Full Text Journal Articles by
Author Kenneth S Kendler

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The Problem of Aggregating Validators for Psychiatric Disorders.

Miriam Solomon, Kenneth S Kendler,

Since the time of the Diagnostic and Statistical Manual of Mental Disorders, 3rd Edition, evidence for the validity of psychiatric disorders has been expressed in the form of validators, which are instances of particular kinds of evidence. There has never been an explicit discussion of how the validators should be ... Read more >>

J Nerv Ment Dis (The Journal of nervous and mental disease)
[2020, :]

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Oral contraceptive use and risk of suicidal behavior among young women.

Alexis C Edwards, Sara Larsson Lönn, Casey Crump, Eve K Mościcki, Jan Sundquist, Kenneth S Kendler, Kristina Sundquist,

BACKGROUND:Oral contraceptive use has been previously associated with an increased risk of suicidal behavior in some, but not all, samples. The use of large, representative, longitudinally-assessed samples may clarify the nature of this potential association. METHODS:We used Swedish national registries to identify women born between 1991 and 1995 (N = ... Read more >>

Psychol Med (Psychological medicine)
[2020, :1-8]

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A method for estimating coherence of molecular mechanisms in major human disease and traits.

Mikhail G Dozmorov, Kellen G Cresswell, Silviu-Alin Bacanu, Carl Craver, Mark Reimers, Kenneth S Kendler,

BACKGROUND:Phenotypes such as height and intelligence, are thought to be a product of the collective effects of multiple phenotype-associated genes and interactions among their protein products. High/low degree of interactions is suggestive of coherent/random molecular mechanisms, respectively. Comparing the degree of interactions may help to better understand the coherence of ... Read more >>

BMC Bioinformatics (BMC bioinformatics)
[2020, 21(1):473]

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A large-scale genome-wide association study meta-analysis of cannabis use disorder.

Emma C Johnson, Ditte Demontis, Thorgeir E Thorgeirsson, Raymond K Walters, Renato Polimanti, Alexander S Hatoum, Sandra Sanchez-Roige, Sarah E Paul, Frank R Wendt, Toni-Kim Clarke, Dongbing Lai, Gunnar W Reginsson, Hang Zhou, June He, David A A Baranger, Daniel F Gudbjartsson, Robbee Wedow, Daniel E Adkins, Amy E Adkins, Jeffry Alexander, Silviu-Alin Bacanu, Tim B Bigdeli, Joseph Boden, Sandra A Brown, Kathleen K Bucholz, Jonas Bybjerg-Grauholm, Robin P Corley, Louisa Degenhardt, Danielle M Dick, Benjamin W Domingue, Louis Fox, Alison M Goate, Scott D Gordon, Laura M Hack, Dana B Hancock, Sarah M Hartz, Ian B Hickie, David M Hougaard, Kenneth Krauter, Penelope A Lind, Jeanette N McClintick, Matthew B McQueen, Jacquelyn L Meyers, Grant W Montgomery, Ole Mors, Preben B Mortensen, Merete Nordentoft, John F Pearson, Roseann E Peterson, Maureen D Reynolds, John P Rice, Valgerdur Runarsdottir, Nancy L Saccone, Richard Sherva, Judy L Silberg, Ralph E Tarter, Thorarinn Tyrfingsson, Tamara L Wall, Bradley T Webb, Thomas Werge, Leah Wetherill, Margaret J Wright, Stephanie Zellers, Mark J Adams, Laura J Bierut, Jason D Boardman, William E Copeland, Lindsay A Farrer, Tatiana M Foroud, Nathan A Gillespie, Richard A Grucza, Kathleen Mullan Harris, Andrew C Heath, Victor Hesselbrock, John K Hewitt, Christian J Hopfer, John Horwood, William G Iacono, Eric O Johnson, Kenneth S Kendler, Martin A Kennedy, Henry R Kranzler, Pamela A F Madden, Hermine H Maes, Brion S Maher, Nicholas G Martin, Matthew McGue, Andrew M McIntosh, Sarah E Medland, Elliot C Nelson, Bernice Porjesz, Brien P Riley, Michael C Stallings, Michael M Vanyukov, Scott Vrieze, , Lea K Davis, Ryan Bogdan, Joel Gelernter, Howard J Edenberg, Kari Stefansson, Anders D Børglum, Arpana Agrawal,

BACKGROUND:Variation in liability to cannabis use disorder has a strong genetic component (estimated twin and family heritability about 50-70%) and is associated with negative outcomes, including increased risk of psychopathology. The aim of the study was to conduct a large genome-wide association study (GWAS) to identify novel genetic variants associated ... Read more >>

Lancet Psychiatry (The lancet. Psychiatry)
[2020, :]

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The Prehistory of Psychiatric Genetics: 1780-1910.

