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Author Kok Yong Chin

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Can telomere length predict bone health? A review of current evidence.

Sok Kuan Wong, Soelaiman Ima-Nirwana, Kok-Yong Chin,

Telomeres are repetitive DNA sequences located at the end of chromosomes that serve as a protective barrier against chromosomal deterioration during cell division. Approximately 50-200 base pairs of nucleotides are lost per cell division, and new repetitive nucleotides are added by the enzyme telomerase, allowing telomere maintenance. Telomere shortening has ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):423-429]

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A Review on the Role of Denosumab in Fracture Prevention.

Kok-Lun Pang, Nie Yen Low, Kok-Yong Chin,

Denosumab is a receptor activator of nuclear factor kappa-Β ligand inhibitor, which suppresses the bone resorption process to preserve bone mass. It is usually recommended to postmenopausal women and men with high fracture risk. With the recent publication of the results from FREEDOM study and its extension, the long-term effect ... Read more >>

Drug Des Devel Ther (Drug design, development and therapy)
[2020, 14:4029-4051]

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Barriers towards Sun Exposure and Strategies to Overcome These Barriers in Female Indoor Workers with Insufficient Vitamin D: A Qualitative Approach.

Nurul Nadiah Shahudin, Mohd Jamil Sameeha, Arimi Fitri Mat Ludin, Zahara Abdul Manaf, Kok-Yong Chin, Nor Aini Jamil,

The prevalence of vitamin D insufficiency is significant even in tropical countries such as Malaysia. Sun exposure is the primary source of vitamin D for most people due to limited intakes of food containing vitamin D and supplements. This study explored the perception of barriers towards sun exposure and strategies ... Read more >>

Nutrients (Nutrients)
[2020, 12(10):]

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Positive association between metabolic syndrome and bone mineral density among Malaysians.

Kok-Yong Chin, Chin Yi Chan, Shaanthana Subramaniam, Norliza Muhammad, Ahmad Fairus, Pei Yuen Ng, Nor Aini Jamil, Noorazah Abd Aziz, Soelaiman Ima-Nirwana, Norazlina Mohamed,

Objectives: Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that elevates the individual risk of cardiovascular diseases. These abnormalities are also known to alter bone remodelling. Therefore, MetS may be associated with osteoporosis. This study aims to determine the association between MetS and its components and bone mineral density ... Read more >>

Int J Med Sci (International journal of medical sciences)
[2020, 17(16):2585-2593]

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Prevalence and factors of T-score discordance between hip and spine among middle-aged and elderly Malaysians.

Chin Yi Chan, Shaanthana Subramaniam, Norazlina Mohamed, Soelaiman Ima-Nirwana, Norliza Muhammad, Ahmad Fairus, Pei Yuen Ng, Nor Aini Jamil, Noorazah Abd Aziz, Kok-Yong Chin,

T-score discordance between hip and spine is a common problem in the diagnosis of osteoporosis based on dual-energy X-ray absorptiometry. Not much information on the prevalence and risk factors of this problem is available in Malaysia. Our study found that factors like age, height, physical activity and menopausal status should ... Read more >>

Arch Osteoporos (Archives of osteoporosis)
[2020, 15(1):142]

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Skeletal Effects of Early-Life Exposure to Soy Isoflavones-A Review of Evidence From Rodent Models.

Kok-Yong Chin, Kok-Lun Pang,

Isoflavones are dietary phytoestrogens commonly found in soy-based products. The widespread presence of isoflavones in soy infant formula and breast milk may have long-lasting effects on the development of sex hormone-sensitive organs like the skeleton. Animal early-life programming models are suitable for testing the skeletal effects of pre- and neonatal ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:563]

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Natural 3D-Printed Bioinks for Skin Regeneration and Wound Healing: A Systematic Review.

Ali Smandri, Abid Nordin, Ng Min Hwei, Kok-Yong Chin, Izhar Abd Aziz, Mh Busra Fauzi,

Three-dimensional bioprinting has rapidly paralleled many biomedical applications and assisted in advancing the printing of complex human organs for a better therapeutic practice. The objective of this systematic review is to highlight evidence from the existing studies and evaluate the effectiveness of using natural-based bioinks in skin regeneration and wound ... Read more >>

Polymers (Basel) (Polymers)
[2020, 12(8):]

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Biochemical and histopathological assessment of liver in a rat model of metabolic syndrome induced by high-carbohydrate high-fat diet.

