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Author Klaus Brechtel

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Heparin-Bonded Stent-Graft for the Treatment of TASC II C and D Femoropopliteal Lesions: 36-Month Results of the Viabahn 25 cm Trial.

Tanja Böhme, Elias Noory, Klaus Brechtel, Dierk Scheinert, Marc Bosiers, Ulrich Beschorner, Thomas Zeller,

<h4>Purpose</h4>To evaluate the 36-month technical and clinical outcome after implantation of the 25-cm Viabahn endoprosthesis with Propaten bioactive surface in TransAtlantic Inter-Society Consensus II C and D lesions of the superficial femoral and proximal popliteal arteries.<h4>Materials and methods</h4>This prospective, multicenter, single-arm trial (<i>ClinicalTrials.gov</i>; identifier NCT01263665) enrolled 71 patients (mean age ... Read more >>

J Endovasc Ther (Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists)
[2021, 28(2):222-228]

Cited: 0 times

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Six-month pivotal results of tack optimized balloon angioplasty using the Tack Endovascular System in below-the-knee arteries.

Patrick J Geraghty, George Adams, Andrej Schmidt, ,

<h4>Objective</h4>No vascular implant is commercially available in the United States to treat post-angioplasty dissections in below-the-knee (BTK) arteries. The Tack Endovascular System (Intact Vascular, Wayne, Pa) is purpose-built to repair postpercutaneous transluminal angioplasty (PTA) BTK dissections. A trial was conducted to investigate the safety and efficacy of the first-of-a-kind implantable ... Read more >>

J Vasc Surg (Journal of vascular surgery)
[2021, 73(3):918-929.e5]

Cited: 0 times

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COMPARE: prospective, randomized, non-inferiority trial of high- vs. low-dose paclitaxel drug-coated balloons for femoropopliteal interventions.

Sabine Steiner, Andrej Schmidt, Thomas Zeller, Gunnar Tepe, Marcus Thieme, Lars Maiwald, Henrik Schröder, Wulf Euringer, Matthias Ulrich, Klaus Brechtel, Steffen Brucks, Erwin Blessing, Johannes Schuster, Ralf Langhoff, Sebastian Schellong, Norbert Weiss, Dierk Scheinert,

<h4>Aims</h4>Drug-coated balloons (DCBs) for femoropopliteal interventions have not been tested against each other. We aimed to directly compare efficacy and safety of a high-dose (In.Pact™) vs. low-dose (Ranger™) DCB with nominal paclitaxel densities of 3.5 vs. 2.0 μg/mm2.<h4>Methods and results</h4>Within a prospective, multicentre, non-inferiority, clinical trial 414 patients with symptomatic femoropopliteal ... Read more >>

Eur Heart J (European heart journal)
[2020, 41(27):2541-2552]

Cited: 1 time

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Tibiopedal and distal femoral retrograde vascular access for challenging chronic total occlusions: predictors for technical success, and complication rates in a large single-center cohort.

Gerd Grözinger, Jan Hallecker, Ulrich Grosse, Roland Syha, Dominik Ketelsen, Klaus Brechtel, Mario Lescan, Konstantin Nikolaou, Christoph Artzner,

<h4>Objective</h4>To evaluate the safety and effectiveness of tibiopedal and distal femoral access for retrograde crossing of chronic total occlusion (CTO) in Rutherford stage III to VI peripheral arterial occlusive disease, and to determine factors that correlate with technical success.<h4>Material and methods</h4>One hundred seventy-one consecutive patients were included in this retrospective ... Read more >>

Eur Radiol (European radiology)
[2021, 31(1):535-542]

Cited: 0 times

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Six-Month Outcomes From the First-in-Human, Single-Arm SELUTION Sustained-Limus-Release Drug-Eluting Balloon Trial in Femoropopliteal Lesions.

Thomas Zeller, Klaus Brechtel, Dirk-Roelfs Meyer, Elias Noory, Ulrich Beschorner, Thomas Albrecht,

<b>Purpose:</b> To evaluate the safety and efficacy of the novel SELUTION sustained-limus-release (SLR) drug-eluting balloon (DEB) in the treatment of femoropopliteal lesions. <b>Materials and Methods:</b> Between October 2016 and May 2017, 50 subjects (mean age 69.6±10.4 years; 29 men) with symptomatic moderate to severe lower limb ischemia (Rutherford categories 2 ... Read more >>

J Endovasc Ther (Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists)
[2020, 27(5):683-690]

Cited: 2 times

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Optimized drug-coated balloon angioplasty of the superficial femoral and proximal popliteal arteries using the Tack Endovascular System: TOBA III 12-month results.

