Full Text Journal Articles by
Author Klaus Remberger

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Failed cartilage repair for early osteoarthritis defects: a biochemical, histological and immunohistochemical analysis of the repair tissue after treatment with marrow-stimulation techniques.

Gunter Kaul, Magali Cucchiarini, Klaus Remberger, Dieter Kohn, Henning Madry,

<h4>Purpose</h4>To examine the entire repair tissue resulting from marrow-stimulation techniques in patients with early osteoarthritis.<h4>Methods</h4>The repair tissue and adjacent articular cartilage after failed marrow-stimulation techniques (microfracture and Pridie drilling) of 5 patients (47-65 years old) with cartilage defects and radiographic early osteoarthritis (Kellgren-Lawrence grading 1 and 2) was removed during total ... Read more >>

Knee Surg Sports Traumatol Arthrosc (Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA)
[2012, 20(11):2315-2324]

Cited: 46 times

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Genomic alterations and allelic imbalances are strong prognostic predictors in osteosarcoma.

Jan Smida, Daniel Baumhoer, Michael Rosemann, Axel Walch, Stefan Bielack, Christopher Poremba, Klaus Remberger, Eberhard Korsching, Wolfram Scheurlen, Christian Dierkes, Stefan Burdach, Gernot Jundt, Michael J Atkinson, Michaela Nathrath,

<h4>Purpose</h4>Osteosarcoma, the most common primary malignant tumor of the bone, is characterized by complex karyotypes with numerous structural and numerical alterations. Despite attempts to establish molecular prognostic markers at the time of diagnosis, the most accepted predictive factor remains the histologic evaluation of necrosis after neoadjuvant chemotherapy. The present approach ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2010, 16(16):4256-4267]

Cited: 58 times

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Prenatal diagnosis of congenital mesoblastic nephroma associated with renal hypertension in a premature child.

Stefan Siemer, Jan Lehmann, Harald Reinhard, Norbert Graf, Gerhard Löffler, Hand Hendrik, Klaus Remberger, Michael Stöckle,

In the present article, we report, for the first time, a prenatal diagnosis of a congenital mesoblastic nephroma in combination with a post-partum hyperreninemia with hypertension. A newborn was delivered at 35 weeks gestation who had an intrauterine diagnosis of a renal mass as early as 32 weeks gestational age ... Read more >>

Int J Urol (International journal of urology : official journal of the Japanese Urological Association)
[2004, 11(1):50-52]

Cited: 4 times

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Naturally occurring T-cell response against mutated p21 ras oncoprotein in pancreatic cancer.

Boris Kubuschok, Frank Neumann, Rainer Breit, Martina Sester, Claudia Schormann, Claudia Wagner, Urban Sester, Frank Hartmann, Mathias Wagner, Klaus Remberger, Martin Schilling, Michael Pfreundschuh,

Mutated p21 ras proteins (muRas) are present in approximately 90% of pancreatic adenocarcinomas and express mutants which can function as cancer-specific antigens. To evaluate the frequency and magnitude of the natural T-cell response against muRas in 19 HLA-A2-positive patients with muRas-positive pancreatic carcinomas, antigen-experienced T lymphocytes in fresh peripheral blood ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2006, 12(4):1365-1372]

Cited: 35 times

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Increased expression of pro-inflammatory cytokines as a cause of lung toxicity after combined treatment with gemcitabine and thoracic irradiation.

Claudia E Rübe, Falk Wilfert, Daniela Uthe, Jochem König, Li Liu, Andreas Schuck, Normann Willich, Klaus Remberger, Christian Rübe,

<h4>Background and purpose</h4>Preclinical evidence suggesting gemcitabine potentiates the anti-tumor effects of irradiation has resulted in clinical trials to evaluate the treatment efficacy of gemcitabine and concurrent thoracic irradiation in non-small-cell lung cancer (NSCLC). Although these studies demonstrated favorable tumor response, this combined treatment modality was accompanied by severe treatment-related toxicities ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2004, 72(2):231-241]

Cited: 34 times

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The 'subsequent artificial neural network' (SANN) approach might bring more classificatory power to ANN-based DNA microarray analyses.

Roland Linder, Dawn Dew, Holger Sudhoff, Dirk Theegarten, Klaus Remberger, Siegfried J Pöppl, Mathias Wagner,

<h4>Motivation</h4>Human decisions often proceed in two steps. Initially those most preferred are chosen followed by a subsequent choice of these preferences. Applying one artificial neural network (ANN), a classification is limited to the preselection process. The final categorization is only possible by a subsequent ANN that distinguishes the pre-chosen classes. ... Read more >>

Bioinformatics (Bioinformatics (Oxford, England))
[2004, 20(18):3544-3552]

Cited: 13 times

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The bronchiolar epithelium as a prominent source of pro-inflammatory cytokines after lung irradiation.

