Full Text Journal Articles by
Author Kim Kristensen

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PREVALENCE OF SARS-COV-2-ANTIBODIES IN DANISH CHILDREN AND ADULTS.

Maren J H Rytter, Ulrikka Nygaard, Ida Nikoline Mandic, Jonathan Peter Glenthøj, Lisbeth Samsø Schmidt, Dina Cortes, Birgitte Smith, Tatjana Zaharov, Mia Johanna Søndergaard, Marie Cecilie Lawaetz, Susanne Saekmose, Lise Heilmann Jensen, Kjeld Schmiegelow, Kim Kristensen,

In Denmark, severe acute respiratory syndrome coronavirus 2 antibodies were assessed in a cross-sectional study among 1033 children visiting pediatric departments and 750 blood donors in June 2020, using a point-of-care test. Antibodies were detected in 17 children (1.6%) and 15 blood donors (2.0%) (P = 0.58). In conclusion, children ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, Publish Ahead of Print:]

Cited: 0 times

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Pharmacokinetics of tablet and liquid formulations of oral 6-mercaptopurine in children with acute lymphoblastic leukemia.

Rikke Hebo Larsen, Lisa Lyngsie Hjalgrim, Kathrine Grell, Kim Kristensen, Line Gerner Pedersen, Emilie Damgaard Brünner, Bodil Als-Nielsen, Kjeld Schmiegelow, Jacob Nersting,

<h4>Purpose</h4>Mercaptopurine (6MP) is essential to cure childhood acute lymphoblastic leukemia (ALL). A liquid 6MP formulation was recently introduced to facilitate oral 6MP administration, especially to children. Its approval and bioequivalence with 6MP tablet were based on comparative pharmacokinetics in 60 healthy adults. Due to potential pharmacokinetic differences between healthy adults ... Read more >>

Cancer Chemother Pharmacol (Cancer chemotherapy and pharmacology)
[2020, 86(1):25-32]

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[Allergy testing in children].

Pernille Lindsø, Kim Kristensen,

Allergy testing in children can be reduced, since it should have no consequences in most cases of asthma and allergic rhinitis. In atopic dermatitis, it should be done, only when food allergy is suspected. Food allergy must be confirmed by provocation except from allergy to peanuts, which may be diagnosed ... Read more >>

Ugeskr Laeger (Ugeskrift for laeger)
[2020, 182(25):]

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Increased insulin receptor binding and increased IGF-1 receptor binding are linked with increased growth of L6hIR cell xenografts in vivo.

Henning Hvid, Tine Glendorf, Jakob Brandt, Rita Slaaby, Anne Lützen, Kim Kristensen, Bo F Hansen,

Insulin analogue X10 has a higher mitogenic potency than native human insulin in vitro and supra-pharmacological doses of insulin X10 increased the incidence of mammary tumours in rats. Compared to native human insulin, insulin X10 has increased binding affinity to the insulin receptor and the IGF-1 receptor, but it is ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):7247]

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Listeria Meningitis in Danish Children 2000-2017: A Rare Event Even in a Country With High Rates of Invasive Listeriosis.

Nadja Hawwa Vissing, Kim Kristensen, Mette Bondo Mønster, Frederik Trier Møller, Jenny Dahl Knudsen, Anja Poulsen, Steen Ethelberg, Ulrikka Nygaard,

Listeria monocytogenes meningitis in Danish children 1 month to 17 years from 2000 to 2017 was identified and patient files reviewed. There were 5 cases, equaling an annual incidence of 0.024 per 100,000 children or 0.014 when excluding 2 immunodeficient children. Even in a country with a high general incidence ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2019, 38(10):e274-e276]

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Intraintestinal and Parenteral Administration of an Insulin Analogue Leads to Comparable Activation of Signaling Downstream of the Insulin Receptor in the Small Intestine.

