Full Text Journal Articles by
Author Kevin Yi Lwern Yap

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Use of virtual reality in the supportive care management of paediatric patients with cancer.

Kevin Yi-Lwern Yap, Dalvin Wan Hong Koh, Valerie Sze Jie Lee, Li Lian Wong,

Paediatric patients with cancer undergo multiple treatments and procedures that can be invasive and painful. Virtual reality technologies could support the management of paediatric cancer. This Review focuses on the physiological and psychological efficacy of virtual reality in supportive care management. Virtual reality has shown potential in reducing pain scores, ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(12):899-908]

Cited: 0 times

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Personalizing symptom monitoring and contact tracing efforts through a COVID-19 web-app.

Kevin Yi-Lwern Yap, Qihuang Xie,

BACKGROUND:The Coronavirus Disease 2019 (COVID-19) pandemic has sparked attention in many countries, especially those that have experienced a steep spike in the number of identified cases. The continued spread of the coronavirus suggests that this situation may be here to stay for a while. Contact tracing is a time-consuming and ... Read more >>

Infect Dis Poverty (Infectious diseases of poverty)
[2020, 9(1):93]

Cited: 0 times

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Patients' Perception of App-based Educational and Behavioural Interventions for Enhancing Oral Anticancer Medication Adherence.

Eskinder Eshetu Ali, Jo Lene Leow, Lita Chew, Kevin Yi-Lwern Yap,

Well-designed smartphone apps can potentially help in enhancing adherence to oral anticancer medications (OAMs). The objective of this study was to evaluate patients' perception on inclusion of various adherence-enhancing strategies as features of an app and their interest in using such app. A cross-sectional survey was conducted at the National ... Read more >>

J Cancer Educ (Journal of cancer education : the official journal of the American Association for Cancer Education)
[2018, 33(6):1306-1313]

Cited: 2 times

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Design Considerations in the Development of App-Based Oral Anticancer Medication Management Systems: a Qualitative Evaluation of Pharmacists' and Patients' Perspectives.

Eskinder Eshetu Ali, Sharlene Si Ling Chan, Huan Yu Poh, Yosua Amadeus Susanto, Thendral Suganya, Jo Lene Leow, Chee Khiang Pang, Lita Chew, Kevin Yi-Lwern Yap,

Smartphone apps can potentially help in enhancing oral anticancer medication (OAM) adherence. Patient adoption and efficacy of such apps depends on inclusion of user-centred and evidence-based features. The objective of this study was to identify important design considerations from the perspectives of patients taking OAMs, caregivers and oncology pharmacists. The ... Read more >>

J Med Syst (Journal of medical systems)
[2019, 43(3):63]

Cited: 1 time

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MedAd-AppQ: A quality assessment tool for medication adherence apps on iOS and android platforms.

Eskinder Eshetu Ali, Amanda Kai Sin Teo, Sherlyn Xue Lin Goh, Lita Chew, Kevin Yi-Lwern Yap,

BACKGROUND:With the recent proliferation of smartphone medication adherence applications (apps), it is increasingly more difficult for patients and clinicians to identify the most useful app. OBJECTIVE:To develop a quality assessment tool for medication adherence apps, and evaluate the quality of such apps from the major app stores. METHODS:In this study, ... Read more >>

Res Social Adm Pharm (Research in social & administrative pharmacy : RSAP)
[2018, 14(12):1125-1133]

Cited: 1 time

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User acceptance of an app-based adherence intervention: Perspectives from patients taking oral anticancer medications.

Eskinder Eshetu Ali, Sharlene Si Ling Chan, Jo Lene Leow, Lita Chew, Kevin Yi-Lwern Yap,

BACKGROUND:Widespread adoption by patients is imperative for the success of app-based interventions for enhancing adherence to oral anticancer medications. Patients' attitudes and beliefs should be evaluated to understand determinants of their acceptance and adoption of such interventions. OBJECTIVE:To identify factors that influence cancer patients' intention to adopt an app-based system ... Read more >>

J Oncol Pharm Pract (Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners)
[2019, 25(2):390-397]

Cited: 6 times

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Herbopolis - A mobile serious game to educate players on herbal medicines.

