Full Text Journal Articles by
Author Khandakar A S M Saadat

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Epigenetic alterations in aging tooth and the reprogramming potential.

Mahshid Hodjat, Fazlullah Khan, Khandakar A S M Saadat,

Tooth compartments and associated supportive tissues exhibit significant alterations during aging, leading to their impaired functioning. Aging not only affects the structure and function of dental tissue but also reduces its capacity to maintain physiological homeostasis and the healing process. Decreased cementocyte viability; diminished regenerative potential of stem cells residing ... Read more >>

Ageing Res Rev (Ageing research reviews)
[2020, 63:101140]

Cited: 0 times

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Long noncoding RNA ERICD interacts with ARID3A via E2F1 and regulates migration and proliferation of osteosarcoma cells.

Kaifee Arman, Khandakar A S M Saadat, Yusuf Z Igci, Esra Bozgeyik, Masa-Aki Ikeda, Ecir A Cakmak, Ahmet Arslan,

Long noncoding RNA (lncRNA) dysregulation is known to be taking part in majority of cancers, including osteosarcoma. In one of our previous studies, we showed that lncRNA MEG3 is being regulated by microRNA-664a (miR-664a) suppresses the migratory potential of osteosarcoma cells (U-2OS). We now report a novel lncRNA, namely, ERICD, ... Read more >>

Cell Biol Int (Cell biology international)
[2020, 44(11):2263-2274]

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Effects of Moringa oleifera Lam Extract (MOLE) in the heat shock protein 70 expression and germ cell apoptosis on experimentally induced cryptorchid testes of rats.

Muhammetnur Tekayev, Nuray Bostancieri, Khandakar A S M Saadat, Mehmet Turker, Mehmet Yuncu, Hasan Ulusal, Hulya Cicek, Kaifee Arman,

Moringa oleifera (Moringaceae) is a plant known for having high antioxidant potency, anticancer, hepatoprotective, cardioprotective etc. and many more activities. Besides these, Moringaceae has the potential for attenuating the male sexual dysfunction. Reactive oxygen species/ROS were increased in cryptorchidism and therefore cause infertility by damaging sperm DNA and germ cell ... Read more >>

Gene (Gene)
[2019, 688:140-150]

Cited: 1 time

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Inhibition of autophagy induces retinal pigment epithelial cell damage by the lipofuscin fluorophore A2E.

Khandakar A S M Saadat, Yusuke Murakami, Xue Tan, Yoko Nomura, Tsutomu Yasukawa, Eiichi Okada, Yasuhiro Ikeda, Yasuo Yanagi,

In this study, we show augmented autophagy in the retinal pigment epithelial cell line ARPE-19 when cultured in the presence of the lipofuscin pigment A2E. A2E alone does not induce RPE cell death, but cell death was induced in the presence of A2E with the autophagy inhibitor 3-methyladenine (3MA), with ... Read more >>

FEBS Open Bio (FEBS open bio)
[2014, 4:1007-1014]

Cited: 14 times

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[Role of ARID3A in E2F target gene expression and cell growth].

Khandakar A S M Saadat,

ARID3A is a member of the AT-rich interaction domain (ARID) family of DNA-binding proteins. ARID3A was isolated as proteins binding to E2F1, and stimulates transcription mediated by the E2F transcription factor that plays a central role in regulating cell cycle progression. However, the function of ARID3A in E2F-target-gene expression has ... Read more >>

Kokubyo Gakkai Zasshi (Kokubyo Gakkai zasshi. The Journal of the Stomatological Society, Japan)
[2013, 80(1):15-20]

Cited: 0 times

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