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Author Kjeld Schmiegelow

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PREVALENCE OF SARS-COV-2-ANTIBODIES IN DANISH CHILDREN AND ADULTS.

Maren J H Rytter, Ulrikka Nygaard, Ida Nikoline Mandic, Jonathan Peter Glenthøj, Lisbeth Samsø Schmidt, Dina Cortes, Birgitte Smith, Tatjana Zaharov, Mia Johanna Søndergaard, Marie Cecilie Lawaetz, Susanne Saekmose, Lise Heilmann Jensen, Kjeld Schmiegelow, Kim Kristensen,

In Denmark, severe acute respiratory syndrome coronavirus 2 antibodies were assessed in a cross-sectional study among 1033 children visiting pediatric departments and 750 blood donors in June 2020, using a point-of-care test. Antibodies were detected in 17 children (1.6%) and 15 blood donors (2.0%) (P = 0.58). In conclusion, children ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, Publish Ahead of Print:]

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Home-based cognitive behavioural therapy for families of young children with cancer (FAMOS): A nationwide randomised controlled trial.

Hanin Salem, Anne E Kazak, Elisabeth Wreford Andersen, Federica Belmonte, Christoffer Johansen, Kjeld Schmiegelow, Jeanette Falck Winther, Peder Skov Wehner, Henrik Hasle, Steen Rosthøj, Pernille E Bidstrup,

<h4>Introduction</h4>Evidence-based knowledge is needed to reduce psychological symptoms in families of young children with cancer after treatment ends.<h4>Objective</h4>To evaluate the effect of a psychotherapeutic intervention, FAMily-Oriented Support (FAMOS) on parents of young children after cancer treatment.<h4>Methods</h4>All families of children aged 0-6 years who had been treated for cancer at one of ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2020, :e28853]

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Nationwide germline whole genome sequencing of 198 consecutive pediatric cancer patients reveals a high incidence of cancer prone syndromes.

Anna Byrjalsen, Thomas V O Hansen, Ulrik K Stoltze, Mana M Mehrjouy, Nanna Moeller Barnkob, Lisa L Hjalgrim, René Mathiasen, Charlotte K Lautrup, Pernille A Gregersen, Henrik Hasle, Peder S Wehner, Ruta Tuckuviene, Peter Wad Sackett, Adrian O Laspiur, Maria Rossing, Rasmus L Marvig, Niels Tommerup, Tina Elisabeth Olsen, David Scheie, Ramneek Gupta, Anne-Marie Gerdes, Kjeld Schmiegelow, Karin Wadt,

<h4>Purpose</h4>Historically, cancer predisposition syndromes (CPSs) were rarely established for children with cancer. This nationwide, population-based study investigated how frequently children with cancer had or were likely to have a CPS.<h4>Methods</h4>Children (0-17 years) in Denmark with newly diagnosed cancer were invited to participate in whole-genome sequencing of germline DNA. Suspicion of ... Read more >>

PLoS Genet (PLoS genetics)
[2020, 16(12):e1009231]

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Interprofessional versus monoprofessional case-based learning in childhood cancer and the effect on healthcare professionals' knowledge and attitudes: study protocol for a randomised trial.

Martha Krogh Topperzer, Marianne Hoffmann, Hanne Bækgaard Larsen, Susanne Rosthøj, Jacob Nersting, Louise Ingerslev Roug, Peter Pontoppidan, Liv Andrés-Jensen, Birgitte Lausen, Kjeld Schmiegelow, Jette Led Sørensen,

<h4>Background</h4>Interprofessional education in childhood cancer is a multifaceted field involving multiple healthcare professionals with general and specialised knowledge and skills. Complex treatment, care and rehabilitation require continuous professional development and maintenance of healthcare professionals' competencies in their field of expertise. However, limited knowledge exists in comparing interprofessional and monoprofessional education. ... Read more >>

BMC Health Serv Res (BMC health services research)
[2020, 20(1):1124]

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Have COVID-19 affected ALL epidemiology?

