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Author Kevin T McVary

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Mirabegron versus Placebo Add-on Therapy in Men with Overactive Bladder Symptoms Receiving Tamsulosin for Underlying Benign Prostatic Hyperplasia: a Safety Analysis from the Randomized, Phase 4 PLUS Study.

Sender Herschorn, Kevin T McVary, Javier Cambronero Santos, Steve Foley, Rita M Kristy, Nurul Choudhury, John Hairston, Steven A Kaplan,

OBJECTIVES:To analyze the safety of mirabegron add-on therapy in men with overactive bladder symptoms concurrently receiving tamsulosin for lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). METHODS:The Phase 4 PLUS study comprised a 4-week run-in period (tamsulosin [0.4 mg]) and a 12-week randomized treatment period (add-on treatment: ... Read more >>

Urology (Urology)
[2020, :]

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Larry E Miller, Bilal Chughtai, Ryan A Dornbier, Kevin T McVary,

J Urol (The Journal of urology)
[2020, 204(5):1025-1026]

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The New American Urological Association Benign Prostatic Hyperplasia Clinical Guidelines: 2019 Update.

Ryan Dornbier, Gaurav Pahouja, Jeffrey Branch, Kevin T McVary,

PURPOSE OF REVIEW:The goal of this paper was to analyze the efficacy of the current modalities available to surgically treat lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). RECENT FINDINGS:There have been significant surgical advancements for the treatment of BPH, including an increasing development and utilization of ... Read more >>

Curr Urol Rep (Current urology reports)
[2020, 21(9):32]

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Parth M Patel, Sarah E Sweigert, Marc Nelson, Gopal Gupta, Marshall Baker, Frances M Weaver, Kevin T McVary,

J. Urol. (The Journal of urology)
[2020, 204(2):336]

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Surgical Reintervention Rate after Prostatic Urethral Lift: Systematic Review and Meta-Analysis Involving over 2,000 Patients.

Larry E Miller, Bilal Chughtai, Ryan A Dornbier, Kevin T McVary,

PURPOSE:The surgical reintervention rate after prostatic urethral lift is not well characterized but has been estimated at 2% to 3% per year. We performed a systematic review and meta-analysis to determine the surgical reintervention rate after prostatic urethral lift. MATERIALS AND METHODS:We systematically searched MEDLINE®, Embase® and the Cochrane Central ... Read more >>

J Urol (The Journal of urology)
[2020, 204(5):1019-1026]

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Penile Prosthesis Implantation and Timing Disparities After Radical Prostatectomy: Results From a Statewide Claims Database.

Petar Bajic, Parth M Patel, Marc H Nelson, Ryan A Dornbier, Eric J Kirshenbaum, Marshall S Baker, Ahmer V Farooq, Kevin T McVary, Gopal N Gupta, Larissa Bresler,

BACKGROUND:Many patients with erectile dysfunction (ED) after radical prostatectomy (RP) improve with conservative therapy but some do not; penile prosthesis implantation rates have been sparsely reported, and have used nonrepresentative data sets. AIM:To characterize rates and timing of penile prosthesis implantation after RP and to identify predictors of implantation using ... Read more >>

J Sex Med (The journal of sexual medicine)
[2020, 17(6):1175-1181]

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A Tower of Babel in Today's Urology: Disagreement in Concepts and Definitions of Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia Re-Treatment.

Kevin T McVary, Steven A Kaplan,

J. Urol. (The Journal of urology)
[2020, 204(2):213-214]

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A novel metric for treatment durability in clinical trials of minimally invasive treatments for benign prostatic hyperplasia.

