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Author Koen Demyttenaere

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Vagus nerve stimulation as adjunctive therapy in patients with difficult-to-treat depression (RESTORE-LIFE): study protocol design and rationale of a real-world post-market study.

Allan H Young, Mario F Juruena, Renske De Zwaef, Koen Demyttenaere,

BACKGROUND:Depressive illness is associated with significant adverse consequences for patients and their families, and for society. Clinical challenges are encountered in the management of patients suffering from depression whether they are designated difficult-to-treat or treatment-resistant. Prospective serial depression treatment trials have shown that less than 40% of patients with major ... Read more >>

BMC Psychiatry (BMC psychiatry)
[2020, 20(1):471]

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How to improve adherence to antidepressant treatments in patients with major depression: a psychoeducational consensus checklist.

Bernardo Dell'Osso, Umberto Albert, Giuseppe Carrà, Maurizio Pompili, Maria Giulia Nanni, Massimo Pasquini, Nicola Poloni, Andrea Raballo, Fabio Sambataro, Gianluca Serafini, Caterina Viganò, Koen Demyttenaere, Roger S McIntyre, Andrea Fiorillo,

Studies conducted in primary care as well as in psychiatric settings show that more than half of patients suffering from major depressive disorder (MDD) have poor adherence to antidepressants. Patients prematurely discontinue antidepressant therapy for various reasons, including patient-related (e.g., misperceptions about antidepressants, side-effects, and lack of tolerability), clinician-related (e.g., ... Read more >>

Ann Gen Psychiatry (Annals of general psychiatry)
[2020, 19:61]

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Trends in (not) using scales in major depression: A categorization and clinical orientation.

Koen Demyttenaere, Liesbeth Jaspers,

BACKGROUND:Standard depression rating scales like the Hamilton Depression Rating Scale and the Montgomery-Åsberg Depression Rating Scale were developed more than 40 years ago. They are mandatory in clinical trials but are for a variety of reasons seldom used in clinical practice. Moreover, most clinicians are less familiar with more recent trends ... Read more >>

Eur Psychiatry (European psychiatry : the journal of the Association of European Psychiatrists)
[2020, 63(1):e91]

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Anhedonia in Depressive Disorder: A Narrative Review.

Jürgen De Fruyt, Bernard Sabbe, Koen Demyttenaere,

Since the introduction of DSM-III anhedonia has become a core depressive criterion and is defined as the loss of interest or pleasure. Although the origin of the word goes back to the end of the 19th century and numerous anhedonic symptoms are described in classic texts on depression, this centrality ... Read more >>

Psychopathology (Psychopathology)
[2020, :1-8]

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What Has Neuroimaging Taught Us on the Neurobiology of Yoga? A Review.

June van Aalst, Jenny Ceccarini, Koen Demyttenaere, Stefan Sunaert, Koen Van Laere,

Yoga is becoming increasingly popular worldwide, with several implicated physical and mental benefits. Here we provide a comprehensive and critical review of the research generated from the existing neuroimaging literature in studies of yoga practitioners. We reviewed 34 international peer-reviewed neuroimaging studies of yoga using magnetic resonance imaging (MRI), positron ... Read more >>

Front Integr Neurosci (Frontiers in integrative neuroscience)
[2020, 14:34]

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Outcome in depression (II): beyond the Hamilton Depression Rating Scale.

Koen Demyttenaere, Glenn Kiekens, Ronny Bruffaerts, Philippe Mortier, Philip Gorwood, Lorcan Martin, Massimo Di Giannantonio,

BACKGROUND.:The Leuven Affect and Pleasure Scale (LAPS) was developed as an outcome measure in major depressive disorder (MDD) tha treflects patient treatment expectations. The present report investigates whether the LAPS negative affect, the LAPS positive affect, and the LAPS hedonic tone have added value on top of the Hamilton Depression ... Read more >>

CNS Spectr (CNS spectrums)
[2020, :1-5]

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Outcome in depression (I): why symptomatic remission is not good enough.