Kjeld Schmiegelow,

Acta Paediatr (Acta paediatrica (Oslo, Norway : 1992))
[2020, :]

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TPMT polymorphisms and minimal residual disease after 6-mercaptopurine post-remission consolidation therapy of childhood acute lymphoblastic leukaemia.

Karin Dreisig, Emilie Damgaard Brünner, Hanne V Marquart, Louise Rold Helt, Jacob Nersting, Thomas Leth Frandsen, Olafur Gisli Jonsson, Mervi Taskinen, Goda Vaitkeviciene, Bendik Lund, Jonas Abrahamsson, Kristi Lepik, Kjeld Schmiegelow,

Bone marrow minimal residual disease (MRD) is the strongest predictor of relapse in children with acute lymphoblastic leukemia (ALL). 6-mercaptopurine (6MP) in ALL therapy has wide inter-individual variation in disposition and is strongly influenced by polymorphisms in the thiopurine methyltransferase (<i>TPMT</i>) gene. In 952 patients treated according to the NOPHO ... Read more >>

Pediatr Hematol Oncol (Pediatric hematology and oncology)
[2020, :1-12]

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QOL-59. CEREBELLAR MUTISM SYNDROME AND THE SURGICAL RISK FACTORS: A PROSPECTIVE MULTICENTRE STUDY OF 500 PATIENTS UNDERGOING TUMOUR SURGERY IN THE POSTERIOR FOSSA

Jonathan Kjær Grønbæk, Morten Wibroe, Sebastian Toescu, Pernilla Grillner, Conor Mallucci, Emanuela Molinari, Kristin Solem, Mia Westerholm-Ormio, Rosita Kiudeliene, Katalin Mudra, Peter Hauser, Kirsten van Baarsen, Eelco Hoving, Julian Zipfel, Karsten Nysom, Kjeld Schmiegelow, Astrid Sehested, Marianne Juhler, René Mathiasen,

Abstract <h4>OBJECTIVE</h4> Cerebellar mutism syndrome (CMS) is a severe neurological complication of tumour surgery in the posterior fossa in childhood. The incidence is reported between 8 and 39%, where CMS sets in within days of surgery and resolves within months, yet long-term sequelae are seen in most patients. This prospective ... Read more >>

Neuro Oncol (Neuro-oncology)
[2020, 22(Suppl 3):iii441-iii441]

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Genome-wide association study across pediatric central nervous system tumors implicates shared predisposition and points to 1q25.2 (PAPPA2) and 11p12 (LRRC4C) as novel candidate susceptibility loci.

Jon Foss-Skiftesvik, Christian Munch Hagen, René Mathiasen, Dea Adamsen, Marie Bækvad-Hansen, Anders D Børglum, Merete Nordentoft, Thomas Werge, Michael Christiansen, Kjeld Schmiegelow, Marianne Juhler, Preben Bo Mortensen, David Michael Hougaard, Jonas Bybjerg-Grauholm,

<h4>Introduction</h4>Central nervous system (CNS) tumors constitute the most common form of solid neoplasms in children, but knowledge on genetic predisposition is sparse. In particular, whether susceptibility attributable to common variants is shared across CNS tumor types in children has not been investigated. The purpose of this study was to explore ... Read more >>

Childs Nerv Syst (Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery)
[2020, :]

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Relapse risk following truncation of PEG-asparaginase in childhood acute lymphoblastic leukemia.

Sofie Gottschalk Højfeldt, Kathrine Grell, Jonas Abrahamsson, Bendik Lund, Kim Vettenranta, Olafur G Jonsson, Thomas Leth Frandsen, Benjamin Ole Wolthers, Hanne Vibeke Hansen Marquart, Goda Vaitkeviciene, Kristi Lepik, Mats Heyman, Kjeld Schmiegelow, Birgitte Klug Albertsen,

Truncation of asparaginase treatment due to asparaginase related toxicities or silent inactivation (SI) is common and may increase relapse risk in acute lymphoblastic leukemia (ALL). We investigated relapse risk following suboptimal asparaginase exposure among 1401 children aged 1-17 years, diagnosed with ALL between July 2008 and February 2016, and treated ... Read more >>

Blood (Blood)
[2020, :]

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Prophylaxis of thromboembolism during therapy with asparaginase in adults with acute lymphoblastic leukaemia.