Marianne Brodmann, Christian Wissgott, Klaus Brechtel, Sigrid Nikol, Thomas Zeller, Michael Lichtenberg, Erwin Blessing, William Gray, ,

<h4>Objective</h4>The Tack Endovascular System (Intact Vascular, Wayne, Pa) combines low-metallic content with focal delivery to seal areas of dissection associated with balloon angioplasty. The device system is designed to treat vascular dissections in the superficial femoral and proximal popliteal arteries. Tack implants exert low radial force and are associated with ... Read more >>

J Vasc Surg (Journal of vascular surgery)
[2020, 72(5):1636-1647.e1]

Cited: 1 time

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Efficacy and safety of a novel paclitaxel-nano-coated balloon for femoropopliteal angioplasty: one-year results of the EffPac trial.

Ulf Teichgräber, Thomas Lehmann, René Aschenbach, Dierk Scheinert, Thomas Zeller, Klaus Brechtel, Erwin Blessing, Michael Lichtenberg, Sebastian Sixt, Steffen Brucks, Ulrich Beschorner, Christof Tobias Klumb, Markus Thieme, ,

AIMS:Although paclitaxel drug-coated balloon (DCB) angioplasty is an established endovascular treatment for peripheral artery disease, restenosis remains a major concern. Thus, we compared a novel paclitaxel-coated DCB with nano-coating technology with uncoated plain old balloon angioplasty (POBA). METHODS AND RESULTS:This multicentre trial randomly assigned 171 patients with stenotic and occlusive ... Read more >>

EuroIntervention (EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology)
[2020, 15(18):e1633-e1640]

Cited: 4 times

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Paclitaxel-Coated Balloon vs Uncoated Balloon Angioplasty for Treatment of In-Stent Restenosis in the Superficial Femoral and Popliteal Arteries: The COPA CABANA Trial.

Gunnar Tepe, Henrik Schroeder, Thomas Albrecht, Peter Reimer, Nicolas Diehm, Jean-Luc Baeriswyl, Klaus Brechtel, Ulrich Speck, Thomas Zeller,

Purpose: To investigate the efficacy and sustainability of drug-coated balloon (DCB) treatment of femoropopliteal in-stent restenosis (ISR). Materials and Methods: An investigator-initiated, prospective, multicenter, 1:1 randomized study enrolled 88 patients for treatment of ISR with DCB (n=47; mean age 68.3±9.6 years; 26 men) or uncoated balloon (n=41; mean age 67.6±10.2 ... Read more >>

J Endovasc Ther (Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists)
[2020, 27(2):276-286]

Cited: 1 time

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Drug-coated Balloon Angioplasty of Femoropopliteal Lesions Maintained Superior Efficacy over Conventional Balloon: 2-year Results of the Randomized EffPac Trial.

Ulf Teichgräber, Thomas Lehmann, René Aschenbach, Dierk Scheinert, Thomas Zeller, Klaus Brechtel, Erwin Blessing, Michael Lichtenberg, Peter von Flotow, Britta Heilmeier, Sebastian Sixt, Steffen Brucks, Christian Erbel, Ulrich Beschorner, Michael Werk, Vicenç Riambau, Andreas Wienke, Christof Tobias Klumb, Markus Thieme,

Background Paclitaxel drug-coated balloon (DCB) catheter angioplasty is the preferred treatment for revascularization of femoropopliteal lesions in peripheral artery disease, but mortality is a safety concern. Purpose To assess 2-year efficacy and safety of DCB angioplasty compared with conventional balloon angioplasty (also known as plain old balloon angioplasty or POBA). ... Read more >>

Radiology (Radiology)
[2020, 295(2):478-487]

Cited: 3 times

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Self-Expanding Versus Balloon-Expandable Stents for Iliac Artery Occlusive Disease: The Randomized ICE Trial.

