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Author Kirsty Brittain

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Impact of adverse childhood experiences on women's psychosocial and HIV-related outcomes and early child development in their offspring.

Kirsty Brittain, Allison Zerbe, Tamsin K Phillips, Yolanda Gomba, Claude A Mellins, Landon Myer, Elaine J Abrams,

Adverse childhood experiences (ACEs) may have a critical influence on adult outcomes and subsequent offspring development, but few data have explored the effects of ACEs in low-resource settings where the burdens of childhood adversity and HIV are high. Among mothers living with HIV in Cape Town, we examined the effects ... Read more >>

Glob Public Health (Global public health)
[2021, :1-13]

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Alcohol use and intimate partner violence in HIV-uninfected pregnant women in Cape Town, South Africa.

Dvora L Joseph Davey, Stanzi M Le Roux, Kirsty Brittain, Kathryn Dovell, Steve Shoptaw, Amanda P Miller, Tamsin K Phillips, Allison Zerbe, Elaine J Abrams, Landon Myer,

In settings with a high burden of HIV, pregnant women often experience a cluster of risk factors, including alcohol use and intimate partner violence (IPV). These interrelated risks are poorly understood among pregnant women at risk of HIV in sub-Saharan Africa. We aim to determine cross-sectional associations between pregnant women's ... Read more >>

AIDS Care (AIDS care)
[2021, :1-6]

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The secret life of young adolescents living with HIV in northern Mozambique - a mixed methods study.

Joana Falcão, Allison Zerbe, Claude Ann Mellins, Joanne Mantell, Kirsty Brittain, Bill Kapogiannis, Eduarda Pimentel de Gusmao, Teresa Beatriz Simione, Elaine J Abrams,

<h4>Background</h4>In Mozambique, HIV infection remains a leading cause of adolescent mortality. With advances in antiretroviral treatment (ART), the population of adolescents living with vertically-acquired HIV is growing. Most studies of adolescents living with HIV (ALHIV) focus on older youth with horizontal infection. As part of a larger study, we examined ... Read more >>

BMC Public Health (BMC public health)
[2021, 21(1):1650]

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HIV-Related Stigma and Psychological Adjustment Among Perinatally HIV-Infected Youth in Cape Town, South Africa.

Alexander Perez, Kirsty Brittain, Nicole Phillips, Dan J Stein, Heather J Zar, Landon Myer, Jacqueline Hoare,

The effect of chronic HIV-infection on psychological adjustment, including the impact of HIV-related stigma in perinatally HIV-infected (PHIV+) youth across Africa is largely unknown. This study examined psychological adjustment and HIV-related stigma using the Strengths and Difficulties Questionnaire (SDQ) and a 10-item stigma questionnaire in a cohort of PHIV+ youth in ... Read more >>

AIDS Behav (AIDS and behavior)
[2021, :]

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Improving retention in antenatal and postnatal care: a systematic review of evidence to inform strategies for adolescents and young women living with HIV.

Kirsty Brittain, Chloe A Teasdale, Bernadette Ngeno, Judith Odondi, Boniface Ochanda, Karryn Brown, Agnes Langat, Surbhi Modi, Elaine J Abrams,

<h4>Introduction</h4>Young pregnant and postpartum women living with HIV (WLHIV) are at high risk of poor outcomes in prevention of mother-to-child transmission services. The aim of this systematic review was to collate evidence on strategies to improve retention in antenatal and/or postpartum care in this population. We also conducted a secondary ... Read more >>

J Int AIDS Soc (Journal of the International AIDS Society)
[2021, 24(8):e25770]

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Characteristics of adolescents aged 15-19 years living with vertically and horizontally acquired HIV in Nampula, Mozambique.

Chloe A Teasdale, Kirsty Brittain, Allison Zerbe, Claude Ann Mellins, Joana Falcao, Aleny Couto, Eduarda Pimentel De Gusmao, Mirriah Vitale, Bill Kapogiannis, Teresa Beatriz Simione, Landon Myer, Joanne Mantell, Christopher Desmond, Elaine J Abrams,

<h4>Background</h4>Adolescents living with HIV (ALHIV) 15-19 years of age are a growing proportion of all people living with HIV globally and the population includes adolescents with vertically acquired HIV (AVH) and behaviorally acquired HIV (ABH).<h4>Methods</h4>We conducted a survey to measure sociodemographic characteristics, educational status, health history, and antiretroviral therapy (ART) ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0250218]

Cited: 1 time

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Longitudinal association between intimate partner violence and viral suppression during pregnancy and postpartum in South African women.