Larry E Miller, Alexis E Te, Samir K Bhattacharyya, Sean Lilienfeld, Ryan A Dornbier, Kevin T McVary,

Introduction: Clinical trial manuscripts commonly report results of individual endpoints. However, durability of a medical treatment may be difficult to determine when evaluating endpoint outcomes individually. We reviewed pivotal trial manuscripts of two minimally invasive benign prostatic hyperplasia (BPH) treatments and estimated the rate of treatment durability using a composite, ... Read more >>

Expert Rev Med Devices (Expert review of medical devices)
[2020, 17(4):365-369]

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Steven A Kaplan, Sender Herschorn, Kevin T McVary, David Staskin, Christopher Chapple, Steve Foley, Javier Cambronero Santos, Rita M Kristy, Nurul Choudhury, John Hairston, Carol R Schermer,

J. Urol. (The Journal of urology)
[2020, 203(6):1171]

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Mirabegron improves sleep measures, nocturia, and lower urinary tract symptoms in those with urinary symptoms associated with disordered sleep.

Robert A Petrossian, Danuta Dynda, Kristin Delfino, Ahmed El-Zawahry, Kevin T McVary,

INTRODUCTION:The role of organized sleep in overall health and quality-of-life (QoL) is critical. Nocturia necessarily disrupts the normal sleep cycle and negatively impacts one's health, work productivity, and QoL. We investigated, for the first time in an exploratory pilot, the effectiveness of mirabegron for improving sleep disturbance and nocturia. MATERIALS ... Read more >>

Can J Urol (The Canadian journal of urology)
[2020, 27(1):10106-10117]

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Disparities in Benign Prostatic Hyperplasia Progression: Predictors of Presentation to the Emergency Department in Urinary Retention.

Parth M Patel, Sarah E Sweigert, Marc Nelson, Gopal Gupta, Marshall Baker, Frances M Weaver, Kevin T McVary,

PURPOSE:This retrospective cohort study evaluates the characteristics of patients who presented to the emergency department with acute urinary retention. MATERIALS AND METHODS:Using the Healthcare Cost and Utilization Project State Emergency Department Databases we conducted a retrospective cohort study of patients who presented to emergency departments in Florida between 2005 and ... Read more >>

J Urol (The Journal of urology)
[2020, 204(2):332-336]

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Efficacy and Safety of Mirabegron versus Placebo Add-On Therapy in Men with Overactive Bladder Symptoms Receiving Tamsulosin for Underlying Benign Prostatic Hyperplasia: A Randomized, Phase 4 Study (PLUS).

Steven A Kaplan, Sender Herschorn, Kevin T McVary, David Staskin, Christopher Chapple, Steve Foley, Javier Cambronero Santos, Rita M Kristy, Nurul Choudhury, John Hairston, Carol R Schermer,

PURPOSE:PLUS investigated the efficacy and safety of mirabegron add-on therapy in men with overactive bladder symptoms receiving tamsulosin for underlying lower urinary tract symptoms attributable to benign prostatic hyperplasia. MATERIALS AND METHODS:In this phase 4 study a 4-week 0.4 mg tamsulosin run-in period was followed by a 12-week, randomized, double-blind, ... Read more >>

J. Urol. (The Journal of urology)
[2020, 203(6):1163-1171]

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Water vapor thermal therapy to alleviate catheter-dependent urinary retention secondary to benign prostatic hyperplasia.

Kevin T McVary, Bradley Holland, J Randolf Beahrs,

BACKGROUND:Water vapor thermal therapy utilizes convectively delivered thermal energy to target ablation of obstructive prostatic tissue. We report results of this thermal therapy for relief of nonneurogenic complete urinary retention associated with BPH. PATIENTS AND METHODS:We conducted a retrospective analysis of 38 catheter-dependent men with complete urinary retention consecutively enrolled ... Read more >>

Prostate Cancer Prostatic Dis (Prostate cancer and prostatic diseases)
[2020, 23(2):303-308]

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Which Drug to Discontinue 3 Months After Combination Therapy of Tadalafil plus Tamsulosin for Men with Lower Urinary Tract Symptom and Erectile Dysfunction? Results of a Prospective Observational Trial.

