Full Text Journal Articles by
Author Kevin P Horn

Advertisement

Find full text journal articles








Long-term Changes in 18F-Flutemetamol Uptake in Nondemented Older Adults.

Kevin Duff, Kevin P Horn, John M Hoffman,

PURPOSE:Longitudinal studies into the variability of F-Flutemetamol uptake are lacking. METHODS/PATIENTS:Therefore, the current study examined change in F-Flutemetamol uptake in 19 nondemented older adults (65 to 82 y old) who were either cognitively intact or had Mild Cognitive Impairment (MCI) who were scanned twice across 3.6 years. RESULTS:Baseline and follow-up composite ... Read more >>

Alzheimer Dis Assoc Disord (Alzheimer disease and associated disorders)
[2019, 33(2):113-117]

Cited: 0 times

View full text PDF listing >>



Lipopolysaccharide endotoxemia induces amyloid-β and p-tau formation in the rat brain.

Li-Ming Wang, Qi Wu, Ryan A Kirk, Kevin P Horn, Ahmed H Ebada Salem, John M Hoffman, Jeffrey T Yap, Joshua A Sonnen, Rheal A Towner, Fernando A Bozza, Rosana S Rodrigues, Kathryn A Morton,

Amyloid beta (Aβ) plaques are not specific to Alzheimer's disease and occur with aging and neurodegenerative disorders. Soluble brain Aβ may be neuroprotective and increases in response to neuroinflammation. Sepsis is associated with neurocognitive compromise. The objective was to determine, in a rat endotoxemia model of sepsis, whether neuroinflammation and ... Read more >>

(American journal of nuclear medicine and molecular imaging)
[2018, 8(2):86-99]

Cited: 6 times

View full text PDF listing >>



Advertisement

Correlation of Glioma Proliferation and Hypoxia by Luciferase, Magnetic Resonance, and Positron Emission Tomography Imaging.

Michael Karsy, David L Gillespie, Kevin P Horn, Lance D Burrell, Jeffery T Yap, Randy L Jensen,

Gliomas are the most common type of primary, malignant brain tumor and significantly impact patients, who have a median survival of ~1 year depending on mutational background. Novel imaging modalities such as luciferase bioluminescence, micro-magnetic resonance imaging (micro-MRI), micro-computerized tomography (micro-CT), and micro-positron emission tomography (micro-PET) have expanded the portfolio of ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2018, 1742:301-320]

Cited: 0 times

View full text PDF listing >>



Is Cancer Protective for Subsequent Alzheimer's Disease Risk? Evidence From the Utah Population Database.

Heidi A Hanson, Kevin P Horn, Kelli M Rasmussen, John M Hoffman, Ken R Smith,

Objective:Several studies have suggested that cancer is associated with a reduced risk of the development of Alzheimer's disease (AD). This study seeks to improve our understanding of the association between cancer and the development of AD by showing how mortality selection alters this relationship. Method:A retrospective cohort study was carried ... Read more >>

J Gerontol B Psychol Sci Soc Sci (The journals of gerontology. Series B, Psychological sciences and social sciences)
[2017, 72(6):1032-1043]

Cited: 7 times

View full text PDF listing >>



Amyloid Positivity Using [18F]Flutemetamol-PET and Cognitive Deficits in Nondemented Community-Dwelling Older Adults.

Dustin B Hammers, Taylor J Atkinson, Bonnie C A Dalley, Kayla R Suhrie, Kevin P Horn, Kelli M Rasmussen, Britney E Beardmore, Lance D Burrell, Kevin Duff, John M Hoffman,

Little research exists examining the relationship between beta-amyloid neuritic plaque density via [18F]flutemetamol binding and cognition; consequently, the purpose of the current study was to compare cognitive performances among individuals having either increased amyloid deposition (Flute+) or minimal amyloid deposition (Flute-). Twenty-seven nondemented community-dwelling adults over the age of 65 ... Read more >>

Am J Alzheimers Dis Other Demen (American journal of Alzheimer's disease and other dementias)
[2017, 32(6):320-328]

Cited: 1 time

View full text PDF listing >>



Relationship between 18F-Flutemetamol uptake and RBANS performance in non-demented community-dwelling older adults.

