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Author Kevin Oeffinger

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Endocrine and metabolic disorders in survivors of childhood cancers and health-related quality of life and physical activity.

Kamnesh R Pradhan, Yan Chen, Sogol Moustoufi-Moab, Kevin Krull, Kevin C Oeffinger, Charles Sklar, Gregory T Armstrong, Kirsten K Ness, Leslie Robison, Yutaka Yasui, Paul C Nathan,

CONTEXT:Childhood cancer survivors experience chronic health conditions that impact health related quality of life (HRQOL) and participation in optimal physical activity. OBJECTIVE:The study aimed to determine independent effects of endocrine and metabolic disorders on HRQOL and physical activity. DESIGN, SETTING, AND PATIENTS:Retrospective cohort with longitudinal follow-up of survivors of childhood ... Read more >>

J. Clin. Endocrinol. Metab. (The Journal of clinical endocrinology and metabolism)
[2019, :]

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Mortality After Breast Cancer Among Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study.

Chaya S Moskowitz, Joanne F Chou, Joseph P Neglia, Ann H Partridge, Rebecca M Howell, Lisa R Diller, Danielle Novetsky Friedman, Dana Barnea, Lindsay M Morton, Lucie M Turcotte, Michael A Arnold, Wendy M Leisenring, Gregory T Armstrong, Leslie L Robison, Kevin C Oeffinger, Tara O Henderson,

PURPOSE:Female survivors of childhood cancer have a high risk of subsequent breast cancer. We describe the ensuing risk for mortality and additional breast cancers. PATIENTS AND METHODS:Female participants in the Childhood Cancer Survivor Study, a cohort of 5-year survivors of cancer diagnosed between 1970 and 1986 before age 21 years, ... Read more >>

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, :JCO1802219]

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Promoting Breast Cancer Surveillance: The EMPOWER Study, a Randomized Clinical Trial in the Childhood Cancer Survivor Study.

Kevin C Oeffinger, Jennifer S Ford, Chaya S Moskowitz, Joanne F Chou, Tara O Henderson, Melissa M Hudson, Lisa Diller, Aaron McDonald, James Ford, Nidha Z Mubdi, Dayton Rinehart, Christopher Vukadinovich, Todd M Gibson, Nassim Anderson, Elena B Elkin, Kathleen Garrett, Margaret Rebull, Wendy Leisenring, Leslie L Robison, Gregory T Armstrong,

PURPOSE:The aim of the current study was to increase the uptake of screening mammography among high-risk women who were treated for a childhood cancer with chest radiotherapy. PATIENTS AND METHODS:Two hundred four female survivors in the Childhood Cancer Survivor Study who were treated with chest radiotherapy with 20 Gy or ... Read more >>

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, :JCO1900547]

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Late-onset anorectal disease and psychosocial impact in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study.

Arin L Madenci, Bryan V Dieffenbach, Qi Liu, Daisuke Yoneoka, Jamie Knell, Todd M Gibson, Yutaka Yasui, Wendy M Leisenring, Rebecca M Howell, Lisa R Diller, Kevin R Krull, Gregory T Armstrong, Kevin C Oeffinger, Andrew J Murphy, Brent R Weil, Christopher B Weldon,

BACKGROUND:The prevalence and associated psychosocial morbidity of late-onset anorectal disease after surgery and radiotherapy for the treatment of childhood cancer are not known. METHODS:A total of 25,530 survivors diagnosed between 1970 and 1999 (median age at cancer diagnosis, 6.1 years; age at survey, 30.2 years) and 5036 siblings were evaluated for late-onset ... Read more >>

Cancer (Cancer)
[2019, :]

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Automated Breast Density Measurements From Chest Computed Tomography Scans.

Touseef A Qureshi, Harini Veeraraghavan, Janice S Sung, Jennifer B Kaplan, Jessica Flynn, Emily S Tonorezos, Suzanne L Wolden, Elizabeth A Morris, Kevin C Oeffinger, Malcolm C Pike, Chaya S Moskowitz,

To develop an automated method for quantifying percent breast density from chest computed tomography (CT) scans. A naïve Bayesian classifier based on gray-level intensities and spatial relationships was developed on CT scans from 10 patients diagnosed with Hodgkin lymphoma (HL) and imaged as part of routine clinical care. The algorithm ... Read more >>

J Med Syst (Journal of medical systems)
[2019, 43(8):242]

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Late Health Outcomes After Contemporary Lymphome Malin de Burkitt Therapy for Mature B-Cell Non-Hodgkin Lymphoma: A Report From the Childhood Cancer Survivor Study.

