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Author Kenneth R Knecht

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Variable Presentation of COVID-19 in Pediatric Patients.

Richard L Crawford, Elijah H Bolin, Parthak Prodhan, Markus S Renno, Kenneth R Knecht,

Infection by SARS-CoV-2 has led to disease referred to as coronavirus disease 2019 which, in children has been described as of multisystem inflammatory syndrome in children. Our experience demonstrates 2 distinct presentations of this syndrome which have different clinical courses and may have differing long-term outcomes. ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(2):e88-e90]

Cited: 0 times

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Donor fraction cell-free DNA and rejection in adult and pediatric heart transplantation.

Marc E Richmond, Steven D Zangwill, Steven J Kindel, Shriprasad R Deshpande, Jacob N Schroder, David P Bichell, Kenneth R Knecht, William T Mahle, Mark A Wigger, Nunzio A Gaglianello, Elfriede Pahl, Pippa M Simpson, Mahua Dasgupta, Paula E North, Mats Hidestrand, Aoy Tomita-Mitchell, Michael E Mitchell,

BACKGROUND:Endomyocardial biopsy (EMB) is the current standard for rejection surveillance in heart transplant recipients. The quantification of donor-specific cell-free DNA (cfDNA) may be an appropriate biomarker for non-invasive rejection surveillance. A multicenter prospective blinded study (DNA-Based Transplant Rejection Test, DTRT) investigated the value of donor fraction (DF), defined as the ... Read more >>

J Heart Lung Transplant (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
[2020, 39(5):454-463]

Cited: 1 time

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Risk Factors for Cardiac and Non-cardiac Causes of Death in Males with Duchenne Muscular Dystrophy.

Carol A Wittlieb-Weber, Kenneth R Knecht, Chet R Villa, Chentel Cunningham, Jennifer Conway, Matthew J Bock, Katheryn E Gambetta, Ashwin K Lal, Kurt R Schumacher, Sabrina P Law, Shriprasad R Deshpande, Shawn C West, Joshua M Friedland-Little, Irene D Lytrivi, Michael A McCulloch, Ryan J Butts, David R Weber, Jonathan N Johnson,

As survival and neuromuscular function in Duchenne muscular dystrophy (DMD) have improved with glucocorticoid (GC) therapy and ventilatory support, cardiac deaths are increasing. Little is known about risk factors for cardiac and non-cardiac causes of death in DMD. A multi-center retrospective cohort study of 408 males with DMD, followed from ... Read more >>

Pediatr Cardiol (Pediatric cardiology)
[2020, 41(4):764-771]

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Outcomes of Myocarditis in Patients with Normal Left Ventricular Systolic Function on Admission.

Spencer B Barfuss, Ryan Butts, Kenneth R Knecht, Adriana Prada-Ruiz, Ashwin K Lal,

The objective of this study was to describe a cohort of patients with clinical myocarditis and normal left ventricular (LV) systolic function on admission. A retrospective chart review at seven tertiary pediatric hospitals identified patients aged < 19 years admitted with an ICD-9 code of myocarditis between 2008 and 2012. Patients were excluded ... Read more >>

Pediatr Cardiol (Pediatric cardiology)
[2019, 40(6):1171-1174]

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Use of advanced heart failure therapies in Duchenne muscular dystrophy.

Carol A Wittlieb-Weber, Chet R Villa, Jennifer Conway, Matthew J Bock, Katheryn E Gambetta, Jonathan N Johnson, Ashwin K Lal, Kurt R Schumacher, Sabrina P Law, Shriprasad R Deshpande, Shawn C West, Joshua M Friedland-Little, Irene D Lytrivi, Michael A McCulloch, Ryan J Butts, David R Weber, Kenneth R Knecht,

<h4>Background</h4>As survival and neuromuscular function in Duchenne Muscular Dystrophy (DMD) improve with glucocorticoid therapy and respiratory advances, the proportion of cardiac deaths is increasing. Little is known about the use and outcomes of advanced heart failure (HF) therapies in this population.<h4>Methods</h4>A retrospective cohort study of 436 males with DMD was ... Read more >>

Prog Pediatr Cardiol (Progress in pediatric cardiology)
[2019, 53:11-14]

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Characteristics of Clinically Diagnosed Pediatric Myocarditis in a Contemporary Multi-Center Cohort.

Ryan J Butts, Gerard J Boyle, Shriprasad R Deshpande, Katheryn Gambetta, Kenneth R Knecht, Carolina A Prada-Ruiz, Marc E Richmond, Shawn C West, Ashwin K Lal,

The objective of this study was to describe a contemporary cohort of pediatric patients hospitalized for clinically suspected myocarditis. A retrospective chart review was performed at seven tertiary pediatric hospitals. Electronic medical records were searched between 2008 and 2012 for patients ≤18 years admitted with an ICD-9 code consistent with myocarditis. Patients ... Read more >>

Pediatr Cardiol (Pediatric cardiology)
[2017, 38(6):1175-1182]

Cited: 8 times

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Hypertrophic Cardiomyopathy in an Adolescent.

