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Author Klaus J Schnake

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Osteoporotic Fractures of the Thoracic and Lumbar Vertebra: Diagnosis and Conservative Treatment-A Systematic Review.

Ulrich Spiegl, Hartmut Bork, Sebastian Grüninger, Uwe Maus, Georg Osterhoff, Max J Scheyerer, Philipp Pieroh, Jörg Schnoor, Christoph-Eckhard Heyde, Klaus J Schnake,

<h4>Background</h4>The prevalence of osteoporotic vertebral body fractures in Europe is 18-26%. Although most of these injuries can be treated conservatively, the underlying concepts have not been defined clearly or uniformly. In this article, we present the current state of the evidence on the diagnosis and conservative treatment of osteoporotic fractures ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, (Forthcoming):]

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The Influence of Surgeon Experience and Subspeciality on the Reliability of the AO Spine Sacral Classification System.

Brian A Karamian, Gregory D Schroeder, Hanna A Levy, Jose A Canseco, Lorin M Benneker, Frank Kandziora, Shanmuganathan Rajasekaran, F Cumhur Öner, Klaus J Schnake, Christopher K Kepler, Alexander R Vaccaro, ,

<h4>Study design</h4>Cross-sectional survey.<h4>Objective</h4>To determine the influence of surgeons' level of experience and subspeciality training on the reliability, reproducibility, and accuracy of sacral fracture classification using the AO spine sacral classification system.<h4>Summary of background data</h4>A surgeons' level of experience or subspecialty may have a significant effect on the reliability and accuracy ... Read more >>

Spine (Phila Pa 1976) (Spine)
[2021, :]

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Update on Upper Cervical Injury Classifications: The New AO Upper Cervical Spine Classification System.

Alexander R Vaccaro, Brian A Karamian, Hannah A Levy, Jose A Canseco, Shanmuganathan Rajasekaran, Lorin M Benneker, F Cumhur Oner, Frank Kandziora, Klaus J Schnake, Christopher K Kepler, Gregory D Schroeder,

The upper cervical spine accounts for the largest proportion of cervical range of motion afforded by a complex system of bony morphology and ligamentous stability. Its unique anatomy, however, also makes it particularly vulnerable during both low and high energy trauma. Trauma to this area, referred to as upper cervical ... Read more >>

Clin Spine Surg (Clinical spine surgery)
[2021, :]

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Validation of the AO Spine Sacral Classification System: Reliability Among Surgeons Worldwide.

Gregory D Schroeder, Brian A Karamian, Jose A Canseco, Luiz R Vialle, Frank Kandziora, Lorin M Benneker, Rajasekaran Shanmuganathan, Jörg H Holstein, Klaus J Schnake, Mark F Kurd, Marcel F Dvorak, Emiliano N Vialle, Andrei F Joaquim, Rishi M Kanna, Michael Fehlings, Jefferson R Wilson, Jens R Chapman, James C Krieg, Conor P Kleweno, Reza Firoozabadi, F Cumhur Öner, Christopher K Kepler, Alexander R Vaccaro,

<h4>Objectives</h4>To 1) demonstrate that the AO Spine Sacral Classification System can be reliably applied by general orthopaedic surgeons, as well as subspecialists, universally around the world, and 2) delineate those injury subtypes which are most difficult to classify reliably in order to refine the classification before evaluating clinical outcomes.<h4>Design</h4>Agreement Study.<h4>Setting</h4>All ... Read more >>

J Orthop Trauma (Journal of orthopaedic trauma)
[2021, :]

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Current Minimally Invasive Surgical Concepts for Sacral Insufficiency Fractures.

Ulrich Josef Albert Spiegl, Klaus J Schnake, Bernhard Ullrich, Max J Scheyerer, Georg Osterhoff, Holger Siekmann,

An increasing incidence of sacral insufficiency fractures in geriatric patients has been documented, representing a major challenge to our healthcare system. Determining the accurate diagnosis requires the use of sectional imaging, including computed tomography and magnetic resonance imaging. Initially, non-surgical treatment is indicated for the majority of patients. If non-surgical ... Read more >>

Z Orthop Unfall (Zeitschrift fur Orthopadie und Unfallchirurgie)
[2021, :]

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Postoperative Spinal Implant Infections (PSII)-A Systematic Review: What Do We Know So Far and What is Critical About It?