Dustin B Hammers, Taylor J Atkinson, Bonnie C A Dalley, Kayla R Suhrie, Britney E Beardmore, Lance D Burrell, Kevin P Horn, Kelli M Rasmussen, Norman L Foster, Kevin Duff, John M Hoffman,

OBJECTIVE:The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) has been used extensively for clinical care and in research for patients with mild cognitive impairment and Alzheimer's disease (AD); however, relatively few studies have evaluated the relationship between RBANS performance and AD imaging biomarkers. The purpose of the current ... Read more >>

Clin Neuropsychol (The Clinical neuropsychologist)
[2017, 31(3):531-543]

Cited: 1 time

View full text PDF listing >>



FDG and FLT-PET for Early measurement of response to 37.5 mg daily sunitinib therapy in metastatic renal cell carcinoma.

Kevin P Horn, Jeffrey T Yap, Neeraj Agarwal, Kathryn A Morton, Dan J Kadrmas, Britney Beardmore, Regan I Butterfield, Kenneth Boucher, John M Hoffman,

Metastatic renal cell carcinoma has a poor prognosis and an intrinsic resistance to standard treatment. Sunitinib is an oral receptor tyrosine kinase inhibitor that has been used as a first-line targeted therapy in metastatic renal cell carcinoma. While computed tomography (CT) is currently the gold standard for response assessment in ... Read more >>

Cancer Imaging (Cancer imaging : the official publication of the International Cancer Imaging Society)
[2015, 15:15]

Cited: 16 times

View full text PDF listing >>



Short-Term Practice Effects and Brain Hypometabolism: Preliminary Data from an FDG PET Study.

Kevin Duff, Kevin P Horn, Norman L Foster, John M Hoffman,

Practice effects are improvements in cognitive test scores due to repeated exposure to the same tests. Typically viewed as error, short-term practice effects have been shown to provide valuable clinical information about diagnosis, prognosis, and treatment outcomes in older patients with mild cognitive impairments. This study examined short-term practice effects ... Read more >>

Arch Clin Neuropsychol (Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists)
[2015, 30(3):264-270]

Cited: 8 times

View full text PDF listing >>



Functional regeneration of respiratory pathways after spinal cord injury.

Warren J Alilain, Kevin P Horn, Hongmei Hu, Thomas E Dick, Jerry Silver,

Spinal cord injuries often occur at the cervical level above the phrenic motor pools, which innervate the diaphragm. The effects of impaired breathing are a leading cause of death from spinal cord injuries, underscoring the importance of developing strategies to restore respiratory activity. Here we show that, after cervical spinal ... Read more >>

Nature (Nature)
[2011, 475(7355):196-200]

Cited: 196 times

View full text PDF listing >>



Multipotent adult progenitor cells prevent macrophage-mediated axonal dieback and promote regrowth after spinal cord injury.

Sarah A Busch, Jason A Hamilton, Kevin P Horn, Fernando X Cuascut, Rochelle Cutrone, Nicholas Lehman, Robert J Deans, Anthony E Ting, Robert W Mays, Jerry Silver,

Macrophage-mediated axonal dieback presents an additional challenge to regenerating axons after spinal cord injury. Adult adherent stem cells are known to have immunomodulatory capabilities, but their potential to ameliorate this detrimental inflammation-related process has not been investigated. Using an in vitro model of axonal dieback as well as an adult ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2011, 31(3):944-953]

Cited: 79 times

View full text PDF listing >>



Immature astrocytes promote CNS axonal regeneration when combined with chondroitinase ABC.

Angela R Filous, Jared H Miller, Yvette M Coulson-Thomas, Kevin P Horn, Warren J Alilain, Jerry Silver,

Regeneration of injured adult CNS axons is inhibited by formation of a glial scar. Immature astrocytes are able to support robust neurite outgrowth and reduce scarring, therefore, we tested whether these cells would have this effect if transplanted into brain injuries. Utilizing an in vitro spot gradient model that recreates ... Read more >>

Dev Neurobiol (Developmental neurobiology)
[2010, 70(12):826-841]

Cited: 46 times

View full text PDF listing >>



A combination immunomodulatory treatment promotes neuroprotection and locomotor recovery after contusion SCI.