Arcangelo Sebastianelli, Pietro Spatafora, Jacopo Frizzi, Omar Saleh, Cosimo De Nunzio, Andrea Tubaro, Linda Vignozzi, Mario Maggi, Sergio Serni, Kevin T McVary, Steven A Kaplan, Stavros Gravas, Christopher Chapple, Mauro Gacci,

BACKGROUND:Safety and efficacy of tamsulosin and tadalafil for men with benign prostatic enlargement (BPE) and/or erectile dysfunction (ED) are defined. However, there are only a few pilot studies on combination therapy with these drugs for men with lower urinary tract symptom (LUTS)/BPE and ED. Moreover, preliminary reports are limited to ... Read more >>

Eur Urol Focus (European urology focus)
[2019, :]

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Use of Surgery for Post-Prostatectomy Incontinence.

Marc Nelson, Ryan Dornbier, Eric Kirshenbaum, Emanuel Eguia, Patrick Sweigert, Marshall Baker, Ahmer Farooq, Kevin T McVary, Chris M Gonzalez, Gopal Gupta, Larissa Bresler,

PURPOSE:Stress urinary incontinence following radical prostatectomy is common and potentially debilitating. Surgical therapy with a urethral sling or an artificial urinary sphincter is an effective option with high patient satisfaction in men in whom conservative measures fail to treat post-prostatectomy incontinence. We sought to characterize the contemporary utilization of surgical ... Read more >>

J. Urol. (The Journal of urology)
[2020, 203(4):786-791]

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Charles Welliver, Lydia Feinstein, Julia B Ward, Chyng-Wen Fwu, Ziya Kirkali, Tamara Bavendam, Brian R Matlaga, Kevin T McVary, ,

J. Urol. (The Journal of urology)
[2020, 203(1):178]

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Infectious Adverse Events Following the Placement of a Penile Prosthesis: A Systematic Review.

Joseph Mahon, Ryan Dornbier, Grace Wegrzyn, Martha M Faraday, Hossein Sadeghi-Nejad, Lawrence Hakim, Kevin T McVary,

INTRODUCTION:Infection remains a prominent concern following penile implantation. Recognition of the risk factors for infection may help to guide surgeons toward reducing the risk of prosthetic contamination. AIM:To gain a further understanding of infectious adverse events following penile prosthesis, we performed a systematic literature review. METHODS:As part of the 2018 ... Read more >>

Sex Med Rev (Sexual medicine reviews)
[2020, 8(2):348-354]

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Surgical Management of Lower Urinary Tract Symptoms Attributed to Benign Prostatic Hyperplasia: AUA Guideline Amendment 2019.

Harris E Foster, Philipp Dahm, Tobias S Kohler, Lori B Lerner, J Kellogg Parsons, Timothy J Wilt, Kevin T McVary,

PURPOSE:Male lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) is common in men and can have negative effects on quality of life (QoL). It is the hope that this Guideline becomes a reference for effective evidence-based surgical management of LUTS/BPH. MATERIALS AND METHODS:The evidence team searched Ovid ... Read more >>

J. Urol. (The Journal of urology)
[2019, 202(3):592-598]

Cited: 2 times

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Trends in Lower Urinary Tract Symptoms Associated with Benign Prostatic Hyperplasia, 2004 to 2013: the Urologic Diseases in America Project.

Charles Welliver, Lydia Feinstein, Julia B Ward, Chyng-Wen Fwu, Ziya Kirkali, Tamara Bavendam, Brian R Matlaga, Kevin T McVary, ,

PURPOSE:Our current understanding of recent trends in the management of lower urinary tract symptoms associated with benign prostatic hyperplasia is incomplete, particularly in younger men. The 2018 Urologic Diseases in America Project attempted to fill this gap by analyzing multiple large administrative claims databases which include men of all ages ... Read more >>

J. Urol. (The Journal of urology)
[2020, 203(1):171-178]

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Tadalafil 5 mg Alone or in Combination with Tamsulosin 0.4 mg for the Management of Men with Lower Urinary Tract Symptoms and Erectile Dysfunction: Results of a Prospective Observational Trial.

