Full Text Journal Articles by
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Metabolomic Profiling in the Characterization of Degenerative Bone and Joint Diseases.

Katherine R Swank, Jamie E Furness, Erin A Baker, Corinn K Gehrke, Stephen P Biebelhausen, Kevin C Baker,

Osteoarthritis and inflammatory arthropathies are a cause of significant morbidity globally. New research elucidating the metabolic derangements associated with a variety of bone and joint disorders implicates various local and systemic metabolites, which further elucidate the underlying molecular mechanisms associated with these destructive disease processes. In osteoarthritis, atty acid metabolism ... Read more >>

Metabolites (Metabolites)
[2020, 10(6):]

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Comparing Rates of Early Pedicle Screw Loosening in Posterolateral Lumbar Fusion with and without Transforaminal Lumbar Interbody Fusion.

David H Kim, Raymond W Hwang, Gyu-Ho Lee, Riya Joshi, Kevin C Baker, Paul Arnold, Rick Sasso, Daniel Park, Jeffrey Fischgrund,

BACKGROUND CONTEXT:Addition of interbody fusion via a transforaminal approach (TLIF) has become a popular surgical option for treatment of degenerative lumbar conditions. Although technically more complicated than posterolateral fusion surgery (PLF), it has been suggested that TLIF provides superior immediate stability and protects against early pedicle screw loosening. This theory ... Read more >>

Spine J (The spine journal : official journal of the North American Spine Society)
[2020, :]

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Protecting children in low-income and middle-income countries from COVID-19.

Salahuddin Ahmed, Tisungane Mvalo, Samuel Akech, Ambrose Agweyu, Kevin Baker, Naor Bar-Zeev, Harry Campbell, William Checkley, Mohammod Jobayer Chisti, Tim Colbourn, Steve Cunningham, Trevor Duke, Mike English, Adegoke G Falade, Nicholas Ss Fancourt, Amy S Ginsburg, Hamish R Graham, Diane M Gray, Madhu Gupta, Laura Hammitt, Anneke C Hesseling, Shubhada Hooli, Abdul-Wahab Br Johnson, Carina King, Miles A Kirby, Claudio F Lanata, Norman Lufesi, Grant A Mackenzie, John P McCracken, Peter P Moschovis, Harish Nair, Osawaru Oviawe, William S Pomat, Mathuram Santosham, James A Seddon, Lineo Keneuoe Thahane, Brian Wahl, Marieke Van der Zalm, Charl Verwey, Lay-Myint Yoshida, Heather J Zar, Stephen Rc Howie, Eric D McCollum,

BMJ Glob Health (BMJ global health)
[2020, 5(5):]

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Traumatic Joint Injury Induces Acute Catabolic Bone Turnover Concurrent with Articular Cartilage Damage in a Rat Model of Post-Traumatic Osteoarthritis

Tristan Maerz, Michael Newton, Mackenzie Fleischer, Samantha Hartner, Karissa Gawronski, Lucas Junginger, Kevin Baker,

ABSTRACT Objective Assess acute alterations in bone turnover, microstructure, and histomorphometry following noninvasive anterior cruciate ligament rupture (ACLR). Methods Twelve female Lewis rats were randomized to receive noninvasive ACLR or Sham loading (n=6/group). I n vivo μCT was performed at 3, 7, 10, and 14 days post-injury to quantify compartment-dependent ... Read more >>

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Determining the Agreement Between an Automated Respiratory Rate Counter and a Reference Standard for Detecting Symptoms of Pneumonia in Children: Protocol for a Cross-Sectional Study in Ethiopia.

Charlotte Ward, Kevin Baker, Sarah Marks, Dawit Getachew, Tedila Habte, Cindy McWhorter, Paul Labarre, Jonathan Howard-Brand, Nathan P Miller, Hayalnesh Tarekegn, Solomie Jebessa Deribessa, Max Petzold, Karin Kallander,

BACKGROUND:Acute respiratory infections (ARIs), primarily pneumonia, are the leading infectious cause of under-5 mortality worldwide. Manually counting respiratory rate (RR) for 60 seconds using an ARI timer is commonly practiced by community health workers to detect fast breathing, an important sign of pneumonia. However, correctly counting breaths manually and classifying ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(4):e16531]

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Automated Respiratory Rate Counter to Assess Children for Symptoms of Pneumonia: Protocol for Cross-Sectional Usability and Acceptability Studies in Ethiopia and Nepal.

Kevin Baker, Alice Maurel, Charlotte Ward, Dawit Getachew, Tedila Habte, Cindy McWhorter, Paul LaBarre, Jonas Karlström, Max Petzold, Karin Källander,

BACKGROUND:Manually counting a child's respiratory rate (RR) for 60 seconds using an acute respiratory infection timer is the World Health Organization (WHO) recommended method for detecting fast breathing as a sign of pneumonia. However, counting the RR is challenging and misclassification of an observed rate is common, often leading to ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(3):e14405]

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Pharmacological tools to mobilise mesenchymal stromal cells into the blood promote bone formation after surgery.

