Full Text Journal Articles by
Author Kevin C Baker

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Metabolomic Profiling in the Characterization of Degenerative Bone and Joint Diseases.

Katherine R Swank, Jamie E Furness, Erin A Baker, Corinn K Gehrke, Stephen P Biebelhausen, Kevin C Baker,

Osteoarthritis and inflammatory arthropathies are a cause of significant morbidity globally. New research elucidating the metabolic derangements associated with a variety of bone and joint disorders implicates various local and systemic metabolites, which further elucidate the underlying molecular mechanisms associated with these destructive disease processes. In osteoarthritis, atty acid metabolism ... Read more >>

Metabolites (Metabolites)
[2020, 10(6):]

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Comparing rates of early pedicle screw loosening in posterolateral lumbar fusion with and without transforaminal lumbar interbody fusion.

David H Kim, Raymond W Hwang, Gyu-Ho Lee, Riya Joshi, Kevin C Baker, Paul Arnold, Rick Sasso, Daniel Park, Jeffrey Fischgrund,

BACKGROUND CONTEXT:Addition of interbody fusion via a transforaminal approach (TLIF) has become a popular surgical option for treatment of degenerative lumbar conditions. Although technically more complicated than posterolateral fusion surgery (PLF), it has been suggested that TLIF provides superior immediate stability and protects against early pedicle screw loosening. This theory ... Read more >>

Spine J (The spine journal : official journal of the North American Spine Society)
[2020, :]

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Pharmacological tools to mobilise mesenchymal stromal cells into the blood promote bone formation after surgery.

Tariq G Fellous, Andia N Redpath, Mackenzie M Fleischer, Sapan Gandhi, Samantha E Hartner, Michael D Newton, Moïra François, Suet-Ping Wong, Kate H C Gowers, Adam M Fahs, Daniel R Possley, Dominique Bonnet, Paula Urquhart, Anna Nicolaou, Kevin C Baker, Sara M Rankin,

Therapeutic approaches requiring the intravenous injection of autologous or allogeneic mesenchymal stromal cells (MSCs) are currently being evaluated for treatment of a range of diseases, including orthopaedic injuries. An alternative approach would be to mobilise endogenous MSCs into the blood, thereby reducing costs and obviating regulatory and technical hurdles associated ... Read more >>

NPJ Regen Med (NPJ Regenerative medicine)
[2020, 5:3]

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Titania nanotube morphologies for osseointegration via models of in vitro osseointegrative potential and in vivo intramedullary fixation.

Erin A Baker, Alexander D Vara, Meagan R Salisbury, Mackenzie M Fleischer, Kevin C Baker, Paul T Fortin, Richard V Roberts, Craig R Friedrich,

As total joint replacements increase annually, new strategies to attain solid bone-implant fixation are needed to increase implant survivorship. This study evaluated two morphologies of titania nanotubes (TiNT) in in vitro experiments and an in vivo rodent model of intramedullary fixation, to simulate joint arthroplasty conditions. TiNT surfaces were prepared ... Read more >>

J. Biomed. Mater. Res. Part B Appl. Biomater. (Journal of biomedical materials research. Part B, Applied biomaterials)
[2020, 108(4):1483-1493]

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Potential significance of facet joint fusion or posteromedial fusion observed on CT imaging following attempted posterolateral or posterior interbody fusion.

David H Kim, Raymond W Hwang, Gyu-Ho Lee, Riya Joshi, Kevin C Baker, Paul Arnold, Rick Sasso, Daniel Park, Jeffrey Fischgrund,

BACKGROUND CONTEXT:Radiologic evidence of successful lumbar fusion has traditionally been based on bridging bone spanning the intertransverse processes (posterolateral fusion or PLF) or disc space (interbody fusion, or IBF). Often, postoperative computed tomography (CT) of unsuccessful PLF and IBF demonstrates bridging bone across the facet joints or connecting the medial ... Read more >>

Spine J (The spine journal : official journal of the North American Spine Society)
[2020, 20(3):337-343]

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Lumbar Spine Fusion Rates With Local Bone in Posterolateral and Combined Posterolateral and Interbody Approaches.

Daniel K Park, Richard Roberts, Paul Arnold, David H Kim, Rick Sasso, Kevin C Baker, Jeffrey S Fischgrund,

Posterolateral lumbar fusion (PLF) used to treat degenerative lumbar conditions still faces pseudarthrosis. Bone graft choice is a key factor; a traditional choice has been autologous iliac crest bone graft (ICBG), but complication rates are quoted up to 39%. Local bone from laminectomy eliminates ICBG harvesting complications. Methods:Two hundred forty-one ... Read more >>

J Am Acad Orthop Surg Glob Res Rev (Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews)
[2019, 3(11):e018]

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Effect of local retropharyngeal steroids on fusion rate after anterior cervical discectomy and fusion.

