Full Text Journal Articles by
Author Kenneth R DeVault

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Editorial: understanding IBS pathophysiology through "converging channels" of research-authors' reply.

Madhusudan Grover, Antonio Berumen, Stephanie Peters, Ting Wei, Margaret Breen-Lyles, William S Harmsen, Irene Busciglio, Duane Burton, Maria Vazquez Roque, Kenneth R DeVault, Michael Camilleri, Michael Wallace, Surendra Dasari, Helmut Neumann, Lesley A Houghton,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(9):1215-1216]

Cited: 0 times

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Intestinal chemosensitivity in irritable bowel syndrome associates with small intestinal TRPV channel expression.

Madhusudan Grover, Antonio Berumen, Stephanie Peters, Ting Wei, Margaret Breen-Lyles, William S Harmsen, Irene Busciglio, Duane Burton, Maria Vazquez Roque, Kenneth R DeVault, Michael Camilleri, Michael Wallace, Surendra Dasari, Helmut Neumann, Lesley A Houghton,

<h4>Background</h4>Irritable bowel syndrome (IBS) patients often experience meal-associated symptoms. However, the underlying mechanisms are unclear.<h4>Aim</h4>To determine small intestinal mechanisms of lipid-induced symptoms and rectal hypersensitivity in IBS METHODS: We recruited 26 IBS patients (12 IBS-C, 14 IBS-D) and 15 healthy volunteers (HV). In vivo permeability was assessed using saccharide excretion ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(9):1179-1192]

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The Perils and Pitfalls of Esophageal Dysmotility in Idiopathic Pulmonary Fibrosis.

Ramsah Cheah, Supphamat Chirnaksorn, Ahmed H Abdelrahim, Laura Horgan, Toby Capstick, John Casey, Daniel Peckham, Alison Boland, Timothy J T Sutherland, Paul Beirne, Augustine S Lee, Kenneth R DeVault, Lesley A Houghton,

<h4>Introduction</h4>Gastroesophageal reflux plays a significant role in idiopathic pulmonary fibrosis (IPF). Given the morbidity and mortality associated with IPF, understanding the mechanisms responsible for reflux is essential if patients are to receive optimal treatment and management, especially given the lack of clear benefit of antireflux therapies. Our aim was to ... Read more >>

Am J Gastroenterol (The American journal of gastroenterology)
[2021, 116(6):1189-1200]

Cited: 0 times

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Lymphocytic Esophagitis: Assessing Risk Factors and Clinical Outcomes.

Himesh B Zaver, Hassan Ghoz, Balkishan J Malviya, Bhaumik Brahmbhatt, William C Palmer, Brian E Lacy, Kenneth R DeVault, Murli Krishna, Yan Bi,

<h4>Background</h4>Lymphocytic esophagitis is a rare esophageal condition. Our knowledge of potential risk factors and treatment outcomes of lymphocytic esophagitis is limited.<h4>Aim</h4>To investigate potential risk factors associated with the development of lymphocytic esophagitis and compare clinical characteristics and treatment outcomes of patients diagnosed with lymphocytic esophagitis to patients diagnosed with eosinophilic ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2021, 66(11):3976-3984]

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Hiatal Hernia Associated with Higher Odds of Dysplasia in Patients with Barrett's Esophagus.

Joshua Y Kwon, Alex M Kesler, Herbert C Wolfsen, Kenneth R DeVault, Paul T Kröner,

<h4>Background</h4>Patients with Barrett's esophagus (BE) are more likely to have associated hiatal hernia (HH) compared to the general population. Studies show that HH are typically longer and wider in patients with BE.<h4>Aims</h4>To determine whether patients with HH have associated increased odds of coexistence of BE by examining inpatient prevalence, as ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2021, 66(8):2717-2723]

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Creation of a score to predict risk of high conscious sedation requirements in patients undergoing endoscopy.

Josiah D McCain, Fernando F Stancampiano, Ernest P Bouras, Kenneth R DeVault, Emily L Gilbert, Taylor Ryan, Alex Maillis, Michael G Heckman, Nancy N Diehl, William C Palmer,

<h4>Background and aims</h4>The administration of intravenous conscious sedation to patients undergoing GI endoscopy carries a risk of cardiopulmonary adverse events. Our study aim was to create a score that stratifies the risk of occurrence of either high-dose conscious sedation requirements or a failed procedure.<h4>Methods</h4>Patients receiving endoscopy via endoscopist-directed conscious sedation ... Read more >>

Gastrointest Endosc (Gastrointestinal endoscopy)
[2020, 91(3):595-605.e3]

Cited: 1 time

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Functional luminal imaging probe: an evolving technology for the diagnosis of esophageal motility disorders.