Hans Krankenberg, Thomas Zeller, Maja Ingwersen, Josefin Schmalstieg, Hans Martin Gissler, Sigrid Nikol, Iris Baumgartner, Nicolas Diehm, Estell Nickling, Stefan Müller-Hülsbeck, Rainer Schmiedel, Giovanni Torsello, Willibald Hochholzer, Christian Stelzner, Klaus Brechtel, Wulf Ito, Ralph Kickuth, Erwin Blessing, Marcus Thieme, Jaroslaw Nakonieczny, Thomas Nolte, Ragnar Gareis, Harald Boden, Sebastian Sixt,

<h4>Objectives</h4>Atherosclerosis of iliac arteries is widespread. As inflow vessels, they are of great clinical significance and increasingly being treated by endovascular means. Most commonly, stents are implanted.<h4>Background</h4>So far, due to a lack of comparative data, no guideline recommendations on the preferable stent type, balloon-expandable stent (BE) or self-expanding stent (SE), ... Read more >>

JACC Cardiovasc Interv (JACC. Cardiovascular interventions)
[2017, 10(16):1694-1704]

Cited: 16 times

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Portal vein recanalization and embolization of the transsplenic puncture tract using an Amplatzer® vascular plug: a case report.

Ulrich Grosse, Klaus Brechtel, Dominik Ketelsen, Roland Syha, Gerd Grözinger, Fabian Springer, Christoph Thomas,

<h4>Background</h4>A transsplenic access for the catheterization of the portal venous system to treat a portal vein thrombosis and/or stenosis entails the risk of intra-abdominal or intrasplenic bleeding complications and has to be seen as an approach of last resort. This is one of few reported cases in the literature where ... Read more >>

BMC Res Notes (BMC research notes)
[2015, 8:193]

Cited: 2 times

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Angioplasty of femoral-popliteal arteries with drug-coated balloons: 5-year follow-up of the THUNDER trial.

Gunnar Tepe, Beatrix Schnorr, Thomas Albrecht, Klaus Brechtel, Claus D Claussen, Bruno Scheller, Ulrich Speck, Thomas Zeller,

<h4>Objectives</h4>The purpose of this study was to evaluate the 5-year follow-up (FU) data of the THUNDER (Local Taxan With Short Time Contact for Reduction of Restenosis in Distal Arteries).<h4>Background</h4>The THUNDER trial was the first study to investigate the treatment of femoropopliteal arteries with a paclitaxel-coated balloon (PCB).<h4>Methods</h4>In 154 patients, femoropopliteal ... Read more >>

JACC Cardiovasc Interv (JACC. Cardiovascular interventions)
[2015, 8(1 Pt A):102-108]

Cited: 77 times

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Heparin-bonded stent-graft for the treatment of TASC II C and D femoropopliteal lesions: the Viabahn-25 cm trial.

Thomas Zeller, Patrick Peeters, Marc Bosiers, Johannes Lammer, Klaus Brechtel, Dierk Scheinert, Aljoscha Rastan, Elias Noory, Ulrich Beschorner,

Purpose: To confirm the performance and safety of the 25-cm Viabahn endoprosthesis with Propaten bioactive surface when used in the treatment of de novo and/or restenotic TransAtlantic Inter-Society Consensus II C and D lesions of the superficial femoral artery and proximal popliteal artery. Methods: The 25-cm Gore Viabahn Endoprosthesis study ... Read more >>

J Endovasc Ther (Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists)
[2014, 21(6):765-774]

Cited: 14 times

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Twelve-month results of a randomized trial comparing mono with dual antiplatelet therapy in endovascularly treated patients with peripheral artery disease.

Frederik F Strobl, Klaus Brechtel, Jörg Schmehl, Thomas Zeller, Maximilian F Reiser, Claus D Claussen, Gunnar Tepe,

<h4>Purpose</h4>To present the 12-month results of a trial investigating the effects of dual antiplatelet therapy on target lesion revascularization (TLR) after balloon angioplasty ± stenting in the femoropopliteal segment.<h4>Methods</h4>A prospective, randomized, single-center, double-blinded and placebo-controlled clinical trial randomly assigned 40 patients to receive pre- and postinterventional therapy with aspirin and ... Read more >>

J Endovasc Ther (Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists)
[2013, 20(5):699-706]

Cited: 26 times

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Perfusion measurements of the calf in patients with peripheral arterial occlusive disease before and after percutaneous transluminal angioplasty using MR arterial spin labeling.

