent, Krishna J Rocha-Singh, ,

<h4>Background</h4>Drug-eluting balloons (DEB) may reduce infrapopliteal restenosis and reintervention rates versus percutaneous transluminal angioplasty (PTA) and improve wound healing/limb preservation.<h4>Objectives</h4>The goal of this clinical trial was to assess the efficacy and safety of IN.PACT Amphirion drug-eluting balloons (IA-DEB) compared to PTA for infrapopliteal arterial revascularization in patients with critical limb ... Read more >>

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2014, 64(15):1568-1576]

Cited: 102 times

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Proceedings from Duke resistant hypertension think tank.

Sreekanth Vemulapalli, Jamy Ard, George L Bakris, Deepak L Bhatt, Alan S Brown, William C Cushman, Keith C Ferdinand, John M Flack, Jerome L Fleg, Barry T Katzen, John B Kostis, Suzanne Oparil, Chet B Patel, Carl J Pepine, Ileana L Piña, Krishna J Rocha-Singh, Raymond R Townsend, Eric D Peterson, Robert M Califf, Manesh R Patel,

To identify patients at increased risk for cardiovascular outcomes, apparent treatment resistant hypertension (aTRH) is defined as having a blood pressure (BP) above goal despite the use of ≥3 antihypertensive therapies of different classes at maximally tolerated doses, ideally including a diuretic. In light of growing scientific interest in the ... Read more >>

Am Heart J (American heart journal)
[2014, 167(6):775-88.e1]

Cited: 11 times

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The impact of sex on angioplasty and primary stenting for femoropopliteal occlusive disease: results of the DURABILITY II trial.

Rami O Tadros, Peter L Faries, Krishna J Rocha-Singh, Sung yup Kim, Rajesh K Malik, Sharif H Ellozy, Michael L Marin, Ageliki G Vouyouka,

<h4>Background</h4>This study investigates the impact of sex on angioplasty and primary stenting for the treatment of claudicants with femoropopliteal occlusive disease (FPOD).<h4>Methods</h4>Two hundred eighty-seven patients enrolled in the Safety and Effectiveness Study of EverFlex Stent to Treat Symptomatic Femoral-popliteal Atherosclerosis (DURABILITY II) trial (a prospective, nonrandomized, core laboratory audited, and ... Read more >>

Ann Vasc Surg (Annals of vascular surgery)
[2014, 28(1):1-9]

Cited: 9 times

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International expert consensus statement: Percutaneous transluminal renal denervation for the treatment of resistant hypertension.

Markus P Schlaich, Roland E Schmieder, George Bakris, Peter J Blankestijn, Michael Böhm, Vito M Campese, Darrel P Francis, Guido Grassi, Dagmara Hering, Richard Katholi, Sverre Kjeldsen, Henry Krum, Felix Mahfoud, Giuseppe Mancia, Franz H Messerli, Krzysztof Narkiewicz, Gianfranco Parati, Krishna J Rocha-Singh, Luis M Ruilope, Lars C Rump, Domenic A Sica, Paul A Sobotka, Costas Tsioufis, Oliver Vonend, Michael A Weber, Bryan Williams, Thomas Zeller, Murray D Esler,

Catheter-based radiofrequency ablation technology to disrupt both efferent and afferent renal nerves has recently been introduced to clinical medicine after the demonstration of significant systolic and diastolic blood pressure reductions. Clinical trial data available thus far have been obtained primarily in patients with resistant hypertension, defined as standardized systolic clinic ... Read more >>

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2013, 62(22):2031-2045]

Cited: 65 times

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Renal sympathetic denervation for treatment-resistant hypertension…in moderation.

Krishna J Rocha-Singh, Richard E Katholi,

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2013, 62(20):1887-1889]

Cited: 0 times

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The United States StuDy for EvalUating EndovasculaR TreAtments of Lesions in the Superficial Femoral Artery and Proximal Popliteal By usIng the Protégé EverfLex NitInol STent SYstem II (DURABILITY II).

Jon S Matsumura, Dai Yamanouchi, Jeffrey A Goldstein, Christopher W Pollock, Marc Bosiers, Greg A Schultz, Dierk Scheinert, Krishna J Rocha-Singh,

<h4>Objective</h4>Angioplasty and stenting are options for revascularization of symptomatic femoral popliteal disease. Although angioplasty alone is effective in short lesions, longer lesions are often treated with stents. Multiple overlapping stents are expensive and may be associated with stent fracture. This trial evaluated the safety and efficacy of a single self-expanding ... Read more >>

J Vasc Surg (Journal of vascular surgery)
[2013, 58(1):73-83.e1]

Cited: 51 times

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Zotarolimus-eluting peripheral stents for the treatment of erectile dysfunction in subjects with suboptimal response to phosphodiesterase-5 inhibitors.

Jason H Rogers, Irwin Goldstein, David E Kandzari, Tobias S Köhler, Curtiss T Stinis, Paula J Wagner, Jeffrey J Popma, Michael R Jaff, Krishna J Rocha-Singh,

<h4>Objectives</h4>This study sought to evaluate the safety and feasibility of zotarolimus-eluting stent implantation in focal atherosclerotic lesions of the internal pudendal arteries among men with erectile dysfunction (ED) and a suboptimal response to phosphodiesterase-5 inhibitors.<h4>Background</h4>ED, a common condition, is often mediated by atherosclerosis. Current treatment options are limited.<h4>Methods</h4>Male subjects with ... Read more >>

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2012, 60(25):2618-2627]

Cited: 23 times

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Reply: To PMID 23177300.

Jason H Rogers, Irwin Goldstein, Krishna J Rocha-Singh,

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2013, 61(25):2569-2570]

Cited: 0 times

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Endovascular therapy for vasculogenic erectile dysfunction.

Jason H Rogers, Krishna J Rocha-Singh,

<h4>Opinion statement</h4>Erectile dysfunction (ED) is an important clinical condition that affects a significant proportion of men. Although there are many etiologies for ED, many cases have a vascular basis that is related to inadequate arterial inflow, veno-occlusive dysfunction, or abnormalities in smooth muscle (cavernosal tissue) relaxation. These vascular abnormalities can ... Read more >>

Curr Treat Options Cardiovasc Med (Current treatment options in cardiovascular medicine)
[2012, 14(2):193-202]

Cited: 7 times

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