Sapan D Gandhi, Steven T Wahlmeier, Philip Louie, Ryan Sauber, Trevor R Tooley, Kevin C Baker, Daniel K Park,

BACKGROUND CONTEXT:Anterior cervical discectomy and fusion (ACDF) is considered the gold standard surgical intervention for cervical myelopathy and radiculopathy. Obtaining a solid fusion is an important goal of ACDF, and doing so has correlated with favorable clinical outcomes. A common complication after surgery is postoperative dysphagia. Multiple techniques have been ... Read more >>

Spine J (The spine journal : official journal of the North American Spine Society)
[2020, 20(2):261-265]

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Longitudinal characterization of intervertebral disc remodeling following acute annular injury in a rat model of degenerative disc disease.

Michael D Newton, Abigail A Marek, Michael Planalp, Daniel K Park, Kevin C Baker, Tristan Maerz,

Objective: Characterize 3D remodeling of the rat intervertebral disc (IVD) following acute annular injury via in vivo micro-computed tomography (µCT), ex vivo contrast-enhanced (CE)-µCT, and histology. Design: Female Lewis rats (N = 4/group) underwent either sham surgery or anterior annular puncture to L3-L4 and L5-L6 (n = 8 IVDs/group) to induce IVD ... Read more >>

Connect. Tissue Res. (Connective tissue research)
[2019, :1-9]

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Analysis of Retrieved Unicompartmental Knee Implants and Tissue: Third-Body Wear as a Potential Contributor to Progression of Arthritis to Adjacent Compartments.

Lige M Kaplan, Matthew P Siljander, James J Verner, Kevin C Baker, Corinn K Gehrke, Meagan R Salisbury, Erin A Baker,

Unicompartmental knee arthroplasty (UKA) for the treatment of single-compartment osteoarthritis has been associated with polyethylene wear and progression of osteoarthritis into adjacent compartments, leading to revision. In this study, damage and clinical failure modes of retrieved UKA implants were investigated and protein expression profiles between articular cartilage adjacent to UKA ... Read more >>

Orthopedics (Orthopedics)
[2019, 42(3):149-157]

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Reply to the Letter to the Editor: Internal Fixation of Osteoporotic Bone.

Kevin D Grant, Eric C Busse, Daniel K Park, Kevin C Baker,

J Am Acad Orthop Surg (The Journal of the American Academy of Orthopaedic Surgeons)
[2018, 26(18):e395]

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Biomechanical properties of the repaired and non-repaired rat supraspinatus tendon in the acute postoperative period.

Michael D Kurdziel, Abigail Davidson, David Ross, Joseph Seta, Shashin Doshi, Kevin C Baker, Tristan Maerz,

PURPOSE:The rat rotator cuff (RC) model is used to study RC pathology and potential treatment; however, native scar-mediated healing allows the rat RC to recover at 4-6 weeks but little is known about acute healing. This study characterized the properties of the repaired and non-repaired rat RC following surgical detachment. MATERIALS ... Read more >>

Connect. Tissue Res. (Connective tissue research)
[2019, 60(3):254-264]

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Effect of Bisphosphonate Pretreatment on Fresh Osteochondral Allografts: Analysis of In Vitro Graft Structure and In Vivo Osseous Incorporation.

Drew D Moore, Kevin C Baker, Erin A Baker, Mackenzie M Fleischer, Michael D Newton, Nicholas Barreras, Zachary M Vaupel, Paul T Fortin,

Fresh allograft transplantation of osteochondral defects restores functional articular cartilage and subchondral bone; however, rapid loss of chondrocyte viability during storage and osteoclast-mediated bone resorption at the graft-host interface after transplantation negatively impact outcomes. The authors present a pilot study evaluating the in vitro and in vivo impact of augmenting ... Read more >>

Orthopedics (Orthopedics)
[2018, 41(3):e376-e382]

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Internal Fixation of Osteoporotic Bone.