Henning Hvid, Jonas Kildegaard, Kim Kristensen, Trine Porsgaard, Mikkel S Jørgensen, Borja Ballarín-González, Jonas Ahnfelt-Rønne, Bo F Hansen, Erica Nishimura,

<h4>Background</h4>Oral delivery of insulin was recently demonstrated to have therapeutic relevance in patients with diabetes. Insulin receptors are expressed in the gastrointestinal tract and can be activated by insulin in the bloodstream, but it is not known if the large amount of insulin in the intestinal lumen required for sufficient ... Read more >>

J Diabetes Sci Technol (Journal of diabetes science and technology)
[2020, 14(1):112-119]

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Plasma creatinine as predictor of delayed elimination of high-dose methotrexate in childhood acute lymphoblastic leukemia: A Danish population-based study.

Diana Schmidt, Kim Kristensen, Henrik Schroeder, Peder Skov Wehner, Steen Rosthøj, Jesper Heldrup, Linn Damsgaard, Kjeld Schmiegelow, Torben Stamm Mikkelsen,

BACKGROUND:Severely delayed elimination of methotrexate (MTX) is difficult to predict in patients treated with high-dose MTX (HD-MTX), but it may cause life-threatening toxicity. It has not been defined how an increase in plasma creatinine can be best used as a predictor for severely delayed MTX elimination, thus providing a guide ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2019, 66(6):e27637]

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[Intravenous fluid therapy in children].

Aurora Undlien, Maren Rytter, Christian Overgaard-Steensen, Kim Kristensen, Juri Lindy Pedersen, Jesper Johannesen, Nadja Vissing, Ulrikka Nygaard,

The standard practice in paediatric departments in Danish hospitals is to prescribe hypotonic maintenance fluids (sodium content 20-40 mmol/l) for children, who are fasting or have a reduced enteral intake. The past decades have provided strong evidence, that this can lead to hypo-natraemia and subsequent neurologic damage or death. We ... Read more >>

Ugeskr Laeger (Ugeskrift for laeger)
[2019, 181(11):]

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Short individualised treatment of bone and joint infections in Danish children.

Allan Bybeck Nielsen, Ulrikka Nygaard, Thomas Hoffmann, Kim Kristensen,

Arch Dis Child (Archives of disease in childhood)
[2019, 104(2):205-206]

Cited: 2 times

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Population Pharmacokinetics of the Antimalarial Amodiaquine: a Pooled Analysis To Optimize Dosing.

Ali Mohamed Ali, Melissa A Penny, Thomas A Smith, Lesley Workman, Philip Sasi, George O Adjei, Francesca Aweeka, Jean-René Kiechel, Vincent Jullien, Marcus J Rijken, Rose McGready, Julia Mwesigwa, Kim Kristensen, Kasia Stepniewska, Joel Tarning, Karen I Barnes, Paolo Denti, ,

Amodiaquine plus artesunate is the recommended antimalarial treatment in many countries where malaria is endemic. However, pediatric doses are largely based on a linear extrapolation from adult doses. We pooled data from previously published studies on the pharmacokinetics of amodiaquine, to optimize the dose across all age groups. Adults and ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2018, 62(10):]

Cited: 2 times

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Comparable risk of childhood asthma after vaginal delivery and emergency caesarean section.

Nis Brix, Lonny Stokholm, Fjola Jonsdottir, Kim Kristensen, Niels Jørgen Secher,

<h4>Introduction</h4>Caesarean section is thought to be a risk factor for childhood asthma, but this association may be caused by confounding from, for instance, familial factors. To address this problem, we used twin pairs to assess the risk of childhood asthma after emergency caesarean section.<h4>Methods</h4>The study was a register-based nation-wide matched ... Read more >>

Dan Med J (Danish medical journal)
[2017, 64(1):]

Cited: 1 time

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Risk Factors for Hospitalization for Respiratory Syncytial Virus Infection: A Population-based Cohort Study of Danish Children.