Sok Kuan Wong, Kok-Yong Chin, Fairus Ahmad, Soelaiman Ima-Nirwana,

This study aimed to evaluate the oxidative stress status, antioxidants capacity, and presence of nonalcoholic fatty liver disease (NAFLD) in an animal model of MetS induced by high-carbohydrate high-fat (HCHF) diet. Male Wistar rats were randomized into two groups, assigned for two different types of diet (standard rat pellet or ... Read more >>

J. Food Biochem. (Journal of food biochemistry)
[2020, :e13371]

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Effects of astaxanthin on the protection of muscle health (Review).

Sok Kuan Wong, Soelaiman Ima-Nirwana, Kok-Yong Chin,

Sarcopenia refers to the involuntary and generalized deterioration of skeletal muscle mass and strength, which may lead to falls, frailty, physical disability, loss of independence, morbidity and mortality. The majority of molecular and cellular changes involved in the degeneration of muscle tissues are mediated by oxidative stress. Therefore, astaxanthin may ... Read more >>

Exp Ther Med (Experimental and therapeutic medicine)
[2020, 20(4):2941-2952]

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Effects of Calcium and Annatto Tocotrienol Supplementation on Bone Loss Induced by Pantoprazole in Male Rats.

Kok-Yong Chin, Benjamin Ka Seng Thong, Rhivaldy Faahim Kamalulloh, Nur Vaizura Mohamad, Sok Kuan Wong, Azlan Mohd Arlamsyah, Rahma Triliana, Ima Nirwana Soelaiman,

Purpose:Prolonged use of proton pump inhibitors may cause bone loss, and limited therapeutic agents are available to prevent this skeletal side effect. The combination of annatto tocotrienol, a bone anabolic agent, with calcium presents a novel strategy to prevent bone loss caused by proton pump inhibitors. This study aims to ... Read more >>

Drug Des Devel Ther (Drug design, development and therapy)
[2020, 14:2561-2572]

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Vitamin C: A Review on its Role in the Management of Metabolic Syndrome.

Sok Kuan Wong, Kok-Yong Chin, Soelaiman Ima-Nirwana,

Oxidative stress and inflammation are two interlinked events that exist simultaneously in metabolic syndrome (MetS) and its related complications. These pathophysiological processes can be easily triggered by each other. This review summarizes the current evidence from animal and human studies on the effects of vitamin C in managing MetS. In ... Read more >>

Int J Med Sci (International journal of medical sciences)
[2020, 17(11):1625-1638]

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Are Oxidative Stress and Inflammation Mediators of Bone Loss due to Estrogen Deficiency? A Review of Current Evidence.

Nur-Vaizura Mohamad, Ima Nirwana Soelaiman, Kok-Yong Chin,

Osteoporosis is one of the major health issues associated with menopause-related estrogen deficiency. Various reports suggest that the hormonal changes related to menopausal transition may lead to derangement of redox homeostasis and ultimately oxidative stress. Estrogen deficiency and oxidative stress may enhance the expression of genes involved in inflammation. All ... Read more >>

Endocr Metab Immune Disord Drug Targets (Endocrine, metabolic & immune disorders drug targets)
[2020, :]

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Is First Trimester Maternal 25-Hydroxyvitamin D Level Related to Adverse Maternal and Neonatal Pregnancy Outcomes? A Prospective Cohort Study among Malaysian Women.

Nor Haslinda Abd Aziz, Noor Azyani Yazid, Rahana Abd Rahman, Norhashima Abd Rashid, Sok Kuan Wong, Nur Vaizura Mohamad, Pei Shan Lim, Kok-Yong Chin,

Information on the role of 25-hydroxyvitamin D (25(OH)D) in preventing adverse pregnancy/neonatal outcomes is limited in Malaysia. This study aims to determine the relationship between the level of maternal 25(OH)D in the first trimester of pregnant women and their pregnancy/neonatal outcomes. A total of 60 pregnant women in the first ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(9):]

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Development of Osteoporosis Screening Algorithm for Population Aged 50 Years and above in Klang Valley, Malaysia.