Tamara O Thomas, Kenneth R Knecht,

J Ark Med Soc (The Journal of the Arkansas Medical Society)
[2016, 113(5):112-114]

Cited: 0 times

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Improved Survival While Waiting and Risk Factors for Death in Pediatric Patients Listed for Cardiac Transplantation.

Dala Zakaria, Elizabeth Frazier, Michiaki Imamura, Xiomara Garcia, Sherry Pye, Kenneth R Knecht, Parthak Prodhan, Jeffrey R Gossett, Christopher J Swearingen, W Robert Morrow,

Our aim is to determine (a) the effect of changes in pre-transplant management and era of listing on survival of children listed for HTx and (b) risk factors for death while waiting. This retrospective study included all children listed between 1/1993 and 12/2009 at our center. Survival was determined using ... Read more >>

Pediatr Cardiol (Pediatric cardiology)
[2017, 38(1):77-85]

Cited: 1 time

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Heart Transplantation in the Short Term After Chemotherapy.

Kenneth R Knecht, Janet Bryant, Xiomara Garcia, Sherry Pye, Parthak Prodhan, Elizabeth A Frazier,

Anthracycline antibiotics are an effective therapy for a variety of neoplastic diseases. Dilated cardiomyopathy is a known risk of their use. Because of the risk of new or recurrent neoplasm with immunosuppression transplantation is often delayed. Our patient developed early cardiomyopathy with congestive heart failure 3 months after completion of ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2015, 37(5):409-410]

Cited: 1 time

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Antibody-mediated rejection is associated with impaired graft function in pediatric heart transplant recipients.

Kenneth R Knecht, Ashley Glover, Amy M Dossey, Mallik Rettiganti, Jeffrey Gossett, Elizabeth A Frazier,

J Heart Lung Transplant (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
[2015, 34(8):1120-1121]

Cited: 2 times

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Longitudinal renal function in pediatric heart transplant recipients: 20-years experience.

Punkaj Gupta, Mallikarjuna Rettiganti, Jeffrey M Gossett, Megan Gardner, Janet C Bryant, Tommy R Noel, Kenneth R Knecht,

This study was initiated to assess the temporal trends of renal function, and define risk factors associated with worsening renal function in pediatric heart transplant recipients in the immediate post-operative period. We performed a single-center retrospective study in children ≤18 yr receiving OHT (1993-2012). The AKIN's validated, three-tiered AKI staging ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2015, 19(2):182-187]

Cited: 0 times

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Cardiovascular safety of stimulant medications.

Kenneth R Knecht,

J Child Adolesc Psychopharmacol (Journal of child and adolescent psychopharmacology)
[2015, 25(2):181]

Cited: 0 times

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Quantification, identification, and relevance of anti-human leukocyte antigen antibodies formed in association with the berlin heart ventricular assist device in children.

Matthew J O'Connor, Terry O Harville, Bobbie Rhodes-Clark, Sherry E Pye, Kenneth R Knecht, Michiaki Imamura, Elizabeth A Frazier, W Robert Morrow,

<h4>Background</h4>Ventricular assist devices (VADs) are increasingly being used in pediatric patients to provide long-term cardiac support. One potential complication of VAD therapy is the development of antibodies directed against human leukocyte antigens (HLA). This phenomenon has not been well described with the Berlin Heart EXCOR VAD, the most commonly used ... Read more >>

Transplantation (Transplantation)
[2013, 95(12):1542-1547]

Cited: 7 times

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Predictors of myocardial recovery in pediatric tachycardia-induced cardiomyopathy.

Jeremy P Moore, Payal A Patel, Kevin M Shannon, Erin L Albers, Jack C Salerno, Maya A Stein, Elizabeth A Stephenson, Shaun Mohan, Maully J Shah, Hiroko Asakai, Andreas Pflaumer, Richard J Czosek, Melanie D Everitt, Jason M Garnreiter, Anthony C McCanta, Andrew L Papez, Carolina Escudero, Shubhayan Sanatani, Nicole B Cain, Prince J Kannankeril, Andras Bratincsak, Ravi Mandapati, Jennifer N A Silva, Kenneth R Knecht, Seshadri Balaji,

<h4>Background</h4>Tachycardia-induced cardiomyopathy (TIC) carries significant risk of morbidity and mortality, although full recovery is possible. Little is known about the myocardial recovery pattern.<h4>Objective</h4>The purpose of this study was to determine the time course and predictors of myocardial recovery in pediatric TIC.<h4>Methods</h4>An international multicenter study of pediatric TIC was conducted. Children ... Read more >>

Heart Rhythm (Heart rhythm)
[2014, 11(7):1163-1169]

Cited: 17 times

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New transplant technique with hemiazygos continuation and interrupted inferior vena cava.

Michiaki Imamura, Boban Abraham, Xiomara Garcia, Kenneth R Knecht, Elizabeth Frazier, Takeshi Shinkawa,

In the presence of left superior vena cava, cardiac transplantation is performed at the risk of left superior vena cava flow obstruction. In patients with hemiazygos continuation with interrupted inferior vena cava, the patency of left superior vena cava is vital. We introduced a new surgical technique to use a ... Read more >>

Ann Thorac Surg (The Annals of thoracic surgery)
[2013, 96(5):1882-1884]

Cited: 1 time

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Gene expression profiling in pediatric heart transplant rejection.

