Full Text Journal Articles by
Author Kim B Jensen


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LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium.

Rosalie T Zwiggelaar, Håvard T Lindholm, Madeleine Fosslie, Marianne Terndrup Pedersen, Yuki Ohta, Alberto Díez-Sánchez, Mara Martín-Alonso, Jenny Ostrop, Mami Matano, Naveen Parmar, Emilie Kvaløy, Roos R Spanjers, Kamran Nazmi, Morten Rye, Finn Drabløs, Cheryl Arrowsmith, John Arne Dahl, Kim B Jensen, Toshiro Sato, Menno J Oudhoff,

Intestinal epithelial homeostasis is maintained by adult intestinal stem cells, which, alongside Paneth cells, appear after birth in the neonatal period. We aimed to identify regulators of neonatal intestinal epithelial development by testing a small library of epigenetic modifier inhibitors in Paneth cell-skewed organoid cultures. We found that lysine-specific demethylase ... Read more >>

Sci Adv (Science advances)
[2020, 6(37):]

Cited: 0 times

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Intestinal Organoids: A Tool for Modelling Diet-Microbiome-Host Interactions.

Josep Rubert, Pawel J Schweiger, Fulvio Mattivi, Kieran Tuohy, Kim B Jensen, Andrea Lunardi,

Dietary patterns, microbiome dysbiosis, and gut microbial metabolites (GMMs) have a pivotal role in the homeostasis of intestinal epithelial cells and in disease progression, such as that of colorectal cancer (CRC). Although GMMs and microorganisms have crucial roles in many biological activities, models for deciphering diet-microbiome-host relationships are largely limited ... Read more >>

Trends Endocrinol Metab (Trends in endocrinology and metabolism: TEM)
[2020, 31(11):848-858]

Cited: 0 times

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Tracing the cellular dynamics of sebaceous gland development in normal and perturbed states.

Marianne Stemann Andersen, Edouard Hannezo, Svetlana Ulyanchenko, Soline Estrach, Yasuko Antoku, Sabrina Pisano, Kim E Boonekamp, Sarah Sendrup, Martti Maimets, Marianne Terndrup Pedersen, Jens V Johansen, Ditte L Clement, Chloe C Feral, Benjamin D Simons, Kim B Jensen,

The sebaceous gland (SG) is an essential component of the skin, and SG dysfunction is debilitating1,2. Yet, the cellular bases for its origin, development and subsequent maintenance remain poorly understood. Here, we apply large-scale quantitative fate mapping to define the patterns of cell fate behaviour during SG development and maintenance. ... Read more >>

Nat Cell Biol (Nature cell biology)
[2019, 21(8):924-932]

Cited: 2 times

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Tracing the origin of adult intestinal stem cells.

Jordi Guiu, Edouard Hannezo, Shiro Yui, Samuel Demharter, Svetlana Ulyanchenko, Martti Maimets, Anne Jørgensen, Signe Perlman, Lene Lundvall, Linn Salto Mamsen, Agnete Larsen, Rasmus H Olesen, Claus Yding Andersen, Lea Langhoff Thuesen, Kristine Juul Hare, Tune H Pers, Konstantin Khodosevich, Benjamin D Simons, Kim B Jensen,

Adult intestinal stem cells are located at the bottom of crypts of Lieberkühn, where they express markers such as LGR51,2 and fuel the constant replenishment of the intestinal epithelium1. Although fetal LGR5-expressing cells can give rise to adult intestinal stem cells3,4, it remains unclear whether this population in the patterned ... Read more >>

Nature (Nature)
[2019, 570(7759):107-111]

Cited: 9 times

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Tissue-Engineering the Intestine: The Trials before the Trials.

Hans Clevers, Ryan K Conder, Vivian S W Li, Matthias P Lutolf, Ludovic Vallier, Sarah Chan, Tracy C Grikscheit, Kim B Jensen, Paolo De Coppi,

Building complex tissues requires the development of innovative interdisciplinary engineering solutions. In this Forum, the INTENS Consortium discuss experimental considerations and challenges for generating a tissue-engineered intestine for the treatment of short bowel syndrome, taking into account cell source, scaffold choice, and design strategy for achieving proper assembly and function. ... Read more >>

Cell Stem Cell (Cell stem cell)
[2019, 24(6):855-859]

Cited: 2 times

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COX-2-PGE2 Signaling Impairs Intestinal Epithelial Regeneration and Associates with TNF Inhibitor Responsiveness in Ulcerative Colitis.