Abigail M Hatcher, Kirsty Brittain, Tamsin K Phillips, Allison Zerbe, Elaine J Abrams, Landon Myer,

<h4>Objective</h4>We examined the longitudinal association between women's exposure to intimate partner violence (IPV) and HIV viral load during pregnancy and postpartum.<h4>Design</h4>Secondary analysis of an HIV-positive cohort enrolled during pregnancy at a South African antenatal clinic.<h4>Methods</h4>Viral load was assessed at 10 study visits and analyzed continuously as log10 copies/ml and suppression ... Read more >>

AIDS (AIDS (London, England))
[2021, 35(5):791-799]

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Measuring retention in HIV care: the impact of data sources and definitions using routine data.

Tamsin K Phillips, Catherine Orrell, Kirsty Brittain, Allison Zerbe, Elaine J Abrams, Landon Myer,

<h4>Objectives</h4>Measuring retention is critical for antiretroviral therapy (ART) management and program monitoring; however, many definitions and data sources, usually from single health facilities, are used. We used routine electronic data, linked across facilities, to examine the impact of definitions and data sources on retention estimates among women in Cape Town, ... Read more >>

AIDS (AIDS (London, England))
[2020, 34(5):749-759]

Cited: 3 times

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Mother-child separation among women living with HIV and their children in the first four years postpartum in South Africa.

Phepo Mogoba, Tamsin K Phillips, Stanzi le Roux, Elton E Mukonda, Kirsty Brittain, Yolanda Gomba, Allison Zerbe, Elaine J Abrams, Landon Myer,

<h4>Objectives</h4>Mother-child pairs may separate during early life, yet the health impacts thereof are unclear. We explored the patterns and impact of separation among women living with HIV (WLHIV) and their children in South Africa.<h4>Methods</h4>WLHIV who had initiated antiretroviral therapy (ART) during pregnancy received HIV viral load (VL) testing and completed ... Read more >>

Trop Med Int Health (Tropical medicine & international health : TM & IH)
[2021, 26(2):173-183]

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High blood pressure at entry into antenatal care and birth outcomes among a cohort of HIV-uninfected women and women living with HIV initiating antiretroviral therapy in South Africa.

Angela M Bengtson, Tamsin K Phillips, Stanzi M le Roux, Kirsty Brittain, Allison Zerbe, Hlengiwe P Madlala, Thokozile R Malaba, Gregory Petro, Elaine J Abrams, Landon Myer,

<h4>Objective</h4>To examine associations between high blood pressure (BP) when entering antenatal care (ANC) and birth outcomes in a cohort of pregnant HIV- and women living with HIV (WLHIV) initiating antiretroviral treatment (ART).<h4>Study design</h4>Prospective cohort study.<h4>Main outcome measures</h4>Cesarean delivery, preterm birth (<37 weeks' gestation), low birthweight (LBW, <2500 g), small-for-gestational age (SGA, <10th ... Read more >>

Pregnancy Hypertens (Pregnancy hypertension)
[2021, 23:79-86]

Cited: 1 time

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"This is My Life We are Talking About": Adaptive Strategies for HIV Care Retention and Treatment Adherence Among Postpartum Women Living with HIV in Cape Town, South Africa.

Alison Z Weber, Jennifer A Pellowski, Kirsty Brittain, Abigail Harrison, Tamsin K Phillips, Allison Zerbe, Elaine J Abrams, Landon Myer,

<h4>Introduction</h4>Retaining postpartum women living with HIV in ongoing care is critical for the health of the mother-child dyad but low adherence to antiretroviral therapy (ART) and retention in HIV care are a global concern. This issue is particularly salient in South Africa, where approximately 50% of women fall out of ... Read more >>

Matern Child Health J (Maternal and child health journal)
[2020, 24(12):1454-1463]

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Does HIV infection modify the relationship between pre-pregnancy body mass index and adverse birth outcomes?

Angela M Bengtson, Tamsin K Phillips, Stanzi M le Roux, Kirsty Brittain, Allison Zerbe, Hlengiwe Madlala, Thokozile Malaba, Gregory Petro, Elaine J Abrams, Landon Myer,

<h4>Background</h4>South Africa faces dual epidemics of HIV and obesity; however, little research has explored whether HIV status influences associations between pre-pregnancy body mass index (BMI) and adverse birth outcomes.<h4>Objectives</h4>To examine associations between pre-pregnancy body mass index (BMI) and adverse birth outcomes, and if they differ by HIV status.<h4>Methods</h4>We followed HIV-uninfected ... Read more >>

Paediatr Perinat Epidemiol (Paediatric and perinatal epidemiology)
[2020, 34(6):713-723]

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Community-based adherence clubs for postpartum women on antiretroviral therapy (ART) in Cape Town, South Africa: a pilot study.