Matthew J Ehrhardt, Yan Chen, John T Sandlund, Elizabeth C Bluhm, Robert J Hayashi, Kerri Becktell, Wendy M Leisenring, Monika L Metzger, Kirsten K Ness, Kevin R Krull, Kevin C Oeffinger, Todd M Gibson, Mitchell S Cairo, Thomas G Gross, Leslie L Robison, Gregory T Armstrong, Yutaka Yasui, Melissa M Hudson, Daniel A Mulrooney,

PURPOSE:The widely used, risk-based Lymphome Malin de Burkitt (LMB) chemotherapy regimen has improved survival rates for children with mature B-cell non-Hodgkin lymphoma (NHL); however, associated late effects remain understudied. We assessed late health outcomes after LMB treatment in the Childhood Cancer Survivor Study. PATIENTS AND METHODS:Multivariable regression models compared chronic ... Read more >>

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, :JCO1900525]

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Traditional cardiovascular risk factors and individual prediction of cardiovascular events in childhood cancer survivors.

Yan Chen, Eric J Chow, Kevin C Oeffinger, William L Border, Wendy M Leisenring, Lillian R Meacham, Daniel A Mulrooney, Charles A Sklar, Marilyn Stovall, Leslie L Robison, Gregory T Armstrong, Yutaka Yasui,

BACKGROUND:Childhood cancer survivors have an increased risk of heart failure, ischemic heart disease, and stroke. They may benefit from prediction models that account for cardiotoxic cancer treatment exposures combined with information on traditional cardiovascular risk factors such as hypertension, dyslipidemia, and diabetes. METHODS:Childhood Cancer Survivor Study participants (n = 22,643) were followed ... Read more >>

J. Natl. Cancer Inst. (Journal of the National Cancer Institute)
[2019, :]

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Impact of exercise on psychological burden in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study.

Emily S Tonorezos, Jennifer S Ford, Linwei Wang, Kirsten K Ness, Yutaka Yasui, Wendy Leisenring, Charles A Sklar, Leslie L Robison, Kevin C Oeffinger, Paul C Nathan, Gregory T Armstrong, Kevin Krull, Lee W Jones,

BACKGROUND:Childhood cancer survivors are at risk for adverse psychological outcomes. Whether exercise can attenuate this risk is unknown. METHODS:In total, 6199 participants in the Childhood Cancer Survivor Study (median age, 34.3 years [range, 22.0-54.0 years]; median age at diagnosis, 10.0 years [range, 0-21.0 years]) completed a questionnaire assessing vigorous exercise and medical/psychological conditions. Outcomes ... Read more >>

Cancer (Cancer)
[2019, :]

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Oncologists' Attitudes and Practice of Addressing Diet, Physical Activity, and Weight Management With Patients With Cancer: Findings of an ASCO Survey of the Oncology Workforce.

Jennifer A Ligibel, Lee W Jones, Abenaa M Brewster, Steven K Clinton, Larissa A Korde, Kevin C Oeffinger, Catherine M Bender, Winston Tan, Janette K Merrill, Sweatha Katta, Catherine M Alfano,

PURPOSE:Obesity and related factors have been linked to cancer risk and outcomes, but little information exists with regard to oncologists' attention to these issues as a part of clinical care. METHODS:Oncology providers actively caring for patients with cancer in the United States and internationally were asked to complete an online ... Read more >>

J Oncol Pract (Journal of oncology practice)
[2019, 15(6):e520-e528]

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Cardio-Oncology Rehabilitation to Manage Cardiovascular Outcomes in Cancer Patients and Survivors: A Scientific Statement From the American Heart Association.