Ryan Wei Xuan Ee, Kai Zhen Yap, Kevin Yi-Lwern Yap,

BACKGROUND:Use of herbal medicines is common. There is a need for education in this area. Mobile games are useful educational tools for motivating learning. A mobile game on herbal medicines can potentially enhance players' herb-related knowledge. Our objective was to develop a mobile game to motivate players to learn more ... Read more >>

Complement Ther Med (Complementary therapies in medicine)
[2018, 39:68-79]

Cited: 1 time

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Prevalence and Determinants of Adherence to Oral Adjuvant Endocrine Therapy among Breast Cancer Patients in Singapore.

Eskinder Eshetu Ali, Ka Lok Cheung, Chee Ping Lee, Jo Lene Leow, Kevin Yi-Lwern Yap, Lita Chew,

OBJECTIVE:The success of oral adjuvant endocrine therapy (OAET) is greatly influenced by patients' level of adherence to treatment. The objective of this study is to measure the prevalence and determinants of adherence to OAET among breast cancer patients in Singapore. METHODS:A cross-sectional survey of patients supplemented by analysis of their ... Read more >>

(Asia-Pacific journal of oncology nursing)
[2017, 4(4):283-289]

Cited: 3 times

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Quality Assessment of Medical Apps that Target Medication-Related Problems.

John Shiguang Loy, Eskinder Eshetu Ali, Kevin Yi-Lwern Yap,

The advent of smartphones has enabled a plethora of medical apps for disease management. As of 2012, there are 40,000 health care-related mobile apps available in the market. Since most of these medical apps do not go through any stringent quality assessment, there is a risk of consumers being misinformed ... Read more >>

J Manag Care Spec Pharm (Journal of managed care & specialty pharmacy)
[2016, 22(10):1124-1140]

Cited: 9 times

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Three-Dimensional Printing of Carbamazepine Sustained-Release Scaffold.

Seng Han Lim, Samuel Ming Yuan Chia, Lifeng Kang, Kevin Yi-Lwern Yap,

Carbamazepine is the first-line anti-epileptic drug for focal seizures and generalized tonic-clonic seizures. Although sustained-release formulations exist, an initial burst of drug release is still present and this results in side effects. Zero-order release formulations reduce fluctuations in serum drug concentrations, thereby reducing side effects. Three-dimensional printing can potentially fabricate ... Read more >>

J Pharm Sci (Journal of pharmaceutical sciences)
[2016, 105(7):2155-2163]

Cited: 7 times

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Gaming Preferences, Motivations, and Experiences of Pharmacy Students in Asia.

Huan Ying Chang, Li Lian Wong, Kai Zhen Yap, Kevin Yi-Lwern Yap,

Serious games are becoming popular in various healthcare domains. However, they should be designed to cater toward learners' perspectives, needs, and specifications in order to be used to their full potential in education. This study investigated the gaming experiences, motivations, and preferences of pharmacy students.An anonymous self-administered survey obtained participant ... Read more >>

Games Health J (Games for health journal)
[2016, 5(1):40-49]

Cited: 3 times

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Student Preferences on Gaming Aspects for a Serious Game in Pharmacy Practice Education: A Cross-Sectional Study.

Huan Ying Chang, David Yan Hong Poh, Li Lian Wong, John Yin Gwee Yap, Kevin Yi-Lwern Yap,

BACKGROUND:Serious games are motivating and provide a safe environment for students to learn from their mistakes without experiencing any negative consequences from their actions. However, little is known about students' gaming preferences and the types of serious games they like to play for education. OBJECTIVE:This study aims to determine the ... Read more >>

(JMIR medical education)
[2015, 1(1):e2]

Cited: 1 time

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Technological preferences of aging cancer patients for delivery services and devices to solve drug-related problems in oncology.

Kevin Yi-Lwern Yap, Yvonne Chia, Xiu Hui Low, Alexandre Chan,

To identify the technological preferences of aging cancer patients with regard to the delivery services and devices for preventing/solving three common drug-related problems (DRPs): medication nonadherence, lack of knowledge in medications, and side effects management.A survey was conducted at a cancer center from May to August 2011. Delivery services included ... Read more >>

Support Care Cancer (Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer)
[2014, 22(10):2733-2740]

Cited: 3 times

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Affordability of cancer treatment for aging cancer patients in Singapore: an analysis of health, lifestyle, and financial burden.

