Full Text Journal Articles by
Author Kevin A Reinard


Find full text journal articles

The Cytoskeleton Effectors Rho-Kinase (ROCK) and Mammalian Diaphanous-Related (mDia) Formin Have Dynamic Roles in Tumor Microtube Formation in Invasive Glioblastoma Cells.

Kathryn N Becker, Krista M Pettee, Amanda Sugrue, Kevin A Reinard, Jason L Schroeder, Kathryn M Eisenmann,

Glioblastoma (GBM) is a progressive and lethal brain cancer. Malignant control of actin and microtubule cytoskeletal mechanics facilitates two major GBM therapeutic resistance strategies-diffuse invasion and tumor microtube network formation. Actin and microtubule reorganization is controlled by Rho-GTPases, which exert their effects through downstream effector protein activation, including Rho-associated kinases ... Read more >>

Cells (Cells)
[2022, 11(9):1559]

Cited: 0 times

View full text PDF listing >>

Targeting the mDia Formin-Assembled Cytoskeleton Is an Effective Anti-Invasion Strategy in Adult High-Grade Glioma Patient-Derived Neurospheres.

Krista M Pettee, Kathryn N Becker, Arthur S Alberts, Kevin A Reinard, Jason L Schroeder, Kathryn M Eisenmann,

High-grade glioma (HGG, WHO Grade IIIā»IV) accounts for the majority of adult primary malignant brain tumors. Failure of current therapies to target invasive glioma cells partly explains the minimal survival advantages: invasive tumors lack easily-defined surgical margins, and are inherently more chemo- and radioresistant. Much work centers upon Rho GTPase-mediated ... Read more >>

Cancers (Basel) (Cancers)
[2019, 11(3):E392]

Cited: 5 times

View full text PDF listing >>



1.4756 s