Allison Zerbe, Kirsty Brittain, Tamsin K Phillips, Victoria O Iyun, Joanna Allerton, Andile Nofemela, Cathy D Kalombo, Landon Myer, Elaine J Abrams,

<h4>Background</h4>With an increasing number of countries implementing Option B+ guidelines of lifelong antiretroviral therapy (ART) for all pregnant and breastfeeding women, there is urgent need to identify effective approaches for retaining this growing and highly vulnerable population in ART care.<h4>Methods</h4>Newly postpartum, breastfeeding women who initiated ART in pregnancy and met ... Read more >>

BMC Health Serv Res (BMC health services research)
[2020, 20(1):621]

Cited: 3 times

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Long-Term Outcomes of HIV-Infected Women Receiving Antiretroviral Therapy After Transferring Out of an Integrated Maternal and Child Health Service in South Africa.

Tamsin K Phillips, Pheposadi Mogoba, Kirsty Brittain, Yolanda Gomba, Allison Zerbe, Landon Myer, Elaine J Abrams,

<h4>Background</h4>Integrated maternal and child health (MCH) services improve women's postpartum antiretroviral therapy (ART) outcomes during breastfeeding; however, long-term outcomes after transfer to general ART services remain unknown.<h4>Methods</h4>The MCH-ART trial demonstrated that maternal retention and viral suppression at 12-months postpartum were improved significantly among women randomized to integrated MCH services continued ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2020, 83(3):202-209]

Cited: 4 times

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Long-term effects of unintended pregnancy on antiretroviral therapy outcomes among South African women living with HIV.

Kirsty Brittain, Tamsin K Phillips, Allison Zerbe, Elaine J Abrams, Landon Myer,

<h4>Objective</h4>Unintended pregnancies are common among women living with HIV, but there are no data on their long-term impact on treatment outcomes. In a cohort of women initiating antiretroviral therapy (ART) during pregnancy, we examined the association between the intendedness of the current pregnancy, measured antenatally, and elevated viral load up ... Read more >>

AIDS (AIDS (London, England))
[2019, 33(5):885-893]

Cited: 3 times

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Neurodevelopment of breastfed HIV-exposed uninfected and HIV-unexposed children in South Africa.

Stanzi M le Roux, Kirsten A Donald, Kirsty Brittain, Tamsin K Phillips, Allison Zerbe, Kelly K Nguyen, Andrea Strandvik, Max Kroon, Elaine J Abrams, Landon Myer,

OBJECTIVES:To assess neurodevelopment of breastfed HIV-exposed uninfected (HEU) and breastfed HIV-unexposed children in the context of universal maternal antiretroviral therapy (ART). DESIGN:Prospective study with antenatal enrolment and follow-up of breastfeeding HEU and HIV-unexposed mother-infant pairs through 12-18 months postpartum. SETTING:Peri-urban community, Cape Town, South Africa. PARTICIPANTS:HEU (n = 215) and HIV-unexposed (n = 306) ... Read more >>

AIDS (AIDS (London, England))
[2018, 32(13):1781-1791]

Cited: 23 times

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Postpartum obesity and weight gain among human immunodeficiency virus-infected and human immunodeficiency virus-uninfected women in South Africa.

Angela M Bengtson, Tamsin K Phillips, Stanzi M le Roux, Kirsty Brittain, Allison Buba, Elaine J Abrams, Landon Myer,

In South Africa, up to 40% of pregnant women are living with human immunodeficiency virus (HIV), and 30-45% are obese. However, little is known about the dual burden of HIV and obesity in the postpartum period. In a cohort of HIV-uninfected and HIV-infected pregnant women initiating antiretroviral therapy in Cape ... Read more >>

Matern Child Nutr (Maternal & child nutrition)
[2020, 16(3):e12949]

Cited: 2 times

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Cost-effectiveness of integrating postpartum antiretroviral therapy and infant care into maternal & child health services in South Africa.

Caitlin M Dugdale, Tamsin K Phillips, Landon Myer, Emily P Hyle, Kirsty Brittain, Kenneth A Freedberg, Lucy Cunnama, Rochelle P Walensky, Allison Zerbe, Milton C Weinstein, Elaine J Abrams, Andrea L Ciaranello, ,

<h4>Background</h4>Poor engagement in postpartum maternal HIV care is a challenge worldwide and contributes to adverse maternal outcomes and vertical transmission. Our objective was to project the clinical and economic impact of integrated postpartum maternal antiretroviral therapy (ART) and pediatric care in South Africa.<h4>Methods</h4>Using the CEPAC computer simulation models, parameterized with ... Read more >>

PLoS One (PloS one)
[2019, 14(11):e0225104]

Cited: 4 times

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Infectious morbidity of breastfed, HIV-exposed uninfected infants under conditions of universal antiretroviral therapy in South Africa: a prospective cohort study.