Cecilie U Rank, Line Stensig Lynggaard, Bodil Als-Nielsen, Wendy Stock, Nina Toft, Ove Juul Nielsen, Thomas Leth Frandsen, Ruta Tuckuviene, Kjeld Schmiegelow,

<h4>Background</h4>The risk of venous thromboembolism is increased in adults and enhanced by asparaginase-based chemotherapy, and venous thromboembolism introduces a secondary risk of treatment delay and premature discontinuation of key anti-leukaemic agents, potentially compromising survival. Yet, the trade-off between benefits and harms of primary thromboprophylaxis in adults with acute lymphoblastic leukaemia (ALL) treated according to asparaginase-based ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2020, 10:CD013399]

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Effects of NT5C2 Germline Variants on 6-Mecaptopurine Metabolism in Children With Acute Lymphoblastic Leukemia.

Chuang Jiang, Wenjian Yang, Takaya Moriyama, Chengcheng Liu, Colton Smith, Wentao Yang, Maoxiang Qian, Ziping Li, Morten Tulstrup, Kjeld Schmiegelow, Kristine R Crews, Hui Zhang, Ching-Hon Pui, William Evans, Mary Relling, Smita Bhatia, Jun J Yang,

6-mercaptopurine (6-MP) is widely used in the treatment of acute lymphoblastic leukemia (ALL), and its cytotoxicity is primarily mediated by thioguanine nucleotide (TGN) metabolites. A recent genomewide association study has identified germline polymorphisms (e.g., rs72846714) in the NT5C2 gene associated with 6-MP metabolism in patients with ALL. However, the full ... Read more >>

Clin Pharmacol Ther (Clinical pharmacology and therapeutics)
[2020, :]

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Meropenem to Children With Febrile Neutropenia Induces Monoresistant Pseudomonas aeruginosa.

Mette B Mønster, Nadja H Vissing, Henrik Schrøder, Dorthe Grosen, Steen Rosthøj, Niels Frimodt-Møller, Mikala Wang, Henrik C Schønheyder, Kjeld Schmiegelow, Ulrik S Justesen, Ulrikka Nygaard,

Antimicrobial resistance in Pseudomonas aeruginosa is a threat to children with cancer. We explored the association between P. aeruginosa resistance and previous antibiotic exposure. All children with cancer and P. aeruginosa bacteremia in 2007 to 2016 in Denmark, a country with an overall resistance rate of ∼3%, were included. Twenty ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2020, 42(8):e783-e787]

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Parent's perspectives of the pathway to diagnosis of childhood cancer: a matter of diagnostic triage.

Line Hjøllund Pedersen, Ayo Wahlberg, Marie Cordt, Kjeld Schmiegelow, Susanne Oksbjerg Dalton, Hanne Bækgaard Larsen,

<h4>Background</h4>Early diagnosis is crucial for the treatment of childhood cancer as it in some cases can prevent progression of disease and improve prognoses. However, childhood cancer can be difficult to diagnose and barriers to early diagnosis are multifactorial. New knowledge about factors influencing the pathway to diagnosis contribute to a ... Read more >>

BMC Health Serv Res (BMC health services research)
[2020, 20(1):969]

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Managing toxicities with asparaginase-based therapies in adult ALL: summary of an ESMO Open-Cancer Horizons roundtable discussion.