Kenneth S Kendler,

While psychiatric genetics has emerged as one of our most dynamic research fields, the historical context in which we view these developments is limited. To provide such a perspective, the author reviews 48 representative texts, published from 1780 to 1910, examining the inheritance of insanity. Six main conclusions emerge. First, ... Read more >>

Am J Psychiatry (The American journal of psychiatry)
[2020, :appiajp202020030326]

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Assessing the Role of Long-Noncoding RNA in Nucleus Accumbens in Subjects with Alcohol Dependence.

John Drake, Gowon O McMichael, Eric Sean Vornholt, Kellen Cresswell, Vernell Williamson, Chris Chatzinakos, Mohammed Mamdani, Siddharth Hariharan, Kenneth S Kendler, Gursharan Kalsi, Brien P Riley, Mikhail Dozmorov, Michael F Miles, Silviu-Alin Bacanu, Vladimir I Vladimirov,

BACKGROUND:Long noncoding RNA (lncRNA) have been implicated in the etiology of alcohol use. Since lncRNA provide another layer of complexity to the transcriptome, assessing their expression in the brain is the first critical step towards understanding lncRNA functions in alcohol use and addiction. Thus, we sought to profile lncRNA expression ... Read more >>

Alcohol Clin Exp Res (Alcoholism, clinical and experimental research)
[2020, :]

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TWAS pathway method greatly enhances the number of leads for uncovering the molecular underpinnings of psychiatric disorders.

Chris Chatzinakos, Foivos Georgiadis, Donghyung Lee, Na Cai, Vladimir I Vladimirov, Anna Docherty, Bradley T Webb, Brien P Riley, Jonathan Flint, Kenneth S Kendler, Nikolaos P Daskalakis, Silviu-Alin Bacanu,

Genetic signal detection in genome-wide association studies (GWAS) is enhanced by pooling small signals from multiple Single Nucleotide Polymorphism (SNP), for example, across genes and pathways. Because genes are believed to influence traits via gene expression, it is of interest to combine information from expression Quantitative Trait Loci (eQTLs) in ... Read more >>

Am J Med Genet B Neuropsychiatr Genet (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics)
[2020, :]

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Modeling Etiology of Smoking During Pregnancy in Swedish Twins, Full-, and Half-Siblings, Reared Together and Apart.

Hermine H Maes, Michael C Neale, Sara Larsson Lonn, Paul Lichtenstein, Jan Sundquist, Kristina Sundquist, Kenneth S Kendler,

INTRODUCTION:Using Swedish nationwide registry data, we investigated the contribution of genetic and environmental risk factors to the etiology of smoking status across stages of pregnancy with increasing degrees of social and psychological pressure to reduce or quit smoking, by twin and sibling modeling. AIMS AND METHODS:Smoking status was available before, ... Read more >>

Nicotine Tob Res (Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco)
[2020, 22(10):1736-1743]

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The evolution of Kraepelin's nosological principles.

Stephan Heckers, Kenneth S Kendler,

Emil Kraepelin developed a new psychiatric nosology in the eight editions of his textbook. Previous papers have explored his construction of particular diagnoses, including dementia praecox and manic-depressive insanity. Here we are providing a close reading of his introductory textbook chapter, that presents his general principles of nosology. We identify ... Read more >>

World Psychiatry (World psychiatry : official journal of the World Psychiatric Association (WPA))
[2020, 19(3):381-388]

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Intersection of familial risk and environmental social control on high-risk drinking and alcohol dependence in a US national sample of adults.

Katherine J Karriker-Jaffe, Karen G Chartier, Cristina B Bares, Kenneth S Kendler, Thomas K Greenfield,

BACKGROUND:Effects of a family history of alcoholism may be moderated by area-level social control factors. We examine whether increased neighborhood alcohol availability (low social control environment) or increased presence of religious adherents in the county (high social control environment) interact with family history in relation to alcohol outcomes. METHODS:Weighted data ... Read more >>

Addict Behav (Addictive behaviors)
[2020, 113:106668]

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Evidence for a Causal Relationship Between Academic Achievement and Cigarette Smoking.