Kevin D Grant, Eric C Busse, Daniel K Park, Kevin C Baker,

Osteoporosis is one of the costliest conditions managed by orthopaedic surgeons. This condition, which is characterized by decreased bone density and thinning of cortical bone, is strongly influenced by complex signaling in both the hormonal and mechanical environments. Osteoporosis cannot be cured; instead, it can only be managed to decrease ... Read more >>

J Am Acad Orthop Surg (The Journal of the American Academy of Orthopaedic Surgeons)
[2018, 26(5):166-174]

Cited: 2 times

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Quantitative evaluation of retrieved reverse total shoulder arthroplasty liner surface deviation and volumetric wear.

Michael D Kurdziel, Michael D Newton, Samantha Hartner, Kevin C Baker, Jerome Michael Wiater,

Polyethylene wear is a known complication in total joint arthroplasty, however, in vivo wear rates in reverse total shoulder arthroplasty (RTSA) remain largely unknown. This study aimed to quantify volumetric and surface deviation changes in retrieved RTSA humeral liners using a novel micro-computed tomography (μCT)-based technique. After IRB-approval, 32 humeral ... Read more >>

J. Orthop. Res. (Journal of orthopaedic research : official publication of the Orthopaedic Research Society)
[2018, 36(7):2007-2014]

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Metabolomic serum profiling after ACL injury in rats: A pilot study implicating inflammation and immune dysregulation in post-traumatic osteoarthritis.

Tristan Maerz, Eric Sherman, Michael Newton, Ali Yilmaz, Praveen Kumar, Stewart F Graham, Kevin C Baker,

ACL rupture is a major risk factor for post-traumatic osteoarthritis (PTOA) development. Little information exists on acute systemic metabolic indicators of disease development. Thirty-six female Lewis rats were randomized to Control or noninvasive anterior cruciate ligament rupture (ACLR) and to three post-injury time points: 72 h, 4 weeks, 10 weeks (n = 6). ... Read more >>

J. Orthop. Res. (Journal of orthopaedic research : official publication of the Orthopaedic Research Society)
[2018, 36(7):1969-1979]

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Nondestructive, indirect assessment of the biomechanical properties of the rat intervertebral disc using contrast-enhanced μCT.

Michael D Newton, Samantha E Hartner, Karissa Gawronski, Erik J Davenport, Shannon C Timmons, Kevin C Baker, Tristan Maerz,

Mechanical characterization of the intervertebral disc involves labor-intensive and destructive experimental methodology. Contrast-enhanced micro-computed tomography is a nondestructive imaging modality for high-resolution visualization and glycosaminoglycan quantification of cartilaginous tissues. The purpose of this study was to determine whether anionic and cationic contrast-enhanced micro-computed tomography of the intervertebral disc can be ... Read more >>

J. Orthop. Res. (Journal of orthopaedic research : official publication of the Orthopaedic Research Society)
[2018, 36(7):2030-2038]

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Fretting and Corrosion Damage in Retrieved Metal-on-Polyethylene Modular Total Hip Arthroplasty Systems: What Is the Importance of Femoral Head Size?

Matthew P Siljander, Erin A Baker, Kevin C Baker, Meagan R Salisbury, Clayton C Thor, James J Verner,

BACKGROUND:Fretting and corrosion at the modular femoral head-femoral neck (taper) interface have been reported in retrieved total hip arthroplasty (THA) prostheses. This study investigated associations among implant design, radiographic factors, and patient factors with corrosion and fretting at the taper interface in retrieved metal-on-polyethylene modular THA prostheses. METHODS:Ninety-two retrieved primary ... Read more >>

J Arthroplasty (The Journal of arthroplasty)
[2018, 33(3):931-938]

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Multidrug-Resistant Organisms in the Setting of Periprosthetic Joint Infection-Diagnosis, Prevention, and Treatment.

Matthew P Siljander, Ali H Sobh, Kevin C Baker, Erin A Baker, Lige M Kaplan,

<label>BACKGROUND</label>Periprosthetic joint infection (PJI) is a rare yet challenging problem in total hip and knee arthroplasties. The management of PJI remains difficult primarily due to the evolution of resistance by the infecting organisms.<label>METHODS</label>This review profiles acquired mechanisms of bacterial resistance and summarizes established and emerging techniques in PJI diagnosis, prevention, ... Read more >>

J Arthroplasty (The Journal of arthroplasty)
[2018, 33(1):185-194]

Cited: 1 time

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Review of Mechanical, Processing, and Immunologic Factors Associated With Outcomes of Fresh Osteochondral Allograft Transplantation of the Talus.