Kenneth R DeVault,

Gastrointest Endosc (Gastrointestinal endoscopy)
[2019, 90(6):924-925]

Cited: 0 times

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Unilateral Versus Bilateral Lung Transplantation: Do Different Esophageal Risk Factors Predict Chronic Allograft Failure?

Anupong Tangaroonsanti, Augustine S Lee, Marcelo F Vela, Michael D Crowell, David Erasmus, Cesar Keller, Jorge Mallea, Francisco Alvarez, Cristina Almansa, Kenneth R DeVault, Lesley A Houghton,

GOALS:To assess the effect of unilateral versus bilateral lung transplantation (LTx) on esophageal motility and gastroesophageal reflux, and the association with the development of obstructive chronic lung allograft dysfunction (o-CLAD). BACKGROUND:We have shown that esophagogastric junction outflow obstruction, incomplete bolus transit, and proximal reflux are all independent risk factors for ... Read more >>

J Clin Gastroenterol (Journal of clinical gastroenterology)
[2019, 53(4):284-289]

Cited: 1 time

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Refractory regurgitation responds to magnetic sphincter augmentation but not to increased proton pump inhibitor dose.

Kenneth R DeVault,

Gastrointest Endosc (Gastrointestinal endoscopy)
[2019, 89(1):23-24]

Cited: 0 times

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Variation in Endoscopic Activity Assessment and Endoscopy Score Validation in Adults With Eosinophilic Esophagitis.

Alain M Schoepfer, Ikuo Hirano, Michael Coslovsky, Marie C Roumet, Marcel Zwahlen, Claudia E Kuehni, David Hafner, Jeffrey A Alexander, Evan S Dellon, Nirmala Gonsalves, John Leung, Christian Bussmann, Margaret H Collins, Robert O Newbury, Thomas C Smyrk, John T Woosley, Guang-Yu Yang, Yvonne Romero, David A Katzka, Glenn T Furuta, Sandeep K Gupta, Seema S Aceves, Mirna Chehade, Jonathan M Spergel, Gary W Falk, Brian A Meltzer, Gail M Comer, Alex Straumann, Ekaterina Safroneeva, ,

<h4>Background & aims</h4>Eosinophilic esophagitis (EoE) is assessed endoscopically (endoscopic activity), based on grades of edema, rings, exudates, furrows, and strictures (EREFS). We examined variations in endoscopic assessments of severity, developed and validated 3 EREFS-based scoring systems, and assessed responsiveness of these systems using data from a randomized placebo-controlled trial of ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2019, 17(8):1477-1488.e10]

Cited: 1 time

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Visual and Automated Computer Analysis Differ Substantially in Detection of Acidic Reflux in Multichannel Intraluminal Impedance-pH Monitoring.

Andree H Koop, Dawn L Francis, Kenneth R DeVault,

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2018, 16(6):979-980]

Cited: 4 times

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Impaired Esophageal Motility and Clearance Post-Lung Transplant: Risk For Chronic Allograft Failure.

Anupong Tangaroonsanti, Augustine S Lee, Michael D Crowell, Marcelo F Vela, Daryl R Jones, David Erasmus, Cesar Keller, Jorge Mallea, Francisco Alvarez, Cristina Almansa, Kenneth R DeVault, Lesley A Houghton,

<h4>Objectives</h4>Gastroesophageal reflux is common in patients post-lung transplantation (LTx) and thus considered a risk factor for aspiration and consequently allograft rejection and the development of chronic allograft failure. However, evidence supporting this remains unclear and often contradictory. Our aim was to examine the role played by esophageal motility on gastroesophageal ... Read more >>

Clin Transl Gastroenterol (Clinical and translational gastroenterology)
[2017, 8(6):e102]

Cited: 6 times

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2016 ACG Presidential Address.

Kenneth R DeVault,

Am J Gastroenterol (The American journal of gastroenterology)
[2017, 112(1):1-3]

Cited: 0 times

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Respiratory disease and the oesophagus: reflux, reflexes and microaspiration.

