Full Text Journal Articles by
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Intradiscal Delivery of Anabolic Growth Factors and a Metalloproteinase Inhibitor in a Rabbit Acute Lumbar Disc Injury Model.

Sapan D Gandhi, Tristan Maerz, Sean Mitchell, Casey Bachison, Daniel K Park, Jeffrey S Fischgrund, Kevin C Baker,

<h4>Background</h4>The purpose of our study was to examine the effect of controlled delivery of TGF-β<sub>3</sub>, BMP-4, and TIMP-2 with a biocompatible biopolymer, chitosan, on an acutely injured intervertebral disc (IVD) in a rabbit model.<h4>Methods</h4>After conducting an in vitro analysis of the chondrogenic capacity of the biomolecule cocktail use (ie, TGF-β<sub>3</sub>, ... Read more >>

Int J Spine Surg (International journal of spine surgery)
[2020, 14(4):585-593]

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Back to Basics in Paediatric Pneumonia-Defining a Breath and Setting Reference Standards to Innovate Respiratory Rate Counting.

King Carina, Baker Kevin, Nantanda Rebecca, Bassat Quique, Qazi Shamim Ahmad, McCollum Eric D,

J Trop Pediatr (Journal of tropical pediatrics)
[2020, :]

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A model identifying characteristics predictive of successful pelvic floor muscle training outcomes among women with stress urinary incontinence.

Kaylee C L Brooks, Kevin Varette, Marie-Andrée Harvey, Magali Robert, Robert J Brison, Andrew Day, Kevin Baker, Vincent Della Zazzera, Eric Sauerbrei, Linda McLean,

<h4>Introduction and hypothesis</h4>The aim of this study was to prospectively identify aspects of baseline demographic, clinical, and pelvic morphology of women with stress urinary incontinence (SUI) that are predictive of cure with physiotherapist-supervised pelvic floor muscle training (PFMT).<h4>Methods</h4>Women ≥18 years old with SUI were recruited from urogynecology and pelvic health physiotherapy ... Read more >>

Int Urogynecol J (International urogynecology journal)
[2020, :]

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Usability and acceptability of a multimodal respiratory rate and pulse oximeter device in case management of children with symptoms of pneumonia: A cross-sectional study in Ethiopia.

Kevin Baker, Charlotte Ward, Alice Maurel, Monica Anna de Cola, Helen Smith, Dawit Getachew, Tedila Habte, Cindy McWhorter, Paul LaBarre, Jonas Karlstrom, Agazi Ameha, Abraham Tariku, Jim Black, Quique Bassat, Karin Källander,

<h4>Aim</h4>Pneumonia is the leading infectious cause of death among children under five globally. Many pneumonia deaths result from inappropriate treatment due to misdiagnosis of signs and symptoms. This study aims to identify whether health extension workers (HEWs) in Ethiopia, using an automated multimodal device (Masimo Rad-G), adhere to required guidelines ... Read more >>

Acta Paediatr (Acta paediatrica (Oslo, Norway : 1992))
[2020, :]

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Response to Letter to the Editor regarding, "potential significance of facet joint fusion or posteromedial fusion observed on CT imaging following attempted posterolateral or posterior interbody fusion".

David H Kim, Raymond W Hwang, Gyu-Ho Lee, Riya Joshi, Kevin C Baker, Paul Arnold, Rick Sasso, Daniel Park, Jeffrey Fischgrund,

Spine J (The spine journal : official journal of the North American Spine Society)
[2020, 20(11):1890-1891]

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Community health worker knowledge, attitudes and practices towards COVID-19: learnings from an online cross-sectional survey using a digital health platform, UpSCALE, in Mozambique

Mitra Feldman, Vera Lacey Krylova, Poppy Farrow, Laura Donovan, Edson Zandamela, Joaquim Rebelo, Maria Rodrigues, Antonio Bulo, Carlos Ferraz, Juan Romero Gonzalez, Humberto Rodrigues, Arantxa Roca-Feltrer, Kevin Baker,

Healthcare workers (HCWs) are at the frontline of the Coronavirus Disease 2019 (COVID-19) pandemic response, yet there is a paucity of literature on their knowledge, attitudes and practices (KAP) in relation to the pandemic. Community Health Workers (CHWs) in Mozambique are known locally as agentes polivalentes elementares (APEs). While technical ... Read more >>

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Traumatic joint injury induces acute catabolic bone turnover concurrent with articular cartilage damage in a rat model of posttraumatic osteoarthritis.