Koen Demyttenaere, Glenn Kiekens, Ronny Bruffaerts, Philippe Mortier, Philip Gorwood, Lorcan Martin, Massimo Di Giannantonio,

BACKGROUND.:The Leuven Affect and Pleasure Scale (LAPS) is a depression outcome measure aiming to better reflect patient treatment expectations. We investigated the evolution of the LAPS and some comparator scales during antidepressant treatment and compared scores of remitters with scores of healthy controls.Methods. A total of 109 outpatients with Diagnostic ... Read more >>

CNS Spectr (CNS spectrums)
[2020, :1-7]

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Long-term Ashtanga yoga practice decreases medial temporal and brainstem glucose metabolism in relation to years of experience.

June van Aalst, Jenny Ceccarini, Georg Schramm, Donatienne Van Weehaeghe, Ahmadreza Rezaei, Koen Demyttenaere, Stefan Sunaert, Koen Van Laere,

BACKGROUND:Yoga is increasingly popular worldwide with several physical and mental benefits, but the underlying neurobiology remains unclear. Whereas many studies have focused on pure meditational aspects, the triad of yoga includes meditation, postures, and breathing. We conducted a cross-sectional study comparing experienced yoga practitioners to yoga-naive healthy subjects using a ... Read more >>

EJNMMI Res (EJNMMI research)
[2020, 10(1):50]

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The blurred line between anxiety and depression: hesitations on comorbidity, thresholds and hierarchy.

Koen Demyttenaere, Elke Heirman,

The delineation of anxiety and depression as well as the relation between anxiety and depression are still subject of debate. Many patients suffering from depression also suffer from anxiety, and many patients with anxiety suffer or will suffer from depression. The co-occurrence or co-morbidity is higher than what could be ... Read more >>

Int Rev Psychiatry (International review of psychiatry (Abingdon, England))
[2020, 32(5-6):455-465]

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How to improve adherence to antidepressant treatments in patients with major depression: a psychoeducational consensus checklist

Bernardo Dell’Osso, Umberto Albert, Giuseppe Carrà, Maurizio Pompili, Maria Giulia Nanni, Massimo Pasquini, Nicola Poloni, Andrea Raballo, Fabio Sambataro, Gianluca Serafini, Caterina Viganò, Koen Demyttenaere, Roger S. McIntyre, Andrea Fiorillo,

Studies conducted in primary care as well as in psychiatric settings show that more than half of patients suffering from major depressive disorder (MDD) have poor adherence to antidepressants. Patients prematurely discontinue antidepressant therapy for various reasons, including patient-related (e.g., misperceptions about antidepressants, side-effects, and lack of tolerability), clinician-related (e.g., ... Read more >>

Ann Gen Psychiatry (Annals of general psychiatry)
[2020, 19:]

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Binge eating and purging in first-year college students: Prevalence, psychiatric comorbidity, and academic performance.

Riccardo Serra, Glenn Kiekens, Johan Vanderlinden, Elske Vrieze, Randy P Auerbach, Corina Benjet, Laurence Claes, Pim Cuijpers, Koen Demyttenaere, David D Ebert, Lorenzo Tarsitani, Jennifer Greif Green, Ronald C Kessler, Matthew K Nock, Phillippe Mortier, Ronny Bruffaerts,

BACKGROUND:Binge eating and purging behaviors (BPB) are common among college students, but evidence is scant on prevalence and associations of BPB with mental health problems and objective academic performance. This study aims to investigate: (a) 12-month prevalence of BPB among college first-year students, (b) comorbidity patterns of BPB with various ... Read more >>

Int J Eat Disord (The International journal of eating disorders)
[2020, 53(3):339-348]

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Vagus nerve stimulation as adjunctive therapy in patients with difficult-to-treat depression (RESTORE-LIFE): study protocol design and rationale of a real-world post-market study

Allan H. Young, Mario F. Juruena, Renske De Zwaef, Koen Demyttenaere,

Background Depressive illness is associated with significant adverse consequences for patients and their families, and for society. Clinical challenges are encountered in the management of patients suffering from depression whether they are designated difficult-to-treat or treatment-resistant. Prospective serial depression treatment trials have shown that less than 40% of patients with ... Read more >>

BMC Psychiatry (BMC psychiatry)
[2020, 20(1):]

Cited: 0 times

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What is treatment resistance in psychiatry? A "difficult to treat" concept.