Kenneth R Knecht, Stewart L MacLeod, Charlotte A Hobbs, Ming Li, W Robert Morrow,

Int J Cardiol (International journal of cardiology)
[2013, 168(5):5052-5053]

Cited: 1 time

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NTproBNP as a marker of rejection in pediatric heart transplant recipients.

Kenneth R Knecht, Molly L Alexander, Christopher J Swearingen, Elizabeth A Frazier,

Acute rejection is a major morbidity in heart transplant recipients; diagnosis is difficult, and rejection must often be treated reactively. Various serum biomarkers have been investigated for non-invasive monitoring of the cardiac allograft. NTproBNP is produced by the ventricular myocardium and may increase with evolving rejection allowing earlier diagnosis. Retrospective ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2012, 16(4):335-339]

Cited: 4 times

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Rapid reduction in donor-specific anti-human leukocyte antigen antibodies and reversal of antibody-mediated rejection with bortezomib in pediatric heart transplant patients.

William Robert Morrow, Elizabeth A Frazier, William T Mahle, Terry O Harville, Sherry E Pye, Kenneth R Knecht, Emily L Howard, R Neal Smith, Robert L Saylors, Xiomara Garcia, Robert D B Jaquiss, E Steve Woodle,

High titer donor-specific antibodies (DSA) and positive crossmatch in cardiac transplant recipients is associated with increased mortality from antibody-mediated rejection (AMR). Although treatment to reduce anti-human leukocyte antigen antibodies using plasmapheresis, intravenous immunoglobulin, and rituximab has been reported to be beneficial, in practice these are often ineffective. Moreover, these interventions ... Read more >>

Transplantation (Transplantation)
[2012, 93(3):319-324]

Cited: 47 times

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Atrial septal dissection late after congenital heart surgery.

Kenneth R Knecht, Michiaki Imamura,

Atrial septal dissection is a rare entity usually seen after surgical mitral valve repair, myocardial infarction, or endocarditis. This is a report of an atrial dissection in a young girl found on routine follow-up echocardiography after repair of atrial and ventricular septal defects. No identifiable predisposing risk was found prior ... Read more >>

Ann Thorac Surg (The Annals of thoracic surgery)
[2011, 92(4):1522-1524]

Cited: 0 times

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Distinct effects of intravascular and extravascular angiotensin II on cerebrovascular circulation of newborn pigs.

Kenneth R Knecht, Charles W Leffler,

Angiotensin II (AngII) is important in regulation of vascular resistance and control of blood flow among organs and tissues. The effect of AngII on the cerebral microvasculature may be mediated or altered by endothelial-derived signals. The aim of this study was to test the hypothesis that blood AngII dilates neonatal ... Read more >>

Exp Biol Med (Maywood) (Experimental biology and medicine (Maywood, N.J.))
[2010, 235(12):1479-1488]

Cited: 3 times

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Time-dependent action of carbon monoxide on the newborn cerebrovascular circulation.

Kenneth R Knecht, Sarah Milam, Daniel A Wilkinson, Alexander L Fedinec, Charles W Leffler,

Carbon monoxide (CO) causes cerebral arteriolar dilation in newborn pigs by the activation of large-conductance Ca(2+)-activated K(+) channels. In adult rat cerebral and skeletal muscle arterioles, CO has been reported to produce constriction caused by the inhibition of nitric oxide (NO) synthase (NOS). We hypothesized that, in contrast to dilation ... Read more >>

Am J Physiol Heart Circ Physiol (American journal of physiology. Heart and circulatory physiology)
[2010, 299(1):H70-5]

Cited: 9 times

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Korotkoff sounds in neonates, infants, and toddlers.

Kenneth R Knecht, John D Seller, Bruce S Alpert,

Korotkoff sounds (KSs) are the clinical norm for noninvasively estimating systemic arterial blood pressure (BP) in children and adults. Their existence and reliability in children <3 years old was unknown. This study addressed the presence and accuracy of KSs in children <3 years. Measurements of the first KS (K1), K4, ... Read more >>

Am J Cardiol (The American journal of cardiology)
[2009, 103(8):1165-1167]

Cited: 2 times

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Comparison of levalbuterol and racemic albuterol combined with ipratropium bromide in acute pediatric asthma: a randomized controlled trial.

Mark E Ralston, Michael S Euwema, Kenneth R Knecht, Timothy J Ziolkowski, Timothy A Coakley, Shane M Cline,

Our study compared levalbuterol (LEV) to the combination of racemic albuterol (RAC) and ipratropium bromide (IB) in 140 patients aged 6-18 years presenting to a tertiary hospital Emergency Department with acute asthma and a peak expired flow rate (PEF)<80% predicted. Patients were randomized to: LEV (<or=6 nebs LEV 1.25 mg); ... Read more >>

J Emerg Med (The Journal of emergency medicine)
[2005, 29(1):29-35]

Cited: 21 times

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