Tristan Maerz, Michael D Newton, Mackenzie Fleischer, Samantha E Hartner, Karissa Gawronski, Lucas Junginger, Kevin C Baker,

Assess acute alterations in bone turnover, microstructure, and histomorphometry following noninvasive anterior cruciate ligament rupture (ACLR). Twelve female Lewis rats were randomized to receive noninvasive ACLR or Sham loading (n = 6/group). In vivo μCT was performed at 3, 7, 10, and 14 days postinjury to quantify compartment-dependent subchondral (SCB) and epiphyseal ... Read more >>

J Orthop Res (Journal of orthopaedic research : official publication of the Orthopaedic Research Society)
[2020, :]

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Surface Modification Techniques to Enhance Osseointegration of Spinal Implants.

Daniel Possley, Erin Baker, Kevin Baker, Jad G Khalil,

Biomechanical function, specifically implantation technique and immediate surgical fixation, of orthopaedic implants is the primary consideration during the development of orthopaedic implants. Biologic and material characteristics are additional factors to include in the design process because of the direct impact on short- and long-term implant performance. The body's initial interaction ... Read more >>

J Am Acad Orthop Surg (The Journal of the American Academy of Orthopaedic Surgeons)
[2020, 28(22):e988-e994]

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Notes from the Field: Travel-Associated Measles in a Person Born Before 1957 - Pinellas County, Florida, 2019.

Kevin M Baker, Abdiel E Laureano-Rosario, Sharlene Edwards,

MMWR Morb Mortal Wkly Rep (MMWR. Morbidity and mortality weekly report)
[2020, 69(38):1378-1379]

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Technical experience and postoperative complications with repeat transperitoneal approach to the lumbar spine in female Lewis rats.

Sapan Gandhi, Michael Newton, Meagan Salisbury, Kevin Baker,

Rat models of lumbar intervertebral disc (IVD) degeneration are widely employed to characterize biologic-based therapeutics, but their anatomy and small size preclude consistent delivery of injectable therapeutics to the lumbar spine via the traditional posterolateral approach. Here, we describe our experience with a repeat ventral transperitoneal approach in female Lewis ... Read more >>

Lab Anim (Laboratory animals)
[2020, :23677220930043]

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Metabolomic Profiling in the Characterization of Degenerative Bone and Joint Diseases.

Katherine R Swank, Jamie E Furness, Erin A Baker, Corinn K Gehrke, Stephen P Biebelhausen, Kevin C Baker,

Osteoarthritis and inflammatory arthropathies are a cause of significant morbidity globally. New research elucidating the metabolic derangements associated with a variety of bone and joint disorders implicates various local and systemic metabolites, which further elucidate the underlying molecular mechanisms associated with these destructive disease processes. In osteoarthritis, atty acid metabolism ... Read more >>

Metabolites (Metabolites)
[2020, 10(6):]

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Comparing rates of early pedicle screw loosening in posterolateral lumbar fusion with and without transforaminal lumbar interbody fusion.

David H Kim, Raymond W Hwang, Gyu-Ho Lee, Riya Joshi, Kevin C Baker, Paul Arnold, Rick Sasso, Daniel Park, Jeffrey Fischgrund,

BACKGROUND CONTEXT:Addition of interbody fusion via a transforaminal approach (TLIF) has become a popular surgical option for treatment of degenerative lumbar conditions. Although technically more complicated than posterolateral fusion surgery (PLF), it has been suggested that TLIF provides superior immediate stability and protects against early pedicle screw loosening. This theory ... Read more >>

Spine J (The spine journal : official journal of the North American Spine Society)
[2020, 20(9):1438-1445]

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Protecting children in low-income and middle-income countries from COVID-19.

Salahuddin Ahmed, Tisungane Mvalo, Samuel Akech, Ambrose Agweyu, Kevin Baker, Naor Bar-Zeev, Harry Campbell, William Checkley, Mohammod Jobayer Chisti, Tim Colbourn, Steve Cunningham, Trevor Duke, Mike English, Adegoke G Falade, Nicholas Ss Fancourt, Amy S Ginsburg, Hamish R Graham, Diane M Gray, Madhu Gupta, Laura Hammitt, Anneke C Hesseling, Shubhada Hooli, Abdul-Wahab Br Johnson, Carina King, Miles A Kirby, Claudio F Lanata, Norman Lufesi, Grant A Mackenzie, John P McCracken, Peter P Moschovis, Harish Nair, Osawaru Oviawe, William S Pomat, Mathuram Santosham, James A Seddon, Lineo Keneuoe Thahane, Brian Wahl, Marieke Van der Zalm, Charl Verwey, Lay-Myint Yoshida, Heather J Zar, Stephen Rc Howie, Eric D McCollum,