Ann Haerskjold, Kim Kristensen, Mads Kamper-Jørgensen, Anne-Marie Nybo Andersen, Henrik Ravn, Lone Graff Stensballe,

<h4>Background</h4>The aim of this study is to identify the risk factors for hospitalization for respiratory syncytial virus (RSV) infection in Danish children.<h4>Methods</h4>This is a population-based cohort study with follow-up till 24 months of age. A total of 421,943 Danish children were divided into 5 groups based on gestational age (23-32, ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2016, 35(1):61-65]

Cited: 8 times

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Cesarean section and disease associated with immune function.

Kim Kristensen, Lonny Henriksen,

<h4>Background</h4>Earlier studies have shown that delivery by cesarean section (CS) is associated with an increased risk of disease associated with immune function in the offspring, but these studies have generally not discriminated between the effect of acute and elective CS.<h4>Objective</h4>We sought to further explore these associations using discrimination between the ... Read more >>

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2016, 137(2):587-590]

Cited: 37 times

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T-cell ALL in ataxia telangiectasia cured with only 7 weeks of anti-leukemic therapy.

Ditte S Hersby, Astrid Sehested, Kim Kristensen, Kjeld Schmiegelow,

A 20-month-old girl diagnosed with T-cell acute lymphoblastic leukemia was treated according to the Nordic NOPHO ALL2000 protocol. The patient developed severe immunosuppression and experienced life-threatening adenovirus infection, which was treated with ribavirin and cidofovir. α-fetoprotein was 20- to 30-fold elevated, and genetic analysis confirmed the diagnosis of ataxia telangiectasia. ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2015, 37(2):154-155]

Cited: 0 times

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Caesarean section and hospitalization for respiratory syncytial virus infection: a population-based study.

Kim Kristensen, Niels Fisker, Ann Haerskjold, Henrik Ravn, Eric A F Simões, Lone Stensballe,

<h4>Background and objective</h4>Hospitalization for respiratory syncytial virus (RSV) infection and asthma share common determinants, and meta-analyses indicate that children delivered by caesarean section (CS) are at increased risk of asthma. We aimed to investigate whether birth by CS is associated with an increased risk of hospitalization for RSV illness.<h4>Methods</h4>This was ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2015, 34(2):145-148]

Cited: 9 times

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[Individualized treatment of osteoarticular infections in children may shorten the treatment course].

Kim Kristensen, Jesper Andersen, Kjeld Gade Hansen, Thomas Hoffmann, Jørgen Kurtzhals, Ulrikka Nygaard, Freddy Karup Pedersen,

Older studies have suggested that antibiotic treatment for less than 21 days in children with osteoarticular infections is associated with relapse, and therefore traditionally these infections have been treated for six weeks with an intravenous phase of one week. However, four new prospective studies suggest that if the duration of ... Read more >>

Ugeskr Laeger (Ugeskrift for laeger)
[2014, 176(30):1403-1406]

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[Lack of clarity about asthma and allergies in children].

Kim Kristensen,

Ugeskr Laeger (Ugeskrift for laeger)
[2013, 175(46):2812]

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[Clinical assessment cannot predict if children are infected with Mycoplasma pneumoniae].

Kim Kristensen, Ulrikka Nygaard, Cristel Sørensen,

This meta-analysis was carried out to detect if clinical signs can predict infection with Mycoplasma pneumoniae in children. The only significant finding was that absence of wheezing was associated with M. pneumoniae-infection. The analysis does not justify changes in the recommendation regarding treatment of pneumonia in children. Empiric therapy with ... Read more >>

Ugeskr Laeger (Ugeskrift for laeger)
[2013, 175(48):2949-2950]

Cited: 0 times

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A population pharmacokinetic and pharmacodynamic study of a peripheral κ-opioid receptor agonist CR665 and oxycodone.

Anne E Olesen, Kim Kristensen, Camilla Staahl, Sherron Kell, Gilbert Y Wong, Lars Arendt-Nielsen, Asbjørn M Drewes,

<h4>Background</h4>Peripherally acting opioids, particularly peripheral κ-opioid agonists, may be effective for treating visceral pain by activating receptors expressed on afferent nerves within the gut.<h4>Objective</h4>The objective of this study was to investigate the pharmacokinetic/pharmacodynamic profile of a novel peripherally selective κ-opioid agonist, CR665 (JNJ-38488502), and compare it to that of oxycodone, ... Read more >>

Clin Pharmacokinet (Clinical pharmacokinetics)
[2013, 52(2):125-137]

Cited: 6 times

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Dietary proteins extend the survival of Salmonella Dublin in a gastric acid environment.