Claudia E Rübe, Daniela Uthe, Falk Wilfert, Daniela Ludwig, Kunyu Yang, Jochem König, Jan Palm, Andreas Schuck, Normann Willich, Klaus Remberger, Christian Rübe,

<h4>Purpose</h4>To study in detail the temporal and spatial release of the pro-inflammatory cytokines tumor necrosis factor alpha, interleukin (IL)-1alpha, and IL-6 in the lung tissue of C57BL/6 mice after thoracic irradiation with 12 Gy.<h4>Methods and materials</h4>C57BL/6J mice were exposed to either sham irradiation or a single fraction of 12 Gy ... Read more >>

Int J Radiat Oncol Biol Phys (International journal of radiation oncology, biology, physics)
[2005, 61(5):1482-1492]

Cited: 64 times

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Latent Epstein-Barr virus (EBV) infection and cytomegalovirus (CMV) infection in synovial tissue of autoimmune chronic arthritis determined by RNA- and DNA-in situ hybridization.

Yasmin Mehraein, Carsten Lennerz, Sandra Ehlhardt, Klaus Remberger, Andreas Ojak, Klaus D Zang,

In rheumatoid arthritis (RA) viral triggers, especially Epstein-Barr virus (EBV) and cytomegalovirus (CMV), have been suggested. By PCR analysis DNA of several viruses among which EBV, CMV, and parvovirus B19 (B19) has been detected in RA synovial fluid and synovial tissue. In 63 synovial tissues of 29 rheumatoid arthritis (RA), ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2004, 17(7):781-789]

Cited: 40 times

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Differential expression of the estrogen receptor beta (ERbeta) in human prostate tissue, premalignant changes, and in primary, metastatic, and recurrent prostatic adenocarcinoma.

Thomas Fixemer, Klaus Remberger, Helmut Bonkhoff,

<h4>Background</h4>Estrogen signaling mediated by the estrogen receptor beta (ERbeta) has potential implications in normal and abnormal prostate growth. Few studies have addressed this issue in human prostate tissue leaving conflicting results on the immunolocalization of the ERbeta in benign and neoplastic lesions.<h4>Methods</h4>Using a new monoclonal antibody, the current study reports ... Read more >>

Prostate (The Prostate)
[2003, 54(2):79-87]

Cited: 116 times

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Lymph node positive prostate cancer: long-term survival data after radical prostatectomy.

Ulrike Zwergel, Jan Lehmann, Bernd Wullich, Ulrich Schreier, Klaus Remberger, Thomas Zwergel, Michael Stoeckle,

PURPOSE: We retrospectively reviewed the outcome in our patients with prostate cancer and regional positive lymph nodes who underwent prostatectomy. MATERIALS AND METHODS: Between January 1984 and December 2002, 147 men were found to have local lymph node metastases after surgery, of whom 135 underwent further androgen ablation, including 88% ... Read more >>

J Urol (The Journal of urology)
[2004, 171(3):1128-1131]

Cited: 39 times

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Detection of parvovirus B19 capsid proteins in lymphocytic cells in synovial tissue of autoimmune chronic arthritis.

Yasmin Mehraein, Carsten Lennerz, Sandra Ehlhardt, Thorsten Venzke, Andreas Ojak, Klaus Remberger, Klaus D Zang,

The pathogenic influence of viral agents in chronic inflammatory joint diseases like rheumatoid arthritis has been discussed for many years. More recently, DNA of several viruses, among them parvovirus B19 (B19), was traceable by PCR analysis in synovial fluid and synovial tissue. To investigate the potential role of parvovirus B19 ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2003, 16(8):811-817]

Cited: 16 times

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Apoptosis resistance of neuroendocrine phenotypes in prostatic adenocarcinoma.

Thomas Fixemer, Klaus Remberger, Helmut Bonkhoff,

<h4>Background</h4>Neuroendocrine (NE) differentiation has been implicated in prostate cancer progression and hormone therapy failure. It has been shown that prostate cancer cells with NE features lack proliferation activity in vitro and in vivo. The current study reports on the apoptotic status of NE phenotypes in human prostate cancer.<h4>Methods</h4>Double-label techniques were ... Read more >>

Prostate (The Prostate)
[2002, 53(2):118-123]

Cited: 50 times

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Estrogen receptor expression in prostate cancer and premalignant prostatic lesions.

H Bonkhoff, T Fixemer, I Hunsicker, K Remberger,

Estrogens have been implicated in prostatic cancerogenesis and tumor progression. The mechanisms underlying estrogen signaling in human prostate tissue, however, remain poorly understood. Using immunohistochemical and in situ hybridization (ISH) techniques, the present study demonstrates the classical estrogen receptor (ERalpha) in premalignant lesions and prostatic adenocarcinoma through the various stages ... Read more >>

Am J Pathol (The American journal of pathology)
[1999, 155(2):641-647]

Cited: 121 times

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