Full Text Journal Articles by
Author Kim Isaacs

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Single-Cell Analysis Reveals Unexpected Cellular Changes and Transposon Expression Signatures in the Colonic Epithelium of Treatment-Naïve Adult Crohn's Disease Patients.

Matt Kanke, Meaghan M Kennedy Ng, Sean Connelly, Manvendra Singh, Matthew Schaner, Michael T Shanahan, Elizabeth A Wolber, Caroline Beasley, Grace Lian, Animesh Jain, Millie D Long, Edward L Barnes, Hans H Herfarth, Kim L Isaacs, Jonathon J Hansen, Muneera Kapadia, Jose Gaston Guillem, Cedric Feschotte, Terrence S Furey, Shehzad Z Sheikh, Praveen Sethupathy,

<h4>Background & aims</h4>The intestinal barrier comprises a monolayer of specialized intestinal epithelial cells (IECs) that are critical in maintaining mucosal homeostasis. Dysfunction within various IEC fractions can alter intestinal permeability in a genetically susceptible host, resulting in a chronic and debilitating condition known as Crohn's disease (CD). Defining the molecular ... Read more >>

Cell Mol Gastroenterol Hepatol (Cellular and molecular gastroenterology and hepatology)
[2022, 13(6):1717-1740]

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Etrolizumab as induction and maintenance therapy for ulcerative colitis in patients previously treated with tumour necrosis factor inhibitors (HICKORY): a phase 3, randomised, controlled trial.

Laurent Peyrin-Biroulet, Ailsa Hart, Peter Bossuyt, Millie Long, Matthieu Allez, Pascal Juillerat, Alessandro Armuzzi, Edward V Loftus, Elham Ostad-Saffari, Astrid Scalori, Young S Oh, Swati Tole, Akiko Chai, Jennifer Pulley, Stuart Lacey, William J Sandborn, ,

<h4>Background</h4>Etrolizumab is a gut-targeted, anti-β7 integrin, monoclonal antibody. In an earlier phase 2 induction study, etrolizumab significantly improved clinical remission compared with placebo in patients with moderately to severely active ulcerative colitis. We aimed to evaluate the efficacy and safety of etrolizumab in patients with moderately to severely active ulcerative ... Read more >>

Lancet Gastroenterol Hepatol (The lancet. Gastroenterology & hepatology)
[2022, 7(2):128-140]

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