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Author Correction: The therapeutic effects of adipose-derived mesenchymal stem cells on obesity and its associated diseases in diet-induced obese mice.

Hala Jaber, Khodr Issa, Ali Eid, Fatima A Saleh,

Sci Rep (Scientific reports)
[2021, 11(1):12482]

Cited: 0 times

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The therapeutic effects of adipose-derived mesenchymal stem cells on obesity and its associated diseases in diet-induced obese mice.

Hala Jaber, Khodr Issa, Ali Eid, Fatima A Saleh,

Obesity is a global public health concern associated with increased risk of several comorbidities. Due to the limited effectiveness of current therapies, new treatment strategies are needed. Our aim was to examine the effect of adipose-derived mesenchymal stem cells (AD-MSCs) on obesity and its associated diseases in a diet-induced obese ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):6291]

Cited: 0 times

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Estrogen increases expression of vascular alpha 2C adrenoceptor through the cAMP/Epac/JNK/AP-1 pathway and potentiates cold-induced vasoconstriction.

Manal M Fardoun, Khodr Issa, Dina Maaliki, Suzanne A Nasser, Elias Baydoun, Ali H Eid,

Cutaneous cold-induced vasoconstriction is a normal physiological reaction mediated by alpha 2C-adrenergic receptors (α2C-ARs) expressed in vascular smooth muscle cells (VSMCs). When this reaction is exaggerated, Raynaud's phenomenon (RP) ensues. RP is more prevalent in females compared to age-matched men. We previously established that 17-β estradiol (estrogen) upregulates α2C-ARs in ... Read more >>

Vascul Pharmacol (Vascular pharmacology)
[2020, 131:106690]

Cited: 4 times

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Amelioration of perivascular adipose inflammation reverses vascular dysfunction in a model of nonobese prediabetic metabolic challenge: potential role of antidiabetic drugs.

Mohammed A W Elkhatib, Ali Mroueh, Rim W Rafeh, Fatima Sleiman, Hosny Fouad, Evan I Saad, Mohamed A Fouda, Ola Elgaddar, Khodr Issa, Ali H Eid, Assaad A Eid, Khaled S Abd-Elrahman, Ahmed F El-Yazbi,

The onset of vascular impairment precedes that of diagnostic hyperglycemia in diabetic patients suggesting a vascular insult early in the course of metabolic dysfunction without a well-defined mechanism. Mounting evidence implicates adipose inflammation in the pathogenesis of insulin resistance and diabetes. It is not certain whether amelioration of adipose inflammation ... Read more >>

Transl Res (Translational research : the journal of laboratory and clinical medicine)
[2019, 214:121-143]

Cited: 4 times

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Marjoram Relaxes Rat Thoracic Aorta Via a PI3-K/eNOS/cGMP Pathway.

Adnan Badran, Elias Baydoun, Ali Samaha, Gianfranco Pintus, Joelle Mesmar, Rabah Iratni, Khodr Issa, Ali H Eid,

Despite pharmacotherapeutic advances, cardiovascular disease (CVD) remains the primary cause of global mortality. Alternative approaches, such as herbal medicine, continue to be sought to reduce this burden. <i>Origanum majorana</i> is recognized for many medicinal values, yet its vasculoprotective effects remain poorly investigated. Here, we subjected rat thoracic aortae to increasing ... Read more >>

Biomolecules (Biomolecules)
[2019, 9(6):]

Cited: 2 times

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The role of α2-adrenergic receptors in hypertensive preeclampsia: A hypothesis.

Dina Maaliki, Khodr Issa, Tuqa Al Shehabi, Ahmed El-Yazbi, Ali H Eid,

Preeclampsia, a major disorder of human pregnancy, manifests as persistent hypertension and proteinuria presenting after 20 weeks of pregnancy. Multiple systemic symptoms might be associated with preeclampsia including thrombocytopenia, liver impairment, pulmonary edema, and cerebral disturbances. However, vascular dysfunction remains the core pathological driver of preeclampsia. Defective placental implantation followed by ... Read more >>

Microcirculation (Microcirculation (New York, N.Y. : 1994))
[2019, 26(1):e12511]

Cited: 0 times

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Cadmium Induces Migration of Colon Cancer Cells: Roles of Reactive Oxygen Species, P38 and Cyclooxygenase-2.