Daniel Karczewski, Klaus J Schnake, Georg Osterhoff, Ulrich Spiegl, Max J Scheyerer, Bernhard Ullrich, Matthias Pumberger,

<h4>Study design</h4>Systematic review.<h4>Objectives</h4>Postoperative spinal implant infections (PSII) are an increasing challenge in the daily clinical routine. This review summarizes existing knowledge in the field of PSII, including definitions, epidemiology, classifications, risk factors, pathogenesis, symptoms, diagnosis, and treatment.<h4>Methods</h4>A systematic review was performed using a structured PubMed analysis, based on the PRISMA ... Read more >>

Global Spine J (Global spine journal)
[2021, :21925682211024198]

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Establishing the Injury Severity of Subaxial Cervical Spine Trauma: Validating the Hierarchical Nature of the AO Spine Subaxial Cervical Spine Injury Classification System.

Gregory D Schroeder, Jose A Canseco, Parthik D Patel, Srikanth N Divi, Brian A Karamian, Frank Kandziora, Emiliano N Vialle, F Cumhur Oner, Klaus J Schnake, Marcel F Dvorak, Jens R Chapman, Lorin M Benneker, Shanmuganathan Rajasekaran, Christopher K Kepler, Alexander R Vaccaro, ,

<h4>Study design</h4>Global cross-sectional survey.<h4>Objective</h4>The aim of this study was to validate the AO Spine Subaxial Cervical Spine Injury Classification by examining the perceived injury severity by surgeon across AO geographical regions and practice experience.<h4>Summary of background data</h4>Previous subaxial cervical spine injury classifications have been limited by subpar interobserver reliability and ... Read more >>

Spine (Phila Pa 1976) (Spine)
[2021, 46(10):649-657]

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Risk Factors for Failure in Conservatively Treated Osteoporotic Vertebral Fractures: A Systematic Review.

Max J Scheyerer, Ulrich J A Spiegl, Sebastian Grueninger, Frank Hartmann, Sebastian Katscher, Georg Osterhoff, Mario Perl, Matthias Pumberger, Gregor Schmeiser, Bernhard W Ullrich, Klaus J Schnake,

<h4>Study design</h4>Systematic review.<h4>Objectives</h4>Osteoporosis is one of the most common diseases of the elderly, whereby vertebral body fractures are in many cases the first manifestation. Even today, the consequences for patients are underestimated. Therefore, early identification of therapy failures is essential. In this context, the aim of the present systematic review ... Read more >>

Global Spine J (Global spine journal)
[2021, :2192568220982279]

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Variation in global treatment for subaxial cervical spine isolated unilateral facet fractures.

Brian A Karamian, Gregory D Schroeder, Martin Holas, Andrei F Joaquim, Jose A Canseco, Shanmuganathan Rajasekaran, Lorin M Benneker, Frank Kandziora, Klaus J Schnake, F Cumhur Öner, Christopher K Kepler, Alexander R Vaccaro, ,

<h4>Purpose</h4>To determine the variation in the global treatment practices for subaxial unilateral cervical spine facet fractures based on surgeon experience, practice setting, and surgical subspecialty.<h4>Methods</h4>A survey was sent to 272 members of the AO Spine Subaxial Injury Classification System Validation Group worldwide. Questions surveyed surgeon preferences with regard to diagnostic ... Read more >>

Eur Spine J (European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society)
[2021, 30(6):1635-1650]

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Concomitant injuries in patients with thoracic vertebral body fractures-a systematic literature review.