Alexandre Chan, Yu Yan Chiang, Xiu Hui Low, Kevin Yi-Lwern Yap, Raymond Ng,

With the expected rise in newly diagnosed cancer cases among the elderly in Singapore, the affordability of cancer treatments, particularly of targeted therapies, will be a growing concern for patients. This study examines the perspectives of aging cancer patients on the financial burden of their cancer treatments.A single-center, prospective study ... Read more >>

Support Care Cancer (Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer)
[2013, 21(12):3509-3517]

Cited: 9 times

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Impact of cancer-related fatigue on chemotherapy-induced nausea and vomiting in Asian cancer patients.

Ken Shing Ho Poon, Man Kit Un, Xiu Hui Low, Yin Ting Cheung, Kevin Yi-Lwern Yap, Alexandre Chan,

INTRODUCTION: Cancer-related fatigue (CRF) has been suggested to be associated with the occurrence of chemotherapy-induced nausea and vomiting (CINV). This study aims to evaluate the potential of CRF in predicting the occurrence of CINV. METHOD: This is a prospective, observational study. Recruited patients received moderately to highly emetogenic single-day chemotherapy ... Read more >>

Pharmacoepidemiol Drug Saf (Pharmacoepidemiology and drug safety)
[2013, 22(12):1345-1351]

Cited: 8 times

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Electronic database to detect drug-drug interactions between antidepressants and oral anticancer drugs from a cancer center in Singapore: implications to clinicians.

Alexandre Chan, Kevin Yi-Lwern Yap, Dorothy Koh, Xiu Hui Low, Yin Ting Cheung, ,

BACKGROUND: Electronic drug interaction databases are often utilized in clinical practice to detect for possible drug-drug interactions between drug pairs. It is uncertain, however, whether most of these detections interactions are clinically important in practice. To demonstrate these issues, this study utilized a comprehensive drug-drug interaction (DDI) electronic database to ... Read more >>

Pharmacoepidemiol Drug Saf (Pharmacoepidemiology and drug safety)
[2011, 20(9):939-947]

Cited: 8 times

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Clinically-relevant anticancer-antidepressant drug interactions.

Alexandre Chan, Terence Rong De Ng, Kevin Yi-Lwern Yap,

INTRODUCTION: Depression is a condition that often arises in patients with cancer. As in many cases, the simultaneous use of anticancer drugs (ACD) and antidepressants (AD) may result in potential drug interactions that can lead to worsened medical outcomes and poorer quality of life in these patients. It is therefore ... Read more >>

Expert Opin Drug Metab Toxicol (Expert opinion on drug metabolism & toxicology)
[2012, 8(2):173-199]

Cited: 7 times

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Antiemetic effectiveness and nausea and vomiting incidence during capecitabine and oxaliplatin chemotherapy.

Alexandre Chan, Sze Huey Tan, Xiu Hui Low, Kevin Yi-Lwern Yap,

BACKGROUND: Capecitabine and oxaliplatin (XELOX) chemotherapy causes nausea and vomiting, despite adequate administration of antiemetics. Furthermore, specific risk factors that increase this risk are not elucidated. OBJECTIVE: To appraise the effectiveness of antiemetics to prevent XELOX-induced nausea and vomiting. METHODS: This was a single-center, prospective, cohort study. Patients were recruited ... Read more >>

Nurs Res (Nursing research)
[2012, 61(6):405-412]

Cited: 4 times

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Exploring Chemotherapy-Induced Toxicities through Multivariate Projection of Risk Factors: Prediction of Nausea and Vomiting.

Kevin Yi-Lwern Yap, Xiu Hui Low, Alexandre Chan,

Many risk factors exist for chemotherapy-induced nausea and vomiting (CINV). This study utilized a multivariate projection technique to identify which risk factors were predictive of CINV in clinical practice. A single-centre, prospective, observational study was conducted from January 2007~July 2010 in Singapore. Patients were on highly (HECs) and moderately emetogenic ... Read more >>

Toxicol Res (Toxicological research)
[2012, 28(2):81-91]

Cited: 4 times

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Assessment of the relationship between adherence with antiemetic drug therapy and control of nausea and vomiting in breast cancer patients receiving anthracycline-based chemotherapy.