Arcangelo Sebastianelli, Pietro Spatafora, Jacopo Frizzi, Omar Saleh, Maurizio Sessa, Cosimo De Nunzio, Andrea Tubaro, Linda Vignozzi, Mario Maggi, Sergio Serni, Kevin T McVary, Steven A Kaplan, Stavros Gravas, Christopher Chapple, Mauro Gacci,

Tadalafil 5 mg represents the standard for men with Erectile dysfunction (ED) and lower urinary tract symptoms (LUTS)/benign prostatic enlargement (BPE). We carried out an observational trial aiming to assess the efficacy and safety of Tadalafil compared with Tadalafil plus Tamsulosin. Seventy-five patients complaining of ED and LUTS were treated ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 8(8):]

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Etiology of Erectile Dysfunction and Duration of Symptoms in Patients Undergoing Penile Prosthesis: A Systematic Review.

Petar Bajic, Joseph Mahon, Martha Faraday, Hossein Sadeghi-Nejad, Lawrence Hakim, Kevin T McVary,

INTRODUCTION:Inadequate treatment of men with erectile dysfunction (ED) subjects them and their partners to lost quality of life, yet little is known about the cause and duration of symptoms that lead to penile prosthesis (PP) placement. AIM:We performed a systematic review addressing cause and duration of symptoms before implantation. METHODS:We ... Read more >>

Sex Med Rev (Sexual medicine reviews)
[2020, 8(2):333-337]

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Prostate Transition Zone Fibrosis is Associated with Clinical Progression in the MTOPS Study.

Jill A Macoska, Kristen S Uchtmann, Glen E Leverson, Kevin T McVary, William A Ricke,

PURPOSE:Medications targeting androgen receptor activity (eg finasteride) or smooth muscle contractility (eg doxazosin) do not resolve lower urinary tract symptoms indicative of lower urinary tract dysfunction in an important subgroup of men. Recently fibrosis has been implicated as another pathobiology contributing to male lower urinary tract symptoms but to our ... Read more >>

J Urol (The Journal of urology)
[2019, 202(6):1240-1247]

Cited: 1 time

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Optimization of Sonic Hedgehog Delivery to the Penis from Self-Assembling Nanofiber Hydrogels to Preserve Penile Morphology after Cavernous Nerve Injury.

Shawn Choe, Elizabeth Kalmanek, Christopher Bond, Daniel A Harrington, Samuel I Stupp, Kevin T McVary, Carol A Podlasek,

Erectile dysfunction (ED) is a significant medical condition, with high impact on patient quality of life. Current treatments are minimally effective in prostatectomy, diabetic and aging patients due to injury to the cavernous nerve (CN); loss of innervation causes extensive smooth muscle (SM) apoptosis, increased collagen and ED. Sonic hedgehog ... Read more >>

Nanomedicine (Nanomedicine : nanotechnology, biology, and medicine)
[2019, 20:102033]

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Resident Impact on Patient & Surgeon Satisfaction and Outcomes: Evidence for Health System Support for Urology Education.

Bradley C Holland, Neil Patel, Randy Sulaver, Bradford Stevenson, Jessica Healey, William Severino, Thomas Baron, David Lieber, David Roszhart, Kevin T McVary, Tobias S Köhler,

OBJECTIVE:To assess the effect of resident involvement on patient and physician satisfaction, we evaluated the outcomes from a private urology group both prior to and after initiation of resident coverage. METHODS:Urologic procedures completed by attending surgeons without residents from October 2010 to December 2011 were compared to the same surgeons ... Read more >>

Urology (Urology)
[2019, 132:49-55]

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Use of Magnetic Induction to Activate a "Touchless" Shape Memory Alloy Implantable Penile Prosthesis.

Brian V Le, Kevin T McVary, Kevin McKenna, Alberto Colombo,

INTRODUCTION:We describe a novel physiologic penile prosthesis that uses shape memory alloy properties to mimic the transition between a flaccid and erect penis using magnetic induction instead of hydraulic pressure. AIM:To evaluate the parameters of magnetic induction to activate a shape memory alloy implantable penile prosthesis. METHODS:We prototyped an implantable ... Read more >>

J Sex Med (The journal of sexual medicine)
[2019, 16(4):596-601]

Cited: 1 time

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