Tariq G Fellous, Andia N Redpath, Mackenzie M Fleischer, Sapan Gandhi, Samantha E Hartner, Michael D Newton, Moïra François, Suet-Ping Wong, Kate H C Gowers, Adam M Fahs, Daniel R Possley, Dominique Bonnet, Paula Urquhart, Anna Nicolaou, Kevin C Baker, Sara M Rankin,

Therapeutic approaches requiring the intravenous injection of autologous or allogeneic mesenchymal stromal cells (MSCs) are currently being evaluated for treatment of a range of diseases, including orthopaedic injuries. An alternative approach would be to mobilise endogenous MSCs into the blood, thereby reducing costs and obviating regulatory and technical hurdles associated ... Read more >>

NPJ Regen Med (NPJ Regenerative medicine)
[2020, 5:3]

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Participant Perceptions on a Fitbit and Facebook Intervention for Young Adult Cancer Survivors: A Qualitative Study.

Evelina M Miropolsky, Kevin Scott Baker, Mark Abbey-Lambertz, Karen Syrjala, Eric J Chow, Rachel Ceballos, Jason A Mendoza,

Purpose: Among cancer survivors, physical activity (PA) is associated with reductions in cancer recurrence, morbidity, and mortality. Most young adult (YA) survivors do not attain adequate PA. Digital modalities, specifically wearable activity monitors with a paired mobile application and private social media group for support offer a promising approach for ... Read more >>

J Adolesc Young Adult Oncol (Journal of adolescent and young adult oncology)
[2020, :]

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Does Chest Attachment of an Automated Respiratory Rate Monitor Influence the Actual Respiratory Rate in Children Under Five?

Daniel Helldén, Kevin Baker, Tedila Habte, Esey Batisso, Nicola Orsini, Karin Källander, Tobias Alfvén,

Pneumonia is one of the leading causes of death in children under 5 years worldwide. In resource-limited settings, WHO recommendations state that pneumonia can be presumptively diagnosed through the presence of cough and/or difficult breathing and a respiratory rate (RR) that is higher than age-specific cutoffs. As a new diagnostic ... Read more >>

Am. J. Trop. Med. Hyg. (The American journal of tropical medicine and hygiene)
[2020, 102(1):20-27]

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Usability and acceptability of an automated respiratory rate counter to assess childhood pneumonia in Nepal.

Karin Källander, Charlotte Ward, Helen Smith, Radheshyam Bhattarai, Ashish Kc, Deepak Timsina, Bikash Lamichhane, Alice Maurel, Parashu Ram Shrestha, Sushil Baral, Cindy McWhorter, Paul LaBarre, Monica Anna de Cola, Kevin Baker,

AIM:Pneumonia is the leading cause of child death after the neonatal period, resulting from late care seeking and inappropriate treatment. Diagnosis involves counting respiratory rate (RR); however, RR counting remains challenging for health workers and miscounting, and misclassification of RR is common. We evaluated the usability of a new automated ... Read more >>

Acta Paediatr. (Acta paediatrica (Oslo, Norway : 1992))
[2020, 109(6):1207-1220]

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Titania nanotube morphologies for osseointegration via models of in vitro osseointegrative potential and in vivo intramedullary fixation.

Erin A Baker, Alexander D Vara, Meagan R Salisbury, Mackenzie M Fleischer, Kevin C Baker, Paul T Fortin, Richard V Roberts, Craig R Friedrich,

As total joint replacements increase annually, new strategies to attain solid bone-implant fixation are needed to increase implant survivorship. This study evaluated two morphologies of titania nanotubes (TiNT) in in vitro experiments and an in vivo rodent model of intramedullary fixation, to simulate joint arthroplasty conditions. TiNT surfaces were prepared ... Read more >>

J. Biomed. Mater. Res. Part B Appl. Biomater. (Journal of biomedical materials research. Part B, Applied biomaterials)
[2020, 108(4):1483-1493]

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Usability and acceptability of an automated respiratory rate counter to assess children for symptoms of pneumonia: A cross-sectional study in Ethiopia.

Charlotte Ward, Kevin Baker, Helen Smith, Alice Maurel, Dawit Getachew, Tedila Habte, Cindy McWhorter, Paul LaBarre, Jonas Karlstrom, Jim Black, Quique Bassat, Agazi Ameha, Abraham Tariku, Max Petzold, Karin Källander,

AIM:Manually counting respiratory rate (RR) is commonly practiced by community health workers to detect fast breathing, an important sign of childhood pneumonia. Correctly counting and classifying breaths manually is challenging, often leading to inappropriate treatment. This study aimed to determine the usability of a new automated RR counter (ChARM) by health ... Read more >>

Acta Paediatr. (Acta paediatrica (Oslo, Norway : 1992))
[2020, 109(6):1196-1206]

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Potential significance of facet joint fusion or posteromedial fusion observed on CT imaging following attempted posterolateral or posterior interbody fusion.