Chikezie N Okeagu, Erin A Baker, Nicholas A Barreras, Zachary M Vaupel, Paul T Fortin, Kevin C Baker,

Osteochondral lesions of the talus (OLTs) are an increasingly implicated cause of ankle pain and instability. Several treatment methods exist with varying clinical outcomes. Due in part to successful osteochondral allografting (OCA) in other joints, such as the knee and shoulder, OCA has gained popularity as a treatment option, especially ... Read more >>

Foot Ankle Int (Foot & ankle international)
[2017, 38(7):808-819]

Cited: 1 time

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Articular cartilage surface roughness as an imaging-based morphological indicator of osteoarthritis: A preliminary investigation of osteoarthritis initiative subjects.

Michael D Newton, Jeffrey Osborne, Karissa Gawronski, Kevin C Baker, Tristan Maerz,

Current imaging-based morphometric indicators of osteoarthritis (OA) using whole-compartment mean cartilage thickness (MCT) and volume changes can be insensitive to mild degenerative changes of articular cartilage (AC) due to areas of adjacent thickening and thinning. The purpose of this preliminary study was to evaluate cartilage thickness-based surface roughness as a ... Read more >>

J. Orthop. Res. (Journal of orthopaedic research : official publication of the Orthopaedic Research Society)
[2017, 35(12):2755-2764]

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Increasing Liner Anteversion Decreases the Interfacial Strength of Polyethylene Liners Cemented Into Titanium-Alloy Acetabular Shells.

Michael D Kurdziel, Kwame A Ennin, Kevin C Baker, James J Verner,

Acetabular component positioning during revision total hip arthroplasty can be suboptimal. Cementation of an acetabular liner into a well-fixed acetabular shell can allow surgeons to correct component version and inclination without the need for extensive revision surgery and progressive pelvic bone loss. However, to date, it is unknown what degree ... Read more >>

J Arthroplasty (The Journal of arthroplasty)
[2016, 31(12):2922-2925]

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Contrast-enhanced μCT of the intervertebral disc: A comparison of anionic and cationic contrast agents for biochemical and morphological characterization.

Michael D Newton, Samantha E Hartner, Shannon Timmons, Nathan D Delaney, Michael G Pirrone, Kevin C Baker, Tristan Maerz,

The objective of this study was to quantify and compare the contrast-enhancing properties of the anionic contrast agent ioxaglate/Hexabrix, and cationic contrast agent CA4+ for biochemical and morphological characterization of the intervertebral disc (IVD) via μCT. Optimal contrast agent concentrations were determined by incubating rat lumbar IVDs in dilutions of ... Read more >>

J. Orthop. Res. (Journal of orthopaedic research : official publication of the Orthopaedic Research Society)
[2017, 35(5):1067-1075]

Cited: 2 times

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Biomechanical Evaluation of All-Polyethylene Pegged Bony Ingrowth Glenoid Fixation Techniques on Implant Micromotion.

Brett P Wiater, James E Moravek, Michael D Kurdziel, Kevin C Baker, J Michael Wiater,

Newer glenoid components that allow for hybrid cement fixation via traditional cementation of peripheral pegs and bony ingrowth into an interference-fit central peg introduce the possibility of long-term biological fixation. However, little biomechanical work has been done on the initial stability of these components and the various fixation options. We ... Read more >>

Am J. Orthop. (American journal of orthopedics (Belle Mead, N.J.))
[2016, 45(4):E211-6]

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Retropharyngeal Steroids and Dysphagia Following Multilevel Anterior Cervical Surgery.

Theodore D Koreckij, Abigail A Davidson, Kevin C Baker, Daniel K Park,

STUDY DESIGN:A retrospective case-control study. OBJECTIVE:The aim of this study was to determine the effect of retropharyngeal steroids on postoperative dysphagia scores and clinical outcomes following multilevel anterior cervical discectomy and fusion (ACDF). SUMMARY OF BACKGROUND DATA:Dysphagia is a well-known complication following ACDF surgery and increased rates of dysphagia are ... Read more >>

Spine (Spine)
[2016, 41(9):E530-4]

Cited: 9 times

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Lumbar pseudarthrosis: a review of current diagnosis and treatment.

Danielle S Chun, Kevin C Baker, Wellington K Hsu,

OBJECT Failed solid bony fusion, or pseudarthrosis, is a well-known complication of lumbar arthrodesis. Recent advances in radiographic technology, biologics, instrumentation, surgical technique, and understanding of the local biology have all aided in the prevention and treatment of pseudarthrosis. Here, the current literature on the diagnosis and management of lumbar ... Read more >>

Neurosurg Focus (Neurosurgical focus)
[2015, 39(4):E10]

Cited: 15 times

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