Kenneth S Kendler, Henrik Ohlsson, Abigail A Fagan, Paul Lichtenstein, Jan Sundquist, Kristina Sundquist,

INTRODUCTION:Academic achievement (AA) is associated with smoking rates. Can we determine the degree to which this relationship is likely a causal one? METHODS:We predict smoking in male conscripts (mean age 18.2) assessed from 1984-1991 (N = 233,248) and pregnant females (mean age 27.7) receiving prenatal care 1972-1990 (N = 494,995) ... Read more >>

Nicotine Tob Res (Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco)
[2020, :]

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Identification of de novo mutations in prenatal neurodevelopment-associated genes in schizophrenia in two Han Chinese patient-sibling family-based cohorts.

Shan Jiang, Daizhan Zhou, Yin-Ying Wang, Peilin Jia, Chunling Wan, Xingwang Li, Guang He, Dongmei Cao, Xiaoqian Jiang, Kenneth S Kendler, Ming Tsuang, Travis Mize, Jain-Shing Wu, Yimei Lu, Lin He, Jingchun Chen, Zhongming Zhao, Xiangning Chen,

Schizophrenia (SCZ) is a severe psychiatric disorder with a strong genetic component. High heritability of SCZ suggests a major role for transmitted genetic variants. Furthermore, SCZ is also associated with a marked reduction in fecundity, leading to the hypothesis that alleles with large effects on risk might often occur de ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2020, 10(1):307]

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The turn to controls and the refinement of the concept of hereditary burden: The 1895 study of Jenny Koller.

Kenneth S Kendler, Astrid Klee,

Throughout the 19th century, many alienists reported the proportion of their patients who were "hereditarily burdened," meaning they had a positive family history for mental illness. The rates of such burden differed widely because different authors used divergent definition of illness and investigated different groups of relatives. Most importantly, no ... Read more >>

Am J Med Genet B Neuropsychiatr Genet (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics)
[2020, 183(7):433-442]

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The Sources of Parent-Child Transmission of Risk for Suicide Attempt and Deaths by Suicide in Swedish National Samples.

Kenneth S Kendler, Henrik Ohlsson, Jan Sundquist, Kristina Sundquist, Alexis C Edwards,

OBJECTIVE:The authors aimed to clarify the sources of parent-child transmission for suicide attempt and death by suicide. METHODS:Three sources of parent-child resemblance (genes plus rearing, genes only, and rearing only) were examined in parents and offspring from four family types from Swedish national samples: intact nuclear families, families with a ... Read more >>

Am J Psychiatry (The American journal of psychiatry)
[2020, 177(10):928-935]

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Within-Family Transmission of Alcohol Use Disorder in Parent-Offspring, Sibling, and Cousin Pairs: A Contagion Model.

Kenneth S Kendler, Henrik Ohlsson, Jan Sundquist, Kristina Sundquist,

To determine whether alcohol use disorder (AUD) is transmitted within families as predicted by contagion, we examined parent-offspring, siblings, and cousin pairs ascertained from Swedish registries with a primary case with AUD. Our outcome variable was AUD registration in at-risk secondary cases. In offspring, risks for AUD registration in the ... Read more >>

J. Nerv. Ment. Dis. (The Journal of nervous and mental disease)
[2020, 208(9):637-645]

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Disentangling Social-Genetic From Rearing-Environment Effects for Alcohol Use Disorder Using Swedish National Data.

Jessica E Salvatore, Sara Larsson Lönn, Jan Sundquist, Kristina Sundquist, Kenneth S Kendler,

Investigations of social-genetic effects, whereby a social partner's genotype affects another's outcomes, can be confounded by the influence of the social partner's rearing environment. We used marital information on more than 300,000 couples from Swedish national data to disentangle social-genetic from rearing-environment effects for alcohol use disorder (AUD). Using observational ... Read more >>

Psychol Sci (Psychological science)
[2020, 31(9):1140-1149]

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The Origin of Our Modern Concept of Depression-The History of Melancholia From 1780-1880: A Review.

Kenneth S Kendler,

The modern concept of depression arose from earlier diagnostic formulations of melancholia over the hundred years from the 1780s to the 1880s. In this historical sketch, this evolution is traced from the writings of 12 authors outlining the central roles played by the concepts of faculty psychology and understandability. Five ... Read more >>

JAMA Psychiatry (JAMA psychiatry)
[2020, 77(8):863-868]

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An Extended Swedish National Adoption Study of Bipolar Disorder Illness and Cross-Generational Familial Association With Schizophrenia and Major Depression.