Yuan Li, Christoffer Soendergaard, Fredrik Holmberg Bergenheim, David M Aronoff, Ginger Milne, Lene Buhl Riis, Jakob Benedict Seidelin, Kim B Jensen, Ole Haagen Nielsen,

BACKGROUND:Inhibition of tumor necrosis factor-α (TNF) signaling is beneficial in the management of ulcerative colitis (UC), but up to one-third of patients do not have a clinical response of relevance to TNF inhibitors during induction therapy (i.e. primary non-responders [PNRs]). Through production of prostaglandins (PGs) and thromboxanes, cyclooxygenase-2 (COX-2) affects ... Read more >>

EBioMedicine (EBioMedicine)
[2018, 36:497-507]

Cited: 7 times

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IL-17R-EGFR axis links wound healing to tumorigenesis in Lrig1+ stem cells.

Xing Chen, Gang Cai, Caini Liu, Junjie Zhao, Chunfang Gu, Ling Wu, Thomas A Hamilton, Cun-Jin Zhang, Jennifer Ko, Liang Zhu, Jun Qin, Allison Vidimos, Shlomo Koyfman, Brian R Gastman, Kim B Jensen, Xiaoxia Li,

Lrig1 marks a distinct population of stem cells restricted to the upper pilosebaceous unit in normal epidermis. Here we report that IL-17A-mediated activation of EGFR plays a critical role in the expansion and migration of Lrig1+ stem cells and their progenies in response to wounding, thereby promoting wound healing and ... Read more >>

J Exp Med (The Journal of experimental medicine)
[2019, 216(1):195-214]

Cited: 13 times

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Lrig1 marks a population of gastric epithelial cells capable of long-term tissue maintenance and growth in vitro.

Pawel J Schweiger, Ditte L Clement, Mahalia E Page, Troels Schepeler, Xiangang Zou, Gabor Sirokmány, Fiona M Watt, Kim B Jensen,

The processes involved in renewal of the epithelium that lines the mouse stomach remain unclear. Apart from the cells in the isthmus, several other populations located deeper in the gastric glands have been suggested to contribute to the maintenance of the gastric epithelium. Here, we reveal that Lrig1 is expressed ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):15255]

Cited: 5 times

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Inhibiting RHOA Signaling in Mice Increases Glucose Tolerance and Numbers of Enteroendocrine and Other Secretory Cells in the Intestine.

Natalia Petersen, Thomas M Frimurer, Marianne Terndrup Pedersen, Kristoffer L Egerod, Nicolai J Wewer Albrechtsen, Jens J Holst, Anne Grapin-Botton, Kim B Jensen, Thue W Schwartz,

BACKGROUND & AIMS:Glucagon-like peptide 1 (GLP1) is produced by L cells in the intestine, and agonists of the GLP1 receptor are effective in the treatment of diabetes. Levels of GLP1 increase with numbers of L cells. Therefore, agents that increase numbers of L cell might be developed for treatment of ... Read more >>

Gastroenterology (Gastroenterology)
[2018, 155(4):1164-1176.e2]

Cited: 8 times

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Dietary Control of Skin Lipid Composition and Microbiome.

Kasper S Moestrup, Yun Chen, Troels Schepeler, Pawel J Schweiger, Kim B Jensen,

J Invest Dermatol (The Journal of investigative dermatology)
[2018, 138(5):1225-1228]

Cited: 0 times

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Loss of PACS-2 delays regeneration in DSS-induced colitis but does not affect the ApcMin model of colorectal cancer.

Sarah L Dombernowsky, Jeanette Schwarz, Jacob Samsøe-Petersen, Reidar Albrechtsen, Kim B Jensen, Gary Thomas, Marie Kveiborg,

PACS-2 is a multifunctional sorting protein that mediates cell homeostasis. We recently identified PACS-2 in a functional genome-wide siRNA screen for novel regulators of the metalloproteinase ADAM17, the main sheddase for ligands of the ErbB receptor family. Of note, we showed that Pacs2-/- mice have significantly reduced EGFR activity and ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(65):108303-108315]

Cited: 2 times

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Intestinal barrier integrity and inflammatory bowel disease: Stem cell-based approaches to regenerate the barrier.