Shaanthana Subramaniam, Chin-Yi Chan, Ima-Nirwana Soelaiman, Norazlina Mohamed, Norliza Muhammad, Fairus Ahmad, Pei-Yuen Ng, Nor Aini Jamil, Noorazah Abd Aziz, Kok-Yong Chin,

Background: The current osteoporosis screening instruments are not optimized to be used among the Malaysian population. This study aimed to develop an osteoporosis screening algorithm based on risk factors for Malaysians. Methods: Malaysians aged ≥50 years (n = 607) from Klang Valley, Malaysia were interviewed and their bone health status ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(7):]

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The Performance of a Calcaneal Quantitative Ultrasound Device, CM-200, in Stratifying Osteoporosis Risk among Malaysian Population Aged 40 Years and Above.

Shaanthana Subramaniam, Chin-Yi Chan, Ima Nirwana Soelaiman, Norazlina Mohamed, Norliza Muhammad, Fairus Ahmad, Pei-Yuen Ng, Nor Aini Jamil, Noorazah Abd Aziz, Kok-Yong Chin,

BACKGROUND:Calcaneal quantitative ultrasound (QUS) is widely used in osteoporosis screening, but the cut-off values for risk stratification remain unclear. This study validates the performance of a calcaneal QUS device (CM-200) using dual-energy X-ray absorptiometry (DXA) as the reference and establishes a new set of cut-off values for CM-200 in identifying ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2020, 10(4):]

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The Role of Inflammation in the Pathogenesis of Osteoarthritis.

Yoke Yue Chow, Kok-Yong Chin,

A joint is the point of connection between two bones in our body. Inflammation of the joint leads to several diseases, including osteoarthritis, which is the concern of this review. Osteoarthritis is a common chronic debilitating joint disease mainly affecting the elderly. Several studies showed that inflammation triggered by factors ... Read more >>

Mediators Inflamm. (Mediators of inflammation)
[2020, 2020:8293921]

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Annatto-Derived Tocotrienol Promotes Mineralization of MC3T3-E1 Cells by Enhancing BMP-2 Protein Expression via Inhibiting RhoA Activation and HMG-CoA Reductase Gene Expression.

Wan Nuraini Wan Hasan, Kok-Yong Chin, Norzana Abd Ghafar, Ima Nirwana Soelaiman,

Purpose:Annatto-derived tocotrienol (AnTT) has been shown to improve bone formation in animal models of osteoporosis and promote differentiation of pre-osteoblastic cells. However, the mechanism of action of AnTT in achieving these effects is unclear. This study aims to investigate the mechanism of action of AnTT on MC3T3-E1 pre-osteoblasts via the ... Read more >>

Drug Des Devel Ther (Drug design, development and therapy)
[2020, 14:969-976]

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A Review of the Potential Application of Osteocyte-Related Biomarkers, Fibroblast Growth Factor-23, Sclerostin, and Dickkopf-1 in Predicting Osteoporosis and Fractures.

Fitri Fareez Ramli, Kok-Yong Chin,

Bone turnover markers (BTMs) derived from the secretory activities of osteoblasts and the matrix-degrading activities of osteoclasts are useful in monitoring the progression of osteoporosis and the efficacy of anti-osteoporotic treatment. However, the usefulness of BTMs in predicting osteoporosis remains elusive. Osteocytes play a central role in regulating bone formation ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2020, 10(3):]

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Nutritional and bone health status in young men with mild-to-moderate intellectual disability and without intellectual disability residing in community setting in Malaysia.

Nor Aini Jamil, Chang Jia Ling, Hawa Izzati Md Ibrahim, Nur Hana Hamzaid, Chin Kok Yong,

BACKGROUND:This study aimed to compare the nutritional and bone health status between young men with mild-to-moderate intellectual disability and those without intellectual disability and to determine predictors for their bone health status. METHOD:A total of 95 men (47 men with intellectual disability; 48 men without intellectual disability), aged 20-39 years, participated ... Read more >>

J Appl Res Intellect Disabil (Journal of applied research in intellectual disabilities : JARID)
[2020, 33(3):632-639]

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Determinants of Bone Health Status in a Multi-Ethnic Population in Klang Valley, Malaysia.