Lesley A Houghton, Augustine S Lee, Huda Badri, Kenneth R DeVault, Jaclyn A Smith,

Gastro-oesophageal reflux is associated with a wide range of respiratory disorders, including asthma, isolated chronic cough, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease and cystic fibrosis. Reflux can be substantial and reach the proximal margins of the oesophagus in some individuals with specific pulmonary diseases, suggesting that this association is ... Read more >>

Nat Rev Gastroenterol Hepatol (Nature reviews. Gastroenterology & hepatology)
[2016, 13(8):445-460]

Cited: 26 times

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Symptoms Have Modest Accuracy in Detecting Endoscopic and Histologic Remission in Adults With Eosinophilic Esophagitis.

Ekaterina Safroneeva, Alex Straumann, Michael Coslovsky, Marcel Zwahlen, Claudia E Kuehni, Radoslaw Panczak, Nadine A Haas, Jeffrey A Alexander, Evan S Dellon, Nirmala Gonsalves, Ikuo Hirano, John Leung, Christian Bussmann, Margaret H Collins, Robert O Newbury, Giovanni De Petris, Thomas C Smyrk, John T Woosley, Pu Yan, Guang-Yu Yang, Yvonne Romero, David A Katzka, Glenn T Furuta, Sandeep K Gupta, Seema S Aceves, Mirna Chehade, Jonathan M Spergel, Alain M Schoepfer, ,

<h4>Background & aims</h4>It is not clear whether symptoms alone can be used to estimate the biologic activity of eosinophilic esophagitis (EoE). We aimed to evaluate whether symptoms can be used to identify patients with endoscopic and histologic features of remission.<h4>Methods</h4>Between April 2011 and June 2014, we performed a prospective, observational ... Read more >>

Gastroenterology (Gastroenterology)
[2016, 150(3):581-590.e4]

Cited: 86 times

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Long-term Outcomes of Patients Receiving a Magnetic Sphincter Augmentation Device for Gastroesophageal Reflux.

Robert A Ganz, Steven A Edmundowicz, Paul A Taiganides, John C Lipham, C Daniel Smith, Kenneth R DeVault, Santiago Horgan, Garth Jacobsen, James D Luketich, Christopher C Smith, Steven C Schlack-Haerer, Shanu N Kothari, Christy M Dunst, Thomas J Watson, Jeffrey Peters, Brant K Oelschlager, Kyle A Perry, Scott Melvin, Willem A Bemelman, André J P M Smout, Dan Dunn,

Based on results from year 2 of a 5-year trial, in 2012 the US Food and Drug Administration approved the use of a magnetic device to augment lower esophageal sphincter function in patients with gastroesophageal reflux disease (GERD). We report the final results of 5 years of follow-up evaluation of ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2016, 14(5):671-677]

Cited: 45 times

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Eosinophilic oesophagitis: relationship of quality of life with clinical, endoscopic and histological activity.

E Safroneeva, M Coslovsky, C E Kuehni, M Zwahlen, N A Haas, R Panczak, T H Taft, I Hirano, E S Dellon, N Gonsalves, J Leung, C Bussmann, J T Woosley, P Yan, Y Romero, G T Furuta, S K Gupta, S S Aceves, M Chehade, A Straumann, A M Schoepfer, ,

<h4>Background</h4>Knowledge about determinants of quality of life (QoL) in eosinophilic oesophagitis (EoO) patients helps to identify patients at risk of experiencing poor QoL and to tailor therapeutic interventions accordingly.<h4>Aim</h4>To evaluate the impact of symptom severity, endoscopic and histological activity on EoE-specific QoL in adult EoE patients.<h4>Methods</h4>Ninety-eight adult EoE patients were ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2015, 42(8):1000-1010]

Cited: 36 times

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Should we consider POEMs for refractory nonachalasia, spastic esophageal disorders? A guarded yes!

Kenneth R DeVault,

Gastrointest Endosc (Gastrointestinal endoscopy)
[2015, 81(5):1178-1180]

Cited: 0 times

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Significant pressure differences between solid-state and water-perfused systems in lower esophageal sphincter measurement.

Philipp Gehwolf, Ronald A Hinder, Kenneth R DeVault, Michael Edlinger, Heinz F Wykypiel, Paul J Klingler,

<h4>Objective</h4>High-resolution manometry of the esophagus has gained worldwide acceptance, using different solid-state catheters. Thus, normal values for lower esophageal sphincter (LES) resting pressure in suspected gastroesophageal reflux disease patients have been established using water-perfused manometry. These standard values are commonly applied using also solid-state techniques, although they have never been ... Read more >>

Surg Endosc (Surgical endoscopy)
[2015, 29(12):3565-3569]

Cited: 6 times

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How do gastroenterologists assess overall activity of eosinophilic esophagitis in adult patients?