Gerd Grözinger, Rolf Pohmann, Fritz Schick, Ulrich Grosse, Roland Syha, Klaus Brechtel, Kilian Rittig, Petros Martirosian,

<h4>Purpose</h4>To evaluate muscle perfusion in patients with peripheral arterial occlusive disease (PAOD) before and after percutaneous transluminal angioplasty (PTA) of the limb by means of MR arterial spin labeling (ASL) perfusion measurements during reactive hyperemia.<h4>Materials and methods</h4>Ten patients with symptomatic PAOD affecting the iliac or femoral vessels were investigated before ... Read more >>

J Magn Reson Imaging (Journal of magnetic resonance imaging : JMRI)
[2014, 40(4):980-987]

Cited: 22 times

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Hybrid debranching and TEVAR of the aortic arch off-pump, in re-do patients with complicated chronic type-A aortic dissections: a critical report.

Klaus Brechtel, Günay Kalender, Ulrich A Stock, Stephen M Wildhirt,

<h4>Background</h4>Patients suffering from acute type A aortic dissection undergo replacement of the ascending aorta, the proximal hemiarch or complete aortic arch, depending on the extent of the individual pathology. In a subset of these treated patients, secondary pathologies of the distal anastomosis or the remaining distal part of the aorta ... Read more >>

J Cardiothorac Surg (Journal of cardiothoracic surgery)
[2013, 8:188]

Cited: 3 times

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High-grade, non-flow-limiting dissections do not negatively impact long-term outcome after paclitaxel-coated balloon angioplasty: an additional analysis from the THUNDER study.

Gunnar Tepe, Thomas Zeller, Beatrix Schnorr, Claus D Claussen, Ulrich Beschorner, Klaus Brechtel, Bruno Scheller, Ulrich Speck,

<h4>Purpose</h4>To investigate the impact of using paclitaxel-coated balloons (PCB) on outcome after post-angioplasty dissection in femoropopliteal arteries.<h4>Methods</h4>The angiograms obtained in the THUNDER study (ClinicalTrials.gov identifier NCT00156624) were analyzed to compare degrees of dissection and angiographic parameters between the control (uncoated balloons, n=43) and treatment (PCBs, n=43) groups before and after ... Read more >>

J Endovasc Ther (Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists)
[2013, 20(6):792-800]

Cited: 17 times

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[Renal failure and recurrent episodes of flash pulmonary edema in a 70-year-old patient].

Ferruh Artunc, Klaus Brechtel, Barbara Kattner, Nora Celebi, Hanno Bunz, Rezo Jorbenadze, Stefan Lutz, Peter Weyrich, Michael Haap,

<h4>History and admission findings</h4>We report on a patient presenting with renal failure who developed mutliple episodes of flash pulmonary edema.<h4>Investigations</h4>Volume retention due to ischemic nephropathy was found to be the cause.<h4>Diagnosis, treatment and course</h4>She was diagnosed to have a high grade renal artery stenosis in a functional solitary kidney and ... Read more >>

Dtsch Med Wochenschr (Deutsche medizinische Wochenschrift (1946))
[2013, 138(27):1410]

Cited: 0 times

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[Thrombosis of the pelvic and leg--conservative procedure or thrombolytic therapy?].

Elko Randrianarisoa, Kilian Rittig, Klaus Brechtel, Winfried Baden, Ferruh Artunc, Bernd Balletshofer,

<h4>History and admission findings</h4>We report on a young female patient with flank pain and a swelling of the lower limb of the left side.<h4>Investigations</h4>In magnetic resonance angiography as well as Doppler-duplex ultrasound an iliofemoral phlebothrombosis of the left side due to vena cava inferior hypoplasia with collateral circulation was diagnosed. ... Read more >>

Dtsch Med Wochenschr (Deutsche medizinische Wochenschrift (1946))
[2013, 138(21):1130]

Cited: 1 time

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Treatment of femoropopliteal in-stent restenosis with paclitaxel-eluting stents.

Thomas Zeller, Michael D Dake, Gunnar Tepe, Klaus Brechtel, Elias Noory, Ulrich Beschorner, Patricia L Kultgen, Aljoscha Rastan,

<h4>Objectives</h4>This study sought to evaluate the outcomes of drug-eluting stent treatment for femoropopliteal in-stent restenosis (ISR).<h4>Background</h4>ISR after femoropopliteal interventions is an increasing problem. Although the role of drug-eluting stents in the treatment of coronary ISR is well defined, no published studies have examined drug-eluting stents in the treatment of femoropopliteal ... Read more >>

JACC Cardiovasc Interv (JACC. Cardiovascular interventions)
[2013, 6(3):274-281]

Cited: 55 times

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Emergence of a multidrug-resistant Haemophilus influenzae strain causing chronic pneumonia in a patient with common variable immunodeficiency.