Susan C Gilchrist, Ana Barac, Philip A Ades, Catherine M Alfano, Barry A Franklin, Lee W Jones, Andre La Gerche, Jennifer A Ligibel, Gabriel Lopez, Kushal Madan, Kevin C Oeffinger, Jeannine Salamone, Jessica M Scott, Ray W Squires, Randal J Thomas, Diane J Treat-Jacobson, Janet S Wright, ,

Cardiovascular disease is a competing cause of death in patients with cancer with early-stage disease. This elevated cardiovascular disease risk is thought to derive from both the direct effects of cancer therapies and the accumulation of risk factors such as hypertension, weight gain, cigarette smoking, and loss of cardiorespiratory fitness. ... Read more >>

Circulation (Circulation)
[2019, 139(21):e997-e1012]

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Cost-Effectiveness of Colonoscopy-Based Colorectal Cancer Screening in Childhood Cancer Survivors.

Andrea Gini, Reinier G S Meester, Homa Keshavarz, Kevin C Oeffinger, Sameera Ahmed, David C Hodgson, Iris Lansdorp-Vogelaar,

BACKGROUND:Childhood Cancer Survivors (CCS) are at increased risk of developing colorectal cancer (CRC) compared to the general population, especially those previously exposed to abdominal or pelvic radiation therapy (APRT). However, the benefits and costs of CRC screening in CCS are unclear. In this study, we evaluated the cost-effectiveness of early-initiated ... Read more >>

J. Natl. Cancer Inst. (Journal of the National Cancer Institute)
[2019, :]

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Therapy-Related Cardiac Risk in Childhood Cancer Survivors: An Analysis of the Childhood Cancer Survivor Study.

James E Bates, Rebecca M Howell, Qi Liu, Yutaka Yasui, Daniel A Mulrooney, Sughosh Dhakal, Susan A Smith, Wendy M Leisenring, Daniel J Indelicato, Todd M Gibson, Gregory T Armstrong, Kevin C Oeffinger, Louis S Constine,

PURPOSE:The impacts of radiotherapy dose and exposed cardiac volume, select chemotherapeutic agents, and age at exposure on risk for late-onset cardiac disease in survivors of childhood cancer remain unresolved. PATIENTS AND METHODS:We determined the rates of severe to fatal cardiac disease in 24,214 5-year survivors in the Childhood Cancer Survivor ... Read more >>

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, 37(13):1090-1101]

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Assessment of Early Radiation-Induced Changes in Left Ventricular Function by Myocardial Strain Imaging After Breast Radiation Therapy.

Anthony F Yu, Alice Y Ho, Lior Z Braunstein, Maria E Thor, Katherine Lee Chuy, Anne Eaton, Elton Mara, Oren Cahlon, Chau T Dang, Kevin C Oeffinger, Richard M Steingart, Jennifer E Liu,

BACKGROUND:Radiation therapy (RT)-induced cardiotoxicity is among the concerning sequelae of breast cancer (BCA) treatment, particularly in HER2-positive BCA patients who receive anthracyclines and trastuzumab-based therapy. The aim of this study was to assess for early RT-induced changes in echocardiographic and circulating biomarkers of left ventricular (LV) function and evaluate their ... Read more >>

J Am Soc Echocardiogr (Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography)
[2019, 32(4):521-528]

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Sleep, emotional distress, and physical health in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study.

Lauren C Daniel, Mingjuan Wang, Daniel A Mulrooney, Deo Kumar Srivastava, Lisa A Schwartz, Kim Edelstein, Tara M Brinkman, Eric S Zhou, Rebecca M Howell, Todd M Gibson, Wendy Leisenring, Kevin C Oeffinger, Joseph Neglia, Leslie L Robison, Gregory T Armstrong, Kevin R Krull,

OBJECTIVE:Sleep disorders are associated with psychological and physical health, although reports in long-term survivors of childhood cancer are limited. We characterized the prevalence and risk factors for behaviors consistent with sleep disorders in survivors and examined longitudinal associations with emotional distress and physical health outcomes. METHODS:Survivors (n = 1933; median [IQR] age = 35 ... Read more >>

Psychooncology (Psycho-oncology)
[2019, 28(4):903-912]

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Late Morbidity and Mortality Among Medulloblastoma Survivors Diagnosed Across Three Decades: A Report From the Childhood Cancer Survivor Study.