Kenneth S Kendler, Henrik Ohlsson, Jan Sundquist, Kristina Sundquist,

Importance:Information about how risk for bipolar disorder is transmitted across generations and how parental risk for bipolar disorder relates to their children's risk for schizophrenia and major depression is limited. Objective:To evaluate the sources of parent-offspring transmission of bipolar disorder and its familial cross-generational association with schizophrenia and major depression. ... Read more >>

JAMA Psychiatry (JAMA psychiatry)
[2020, 77(8):814-822]

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Data mining algorithm predicts a range of adverse outcomes in major depression.

Hanna M van Loo, Tim B Bigdeli, Yuri Milaneschi, Steven H Aggen, Kenneth S Kendler,

BACKGROUND:Course of illness in major depression (MD) is highly varied, which might lead to both under- and overtreatment if clinicians adhere to a 'one-size-fits-all' approach. Novel opportunities in data mining could lead to prediction models that can assist clinicians in treatment decisions tailored to the individual patient. This study assesses ... Read more >>

J Affect Disord (Journal of affective disorders)
[2020, 276:945-953]

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Polygenic Risk Scores for Subtyping of Schizophrenia.

Jingchun Chen, Travis Mize, Jain-Shing Wu, Elliot Hong, Vishwajit Nimgaonkar, Kenneth S Kendler, Daniel Allen, Edwin Oh, Alison Netski, Xiangning Chen,

Schizophrenia is a complex disorder with many comorbid conditions. In this study, we used polygenic risk scores (PRSs) from schizophrenia and comorbid traits to explore consistent cluster structure in schizophrenia patients. With 10 comorbid traits, we found a stable 4-cluster structure in two datasets (MGS and SSCCS). When the same ... Read more >>

(Schizophrenia research and treatment)
[2020, 2020:1638403]

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Eugen Bleuler's Views on the Genetics of Schizophrenia in 1917.

Kenneth S Kendler,

In 1917, Eugen Bleuler published an article (Mendelismus bei Psychosen, speziell bei der Schizophrenie [Mendelism in the Psychoses, especially Schizophrenia]) in response to the recently published first systematic family study of dementia praecox (DP) by Ernst Rüdin, then working under Kraepelin in Munich. Although briefly commented upon by David Rosenthal ... Read more >>

Schizophr Bull (Schizophrenia bulletin)
[2020, 46(4):758-764]

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A Multilevel Mediational Model of the Association of Neighborhood Deprivation With Risk for Nonaffective Psychosis.

Kenneth S Kendler, Henrik Ohlsson,

JAMA Psychiatry (JAMA psychiatry)
[2020, 77(7):668-670]

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Specific antisocial and borderline personality disorder criteria and general substance use: A twin study.

Tom Rosenström, Fartein Ask Torvik, Eivind Ystrom, Steven H Aggen, Nathan A Gillespie, Robert F Krueger, Nikolai Olavi Czajkowski, Kenneth S Kendler, Ted Reichborn-Kjennerud,

Antisocial (ASPD) and borderline (BPD) personality disorders (PDs) are associated with increased risk for substance use. They are "specific" risk factors among PDs in that they withstand adjusting for the other PDs, whereas the reverse does not hold. Specificity is a classic sign of causation. This empirical work addresses 3 ... Read more >>

Personal Disord (Personality disorders)
[2020, :]

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Tracing the Roots of Dementia Praecox: The Emergence of Verrücktheit as a Primary Delusional-Hallucinatory Psychosis in German Psychiatry From 1860 to 1880.

Kenneth S Kendler,

While the roots of mania and melancholia can be traced to the 18th century and earlier, we have no such long historical narrative for dementia praecox (DP). I, here, provide part of that history, beginning with Kraepelin's chapter on Verrücktheit for his 1883 first edition textbook, which, over the ensuing ... Read more >>

Schizophr Bull (Schizophrenia bulletin)
[2020, 46(4):765-773]

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Nature of the Causal Relationship Between Academic Achievement and the Risk for Alcohol Use Disorder.

Kenneth S Kendler, Henrik Ohlsson, Abigail A Fagan, Paul Lichtenstein, Jan Sundquist, Kristina Sundquist,

OBJECTIVE:We evaluated the claim that interventions to improve academic achievement can reduce the risk for alcohol use disorder (AUD). METHOD:Using nationwide data for individuals born in Sweden from 1972 to 1981 (n = 930,182), we conducted instrumental variable and co-relative analyses of the association between academic achievement and AUD with ... Read more >>

J Stud Alcohol Drugs (Journal of studies on alcohol and drugs)
[2020, 81(4):446-453]

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