BMJ Glob Health (BMJ global health)
[2020, 5(5):]

Cited: 2 times

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Traumatic Joint Injury Induces Acute Catabolic Bone Turnover Concurrent with Articular Cartilage Damage in a Rat Model of Post-Traumatic Osteoarthritis

Tristan Maerz, Michael Newton, Mackenzie Fleischer, Samantha Hartner, Karissa Gawronski, Lucas Junginger, Kevin Baker,

<h4>ABSTRACT</h4> <h4>Objective</h4> Assess acute alterations in bone turnover, microstructure, and histomorphometry following noninvasive anterior cruciate ligament rupture (ACLR). <h4>Methods</h4> Twelve female Lewis rats were randomized to receive noninvasive ACLR or Sham loading (n=6/group). I n vivo μCT was performed at 3, 7, 10, and 14 days post-injury to quantify compartment-dependent ... Read more >>

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Automated Respiratory Rate Counter to Assess Children for Symptoms of Pneumonia: Protocol for Cross-Sectional Usability and Acceptability Studies in Ethiopia and Nepal.

Kevin Baker, Alice Maurel, Charlotte Ward, Dawit Getachew, Tedila Habte, Cindy McWhorter, Paul LaBarre, Jonas Karlström, Max Petzold, Karin Källander,

<h4>Background</h4>Manually counting a child's respiratory rate (RR) for 60 seconds using an acute respiratory infection timer is the World Health Organization (WHO) recommended method for detecting fast breathing as a sign of pneumonia. However, counting the RR is challenging and misclassification of an observed rate is common, often leading to ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(3):e14405]

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Determining the Agreement Between an Automated Respiratory Rate Counter and a Reference Standard for Detecting Symptoms of Pneumonia in Children: Protocol for a Cross-Sectional Study in Ethiopia.

Charlotte Ward, Kevin Baker, Sarah Marks, Dawit Getachew, Tedila Habte, Cindy McWhorter, Paul Labarre, Jonathan Howard-Brand, Nathan P Miller, Hayalnesh Tarekegn, Solomie Jebessa Deribessa, Max Petzold, Karin Kallander,

<h4>Background</h4>Acute respiratory infections (ARIs), primarily pneumonia, are the leading infectious cause of under-5 mortality worldwide. Manually counting respiratory rate (RR) for 60 seconds using an ARI timer is commonly practiced by community health workers to detect fast breathing, an important sign of pneumonia. However, correctly counting breaths manually and classifying ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(4):e16531]

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Pharmacological tools to mobilise mesenchymal stromal cells into the blood promote bone formation after surgery.

Tariq G Fellous, Andia N Redpath, Mackenzie M Fleischer, Sapan Gandhi, Samantha E Hartner, Michael D Newton, Moïra François, Suet-Ping Wong, Kate H C Gowers, Adam M Fahs, Daniel R Possley, Dominique Bonnet, Paula Urquhart, Anna Nicolaou, Kevin C Baker, Sara M Rankin,

Therapeutic approaches requiring the intravenous injection of autologous or allogeneic mesenchymal stromal cells (MSCs) are currently being evaluated for treatment of a range of diseases, including orthopaedic injuries. An alternative approach would be to mobilise endogenous MSCs into the blood, thereby reducing costs and obviating regulatory and technical hurdles associated ... Read more >>

NPJ Regen Med (NPJ Regenerative medicine)
[2020, 5:3]

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Does Chest Attachment of an Automated Respiratory Rate Monitor Influence the Actual Respiratory Rate in Children Under Five?

Daniel Helldén, Kevin Baker, Tedila Habte, Esey Batisso, Nicola Orsini, Karin Källander, Tobias Alfvén,

Pneumonia is one of the leading causes of death in children under 5 years worldwide. In resource-limited settings, WHO recommendations state that pneumonia can be presumptively diagnosed through the presence of cough and/or difficult breathing and a respiratory rate (RR) that is higher than age-specific cutoffs. As a new diagnostic ... Read more >>

Am J Trop Med Hyg (The American journal of tropical medicine and hygiene)
[2020, 102(1):20-27]

Cited: 1 time

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Usability and acceptability of an automated respiratory rate counter to assess children for symptoms of pneumonia: A cross-sectional study in Ethiopia.