Stanzi M le Roux, Elaine J Abrams, Kirsten A Donald, Kirsty Brittain, Tamsin K Phillips, Allison Zerbe, David M le Roux, Max Kroon, Landon Myer,

<h4>Background</h4>Without breastfeeding and maternal antiretroviral therapy (ART), HIV-exposed uninfected (HEU) infants have greater infectious morbidity than HIV-unexposed (HU) infants. We hypothesised that with the introduction of universal maternal ART, breastfed HEU and HU infants would have similar morbidity.<h4>Methods</h4>We prospectively studied a cohort of HIV-infected pregnant women initiating ART, and a ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(3):220-231]

Cited: 12 times

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The injection or the injection? Restricted contraceptive choices among women living with HIV.

Catriona A Towriss, Tamsin K Phillips, Kirsty Brittain, Allison Zerbe, Elaine J Abrams, Landon Myer,

Historically, women living with HIV (WLWH) have been vulnerable to biased advice from healthcare workers regarding contraception and childbearing. However, antiretroviral therapy (ART) has made motherhood safer, prompting a re-examination of whether contraceptive services enable the realisation of WLWH's reproductive intentions. We use longitudinal quantitative data on contraceptive choice and ... Read more >>

Sex Reprod Health Matters (Sexual and reproductive health matters)
[2019, 27(1):1628593]

Cited: 2 times

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Mental Health and Functional Competence in the Cape Town Adolescent Antiretroviral Cohort.

Jacqueline Hoare, Nicole Phillips, Kirsty Brittain, Landon Myer, Heather J Zar, Dan J Stein,

<h4>Background</h4>The impact of HIV and antiretrovirals (ART) on long-term mental health in perinatally infected children has not been well studied in sub-Saharan Africa where HIV is most prevalent.<h4>Setting</h4>Cape Town, South Africa.<h4>Methods</h4>We investigated mental health measures, including depression, anxiety, attention-deficit hyperactivity disorder, motivation, disruptive behavior, and functioning in perinatally infected adolescents ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2019, 81(4):e109-e116]

Cited: 6 times

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Impact of HIV-Status Disclosure on HIV Viral Load in Pregnant and Postpartum Women on Antiretroviral Therapy.

Kirsty Brittain, Claude A Mellins, Robert H Remien, Tamsin K Phillips, Allison Zerbe, Elaine J Abrams, Landon Myer,

BACKGROUND:HIV-status disclosure is widely encouraged by counseling services, in part because it is thought to improve antiretroviral therapy (ART) adherence and thus HIV viral suppression. However, few longitudinal studies have examined the impact of disclosure on HIV viral load (VL) during pregnancy and postpartum. METHODS:We explored these associations among 1187 ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2019, 81(4):379-386]

Cited: 6 times

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A Comparison of Plasma Efavirenz and Tenofovir, Dried Blood Spot Tenofovir-Diphosphate, and Self-Reported Adherence to Predict Virologic Suppression Among South African Women.

Tamsin K Phillips, Phumla Sinxadi, Elaine J Abrams, Allison Zerbe, Catherine Orrell, Nai-Chung Hu, Kirsty Brittain, Yolanda Gomba, Jennifer Norman, Lubbe Wiesner, Landon Myer, Gary Maartens,

<h4>Background</h4>Tenofovir-diphosphate (TFV-DP) in dried blood spots (DBS) is an objective long-term adherence measure, but data are limited on its ability to predict virologic suppression (VS) in people on antiretroviral (ARV) treatment. There are also no data comparing DBS TFV-DP with plasma ARV concentrations as predictors of VS.<h4>Methods</h4>Women who were on ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2019, 81(3):311-318]

Cited: 7 times

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"You must leave but I didn't want to leave": qualitative evaluation of the integration of ART into postnatal maternal and child health services in Cape Town, South Africa.

Jennifer A Pellowski, Alison Z Weber, Tamsin K Phillips, Kirsty Brittain, Allison Zerbe, Elaine J Abrams, Landon Myer,

Postpartum HIV care retention rates are well below retention rates of the general adult population. The Maternal-Child Health Antiretroviral Therapy (MCH-ART) trial tested the benefit of integrating postpartum maternal ART and pediatric care through the end of breastfeeding compared to the standard of care of immediate postpartum referral of mother ... Read more >>

AIDS Care (AIDS care)
[2020, 32(4):480-485]

Cited: 4 times

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Re-recruiting postpartum women living with HIV into a follow-up study in Cape Town, South Africa.

Phepo Mogoba, Yolanda Gomba, Kirsty Brittain, Tamsin K Phillips, Allison Zerbe, Landon Myer, Elaine J Abrams,

<h4>Objective</h4>Recruitment and retention present major challenges to longitudinal research in maternal and child health, yet there are few insights into optimal strategies that can be employed in low-resource settings. Following prior participation in a longitudinal study following women living with HIV through pregnancy and breastfeeding in Cape Town, women were ... Read more >>

BMC Res Notes (BMC research notes)
[2019, 12(1):461]

Cited: 1 time

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