Ulrich J Spiegl, Georg Osterhoff, Philipp Bula, Frank Hartmann, Max J Scheyerer, Klaus J Schnake, Bernhard W Ullrich,

<h4>Purpose</h4>The aim of this study was to give a systematic overview over the rate and location of concomitant injuries, the probability of suffering from neurological deficits, and to give evidence of the timing of surgery in severely injured patients with unstable thoracic vertebral body fractures.<h4>Methods</h4>This review is based on articles ... Read more >>

Arch Orthop Trauma Surg (Archives of orthopaedic and trauma surgery)
[2021, :]

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Biomechanics and clinical outcome after posterior stabilization of mid-thoracic vertebral body fractures: a systematic literature review.

Ulrich J Spiegl, Georg Osterhoff, Philipp Bula, Frank Hartmann, Max J Scheyerer, Klaus J Schnake, Bernhard W Ullrich,

<h4>Purpose</h4>The aim of this review is to systematically screen the literature for clinical and biomechanical studies dealing with posterior stabilization of acute traumatic mid-thoracic vertebral fractures in patients with normal bone quality.<h4>Methods</h4>This review is based on articles retrieved by a systematic search in the PubMed and Web of Science database ... Read more >>

Eur J Trauma Emerg Surg (European journal of trauma and emergency surgery : official publication of the European Trauma Society)
[2020, :]

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The Subaxial Cervical AO Spine Injury Score.

Jose A Canseco, Gregory D Schroeder, Taylor M Paziuk, Brian A Karamian, Frank Kandziora, Emiliano N Vialle, F Cumhur Oner, Klaus J Schnake, Marcel F Dvorak, Jens R Chapman, Lorin M Benneker, Shanmuganathan Rajasekaran, Christopher K Kepler, Alexander R Vaccaro,

<h4>Study design</h4>Global cross-sectional survey.<h4>Objective</h4>To develop an injury score for the AO Spine Subaxial Cervical Spine Injury Classification System.<h4>Methods</h4>Respondents numerically graded each variable within the classification system for severity. Based on the results, and with input from the AO Spine Trauma Knowledge Forum, the Subaxial Cervical AO Spine Injury Score was ... Read more >>

Global Spine J (Global spine journal)
[2020, :2192568220974339]

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Reliability and Validity of the English Version of the AOSpine PROST (Patient Reported Outcome Spine Trauma).

Said Sadiqi, Marcel F Dvorak, Alexander R Vaccaro, Gregory D Schroeder, Marcel W Post, Lorin M Benneker, Frank Kandziora, S Rajasekaran, Klaus J Schnake, Emiliano N Vialle, F Cumhur Oner,

<h4>Study design</h4>Multicenter validation study.<h4>Objective</h4>The aim of this study was to translate and adapt the AOSpine PROST (Patient Reported Outcome Spine Trauma) into English, and test its psychometric properties among North-American spine trauma patients.<h4>Summary of background data</h4>In the absence of an outcome instrument specifically designed and validated for traumatic spinal column ... Read more >>

Spine (Phila Pa 1976) (Spine)
[2020, 45(17):E1111-E1118]

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Reliability, validity and responsiveness of the Dutch version of the AOSpine PROST (Patient Reported Outcome Spine Trauma).

Said Sadiqi, Marcel W Post, Allard J Hosman, Marcel F Dvorak, Jens R Chapman, Lorin M Benneker, Frank Kandziora, S Rajasekaran, Klaus J Schnake, Alexander R Vaccaro, F Cumhur Oner,

<h4>Purpose</h4>To validate the Dutch version of AOSpine PROST (Patient Reported Outcome Spine Trauma).<h4>Methods</h4>Patients were recruited from two level-1 trauma centers from the Netherlands. Next to the AOSpine PROST, patients also filled out SF-36 for concurrent validity. Descriptive statistics were used to analyze the characteristics. Content validity was assessed by evaluating ... Read more >>

Eur Spine J (European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society)
[2021, 30(9):2631-2644]

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Regional and experiential differences in surgeon preference for the treatment of cervical facet injuries: a case study survey with the AO Spine Cervical Classification Validation Group.