Patrick W Burke, Dieter Hoelzer, Jae H Park, Kjeld Schmiegelow, Dan Douer,

With recent prospective clinical trials that used paediatric regimens with multiple doses of pegylated form of asparaginase (PEG asparaginase) in adults reporting significantly improved survival compared with historical data with regimens that used less asparaginase, PEG asparaginase is increasingly being used in the treatment of adult acute lymphoblastic leukaemia (ALL). ... Read more >>

ESMO Open (ESMO open)
[2020, 5(5):]

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Correction: Flow cytometric detection of leukemic blasts in cerebrospinal fluid predicts risk of relapse in childhood acute lymphoblastic leukemia: a Nordic Society of Pediatric Hematology and Oncology study.

Maria Thastrup, Hanne Vibeke Marquart, Mette Levinsen, Kathrine Grell, Jonas Abrahamsson, Birgitte Klug Albertsen, Thomas Leth Frandsen, Arja Harila-Saari, Päivi Maria Lähteenmäki, Riitta Niinimäki, Cornelis Jan Pronk, Aina Ulvmoen, Goda Vaitkevičienė, Mervi Taskinen, Kjeld Schmiegelow, ,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Leukemia (Leukemia)
[2020, 34(10):2822]

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Radio-Resistance and DNA Repair in Pediatric Diffuse Midline Gliomas.

Henriette Pedersen, Kjeld Schmiegelow, Petra Hamerlik,

Malignant gliomas (MG) are among the most prevalent and lethal primary intrinsic brain tumors. Although radiotherapy (RT) is the most effective nonsurgical therapy, recurrence is universal. Dysregulated DNA damage response pathway (DDR) signaling, rampant genomic instability, and radio-resistance are among the hallmarks of MGs, with current therapies only offering palliation. ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(10):]

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Combining epigenetic therapy with venetoclax overcomes alemtuzumab resistance in T-cell prolymphocytic leukemia. A case report of a 26-year-old man with a prior history of T-cell acute lymphoblastic leukemia and GI-T lymphoma.

Michael Asger Andersen, Rebecca Valentin, Lene Dissing Sjö, Line Borgwardt, Kjeld Schmiegelow, Mette Klarskov Andersen, Rasmus L Marvig, Christina Westmose Yde, Carsten Utoft Niemann,

Acta Oncol (Acta oncologica (Stockholm, Sweden))
[2020, 59(12):1547-1551]

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Increasing completion of asparaginase treatment in childhood acute lymphoblastic leukaemia (ALL): summary of an expert panel discussion.

André Baruchel, Patrick Brown, Carmelo Rizzari, Lewis Silverman, Inge van der Sluis, Benjamin Ole Wolthers, Kjeld Schmiegelow,

Insufficient exposure to asparaginase therapy is a barrier to optimal treatment and survival in childhood acute lymphoblastic leukaemia (ALL). Three important reasons for inactivity or discontinuation of asparaginase therapy are infusion related reactions (IRRs), pancreatitis and life-threatening central nervous system (CNS). For IRRs, real-time therapeutic drug monitoring (TDM) and premedication ... Read more >>

ESMO Open (ESMO open)
[2020, 5(5):]

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Everyday life challenges among adolescent and young adult survivors of childhood acute lymphoblastic leukemia: An in-depth qualitative study.

Liv Andrés-Jensen, Hanne Baekgaard Larsen, Christoffer Johansen, Thomas Leth Frandsen, Kjeld Schmiegelow, Ayo Wahlberg,

<h4>Objective</h4>As survival rates increase, growing numbers of childhood acute lymphoblastic leukemia (ALL) survivors are at risk for somatic and psychosocial late effects. Adolescent and young adult (AYA) survivors represent a distinct and vulnerable group. This study aimed to explore how AYA survivors of childhood ALL experience everyday life after cancer ... Read more >>

Psychooncology (Psycho-oncology)
[2020, 29(10):1630-1637]

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Maintenance therapy of childhood acute lymphoblastic leukemia: Do all roads lead to Rome?

Kjeld Schmiegelow,

Pediatr Blood Cancer (Pediatric blood & cancer)
[2020, 67(11):e28418]

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Management of Asparaginase Toxicity in AYAs with ALL.