David H Kim, Raymond W Hwang, Gyu-Ho Lee, Riya Joshi, Kevin C Baker, Paul Arnold, Rick Sasso, Daniel Park, Jeffrey Fischgrund,

BACKGROUND CONTEXT:Radiologic evidence of successful lumbar fusion has traditionally been based on bridging bone spanning the intertransverse processes (posterolateral fusion or PLF) or disc space (interbody fusion, or IBF). Often, postoperative computed tomography (CT) of unsuccessful PLF and IBF demonstrates bridging bone across the facet joints or connecting the medial ... Read more >>

Spine J (The spine journal : official journal of the North American Spine Society)
[2020, 20(3):337-343]

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More work needs to be done to ensure that better pneumonia diagnostics aids are developed and launched to better support frontline health workers-A response to "Are respiratory rate counters really so bad" by Ansermino et al.

Kevin Baker, Tobias Alfvén, Karin Källander,

EClinicalMedicine (EClinicalMedicine)
[2019, 16:15]

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Lumbar Spine Fusion Rates With Local Bone in Posterolateral and Combined Posterolateral and Interbody Approaches.

Daniel K Park, Richard Roberts, Paul Arnold, David H Kim, Rick Sasso, Kevin C Baker, Jeffrey S Fischgrund,

Posterolateral lumbar fusion (PLF) used to treat degenerative lumbar conditions still faces pseudarthrosis. Bone graft choice is a key factor; a traditional choice has been autologous iliac crest bone graft (ICBG), but complication rates are quoted up to 39%. Local bone from laminectomy eliminates ICBG harvesting complications. Methods:Two hundred forty-one ... Read more >>

J Am Acad Orthop Surg Glob Res Rev (Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews)
[2019, 3(11):e018]

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Von Willebrand factor delays liver repair after acetaminophen-induced acute liver injury in mice.

Dafna Groeneveld, Holly Cline-Fedewa, Kevin S Baker, Kurt J Williams, Robert A Roth, Karen Mittermeier, Ton Lisman, Joseph S Palumbo, James P Luyendyk,

BACKGROUND & AIM:Acetaminophen (APAP)-induced acute liver failure is associated with substantial alterations in the hemostatic system. In mice, platelets accumulate in the liver after APAP overdose and appear to promote liver injury. Interestingly, patients with acute liver injury have highly elevated levels of the platelet-adhesive protein von Willebrand factor (VWF), ... Read more >>

J. Hepatol. (Journal of Hepatology)
[2020, 72(1):146-155]

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Visual Analysis of a Computer-Aided Diagnosis System for Pancreatic Lesions.

Konstantin Dmitriev, Joseph Marino, Kevin Baker, Arie E Kaufman,

Machine learning is a powerful and effective tool for medical image analysis to perform computer-aided diagnosis (CAD). Having great potential in improving the accuracy of a diagnosis, CAD systems are often analyzed in terms of the final accuracy, leading to a limited understanding of the internal decision process, impossibility to ... Read more >>

IEEE Trans Vis Comput Graph (IEEE transactions on visualization and computer graphics)
[2019, :]

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Effect of local retropharyngeal steroids on fusion rate after anterior cervical discectomy and fusion.

Sapan D Gandhi, Steven T Wahlmeier, Philip Louie, Ryan Sauber, Trevor R Tooley, Kevin C Baker, Daniel K Park,

BACKGROUND CONTEXT:Anterior cervical discectomy and fusion (ACDF) is considered the gold standard surgical intervention for cervical myelopathy and radiculopathy. Obtaining a solid fusion is an important goal of ACDF, and doing so has correlated with favorable clinical outcomes. A common complication after surgery is postoperative dysphagia. Multiple techniques have been ... Read more >>

Spine J (The spine journal : official journal of the North American Spine Society)
[2020, 20(2):261-265]

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Direct Amplification of Tissue Factor:Factor VIIa Procoagulant Activity by Bile Acids Drives Intrahepatic Coagulation.

Kevin S Baker, Anna K Kopec, Asmita Pant, Lauren G Poole, Holly Cline-Fedewa, Dora Ivkovich, Mojtaba Olyaee, Benjamin L Woolbright, Adam Miszta, Hartmut Jaeschke, Alisa S Wolberg, James P Luyendyk,

OBJECTIVE:Regulation of TF (tissue factor):FVIIa (coagulation factor VIIa) complex procoagulant activity is especially critical in tissues where plasma can contact TF-expressing cells. One example is the liver, where hepatocytes are routinely exposed to plasma because of the fenestrated sinusoidal endothelium. Although liver-associated TF contributes to coagulation, the mechanisms controlling the ... Read more >>

Arterioscler. Thromb. Vasc. Biol. (Arteriosclerosis, thrombosis, and vascular biology)
[2019, 39(10):2038-2048]

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Longitudinal characterization of intervertebral disc remodeling following acute annular injury in a rat model of degenerative disc disease.