Fredrik E O Holmberg, Jannie Pedersen, Peter Jørgensen, Christoffer Soendergaard, Kim B Jensen, Ole H Nielsen,

Disruption of normal barrier function is a fundamental factor in the pathogenesis of inflammatory bowel disease, which includes increased epithelial cell death, modified mucus configuration, altered expression and distribution of tight junction proteins, along with a decreased expression of antimicrobial peptides. Inflammatory bowel disease is associated with life-long morbidity for ... Read more >>

J Tissue Eng Regen Med (Journal of tissue engineering and regenerative medicine)
[2018, 12(4):923-935]

Cited: 11 times

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A genetically inducible porcine model of intestinal cancer.

Morten M Callesen, Sigrid S Árnadóttir, Iben Lyskjaer, Mai-Britt W Ørntoft, Søren Høyer, Frederik Dagnaes-Hansen, Ying Liu, Rong Li, Henrik Callesen, Mads H Rasmussen, Martin F Berthelsen, Martin K Thomsen, Pawel J Schweiger, Kim B Jensen, Søren Laurberg, Torben F Ørntoft, Jannik E Elverløv-Jakobsen, Claus L Andersen,

Transgenic porcine cancer models bring novel possibilities for research. Their physical similarities with humans enable the use of surgical procedures and treatment approaches used for patients, which facilitates clinical translation. Here, we aimed to develop an inducible oncopig model of intestinal cancer. Transgenic (TG) minipigs were generated using somatic cell ... Read more >>

Mol Oncol (Molecular oncology)
[2017, 11(11):1616-1629]

Cited: 5 times

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Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids.

Fotios Sampaziotis, Alexander W Justin, Olivia C Tysoe, Stephen Sawiak, Edmund M Godfrey, Sara S Upponi, Richard L Gieseck, Miguel Cardoso de Brito, Natalie Lie Berntsen, María J Gómez-Vázquez, Daniel Ortmann, Loukia Yiangou, Alexander Ross, Johannes Bargehr, Alessandro Bertero, Mariëlle C F Zonneveld, Marianne T Pedersen, Matthias Pawlowski, Laura Valestrand, Pedro Madrigal, Nikitas Georgakopoulos, Negar Pirmadjid, Gregor M Skeldon, John Casey, Wenmiao Shu, Paulina M Materek, Kirsten E Snijders, Stephanie E Brown, Casey A Rimland, Ingrid Simonic, Susan E Davies, Kim B Jensen, Matthias Zilbauer, William T H Gelson, Graeme J Alexander, Sanjay Sinha, Nicholas R F Hannan, Thomas A Wynn, Tom H Karlsen, Espen Melum, Athina E Markaki, Kourosh Saeb-Parsy, Ludovic Vallier,

The treatment of common bile duct (CBD) disorders, such as biliary atresia or ischemic strictures, is restricted by the lack of biliary tissue from healthy donors suitable for surgical reconstruction. Here we report a new method for the isolation and propagation of human cholangiocytes from the extrahepatic biliary tree in ... Read more >>

Nat. Med. (Nature medicine)
[2017, 23(8):954-963]

Cited: 41 times

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Cell biology: Unconventional translation in cancer.

Marianne Terndrup Pedersen, Kim B Jensen,

Nature (Nature)
[2017, 541(7638):471-472]

Cited: 1 time

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Bimodal skin progenitors-a matter of place and time.

Svetlana Ulyanchenko, Kim B Jensen,

EMBO J (The EMBO journal)
[2016, 35(24):2628-2630]

Cited: 0 times

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Isolation and In Vitro Characterization of Epidermal Stem Cells.

Kasper S Moestrup, Marianne S Andersen, Kim B Jensen,

Colony-forming assays represent prospective methods, where cells isolated from enzymatically dissociated tissues or from tissue cultures are assessed for their proliferative capacity in vitro. Complex tissues such as the epithelial component of the skin (the epidermis) are characterized by a substantial cellular heterogeneity. Analysis of bulk populations of cells by ... Read more >>

Methods Mol. Biol. (Methods in molecular biology (Clifton, N.J.))
[2017, 1553:67-83]

Cited: 3 times

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Modeling human disease using organotypic cultures.