Christopher A Iannotti, Megan Clark, Kevin P Horn, Nico van Rooijen, Jerry Silver, Michael P Steinmetz,

The present study assessed the ability of a combined immunomodulatory treatment using (1) selective depletion of peripheral macrophages with liposomal-encapsulated clodronate, and (2) rolipram, a type 4 phosphodiesterase (PDE4) inhibitor, to promote neuroprotection and improve locomotor recovery following experimental contusion SCI. We demonstrate that delivery of either liposomal clodronate or ... Read more >>

Exp. Neurol. (Experimental neurology)
[2011, 230(1):3-15]

Cited: 28 times

View full text PDF listing >>



Adult NG2+ cells are permissive to neurite outgrowth and stabilize sensory axons during macrophage-induced axonal dieback after spinal cord injury.

Sarah A Busch, Kevin P Horn, Fernando X Cuascut, Alicia L Hawthorne, Lianhua Bai, Robert H Miller, Jerry Silver,

We previously demonstrated that activated ED1+ macrophages induce extensive axonal dieback of dystrophic sensory axons in vivo and in vitro. Interestingly, after spinal cord injury, the regenerating front of axons is typically found in areas rich in ED1+ cells, but devoid of reactive astrocyte processes. These observations suggested that another ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2010, 30(1):255-265]

Cited: 96 times

View full text PDF listing >>



PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration.

Yingjie Shen, Alan P Tenney, Sarah A Busch, Kevin P Horn, Fernando X Cuascut, Kai Liu, Zhigang He, Jerry Silver, John G Flanagan,

Chondroitin sulfate proteoglycans (CSPGs) present a barrier to axon regeneration. However, no specific receptor for the inhibitory effect of CSPGs has been identified. We showed that a transmembrane protein tyrosine phosphatase, PTPsigma, binds with high affinity to neural CSPGs. Binding involves the chondroitin sulfate chains and a specific site on ... Read more >>

Science (Science (New York, N.Y.))
[2009, 326(5952):592-596]

Cited: 319 times

View full text PDF listing >>



Overcoming macrophage-mediated axonal dieback following CNS injury.

Sarah A Busch, Kevin P Horn, Daniel J Silver, Jerry Silver,

Trauma to the adult CNS initiates multiple processes including primary and secondary axotomy, inflammation, and glial scar formation that have devastating effects on neuronal regeneration. After spinal cord injury, the infiltration of phagocytic macrophages coincides with long-distance axonal retraction from the initial site of injury, a deleterious phenomenon known as ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2009, 29(32):9967-9976]

Cited: 117 times

View full text PDF listing >>



Light-induced rescue of breathing after spinal cord injury.

Warren J Alilain, Xiang Li, Kevin P Horn, Rishi Dhingra, Thomas E Dick, Stefan Herlitze, Jerry Silver,

Paralysis is a major consequence of spinal cord injury (SCI). After cervical SCI, respiratory deficits can result through interruption of descending presynaptic inputs to respiratory motor neurons in the spinal cord. Expression of channelrhodopsin-2 (ChR2) and photostimulation in neurons affects neuronal excitability and produces action potentials without any kind of ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2008, 28(46):11862-11870]

Cited: 82 times

View full text PDF listing >>



A point mutation in the Aspergillus nidulans sonBNup98 nuclear pore complex gene causes conditional DNA damage sensitivity.

Colin P C De Souza, Shahr B Hashmi, Kevin P Horn, Stephen A Osmani,

The nuclear pore complex (NPC) is embedded in the nuclear envelope where it mediates transport between the cytoplasm and nucleus and helps to organize nuclear architecture. We previously isolated sonB1, a mutation encoding a single amino acid substitution within the Aspergillus nidulans SONBnNup98 NPC protein (nucleoporin). Here we demonstrate that ... Read more >>

Genetics (Genetics)
[2006, 174(4):1881-1893]

Cited: 12 times

View full text PDF listing >>



The SONB(NUP98) nucleoporin interacts with the NIMA kinase in Aspergillus nidulans.

Colin P C De Souza, Kevin P Horn, Kathryn Masker, Stephen A Osmani,

The Aspergillus nidulans NIMA kinase is essential for mitotic entry. At restrictive temperature, temperature-sensitive nimA alleles arrest in G2, before accumulation of NIMA in the nucleus. We performed a screen for extragenic suppressors of the nimA1 allele and isolated two cold-sensitive son (suppressor of nimA1) mutants. The sonA1 mutant encoded ... Read more >>

Genetics (Genetics)
[2003, 165(3):1071-1081]

Cited: 33 times

View full text PDF listing >>





Advertisement

Disclaimer
1.1165 s