Koen Demyttenaere,

(World psychiatry : official journal of the World Psychiatric Association (WPA))
[2019, 18(3):354-355]

Cited: 1 time

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Integrating Patients' Expectations into the Management of Their Depression: Report of a Symposium at the European College of Neuropsychopharmacology Congress.

Koen Demyttenaere, Ellen Frank, David Castle, Elif Cindik-Herbrüggen,

A symposium held at the 31st European College of Neuropsychopharmacology congress in October 2018 in Barcelona, Spain discussed patients' expectations of treatment of their depression and how these can be integrated into patient management. Since treatment non-compliance is a major problem in patients suffering from depression, it is important to ... Read more >>

Adv Ther (Advances in therapy)
[2019, 36(Suppl 3):73-90]

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Association of Cohort and Individual Substance Use With Risk of Transitioning to Drug Use, Drug Use Disorder, and Remission From Disorder: Findings From the World Mental Health Surveys.

Louisa Degenhardt, Chrianna Bharat, Meyer D Glantz, Nancy A Sampson, Ali Al-Hamzawi, Jordi Alonso, Laura H Andrade, Brendan Bunting, Alfredo Cia, Giovanni de Girolamo, Peter De Jonge, Koen Demyttenaere, Oye Gureje, Josep Maria Haro, Meredith G Harris, Yanling He, Hristo Hinkov, Aimee Nasser Karam, Elie G Karam, Andrzej Kiejna, Viviane Kovess-Masfety, Victor Lasebikan, Sing Lee, Daphna Levinson, Maria Elena Medina-Mora, Zeina Mneimneh, Fernando Navarro-Mateu, Marina Piazza, José Posada-Villa, Kate Scott, Dan J Stein, Hisateru Tachimori, Nathan Tintle, Yolanda Torres, Ronald C Kessler, ,

Importance:Limited empirical research has examined the extent to which cohort-level prevalence of substance use is associated with the onset of drug use and transitioning into greater involvement with drug use. Objective:To use cross-national data to examine time-space variation in cohort-level drug use to assess its associations with onset and transitions ... Read more >>

JAMA Psychiatry (JAMA psychiatry)
[2019, 76(7):708-720]

Cited: 2 times

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Medication-Induced Akathisia with Newly Approved Antipsychotics in Patients with a Severe Mental Illness: A Systematic Review and Meta-Analysis.

Koen Demyttenaere, Johan Detraux, Giorgio Racagni, Kristof Vansteelandt,

BACKGROUND:Akathisia is a common and distressing movement disorder that can be associated with the use of antipsychotics. It is characterized by a subjective (inner restlessness) and an objective (excessive movements) component. Akathisia can have a negative impact on clinical outcome and even lead to treatment discontinuation. Although medication-induced akathisia is ... Read more >>

CNS Drugs (CNS drugs)
[2019, 33(6):549-566]

Cited: 1 time

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Childhood generalized specific phobia as an early marker of internalizing psychopathology across the lifespan: results from the World Mental Health Surveys.

Ymkje Anna de Vries, Ali Al-Hamzawi, Jordi Alonso, Guilherme Borges, Ronny Bruffaerts, Brendan Bunting, José Miguel Caldas-de-Almeida, Alfredo H Cia, Giovanni De Girolamo, Rumyana V Dinolova, Oluyomi Esan, Silvia Florescu, Oye Gureje, Josep Maria Haro, Chiyi Hu, Elie G Karam, Aimee Karam, Norito Kawakami, Andrzej Kiejna, Viviane Kovess-Masfety, Sing Lee, Zeina Mneimneh, Fernando Navarro-Mateu, Marina Piazza, Kate Scott, Margreet Ten Have, Yolanda Torres, Maria Carmen Viana, Ronald C Kessler, Peter de Jonge, ,

BACKGROUND:Specific phobia (SP) is a relatively common disorder associated with high levels of psychiatric comorbidity. Because of its early onset, SP may be a useful early marker of internalizing psychopathology, especially if generalized to multiple situations. This study aimed to evaluate the association of childhood generalized SP with comorbid internalizing ... Read more >>

BMC Med (BMC medicine)
[2019, 17(1):101]

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Pre-marital predictors of marital violence in the WHO World Mental Health (WMH) Surveys.