Pawel J Schweiger, Kim B Jensen,

Reliable disease models are needed in order to improve quality of healthcare. This includes gaining better understanding of disease mechanisms, developing new therapeutic interventions and personalizing treatment. Up-to-date, the majority of our knowledge about disease states comes from in vivo animal models and in vitro cell culture systems. However, it ... Read more >>

Curr. Opin. Cell Biol. (Current opinion in cell biology)
[2016, 43:22-29]

Cited: 17 times

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Stem cell heterogeneity revealed.

Marianne S Andersen, Kim B Jensen,

The skin forms a protective, water-impermeable barrier consisting of heavily crosslinked epithelial cells. However, the specific role of stem cells in sustaining this barrier remains a contentious issue. A detailed analysis of the interfollicular epidermis now proposes a model for how a composite of cells with different properties are involved ... Read more >>

Nat Cell Biol (Nature cell biology)
[2016, 18(6):587-589]

Cited: 0 times

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From Definitive Endoderm to Gut-a Process of Growth and Maturation.

Jordi Guiu, Kim B Jensen,

The intestine and colon carries out vital functions, and their lifelong maintenance is of the upmost importance. Research over the past decades has carefully addressed bowel function, how it is maintained and begun to unravel how disorders such as cancer and inflammatory bowel disease form. In contrast, very little is ... Read more >>

Stem Cells Dev. (Stem cells and development)
[2015, 24(17):1972-1983]

Cited: 3 times

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Hippo signalling directs intestinal fate.

Marie Le Bouteiller, Kim B Jensen,

Hippo signalling has been associated with many important tissue functions including the regulation of organ size. In the intestinal epithelium differing functions have been proposed for the effectors of Hippo signalling, YAP and TAZ1. These are now shown to have a dual role in the intestinal epithelium, regulating both stem ... Read more >>

Nat. Cell Biol. (Nature cell biology)
[2015, 17(1):5-6]

Cited: 5 times

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Heterogeneity and plasticity of epidermal stem cells.

Troels Schepeler, Mahalia E Page, Kim B Jensen,

The epidermis is an integral part of our largest organ, the skin, and protects us against the hostile environment. It is a highly dynamic tissue that, during normal steady-state conditions, undergoes constant turnover. Multiple stem cell populations residing in autonomously maintained compartments facilitate this task. In this Review, we discuss ... Read more >>

Development (Development (Cambridge, England))
[2014, 141(13):2559-2567]

Cited: 40 times

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Biological techniques: An embryonic view of tumour development.

Pawel J Schweiger, Kim B Jensen,

Nature (Nature)
[2013, 501(7466):171-172]

Cited: 0 times

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The epidermis comprises autonomous compartments maintained by distinct stem cell populations.

Mahalia E Page, Patrick Lombard, Felicia Ng, Berthold Göttgens, Kim B Jensen,

The complex anatomy of the epidermis contains multiple adult stem cell populations, but the extent to which they functionally overlap during homeostasis, wound healing, and tumor initiation remains poorly defined. Here, we demonstrate that Lrig1(+ve) cells are highly proliferative epidermal stem cells. Long-term clonal analysis reveals that Lrig1(+ve) cells maintain ... Read more >>

Cell Stem Cell (Cell stem cell)
[2013, 13(4):471-482]

Cited: 120 times

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Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury.

Robert P Fordham, Shiro Yui, Nicholas R F Hannan, Christoffer Soendergaard, Alison Madgwick, Pawel J Schweiger, Ole H Nielsen, Ludovic Vallier, Roger A Pedersen, Tetsuya Nakamura, Mamoru Watanabe, Kim B Jensen,

Regeneration and homeostasis in the adult intestinal epithelium is driven by proliferative resident stem cells, whose functional properties during organismal development are largely unknown. Here, we show that human and mouse fetal intestine contains proliferative, immature progenitors, which can be expanded in vitro as Fetal Enterospheres (FEnS). A highly similar ... Read more >>

Cell Stem Cell (Cell stem cell)
[2013, 13(6):734-744]

Cited: 127 times

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