Tina Birk, Kim Kristensen, Anne Harboe, Tina Beck Hansen, Hanne Ingmer, Rob De Jonge, Katsuhisa Takumi, Søren Aabo,

The pH of the human stomach is dynamic and changes over time, depending on the composition of the food ingested and a number of host-related factors such as age. To evaluate the number of bacteria surviving the gastric acid barrier, we have developed a simple gastric acid model, in ... Read more >>

J Food Prot (Journal of food protection)
[2012, 75(2):353-358]

Cited: 2 times

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Chronic diseases, chromosomal abnormalities, and congenital malformations as risk factors for respiratory syncytial virus hospitalization: a population-based cohort study.

Kim Kristensen, Thomas Hjuler, Henrik Ravn, Eric A F Simões, Lone G Stensballe,

BACKGROUND: Little is known about how chronic conditions other than prematurity, heart disease, and Down syndrome affect the risk and severity of hospitalization for respiratory syncytial virus (RSV). We assess the risk and severity of RSV hospitalization in children with chronic conditions in this register-based, population-based cohort study. METHODS: Data ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2012, 54(6):810-817]

Cited: 58 times

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[Tubercular meningitis with severe hyponatraemia caused by cerebral salt wasting].

Jeanette Tinggaard, Ida Maria Schmidt, Kim Kristensen,

We describe two children, who were admitted with severe hyponatraemia and dehydration. In both children the hyponatraemia was due to cerebral salt wasting caused by tubercular meningitis. Differential diagnosis and pathophysiology is discussed. It is important to discriminate between cerebral salt wasting and inappropriate secretion of antidiuretic hormone since the ... Read more >>

Ugeskr Laeger (Ugeskrift for laeger)
[2011, 173(37):2273-2274]

Cited: 2 times

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[Recombinant human DNase in conditions other than cystic fibrosis].

Kim Kristensen,

Recombinant human DNase (rhDNase) reduces viscosity of sputum. Effect has been documented in cystic fibrosis and postoperatively in paediatric heart disease. Single dose treatment with rhDNase in paediatric asthma has no effect. In respiratory syncytial virus infection, treatment with rhDNase may be associated with increased need for supplemental oxygen. In ... Read more >>

Ugeskr Laeger (Ugeskrift for laeger)
[2010, 172(8):616-619]

Cited: 1 time

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[Purpura fulminans].

Karina Jordan, Kim Kristensen,

Varicella-associated purpura fulminans (PF) is a rare complication to varicella infection. The condition is due to autoantibodies directed against protein S which forms part of the anticoagulation system. Lack of protein S leads to disseminated intravascular coagulation in the small vessels, which causes thrombosis and ischemia. Despite early treatment, amputation ... Read more >>

Ugeskr Laeger (Ugeskrift for laeger)
[2010, 172(28):2064-2065]

Cited: 0 times

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Respiratory syncytial virus neutralizing antibodies in cord blood, respiratory syncytial virus hospitalization, and recurrent wheeze.

Lone Graff Stensballe, Henrik Ravn, Kim Kristensen, Kenneth Agerskov, Tiffany Meakins, Peter Aaby, Eric A F Simões,

<h4>Background</h4>Respiratory syncytial virus (RSV) hospitalization is associated with wheeze.<h4>Objective</h4>To examine the influence of maternally derived RSV neutralizing antibodies in cord blood on RSV hospitalization and recurrent wheeze in infancy.<h4>Methods</h4>Among children from the Danish National Birth Cohort, we selected a subcohort of 459 randomly selected children, 408 children with RSV hospitalization, ... Read more >>

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2009, 123(2):398-403]

Cited: 51 times

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