Michael D Newton, Abigail A Marek, Michael Planalp, Daniel K Park, Kevin C Baker, Tristan Maerz,

Objective: Characterize 3D remodeling of the rat intervertebral disc (IVD) following acute annular injury via in vivo micro-computed tomography (µCT), ex vivo contrast-enhanced (CE)-µCT, and histology. Design: Female Lewis rats (N = 4/group) underwent either sham surgery or anterior annular puncture to L3-L4 and L5-L6 (n = 8 IVDs/group) to induce IVD ... Read more >>

Connect. Tissue Res. (Connective tissue research)
[2019, :1-9]

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Performance of Four Respiratory Rate Counters to Support Community Health Workers to Detect the Symptoms of Pneumonia in Children in Low Resource Settings: A Prospective, Multicentre, Hospital-Based, Single-Blinded, Comparative Trial.

Kevin Baker, Tobias Alfvén, Akasiima Mucunguzi, Alexandra Wharton-Smith, Emily Dantzer, Tedila Habte, Lena Matata, Diana Nanyumba, Morris Okwir, Monica Posada, Anteneh Sebsibe, Jill Nicholson, Madeleine Marasciulo, Rasa Izadnegahdar, Max Petzold, Karin Källander,

Background:Pneumonia is one of the leading causes of death in children under-five globally. The current diagnostic criteria for pneumonia are based on increased respiratory rate (RR) or chest in-drawing in children with cough and/or difficulty breathing. Accurately counting RR is difficult for community health workers (CHWs). Current RR counting devices ... Read more >>

EClinicalMedicine (EClinicalMedicine)
[2019, 12:20-30]

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IL-1 Family Members in Cancer; Two Sides to Every Story.

Kevin J Baker, Aileen Houston, Elizabeth Brint,

The IL-1 family of cytokines currently comprises of seven ligands with pro-inflammatory activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) as well as two ligands with anti-inflammatory activity (IL-37, IL-38). These cytokines are known to play a key role in modulating both the innate and adaptive immunes response, with ... Read more >>

Front Immunol (Frontiers in immunology)
[2019, 10:1197]

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Analysis of Retrieved Unicompartmental Knee Implants and Tissue: Third-Body Wear as a Potential Contributor to Progression of Arthritis to Adjacent Compartments.

Lige M Kaplan, Matthew P Siljander, James J Verner, Kevin C Baker, Corinn K Gehrke, Meagan R Salisbury, Erin A Baker,

Unicompartmental knee arthroplasty (UKA) for the treatment of single-compartment osteoarthritis has been associated with polyethylene wear and progression of osteoarthritis into adjacent compartments, leading to revision. In this study, damage and clinical failure modes of retrieved UKA implants were investigated and protein expression profiles between articular cartilage adjacent to UKA ... Read more >>

Orthopedics (Orthopedics)
[2019, 42(3):149-157]

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Metadata Correction: Performance, Acceptability, and Usability of Respiratory Rate Timers and Pulse Oximeters When Used by Frontline Health Workers to Detect Symptoms of Pneumonia in Sub-Saharan Africa and Southeast Asia: Protocol for a Two-Phase, Multisite, Mixed-Methods Trial.

Kevin Baker, Mucunguzi Akasiima, Alexandra Wharton-Smith, Tedila Habte, Lena Matata, Diana Nanyumba, Morris Okwir, Anteneh Sebsibe, Madeleine Marasciulo, Max Petzold, Karin Källander,

JMIR Res Protoc (JMIR research protocols)
[2019, 8(3):e13755]

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Lasting effects of cancer and its treatment on employment and finances in adolescent and young adult cancer survivors.

Tyler G Ketterl, Karen L Syrjala, Jacqueline Casillas, Linda A Jacobs, Steven C Palmer, Mary S McCabe, Patricia A Ganz, Linda Overholser, Ann Partridge, Emily Jo Rajotte, Abby R Rosenberg, Betsy Risendal, Donald L Rosenstein, Kevin Scott Baker,

BACKGROUND:The impact of cancer and its treatment on employment and financial burden in adolescents/young adults (AYAs) is not fully known. METHODS:Eligibility for this cross-sectional study of AYA cancer survivors included the diagnosis of a malignancy between ages 18 and 39 years and survey completion within 1 to 5 years from diagnosis and ... Read more >>

Cancer (Cancer)
[2019, 125(11):1908-1917]

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