Cara M Stokes, Jordi Alonso, Laura Helena Andrade, Lukoye Atwoli, Graça Cardoso, Wai Tat Chiu, Rumyana V Dinolova, Oye Gureje, Aimee N Karam, Elie G Karam, Ronald C Kessler, Somnath Chatterji, Andrew King, Sing Lee, Zeina Mneimneh, Bibilola D Oladeji, Maria Petukhova, Charlene Rapsey, Nancy A Sampson, Kate Scott, Amy Street, Maria Carmen Viana, Michelle A Williams, Robert M Bossarte, ,

PURPOSE:Intimate partner violence (IPV) is a pervasive public health problem. Existing research has focused on reports from victims and few studies have considered pre-marital factors. The main objective of this study was to identify pre-marital predictors of IPV in the current marriage using information obtained from husbands and wives. METHODS:Data ... Read more >>

Soc Psychiatry Psychiatr Epidemiol (Social psychiatry and psychiatric epidemiology)
[2020, 55(3):393-405]

Cited: 1 time

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Suicidal thoughts and behaviors among college students and same-aged peers: results from the World Health Organization World Mental Health Surveys.

Philippe Mortier, Randy P Auerbach, Jordi Alonso, William G Axinn, Pim Cuijpers, David D Ebert, Jennifer G Green, Irving Hwang, Ronald C Kessler, Howard Liu, Matthew K Nock, Stephanie Pinder-Amaker, Nancy A Sampson, Alan M Zaslavsky, Jibril Abdulmalik, Sergio Aguilar-Gaxiola, Ali Al-Hamzawi, Corina Benjet, Koen Demyttenaere, Silvia Florescu, Giovanni De Girolamo, Oye Gureje, Josep Maria Haro, Chiyi Hu, Yueqin Huang, Peter De Jonge, Elie G Karam, Andrzej Kiejna, Viviane Kovess-Masfety, Sing Lee, John J Mcgrath, Siobhan O'neill, Vladimir Nakov, Beth-Ellen Pennell, Marina Piazza, José Posada-Villa, Charlene Rapsey, Maria Carmen Viana, Miguel Xavier, Ronny Bruffaerts,

PURPOSE:The primary aims are to (1) obtain representative prevalence estimates of suicidal thoughts and behaviors (STB) among college students worldwide and (2) investigate whether STB is related to matriculation to and attrition from college. METHODS:Data from the WHO World Mental Health Surveys were analyzed, which include face-to-face interviews with 5750 ... Read more >>

Soc Psychiatry Psychiatr Epidemiol (Social psychiatry and psychiatric epidemiology)
[2018, 53(3):279-288]

Cited: 8 times

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A comparison of DSM-5 and DSM-IV agoraphobia in the World Mental Health Surveys.

Annelieke M Roest, Ymkje Anna de Vries, Carmen C W Lim, Hans-Ulrich Wittchen, Dan J Stein, Tomasz Adamowski, Ali Al-Hamzawi, Evelyn J Bromet, Maria Carmen Viana, Giovanni de Girolamo, Koen Demyttenaere, Silvia Florescu, Oye Gureje, Josep Maria Haro, Chiyi Hu, Elie G Karam, José Miguel Caldas-de-Almeida, Norito Kawakami, Jean Pierre Lépine, Daphna Levinson, Maria E Medina-Mora, Fernando Navarro-Mateu, Siobhan O'Neill, Marina Piazza, José A Posada-Villa, Tim Slade, Yolanda Torres, Ronald C Kessler, Kate M Scott, Peter de Jonge, ,

BACKGROUND:The Diagnostic and Statistical Manual of Mental Disorders, version 5 (DSM-5) definition of agoraphobia (AG) as an independent diagnostic entity makes it timely to re-examine the epidemiology of AG. Study objective was to present representative data on the characteristics of individuals who meet DSM-IV criteria for AG (AG without a ... Read more >>

Depress Anxiety (Depression and anxiety)
[2019, 36(6):499-510]

Cited: 1 time

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Studying treatment-effect heterogeneity in precision medicine through induced subgroups.