Sara Naji, Khodr Issa, Assaad Eid, Rabah Iratni, Ali H Eid,

BACKGROUND/AIMS:Cadmium (Cd) is a heavy metal contaminant whose toxicity is associated with colorectal cancer (CRC). However, the underlying molecular mechanisms of Cd-induced CRC malignancy remain obscure. METHODS:A monolayer scratch assay was employed to assess the migration of HT-29 human adenocarcinoma cells. Luciferase reporter assay was used to determine cyclooxygenase-2 (COX-2) transcriptional activity, ... Read more >>

Cell Physiol Biochem (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology)
[2019, 52(6):1517-1534]

Cited: 5 times

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MicroRNAs as Potential Pharmaco-targets in Ischemia-Reperfusion Injury Compounded by Diabetes.

Hassan Dehaini, Hussein Awada, Ahmed El-Yazbi, Fouad A Zouein, Khodr Issa, Assaad A Eid, Maryam Ibrahim, Adnan Badran, Elias Baydoun, Gianfranco Pintus, Ali H Eid,

<h4>Background</h4>Ischemia-Reperfusion (I/R) injury is the tissue damage that results from re-oxygenation of ischemic tissues. There are many players that contribute to I/R injury. One of these factors is the family of microRNAs (miRNAs), which are currently being heavily studied. This review aims to critically summarize the latest papers that attributed ... Read more >>

Cells (Cells)
[2019, 8(2):]

Cited: 12 times

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Ziziphus nummularia Inhibits Inflammation-Induced Atherogenic Phenotype of Human Aortic Smooth Muscle Cells.

Manal Fardoun, Tuqa Al-Shehabi, Ahmed El-Yazbi, Khodr Issa, Fouad Zouein, Dina Maaliki, Rabah Iratni, Ali H Eid,

Cardiovascular disease (CVD) continues to be the leading cause of death worldwide. Atherosclerosis is a CVD characterized by plaque formation resulting from inflammation-induced insults to endothelial cells, monocytes, and vascular smooth muscle cells (VSMCs). Despite significant advances, current treatments for atherosclerosis remain insufficient, prompting the search for alternative modalities, including ... Read more >>

Oxid Med Cell Longev (Oxidative medicine and cellular longevity)
[2017, 2017:4134093]

Cited: 9 times

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Raynaud's Phenomenon: A Brief Review of the Underlying Mechanisms.

Manal M Fardoun, Joseph Nassif, Khodr Issa, Elias Baydoun, Ali H Eid,

Raynaud's phenomenon (RP) is characterized by exaggerated cold-induced vasoconstriction. This augmented vasoconstriction occurs by virtue of a reflex response to cooling via the sympathetic nervous system as well as by local activation of α<sub>2C</sub> adrenoceptors (α<sub>2C</sub>-AR). In a cold-initiated, mitochondrion-mediated mechanism involving reactive oxygen species and the Rho/ROCK pathway, cytoskeletal ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2016, 7:438]

Cited: 15 times

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Efficient extra- and intracellular alkalinization improves cardiovascular functions in severe lactic acidosis induced by hemorrhagic shock.

Antoine Kimmoun, Nicolas Ducrocq, Nacira Sennoun, Khodr Issa, Charlène Strub, Jean-Marie Escanyé, Sébastien Leclerc, Bruno Levy,

<h4>Background</h4>Lactic acidosis is associated with cardiovascular failure. Buffering with sodium bicarbonate is proposed in severe lactic acidosis. Bicarbonate induces carbon dioxide generation and hypocalcemia, both cardiovascular depressant factors. The authors thus investigated the cardiovascular and metabolic effects of an adapted sodium bicarbonate therapy, including prevention of carbon dioxide increase with ... Read more >>

Anesthesiology (Anesthesiology)
[2014, 120(4):926-934]

Cited: 12 times

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