Yvonne Pfeifer, Ines Meisinger, Klaus Brechtel, Sabine Gröbner,

We report the emergence of a multidrug-resistant Haemophilus influenzae strain in a patient with common variable immunodeficiency suffering from recurrent bronchopneumonia caused by H. influenzae. After the patient had received several antibiotic therapies, a strain was isolated showing resistance to ampicillin, ampicillin/sulbactam, cefazolin, cefuroxime, ciprofloxacin, and clarithromycin. Polymerase chain reaction ... Read more >>

Microb Drug Resist (Microbial drug resistance (Larchmont, N.Y.))
[2013, 19(1):1-5]

Cited: 8 times

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Endovascular treatment for extensive aortoiliac artery reconstruction: a single-center experience based on 1712 interventions.

Sebastian Sixt, Hans Krankenberg, Charlotte Möhrle, Mathias Kaspar, Thilo Tübler, Aljoscha Rastan, Klaus Brechtel, Roland Macharzina, Franz-Josef Neumann, Thomas Zeller,

<h4>Purpose</h4>To determine the clinical and technical outcomes following endovascular therapy for aortoiliac occlusive disease, including complex reconstruction of the aortic bifurcation.<h4>Methods</h4>A retrospective database search identified 1184 consecutive patients (864 men; mean age 64±10 years) who underwent 1712 procedures to treat target lesions in the distal aorta and iliac arteries from ... Read more >>

J Endovasc Ther (Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists)
[2013, 20(1):64-73]

Cited: 13 times

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Hepatocellular carcinoma: initial tumour response after short-term and long-interval chemoembolization with drug-eluting beads using modified RECIST.

Roland Syha, Dominik Ketelsen, Stefan Heller, Jörg Schmehl, Stefanie Mangold, Martin Heuschmid, Fabian Springer, Claus D Claussen, Klaus Brechtel,

<h4>Objective</h4>The aim of this study was to evaluate the initial tumour response after one, respectively, two transarterial chemoembolizations (TACE) with drug-eluting (DC) beads in patients with hepatocellular carcinoma (HCC).<h4>Methods</h4>A total of 26 patients with clinically approved HCC underwent one or two TACE with DC Beads within 6 weeks and were ... Read more >>

Eur J Gastroenterol Hepatol (European journal of gastroenterology & hepatology)
[2012, 24(11):1325-1332]

Cited: 9 times

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Safety and Efficacy of the Prostar XL Vascular Closing Device for Percutaneous Closure of Large Arterial Access Sites.

Christoph Thomas, Volker Steger, Stefan Heller, Martin Heuschmid, Dominik Ketelsen, Claus D Claussen, Klaus Brechtel,

Purpose. The purpose of this study is to retrospectively evaluate the efficacy and safety of the Prostar XL device for percutaneous large access site closure in an unselected patient and operator collective. Materials and Methods. All patients (n = 50) who had received percutaneous vascular closing with the Prostar XL ... Read more >>

Radiol Res Pract (Radiology research and practice)
[2013, 2013:875484]

Cited: 9 times

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A prospective randomized multicenter comparison of balloon angioplasty and infrapopliteal stenting with the sirolimus-eluting stent in patients with ischemic peripheral arterial disease: 1-year results from the ACHILLES trial.

Dierk Scheinert, Konstantinos Katsanos, Thomas Zeller, Renate Koppensteiner, Philip Commeau, Marc Bosiers, Hans Krankenberg, Iris Baumgartner, Dimitris Siablis, Johannes Lammer, Mariella Van Ransbeeck, Ayesha C Qureshi, Hans-Peter Stoll, ,

<h4>Objectives</h4>The study investigated the efficacy and safety of a balloon expandable, sirolimus-eluting stent (SES) in patients with symptomatic infrapopliteal arterial disease.<h4>Background</h4>Results of infrapopliteal interventions using balloon angioplasty and/or bare stents are limited by a relatively high restenosis rate, which could be potentially improved by stabilizing the lesion with a SES.<h4>Methods</h4>Two ... Read more >>

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2012, 60(22):2290-2295]

Cited: 96 times

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