Aniek Sies, Koen Demyttenaere, Iven Van Mechelen,

Precision medicine, in the sense of tailoring the choice of medical treatment to patients' pretreatment characteristics, is nowadays gaining a lot of attention. Preferably, this tailoring should be realized in an evidence-based way, with key evidence in this regard pertaining to subgroups of patients that respond differentially to treatment (i.e., ... Read more >>

J Biopharm Stat (Journal of biopharmaceutical statistics)
[2019, 29(3):491-507]

Cited: 0 times

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The Impact of (the Concept of) Treatment-Resistant Depression: An Opinion Review.

Koen Demyttenaere, Zeno Van Duppen,

Treatment-resistant depression refers to major depressive disorder, treatment of the disorder, and failure to obtain an "acceptable" outcome. Regarding the disorder, the heterogeneous concept of major depressive disorder and the multiple definitions of treatment-resistant depression, hesitating between a categorical and a more dimensional approach, as well as the divergence between ... Read more >>

Int. J. Neuropsychopharmacol. (The international journal of neuropsychopharmacology)
[2019, 22(2):85-92]

Cited: 1 time

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Mental health problems in college freshmen: Prevalence and academic functioning.

Ronny Bruffaerts, Philippe Mortier, Glenn Kiekens, Randy P Auerbach, Pim Cuijpers, Koen Demyttenaere, Jennifer G Green, Matthew K Nock, Ronald C Kessler,

BACKGROUND:Mental health problems in college and their associations with academic performance are not well understood. The main aim of this study was to investigate to what extent mental health problems are associated with academic functioning. METHODS:As part of the World Mental Health Surveys International College Student project, 12-month mental health ... Read more >>

J Affect Disord (Journal of affective disorders)
[2018, 225:97-103]

Cited: 44 times

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Lifetime and 12-month treatment for mental disorders and suicidal thoughts and behaviors among first year college students.

Ronny Bruffaerts, Philippe Mortier, Randy P Auerbach, Jordi Alonso, Alicia E Hermosillo De la Torre, Pim Cuijpers, Koen Demyttenaere, David D Ebert, Jennifer Greif Green, Penelope Hasking, Dan J Stein, Edel Ennis, Matthew K Nock, Stephanie Pinder-Amaker, Nancy A Sampson, Gemma Vilagut, Alan M Zaslavsky, Ronald C Kessler, ,

OBJECTIVES:Mental disorders and suicidal thoughts and behaviors (STB) are common and burdensome among college students. Although available evidence suggests that only a small proportion of the students with these conditions receive treatment, broad-based data on patterns of treatment are lacking. The aim of this study is to examine the receipt ... Read more >>

Int J Methods Psychiatr Res (International journal of methods in psychiatric research)
[2019, 28(2):e1764]

Cited: 7 times

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Mental disorder comorbidity and suicidal thoughts and behaviors in the World Health Organization World Mental Health Surveys International College Student initiative.

Randy P Auerbach, Philippe Mortier, Ronny Bruffaerts, Jordi Alonso, Corina Benjet, Pim Cuijpers, Koen Demyttenaere, David D Ebert, Jennifer Greif Green, Penelope Hasking, Sue Lee, Christine Lochner, Margaret McLafferty, Matthew K Nock, Maria V Petukhova, Stephanie Pinder-Amaker, Anthony J Rosellini, Nancy A Sampson, Gemma Vilagut, Alan M Zaslavsky, Ronald C Kessler, ,

OBJECTIVES:Comorbidity is a common feature of mental disorders. However, needs assessment surveys focus largely on individual disorders rather than on comorbidity even though the latter is more important for predicting suicidal thoughts and behaviors. In the current report, we take a step beyond this conventional approach by presenting data on ... Read more >>

Int J Methods Psychiatr Res (International journal of methods in psychiatric research)
[2019, 28(2):e1752]

Cited: 7 times

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