Charlotte Ward, Kevin Baker, Helen Smith, Alice Maurel, Dawit Getachew, Tedila Habte, Cindy McWhorter, Paul LaBarre, Jonas Karlstrom, Jim Black, Quique Bassat, Agazi Ameha, Abraham Tariku, Max Petzold, Karin Källander,

<h4>Aim</h4>Manually counting respiratory rate (RR) is commonly practiced by community health workers to detect fast breathing, an important sign of childhood pneumonia. Correctly counting and classifying breaths manually is challenging, often leading to inappropriate treatment. This study aimed to determine the usability of a new automated RR counter (ChARM) by health ... Read more >>

Acta Paediatr (Acta paediatrica (Oslo, Norway : 1992))
[2020, 109(6):1196-1206]

Cited: 2 times

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Usability and acceptability of an automated respiratory rate counter to assess childhood pneumonia in Nepal.

Karin Källander, Charlotte Ward, Helen Smith, Radheshyam Bhattarai, Ashish Kc, Deepak Timsina, Bikash Lamichhane, Alice Maurel, Parashu Ram Shrestha, Sushil Baral, Cindy McWhorter, Paul LaBarre, Monica Anna de Cola, Kevin Baker,

AIM:Pneumonia is the leading cause of child death after the neonatal period, resulting from late care seeking and inappropriate treatment. Diagnosis involves counting respiratory rate (RR); however, RR counting remains challenging for health workers and miscounting, and misclassification of RR is common. We evaluated the usability of a new automated ... Read more >>

Acta Paediatr (Acta paediatrica (Oslo, Norway : 1992))
[2020, 109(6):1207-1220]

Cited: 1 time

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Potential significance of facet joint fusion or posteromedial fusion observed on CT imaging following attempted posterolateral or posterior interbody fusion.

David H Kim, Raymond W Hwang, Gyu-Ho Lee, Riya Joshi, Kevin C Baker, Paul Arnold, Rick Sasso, Daniel Park, Jeffrey Fischgrund,

BACKGROUND CONTEXT:Radiologic evidence of successful lumbar fusion has traditionally been based on bridging bone spanning the intertransverse processes (posterolateral fusion or PLF) or disc space (interbody fusion, or IBF). Often, postoperative computed tomography (CT) of unsuccessful PLF and IBF demonstrates bridging bone across the facet joints or connecting the medial ... Read more >>

Spine J (The spine journal : official journal of the North American Spine Society)
[2020, 20(3):337-343]

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Titania nanotube morphologies for osseointegration via models of in vitro osseointegrative potential and in vivo intramedullary fixation.

Erin A Baker, Alexander D Vara, Meagan R Salisbury, Mackenzie M Fleischer, Kevin C Baker, Paul T Fortin, Richard V Roberts, Craig R Friedrich,

As total joint replacements increase annually, new strategies to attain solid bone-implant fixation are needed to increase implant survivorship. This study evaluated two morphologies of titania nanotubes (TiNT) in in vitro experiments and an in vivo rodent model of intramedullary fixation, to simulate joint arthroplasty conditions. TiNT surfaces were prepared ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2020, 108(4):1483-1493]

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More work needs to be done to ensure that better pneumonia diagnostics aids are developed and launched to better support frontline health workers-A response to "Are respiratory rate counters really so bad" by Ansermino et al.

Kevin Baker, Tobias Alfvén, Karin Källander,

EClinicalMedicine (EClinicalMedicine)
[2019, 16:15]

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Von Willebrand factor delays liver repair after acetaminophen-induced acute liver injury in mice.

Dafna Groeneveld, Holly Cline-Fedewa, Kevin S Baker, Kurt J Williams, Robert A Roth, Karen Mittermeier, Ton Lisman, Joseph S Palumbo, James P Luyendyk,

<h4>Background & aim</h4>Acetaminophen (APAP)-induced acute liver failure is associated with substantial alterations in the hemostatic system. In mice, platelets accumulate in the liver after APAP overdose and appear to promote liver injury. Interestingly, patients with acute liver injury have highly elevated levels of the platelet-adhesive protein von Willebrand factor (VWF), ... Read more >>

J Hepatol (Journal of hepatology)
[2020, 72(1):146-155]

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Lumbar Spine Fusion Rates With Local Bone in Posterolateral and Combined Posterolateral and Interbody Approaches.

Daniel K Park, Richard Roberts, Paul Arnold, David H Kim, Rick Sasso, Kevin C Baker, Jeffrey S Fischgrund,

Posterolateral lumbar fusion (PLF) used to treat degenerative lumbar conditions still faces pseudarthrosis. Bone graft choice is a key factor; a traditional choice has been autologous iliac crest bone graft (ICBG), but complication rates are quoted up to 39%. Local bone from laminectomy eliminates ICBG harvesting complications.<h4>Methods</h4>Two hundred forty-one patients ... Read more >>

J Am Acad Orthop Surg Glob Res Rev (Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews)
[2019, 3(11):e018]

Cited: 1 time

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