Jose A Canseco, Gregory D Schroeder, Parthik D Patel, Giovanni Grasso, Michael Chang, Frank Kandziora, Emiliano N Vialle, F Cumhur Oner, Klaus J Schnake, Marcel F Dvorak, Jens R Chapman, Lorin M Benneker, Shanmuganathan Rajasekaran, Christopher K Kepler, Alexander R Vaccaro, ,

<h4>Purpose</h4>The management of cervical facet dislocation injuries remains controversial. The main purpose of this investigation was to identify whether a surgeon's geographic location or years in practice influences their preferred management of traumatic cervical facet dislocation injuries.<h4>Methods</h4>A survey was sent to 272 AO Spine members across all geographic regions and ... Read more >>

Eur Spine J (European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society)
[2021, 30(2):517-523]

Cited: 6 times

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Development and reliability of the AOSpine CROST (Clinician Reported Outcome Spine Trauma): a tool to evaluate and predict outcomes from clinician's perspective.

Said Sadiqi, Sander P J Muijs, Jeroen J M Renkens, Marcel W Post, Lorin M Benneker, Jens R Chapman, Frank Kandziora, Klaus J Schnake, Emiliano N Vialle, Alexander R Vaccaro, F Cumhur Oner,

<h4>Purpose</h4>To report on the development of AOSpine CROST (Clinician Reported Outcome Spine Trauma) and results of an initial reliability study.<h4>Methods</h4>The AOSpine CROST was developed using an iterative approach of multiple cycles of development, review, and revision including an expert clinician panel. Subsequently, a reliability study was performed among an expert ... Read more >>

Eur Spine J (European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society)
[2020, 29(10):2550-2559]

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AOSpine-Spine Trauma Classification System: The Value of Modifiers: A Narrative Review With Commentary on Evolving Descriptive Principles.

Srikanth N Divi, Gregory D Schroeder, F Cumhur Oner, Frank Kandziora, Klaus J Schnake, Marcel F Dvorak, Lorin M Benneker, Jens R Chapman, Alexander R Vaccaro,

<h4>Study design</h4>Narrative review.<h4>Objectives</h4>To describe the current AOSpine Trauma Classification system for spinal trauma and highlight the value of patient-specific modifiers for facilitating communication and nuances in treatment.<h4>Methods</h4>The classification for spine trauma previously developed by The AOSpine Knowledge Forum is reviewed and the importance of case modifiers in this system is ... Read more >>

Global Spine J (Global spine journal)
[2019, 9(1 Suppl):77S-88S]

Cited: 9 times

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[Hounsfield units as a measure of bone density-applications in spine surgery].

Max J Scheyerer, Bernhard Ullrich, Georg Osterhoff, Ulrich A Spiegl, Klaus J Schnake, ,

Despite today's good diagnostic and therapeutic options for osteoporosis, the number of unidentified cases is very high and therapy is therefore usually inadequate. Frequently, the diagnosis of osteoporosis is made only after the occurrence of a fracture. The reason for this, apart from the costs incurred as well as the additional ... Read more >>

Unfallchirurg (Der Unfallchirurg)
[2019, 122(8):654-661]

Cited: 2 times

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Does Riluzole Influence Bone Formation?: An In Vitro Study of Human Mesenchymal Stromal Cells and Osteoblast.

Gregory D Schroeder, Christopher K Kepler, Sibylle Grad, Mauro Alini, Taolin Fang, Dessislava Z Markova, John D Koerner, Shanmuganathan Rajasekaran, Jens Chapman, Frank Kandziora, Klaus J Schnake, Marcel F Dvorak, F Cumhur Oner, Alexander R Vaccaro,

<h4>Study design</h4>A post-test design biological experiment.<h4>Objective</h4>The aim of this study was to evaluate the osteogenic effects of riluzole on human mesenchymal stromal cells and osteoblasts.<h4>Summary of background data</h4>Riluzole may benefit patients with spinal cord injury (SCI) from a neurologic perspective, but little is known about riluzole's effect on bone formation, ... Read more >>

Spine (Phila Pa 1976) (Spine)
[2019, 44(16):1107-1117]

Cited: 1 time

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[Quantification of treatment success for geriatric sacral fractures].