Alexandre Chan, Xiu Hui Low, Kevin Yi-Lwern Yap,

BACKGROUND: There are little prevalence data in the literature on nonadherence to outpatient antiemetic regimens for prophylaxis of chemotherapy-induced nausea and vomiting (CINV). It is unclear whether adherence with outpatient antiemetic regimens is associated with better CINV control. Our previous survey research supports the work of clinical pharmacists in collaborative ... Read more >>

J Manag Care Pharm (Journal of managed care pharmacy : JMCP)
[2012, 18(5):385-394]

Cited: 19 times

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Computational prediction of state anxiety in Asian patients with cancer susceptible to chemotherapy-induced nausea and vomiting.

Kevin Yi-Lwern Yap, Xiu Hui Low, Wai Keung Chui, Alexandre Chan, ,

State anxiety, a risk factor for chemotherapy-induced nausea and vomiting (CINV), is a subjective symptom and difficult to quantify. Clinicians need appropriate anxiety measures to assess patients' risks of CINV. This study aimed to determine the anxiety characteristics that can predict CINV based on computational analysis of an objective assessment ... Read more >>

J Clin Psychopharmacol (Journal of clinical psychopharmacology)
[2012, 32(2):207-217]

Cited: 16 times

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Utilizing mobile networks for the detection of clinically relevant interactions between chemotherapy regimens and complementary and alternative medicines.

Kevin Yi-Lwern Yap, Cheng Shang See, En Yi Kuo, Wai Keung Chui, Alexandre Chan,

OBJECTIVES: Patients with cancer who use complementary and alternative medicines (CAMs) in conjunction with chemotherapy treatment are at risk of manifesting anticancer drug-CAM interactions (DCIs), which may lead to negative therapeutic outcomes. This article describes a novel iPhone application developed for the Mobile Internet, called OncoRx-MI, which identifies DCIs of ... Read more >>

J Altern Complement Med (Journal of alternative and complementary medicine (New York, N.Y.))
[2012, 18(2):165-174]

Cited: 1 time

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Development of a chemotherapy regimen interaction database for the mobile internet: detecting interactions with psychotropics through OncoRx-MI.

Kevin Yi-Lwern Yap, Wai Keung Chui, Alexandre Chan, ,

INTRODUCTION: Cancer patients are at high risks of drug-drug interactions (DDIs). Clinicians need to know the magnitude of DDIs so as to better manage their patients' drug therapies. We have previously created a novel interaction database for oncology prescriptions (OncoRx). In this project, we leverage on 3G networks to further ... Read more >>

Inform Health Soc Care (Informatics for health & social care)
[2011, 36(3):132-146]

Cited: 1 time

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OncoRx-IQ: a tool for quality assessment of online anticancer drug interactions.

Kevin Yi-Lwern Yap, Sreemanee Raaj, Alexandre Chan,

The quality of online anticancer drug interaction information varies among online drug databases. We describe the creation of OncoRx-IQ, a tool which assesses the information quality of online drug databases for anticancer drug interactions, and a pilot study done with the tool.OncoRx-IQ was designed in the form of a questionnaire ... Read more >>

Int J Qual Health Care (International journal for quality in health care : journal of the International Society for Quality in Health Care)
[2010, 22(2):93-106]

Cited: 4 times

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Drug-drug interactions between oral antiepileptics and oral anticancer drugs: implications to clinicians.

Yin Ting Cheung, Kevin Yi-Lwern Yap, Wai Keung Chui, Alexandre Chan,

BACKGROUND: Existing research has suggested that there can be potential drug-drug interaction (DDI) between antiepileptic drugs (AED) and anticancer drugs (ACD). However, information on the prevalence of patients on concurrent oral AED and oral ACD is limited. METHODS: A retrospective study was conducted at the National Cancer Centre Singapore. Prevalence ... Read more >>

Eur Neurol (European neurology)
[2010, 64(2):88-94]

Cited: 1 time

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