Chin Yi Chan, Shaanthana Subramaniam, Norazlina Mohamed, Soelaiman Ima-Nirwana, Norliza Muhammad, Ahmad Fairus, Pei Yuen Ng, Nor Aini Jamil, Noorazah Abd Aziz, Kok-Yong Chin,

Background and objectives: Studies on osteoporosis risk factors are limited in Malaysia, so this study assesses the factors associated with bone health assessed using dual-energy X-ray absorptiometry (DXA) among Malaysians aged ≥40 years. Subjects and Methods: Data on demography, medical history, dietary and lifestyle practices of 786 Malaysians (51.4% women) ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(2):]

Cited: 1 time

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A Review on the Role of Denosumab in Fracture Prevention

Kok-Lun Pang, Nie Yen Low, Kok-Yong Chin,

Abstract Denosumab is a receptor activator of nuclear factor kappa-Β ligand inhibitor, which suppresses the bone resorption process to preserve bone mass. It is usually recommended to postmenopausal women and men with high fracture risk. With the recent publication of the results from FREEDOM study and its extension, the long-term ... Read more >>

Drug Des Devel Ther (Drug design, development and therapy)
[2020, 14:4029-4051]

Cited: 0 times

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Effects of Calcium and Annatto Tocotrienol Supplementation on Bone Loss Induced by Pantoprazole in Male Rats

Kok-Yong Chin, Benjamin Ka Seng Thong, Rhivaldy Faahim Kamalulloh, Nur Vaizura Mohamad, Sok Kuan Wong, Azlan Mohd Arlamsyah, Rahma Triliana, Ima Nirwana Soelaiman,

Purpose Prolonged use of proton pump inhibitors may cause bone loss, and limited therapeutic agents are available to prevent this skeletal side effect. The combination of annatto tocotrienol, a bone anabolic agent, with calcium presents a novel strategy to prevent bone loss caused by proton pump inhibitors. This study aims ... Read more >>

Drug Des Devel Ther (Drug design, development and therapy)
[2020, 14:2561-2572]

Cited: 0 times

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Skeletal Effects of Early-Life Exposure to Soy Isoflavones—A Review of Evidence From Rodent Models

Kok-Yong Chin, Kok-Lun Pang,

Isoflavones are dietary phytoestrogens commonly found in soy-based products. The widespread presence of isoflavones in soy infant formula and breast milk may have long-lasting effects on the development of sex hormone-sensitive organs like the skeleton. Animal early-life programming models are suitable for testing the skeletal effects of pre- and neonatal ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:]

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The performance of osteoporosis self-assessment tool for Asians (OSTA) in identifying the risk of osteoporosis among Malaysian population aged 40 years and above.

Shaanthana Subramaniam, Chin-Yi Chan, Ima-Nirwana Soelaiman, Norazlina Mohamed, Norliza Muhammad, Fairus Ahmad, Pei-Yuen Ng, Nor Aini Jamil, Noorazah Abd Aziz, Kok-Yong Chin,

The concordance between osteoporosis self-assessment tool for Asians (OSTA) and dual-energy X-ray absorptiometry (DXA) was fair in the study. Modification of OSTA cutoff values improved its sensitivity to identify subjects at risk for suboptimal bone health (osteopenia/osteoporosis) and osteoporosis. PURPOSE:Osteoporosis self-assessment tool for Asians (OSTA) is a convenient screening algorithm used ... Read more >>

Arch Osteoporos (Archives of osteoporosis)
[2019, 14(1):117]

Cited: 2 times

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Knowledge, Attitude and Practice Related to Vitamin D and Its Relationship with Vitamin D Status among Malay Female Office Workers.

Nor Aini Jamil, Nurul Nadiah Shahudin, Nur Surfina Abdul Aziz, Chew Jia Qi, Wan Az Aleesa Wan Aminuddin, Arimi Fitri Mat Ludin, Kok-Yong Chin, Zahara Abd Manaf, Norlida Mat Daud,

This study assessed knowledge, attitude and practice (KAP) related to vitamin D and its relationship with vitamin D status among Malay female office workers. A total of 147 women aged between 20 and 55 years were recruited from a university in Kuala Lumpur. They answered questionnaires related to KAP on ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2019, 16(23):]

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