Kjeld Schmiegelow, Cecilie Utke Rank,

Clin Lymphoma Myeloma Leuk (Clinical lymphoma, myeloma & leukemia)
[2020, 20 Suppl 1:S12-S13]

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Cationic amphiphilic drugs induce elevation in lysoglycerophospholipid levels and cell death in leukemia cells.

Inger Ødum Nielsen, Line Groth-Pedersen, Jano Dicroce-Giacobini, Anna Sofie Holm Jonassen, Monika Mortensen, Mesut Bilgin, Kjeld Schmiegelow, Marja Jäättelä, Kenji Maeda,

<h4>Introduction</h4>Repurposing of cationic amphiphilic drugs (CADs) emerges as an attractive therapeutic solution against various cancers, including leukemia. CADs target lysosomal lipid metabolism and preferentially kill cancer cells via induction of lysosomal membrane permeabilization, but the exact effects of CADs on the lysosomal lipid metabolism remain poorly illuminated.<h4>Objectives</h4>We aimed to systematically ... Read more >>

Metabolomics (Metabolomics : Official journal of the Metabolomic Society)
[2020, 16(9):91]

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Effects of germline DHFR and FPGS variants on methotrexate metabolism and relapse of leukemia.

Morten Tulstrup, Takaya Moriyama, Chuang Jiang, Marie Grosjean, Jacob Nersting, Jonas Abrahamsson, Kathrine Grell, Lisa Lyngsie Hjalgrim, Ólafur Gísli Jónsson, Jukka Kanerva, Bendik Lund, Stine Nygaard Nielsen, Rikke Linnemann Nielsen, Ulrik Overgaard, Petter Quist-Paulsen, Kaie Pruunsild, Goda Vaitkeviciene, Benjamin Ole Wolthers, Hui Zhang, Ramneek Gupta, Jun J Yang, Kjeld Schmiegelow,

Methotrexate (MTX) during maintenance therapy is essential for curing acute lymphoblastic leukemia (ALL), but dosing strategies aiming at adequate treatment intensity are challenged by interindividual differences in drug disposition. To evaluate genetic factors associated with MTX metabolism, we performed a genome-wide association study in 447 ALL cases from the Nordic ... Read more >>

Blood (Blood)
[2020, 136(10):1161-1168]

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Polygenic risk score-analysis of thromboembolism in patients with acute lymphoblastic leukemia.

Kirsten Brunsvig Jarvis, Rikke Linnemann Nielsen, Ramneek Gupta, Freja Dahl Hede, Pasi Huttunen, Ólafur Gisli Jónsson, Cecilie Utke Rank, Susanna Ranta, Kadri Saks, Sonata Saulyte Trakymiene, Ruta Tuckuviene, Morten Tulstrup, , Ellen Ruud, Kjeld Schmiegelow, Marissa LeBlanc,

<h4>Introduction</h4>Thromboembolism (TE) is a common and serious toxicity of acute lymphoblastic leukemia (ALL) treatment, but studies of genetic predisposition have been underpowered with conflicting results. We tested whether TE in ALL and TE in the general adult population have a shared genetic etiology.<h4>Materials and methods</h4>We prospectively registered TE events and ... Read more >>

Thromb Res (Thrombosis research)
[2020, 196:15-20]

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Smartphone App to Self-Monitor Nausea During Pediatric Chemotherapy Treatment: User-Centered Design Process.

Astrid Eliasen, Mikkel Kramme Abildtoft, Niels Steen Krogh, Catherine Rechnitzer, Jesper Sune Brok, René Mathiasen, Kjeld Schmiegelow, Kim Peder Dalhoff,

<h4>Background</h4>Nausea and vomiting are common and distressing side effects for children receiving chemotherapy. Limited evidence is available to guide antiemetic recommendations; therefore, prospective and reliable evaluation of antiemetic efficacy is needed. Smartphone apps can be used to effortlessly and precisely collect patient-reported outcomes in real time.<h4>Objective</h4>Our objective was to develop ... Read more >>

JMIR Mhealth Uhealth (JMIR mHealth and uHealth)
[2020, 8(7):e18564]

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