Georg Osterhoff, Max J Scheyerer, Ulrich J Spiegl, Klaus J Schnake, Holger Siekmann, ,

<h4>Background</h4>Geriatric sacral fractures represent an independent fracture entity of increasing incidence and growing socioeconomic relevance. The goals of treatment are very different to those in younger patients with high-energy pelvic fractures. Hence, new outcome measurement instruments are required in order to assess the success of treatment.<h4>Objective</h4>Literature review summarizing existing concepts ... Read more >>

Unfallchirurg (Der Unfallchirurg)
[2019, 122(4):293-298]

Cited: 0 times

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The relationship between functionality and erector spinae activity in patients with specific low back pain during dynamic and static movements.

Sebastian Becker, Ferdinand Bergamo, Klaus J Schnake, Sylvia Schreyer, Ingo V Rembitzki, Catherine Disselhorst-Klug,

<h4>Background</h4>Alterations in the activity of the lumbar erector spinae (LES) muscles on both sides of the spine have been inconsistently reported in patients with specific low back pain (sLBP) after measuring the muscular activity with surface electromyography (sEMG). It also remains unclear whether these alterations in LES activity can be ... Read more >>

Gait Posture (Gait & posture)
[2018, 66:208-213]

Cited: 3 times

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Nonsurgical and Surgical Management of Osteoporotic Vertebral Body Fractures: Recommendations of the Spine Section of the German Society for Orthopaedics and Trauma (DGOU).

Thomas R Blattert, Klaus J Schnake, Oliver Gonschorek, Erol Gercek, Frank Hartmann, Sebastian Katscher, Sven Mörk, Robert Morrison, Michael Müller, Axel Partenheimer, Stefan Piltz, Michael A Scherer, Bernhard W Ullrich, Akhil Verheyden, Volker Zimmermann, ,

<h4>Study design</h4>Prospective clinical cohort study (data collection); expert opinion (recommendation development).<h4>Objectives</h4>Treatment options for nonsurgical and surgical management of osteoporotic vertebral body fractures are widely differing. Based on current literature, the knowledge of the experts, and their classification for osteoporotic fractures (OF classification) the Spine Section of the German Society for ... Read more >>

Global Spine J (Global spine journal)
[2018, 8(2 Suppl):50S-55S]

Cited: 12 times

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Radiofrequency facet joint denervation in the lumbar spine.

Doina Thomas, Klaus J Schnake,

Eur Spine J (European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society)
[2017, 26(Suppl 3):427-428]

Cited: 0 times

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Answer to the Letter to the Editor of A. Piazzolla et al. concerning, "The Surgical Algorithm for the AOSpine, Thoracolumbar Spine Injury Classification System" by A. R. Vaccaro et al.; Eur Spine J (2016); 25(4):1087-1094.

Alexander R Vaccaro, Gregory D Schroeder, Christopher K Kepler, F Cumhur Oner, Luiz R Vialle, Frank Kandziora, John D Koerner, Mark F Kurd, Max Reinhold, Klaus J Schnake, Jens Chapman, Bizhan Aarabi, Michael G Fehlings, Marcel F Dvorak,

Eur Spine J (European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society)
[2017, 26(8):2216-2217]

Cited: 0 times

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Development of the AOSpine Patient Reported Outcome Spine Trauma (AOSpine PROST): a universal disease-specific outcome instrument for individuals with traumatic spinal column injury.

Said Sadiqi, A Mechteld Lehr, Marcel W Post, Marcel F Dvorak, Frank Kandziora, S Rajasekaran, Klaus J Schnake, Alexander R Vaccaro, F Cumhur Oner,

<h4>Purpose</h4>To report on the multi-phase process used in developing the AOSpine Patient Reported Outcome Spine Trauma (AOSpine PROST), as well as the results of its application in a pilot study.<h4>Methods</h4>The International Classification of Functioning, Disability and Health (ICF) methodology was used as the basis for the development of this tool. ... Read more >>

Eur Spine J (European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society)
[2017, 26(5):1550-1557]

Cited: 2 times

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