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Author Kornelia Edes

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Gestational Psittacosis Resulting in Neonatal Death Identified by Next-Generation RNA Sequencing of Postmortem, Formalin-Fixed Lung Tissue.

Litty Paul, Jessica Comstock, Kornelia Edes, Robert Schlaberg,

Psittacosis is a rare zoonosis that can cause severe disease and adverse outcomes during pregnancy. We identified a previously elusive case of psittacosis causing premature delivery and infant death by next-generation RNA sequencing of postmortem tissues. Hypothesis-free pathogen detection in postmortem specimens can increase the yield of epidemiologic and cause-of-death ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(8):ofy172]

Cited: 0 times

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Fecal Host Transcriptomics for Non-Invasive Human Mucosal Immune Profiling: Proof of Concept in Clostridium Difficile Infection.

Robert Schlaberg, Amanda Barrett, Kornelia Edes, Michael Graves, Litty Paul, Jenna Rychert, Bert K Lopansri, Daniel T Leung,

Background:Host factors play an important role in pathogenesis and disease outcome in Clostridium difficile infection (CDI), and characterization of these responses could uncover potential host biomarkers to complement existing microbe-based diagnostics. Methods:We extracted RNA from fecal samples of patients with CDI and profiled human mRNA using amplicon-based next-generation sequencing (NGS). ... Read more >>

Pathog Immun (Pathogens & immunity)
[2018, 3(2):164-180]

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Active BRAF-V600E is the key player in generation of a sessile serrated polyp-specific DNA methylation profile.

Somaye Dehghanizadeh, Vahid Khoddami, Timothy L Mosbruger, Sue S Hammoud, Kornelia Edes, Therese S Berry, Michelle Done, Wade S Samowitz, James A DiSario, Daniel G Luba, Randall W Burt, David A Jones,

Sessile serrated polyps (SSPs) have emerged as important precursors for a large number of sporadic colorectal cancers. They are difficult to detect during colonoscopy due to their flat shape and the excessive amounts of secreted mucin that cover the polyps. The underlying genetic and epigenetic basis for the emergence of ... Read more >>

PLoS One (PloS one)
[2018, 13(3):e0192499]

Cited: 3 times

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Fecal Host Transcriptomics for Noninvasive Mucosal Immune Profiling in Human Infection.

Robert Schlaberg, Jenna Rychert, Michael Graves, Kornelia Edes, Bert K Lopansri, Daniel Leung,

AbstractBackground infection (CDI) is the most common hospital-associated infection in the US. However, asymptomatic carriage is common, and use of microbial nucleic acid amplification tests have been suggested to lead to over-diagnosis. Host factors play an important role in pathogenesis and disease outcome in CDI, and characterization of these ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2017, 4(Suppl 1):S607-S607]

Cited: 0 times

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Juxtaposition of chemical and mutation-induced developmental defects in zebrafish reveal a copper-chelating activity for kalihinol F.

Imelda T Sandoval, Elizabeth J Manos, Ryan M Van Wagoner, Richard Glenn C Delacruz, Kornelia Edes, Dennis R Winge, Chris M Ireland, David A Jones,

A major hurdle in using complex systems for drug screening is the difficulty of defining the mechanistic targets of small molecules. The zebrafish provides an excellent model system for juxtaposing developmental phenotypes with mechanism discovery using organism genetics. We carried out a phenotype-based screen of uncharacterized small molecules in zebrafish ... Read more >>

Chem Biol (Chemistry & biology)
[2013, 20(6):753-763]

Cited: 10 times

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Alkylation of the tumor suppressor PTEN activates Akt and β-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer.

Tracy M Covey, Kornelia Edes, Gary S Coombs, David M Virshup, Frank A Fitzpatrick,

PTEN, a phosphoinositide-3-phosphatase, serves dual roles as a tumor suppressor and regulator of cellular anabolic/catabolic metabolism. Adaptation of a redox-sensitive cysteinyl thiol in PTEN for signal transduction by hydrogen peroxide may have superimposed a vulnerability to other mediators of oxidative stress and inflammation, especially reactive carbonyl species, which are commonly ... Read more >>

PLoS One (PloS one)
[2010, 5(10):e13545]

Cited: 42 times

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JS-K, a nitric oxide prodrug, has enhanced cytotoxicity in colon cancer cells with knockdown of thioredoxin reductase 1.

Kornelia Edes, Pamela Cassidy, Paul J Shami, Philip J Moos,

The selenoenzyme thioredoxin reductase 1 has a complex role relating to cell growth. It is induced as a component of the cellular response to potentially mutagenic oxidants, but also appears to provide growth advantages to transformed cells by inhibiting apoptosis. In addition, selenocysteine-deficient or alkylated forms of thioredoxin reductase 1 ... Read more >>

PLoS One (PloS one)
[2010, 5(1):e8786]

Cited: 5 times

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Oxidation of 2-Cys-peroxiredoxins by arachidonic acid peroxide metabolites of lipoxygenases and cyclooxygenase-2.

Pauline Cordray, Kelly Doyle, Kornelia Edes, Philip J Moos, Frank A Fitzpatrick,

Human peroxiredoxins serve dual roles as anti-oxidants and regulators of H(2)O(2)-mediated cell signaling. The functional versatility of peroxiredoxins depends on progressive oxidation of key cysteine residues. The sulfinic or sulfonic forms of peroxiredoxin lose their peroxidase activity, which allows cells to accumulate H(2)O(2) for signaling or pathogenesis in inflammation, cancer, ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2007, 282(45):32623-32629]

Cited: 21 times

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Thioredoxin reductase is required for the inactivation of tumor suppressor p53 and for apoptosis induced by endogenous electrophiles.

Pamela B Cassidy, Kornelia Edes, Chad C Nelson, Krishna Parsawar, F A Fitzpatrick, Philip J Moos,

Previous studies demonstrate that the covalent modification of thioredoxin reductase (TrxR) by both endogenous and exogenous electrophiles results in disruption of the conformation of the tumor suppressor protein p53. Here we report that the loss of normal cellular TrxR enzymatic activity by electrophilic modification or deletion of the C-terminal catalytic ... Read more >>

Carcinogenesis (Carcinogenesis)
[2006, 27(12):2538-2549]

Cited: 56 times

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Curcumin impairs tumor suppressor p53 function in colon cancer cells.

Philip J Moos, Kornelia Edes, James E Mullally, Frank A Fitzpatrick,

Curcumin (diferuloylmethane) is being considered as a potential chemopreventive agent in humans. In vitro it inhibits transcription by NF-kappaB, and the activity of lipoxygenase or cyclooxygenase enzymes, which facilitate tumor progression. In vivo it is protective in rodent models of chemical carcinogenesis. Curcumin contains an alpha,beta-unsaturated ketone, a reactive chemical ... Read more >>

Carcinogenesis (Carcinogenesis)
[2004, 25(9):1611-1617]

Cited: 60 times

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Electrophilic prostaglandins and lipid aldehydes repress redox-sensitive transcription factors p53 and hypoxia-inducible factor by impairing the selenoprotein thioredoxin reductase.

Philip J Moos, Kornelia Edes, Pamela Cassidy, Edmond Massuda, F A Fitzpatrick,

Tumor suppressor p53 exhibits an enigmatic phenotype in cells exposed to electrophilic, cyclopentenone prostaglandins of the A and J series. Namely, cells harboring a wild-type p53 gene accumulate p53 protein that is conformationally and functionally impaired. This occurs via an unknown molecular mechanism. We report that electrophilic cyclopentenone prostaglandins covalently ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2003, 278(2):745-750]

Cited: 93 times

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