Full Text Journal Articles by
Author Kh Shamsur Rahman

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Multi-peptide ELISAs overcome cross-reactivity and inadequate sensitivity of conventional Chlamydia pneumoniae serology.

Kh Shamsur Rahman, Bernhard Kaltenboeck,

Cross-reactivity of classical chlamydial antigens compromises Chlamydia (C.) pneumoniae serology. By testing with 185 human antisera, we expanded 18 previously discovered C. pneumoniae-specific B-cell epitopes to 48 peptide antigens from 12 C. pneumoniae immunodominant proteins. For specific detection of antibodies against C. pneumoniae, we developed novel ELISAs with strongly reactive individual ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):15078]

Cited: 0 times

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Inadequate Reference Datasets Biased toward Short Non-epitopes Confound B-cell Epitope Prediction.

Kh Shamsur Rahman, Erfan Ullah Chowdhury, Konrad Sachse, Bernhard Kaltenboeck,

X-ray crystallography has shown that an antibody paratope typically binds 15-22 amino acids (aa) of an epitope, of which 2-5 randomly distributed amino acids contribute most of the binding energy. In contrast, researchers typically choose for B-cell epitope mapping short peptide antigens in antibody binding assays. Furthermore, short 6-11-aa epitopes, ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2016, 291(28):14585-14599]

Cited: 10 times

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Host adaptation of Chlamydia pecorum towards low virulence evident in co-evolution of the ompA, incA, and ORF663 Loci.

Khalil Yousef Mohamad, Bernhard Kaltenboeck, Kh Shamsur Rahman, Simone Magnino, Konrad Sachse, Annie Rodolakis,

Chlamydia (C.) pecorum, an obligate intracellular bacterium, may cause severe diseases in ruminants, swine and koalas, although asymptomatic infections are the norm. Recently, we identified genetic polymorphisms in the ompA, incA and ORF663 genes that potentially differentiate between high-virulence C. pecorum isolates from diseased animals and low-virulence isolates from asymptomatic ... Read more >>

PLoS ONE (PloS one)
[2014, 9(8):e103615]

Cited: 11 times

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Asymptomatic endemic Chlamydia pecorum infections reduce growth rates in calves by up to 48 percent.

Anil Poudel, Theodore H Elsasser, Kh Shamsur Rahman, Erfan U Chowdhury, Bernhard Kaltenboeck,

Intracellular Chlamydia (C.) bacteria cause in cattle some acute but rare diseases such as abortion, sporadic bovine encephalomyelitis, kerato-conjunctivitis, pneumonia, enteritis and polyarthritis. More frequent, essentially ubiquitous worldwide, are low-level, asymptomatic chlamydial infections in cattle. We investigated the impact of these naturally acquired infections in a cohort of 51 female ... Read more >>

PLoS ONE (PloS one)
[2012, 7(9):e44961]

Cited: 22 times

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