Alain M Schoepfer, Radoslaw Panczak, Marcel Zwahlen, Claudia E Kuehni, Michael Coslovsky, Elisabeth Maurer, Nadine A Haas, Jeffrey A Alexander, Evan S Dellon, Nirmala Gonsalves, Ikuo Hirano, John Leung, Christian Bussmann, Margaret H Collins, Robert O Newbury, Giovanni De Petris, Thomas C Smyrk, John T Woosley, Pu Yan, Guang-Yu Yang, Yvonne Romero, David A Katzka, Glenn T Furuta, Sandeep K Gupta, Seema S Aceves, Mirna Chehade, Carine Blanchard, Alex Straumann, Ekaterina Safroneeva, ,

<h4>Objectives</h4>There is no "gold standard" for assessing disease activity in patients with eosinophilic esophagitis (EoE). We aimed to compare physicians' judgment of EoE activity with patients' judgment of symptom severity. We also aimed to examine the relative contribution of symptoms as well as endoscopic and histologic findings in shaping physicians' ... Read more >>

Am J Gastroenterol (The American journal of gastroenterology)
[2015, 110(3):402-414]

Cited: 22 times

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Development and validation of a symptom-based activity index for adults with eosinophilic esophagitis.

Alain M Schoepfer, Alex Straumann, Radoslaw Panczak, Michael Coslovsky, Claudia E Kuehni, Elisabeth Maurer, Nadine A Haas, Yvonne Romero, Ikuo Hirano, Jeffrey A Alexander, Nirmala Gonsalves, Glenn T Furuta, Evan S Dellon, John Leung, Margaret H Collins, Christian Bussmann, Peter Netzer, Sandeep K Gupta, Seema S Aceves, Mirna Chehade, Fouad J Moawad, Felicity T Enders, Kathleen J Yost, Tiffany H Taft, Emily Kern, Marcel Zwahlen, Ekaterina Safroneeva, ,

<h4>Background & aims</h4>Standardized instruments are needed to assess the activity of eosinophilic esophagitis (EoE) and to provide end points for clinical trials and observational studies. We aimed to develop and validate a patient-reported outcome (PRO) instrument and score, based on items that could account for variations in patient assessments of ... Read more >>

Gastroenterology (Gastroenterology)
[2014, 147(6):1255-66.e21]

Cited: 83 times

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A comparison of patient satisfaction with sedation between fentanyl/midazolam and meperidine/midazolam in patients undergoing endoscopy.

Neal C Patel, Michael G Heckman, William C Palmer, David Cangemi, Kenneth R DeVault,

Am J Gastroenterol (The American journal of gastroenterology)
[2014, 109(5):772-774]

Cited: 1 time

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Gastroesophageal reflux disease and the elderly.

Sami R Achem, Kenneth R DeVault,

Gastroesophageal reflux disease is a common disorder in all patients but a particular problem in the elderly, for whom the disease often presents with advanced mucosal damage and other complications. Symptoms are also not as reliable an indication of disease severity in older patients. Likewise, therapy is more difficult because ... Read more >>

Gastroenterol Clin North Am (Gastroenterology clinics of North America)
[2014, 43(1):147-160]

Cited: 16 times

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Could aspiration therapy for obesity be an effective and safe alternative to traditional bariatric surgery?

Kenneth R Devault,

Gastroenterology (Gastroenterology)
[2013, 145(6):1188-1190]

Cited: 1 time

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Introduction of mechanical sphincter augmentation for gastroesophageal reflux disease into practice: early clinical outcomes and keys to successful adoption.

C Daniel Smith, Kenneth R DeVault, Mauricia Buchanan,

<h4>Background</h4>A new device for mechanical sphincter augmentation (MSA) of the lower esophageal sphincter was approved by the FDA on March 22, 2012. We report early experience with MSA, specifically addressing postoperative management.<h4>Study design</h4>Between October 1, 2011 and June 1, 2013, 150 patients were evaluated for MSA. Of these, 66 patients ... Read more >>

J Am Coll Surg (Journal of the American College of Surgeons)
[2014, 218(4):776-781]

Cited: 14 times

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