Ralph Salloum, Yan Chen, Yutaka Yasui, Roger Packer, Wendy Leisenring, Elizabeth Wells, Allison King, Rebecca Howell, Todd M Gibson, Kevin R Krull, Leslie L Robison, Kevin C Oeffinger, Maryam Fouladi, Gregory T Armstrong,

PURPOSE:Treatment of medulloblastoma has evolved from surgery and radiotherapy to contemporary multimodal regimens. However, the impact on long-term health outcomes remains unknown. METHODS:Cumulative incidence of late mortality (5 or more years from diagnosis), subsequent neoplasms (SNs), and chronic health conditions were evaluated in the Childhood Cancer Survivor Study among 5-year ... Read more >>

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, 37(9):731-740]

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Derivation of Anthracycline and Anthraquinone Equivalence Ratios to Doxorubicin for Late-Onset Cardiotoxicity.

Elizabeth A M Feijen, Wendy M Leisenring, Kayla L Stratton, Kirsten K Ness, Helena J H van der Pal, Elvira C van Dalen, Gregory T Armstrong, Gregory J Aune, Daniel M Green, Melissa M Hudson, Jacqueline Loonen, Kevin C Oeffinger, Leslie L Robison, Yutaka Yasui, Leontien C M Kremer, Eric J Chow,

Importance:Anthracyclines are part of many effective pediatric cancer treatment protocols. Most pediatric oncology treatment groups assume that the hematologic toxicity of anthracycline agents is equivalent to their cardiotoxicity; for example, Children's Oncology Group substitution rules consider daunorubicin and epirubicin isoequivalent to doxorubicin, whereas mitoxantrone and idarubicin are considered 4 to ... Read more >>

JAMA Oncol (JAMA oncology)
[2019, :]

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Childhood leukemia, late effects, and a person-centric model of follow-up.

Miranda M Fidler-Benaoudia, Kevin C Oeffinger,

J. Natl. Cancer Inst. (Journal of the National Cancer Institute)
[2019, :]

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Advanced Practice Providers and Survivorship Care: They Can Deliver.

Bridgette Thom, Annelies H Boekhout, Stacie Corcoran, Roberto Adsuar, Kevin C Oeffinger, Mary S McCabe,

INTRODUCTION::As the number of cancer survivors grows, new models of survivorship care are being implemented, but there is limited evaluation to date. This retrospective review assesses the concordance of care provided to adult-onset cancer survivors by advanced practice providers (nurse practitioners and physician assistants) with Institute of Medicine guidelines for ... Read more >>

J Oncol Pract (Journal of oncology practice)
[2019, 15(3):e230-e237]

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Care coordination for complex cancer survivors in an integrated safety-net system: a study protocol.

Simon J Craddock Lee, Katelyn K Jetelina, Emily Marks, Eric Shaw, Kevin Oeffinger, Deborah Cohen, Noel O Santini, John V Cox, Bijal A Balasubramanian,

BACKGROUND:The growing numbers of cancer survivors challenge delivery of high-quality survivorship care by healthcare systems. Innovative ways to improve care coordination for patients with cancer and multiple chronic conditions ("complex cancer survivors") are needed to achieve better care outcomes, improve patient experience of care, and lower cost. Our study, Project ... Read more >>

BMC Cancer (BMC cancer)
[2018, 18(1):1204]

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Long-term health and social function in adult survivors of paediatric astrocytoma: A report from the Childhood Cancer Survivor Study.

Karen E Effinger, Kayla L Stratton, Paul Graham Fisher, Kirsten K Ness, Kevin R Krull, Kevin C Oeffinger, Gregory T Armstrong, Leslie L Robison, Melissa M Hudson, Wendy M Leisenring, Paul C Nathan,

BACKGROUND:Although paediatric astrocytoma has an excellent 5-year survival rate, survivors remain at risk for morbidity and late mortality. This study aimed to estimate the risk of late mortality, chronic conditions, poor health status and social impairment in ageing paediatric astrocytoma survivors. METHODS:We longitudinally evaluated 1182 5-year astrocytoma survivors diagnosed between ... Read more >>

Eur. J. Cancer (European journal of cancer (Oxford, England : 1990))
[2019, 106:171-180]

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DNA methylation and obesity in survivors of pediatric acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study.

Philip J Lupo, Austin L Brown, Vidal M Arroyo, Kala Y Kamdar, John W Belmont, Michael E Scheurer, Wendy M Leisenring, M. Monica Gramatges, M. Fatih Okcu, Yutaka Yasui, Kevin C Oeffinger, Leslie L Robison, Gregory T Armstrong, Smita Bhatia,

Because survivors of pediatric acute lymphoblastic leukemia (ALL) are more likely to be obese than unaffected contemporaries, we compared DNA methylation profiles between normal-weight and obese survivors at adiposity-associated CpG sites previously-reported by epigenome-wide association studies (EWAS) of body mass index (BMI) in the general population. We selected 96 ALL ... Read more >>

Genes Chromosomes Cancer (Genes, chromosomes & cancer)
[2019, 58(1):52-59]

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Incorporating Multiple Perspectives Into the Development of an Electronic Survivorship Platform for Head and Neck Cancer.

Talya Salz, Rebecca B Schnall, Mary S McCabe, Kevin C Oeffinger, Stacie Corcoran, Andrew J Vickers, Andrew L Salner, Ellen Dornelas, Nirupa J Raghunathan, Elizabeth Fortier, Janet McKiernan, David J Finitsis, Susan Chimonas, Shrujal Baxi,

PURPOSE:To improve the care of survivors of head and neck cancer, we developed the Head and Neck Survivorship Tool: Assessment and Recommendations (HN-STAR). HN-STAR is an electronic platform that incorporates patient-reported outcomes into a clinical decision support tool for use at a survivorship visit. Selections in the clinical decision support ... Read more >>

JCO Clin Cancer Inform (JCO clinical cancer informatics)
[2018, 2:1-15]

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Temporal patterns in the risk of chronic health conditions in survivors of childhood cancer diagnosed 1970-99: a report from the Childhood Cancer Survivor Study cohort.

Todd M Gibson, Sogol Mostoufi-Moab, Kayla L Stratton, Wendy M Leisenring, Dana Barnea, Eric J Chow, Sarah S Donaldson, Rebecca M Howell, Melissa M Hudson, Anita Mahajan, Paul C Nathan, Kirsten K Ness, Charles A Sklar, Emily S Tonorezos, Christopher B Weldon, Elizabeth M Wells, Yutaka Yasui, Gregory T Armstrong, Leslie L Robison, Kevin C Oeffinger,

BACKGROUND:Treatments for childhood cancer have evolved over the past 50 years, with the goal of maximising the proportion of patients who achieve long-term survival, while minimising the adverse effects of therapy. We aimed to assess incidence patterns of serious chronic health conditions in long-term survivors of childhood cancer across three ... Read more >>

Lancet Oncol. (The Lancet. Oncology)
[2018, 19(12):1590-1601]

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Automating Treatment Summary Development Using Electronic Billing Information: A Pilot Study of Survivors of Head and Neck Cancer.

Shrujal S Baxi, Ranjit Sukhu, Elizabeth Fortier, Kevin Oeffinger, Stacie Corcoran, Andrew Salner, Andrew J Vickers, Mary S McCabe, Talya Salz,

PURPOSE::Although the provision of a treatment summary (TS) is a quality indicator in oncology, routine delivery of TSs remains challenging. Automatic TS generation could facilitate use, but data on accuracy are lacking in complex cancers such as head and neck cancer (HNC). We developed and evaluated an electronic platform to ... Read more >>

J Oncol Pract (Journal of oncology practice)
[2019, 15(1):e84-e90]

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Association of Exercise With Mortality in Adult Survivors of Childhood Cancer.

Jessica M Scott, Nan Li, Qi Liu, Yutaka Yasui, Wendy Leisenring, Paul C Nathan, Todd Gibson, Saro H Armenian, Tormod S Nilsen, Kevin C Oeffinger, Kirsten K Ness, Scott C Adams, Leslie L Robison, Gregory T Armstrong, Lee W Jones,

Importance:Adult survivors of childhood cancer are at excess risk for mortality compared with the general population. Whether exercise attenuates this risk is not known. Objective:To examine the association between vigorous exercise and change in exercise with mortality in adult survivors of childhood cancer. Design, Setting, and Participants:Multicenter cohort analysis among ... Read more >>

JAMA Oncol (JAMA oncology)
[2018, 4(10):1352-1358]

Cited: 1 time

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