Full Text Journal Articles by
Author Kenneth A Ellenbogen

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Usefulness of Multisite Ventricular Pacing in Nonresponders to Cardiac Resynchronization Therapy.

Samir Saba, Devi Nair, Christopher R Ellis, Allen Ciuffo, Marilyn Cox, Nigel Gupta, Saumya Sharma, Sandeep Jain, Marshall Winner, Sharda Mehta, Torri Simon, Ken Stein, Kenneth A Ellenbogen, ,

Cardiac resynchronization therapy (CRT) is an established treatment for heart failure patients with myocardial dysfunction and delayed ventricular activation, but approximately 25% to 40% of patients do not respond to CRT. Left ventricular (LV) multisite pacing (MSP) has been proposed as a tool to improve CRT response. The goal of ... Read more >>

Am J Cardiol (The American journal of cardiology)
[2021, :]

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Outcomes Associated With Catheter Ablation of Ventricular Tachycardia in Patients With Cardiac Sarcoidosis.

Konstantinos C Siontis, Pasquale Santangeli, Daniele Muser, Francis E Marchlinski, Katja Zeppenfeld, Jarieke C Hoogendoorn, Calambur Narasimhan, William H Sauer, Matthew M Zipse, Suraj Kapa, Vasanth Vedantham, David G Rosenthal, Melissa R Robinson, Kristen K Patton, Francis Murgatroyd, Alexandru B Chicos, Kyoko Soejima, Henri Roukoz, Frederic Sacher, Adarsh Bhan, Jason Appelbaum, Timm Dickfeld, Pranav Mankad, Kenneth A Ellenbogen, Jordana Kron, Hyungjin Myra Kim, James Froehlich, Kim A Eagle, Frank M Bogun, Thomas C Crawford,

<h4>Importance</h4>Ventricular tachycardia (VT) is associated with high mortality in patients with cardiac sarcoidosis (CS), and medical management of CS-associated VT is limited by high failure rates. The role of catheter ablation has been investigated in small, single-center studies.<h4>Objective</h4>To investigate outcomes associated with VT ablation in patients with CS.<h4>Design, setting, and ... Read more >>

JAMA Cardiol (JAMA cardiology)
[2021, :]

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Clinical Performance of Implantable Cardioverter Defibrillator Lead Monitoring Diagnostics.

Jeanne E Poole, Charles D Swerdlow, Khaldoun G Tarakji, Suneet Mittal, Kenneth A Ellenbogen, Arnold J Greenspon, Charles Kennergren, Berit T Philbert, JoEllyn Moore, R Chris Jones, Robert D Schaller, Riple Hansalia, Timothy Simmers, Attila Mihalcz, Becky DeBus, Daniel R Lexcen, Bruce Gunderson, Bruce L Wilkoff,

<h4>Background</h4>Implantable cardioverter defibrillator (ICD) lead monitoring diagnostic alerts facilitate diagnosis of structural lead failure.<h4>Objective</h4>To prospectively study the performance of Medtronic ICD lead monitoring alerts.<h4>Methods</h4>A pre-specified ancillary WRAP-IT sub-study was conducted in ICD patients with all available alerts enabled. Investigators reported possible lead system events (LSE), with or without an alert. ... Read more >>

Heart Rhythm (Heart rhythm)
[2021, :]

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Sex Differences in Ablation Strategy, Lesion Sets, and Complications of Catheter Ablation for Atrial Fibrillation: An Analysis From the GWTG-AFIB Registry.

Fahd N Yunus, Alexander C Perino, DaJuanicia N Holmes, Roland A Matsouaka, Anne B Curtis, Kenneth A Ellenbogen, David S Frankel, Bradley P Knight, Andrea M Russo, William R Lewis, Jonathan P Piccini, Mintu P Turakhia, ,

<h4>Background</h4>When presenting for atrial fibrillation (AF) ablation, women, compared with men, tend to have more nonpulmonary vein triggers and advanced atrial disease. Whether this informs differences in AF ablation strategy is not well described. We aimed to characterize ablation strategy and complications by sex, using the Get With The Guidelines-AF ... Read more >>

Circ Arrhythm Electrophysiol (Circulation. Arrhythmia and electrophysiology)
[2021, 14(11):e009790]

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Rate-related QRS morphological changes in left bundle branch pacing: A case report.

Yajun Ji, Yubin Zhang, Kenneth A Ellenbogen, Weijian Huang, Yali Yang,

Studies have shown that a permanent left bundle branch pacing (LBBP) is feasible and may be clinically beneficial. The paced QRS morphology in a permanent LBBP typically manifests as a right bundle branch block pattern (RBBB) because the left ventricle is activated earlier than the right ventricle. We present one ... Read more >>

J Electrocardiol (Journal of electrocardiology)
[2021, 69:136-139]

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Cardiac resynchronization therapy via left bundle branch pacing vs. optimized biventricular pacing with adaptive algorithm in heart failure with left bundle branch block: a prospective, multi-centre, observational study.

Xueying Chen, Yang Ye, Zhongkai Wang, Qinchun Jin, Zhaohui Qiu, Jingfeng Wang, Shengmei Qin, Jin Bai, Wei Wang, Yixiu Liang, Haiyan Chen, Xia Sheng, Feng Gao, Xianxian Zhao, Guosheng Fu, Kenneth A Ellenbogen, Yangang Su, Junbo Ge,

<h4>Aims</h4>The purpose of our study was to evaluate the feasibility and efficacy of cardiac resynchronization therapy (CRT) via left bundle branch pacing (LBBP-CRT) compared with optimized biventricular pacing (BVP) with adaptive algorithm (BVP-aCRT) in heart failure with reduced left ventricular ejection fraction ≤35% (HFrEF) and left bundle branch block (LBBB).<h4>Methods ... Read more >>

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2021, :]

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Interpreting device diagnostics for lead failure.

Charles D Swerdlow, Sylvain Ploux, Jeanne E Poole, Sandeep G Nair, Adam Himes, Kenneth A Ellenbogen,

Implantable cardioverter-defibrillators (ICDs) incorporate automated, lead-monitoring alerts (alerts) and other diagnostics to detect defibrillation lead failure (LF) and minimize its adverse clinical consequences. Partial conductor fractures cause oversensing, but pacing or high-voltage alerts for high impedance detect only complete conductor fracture. In both pacing and high-voltage insulation breaches, low-impedance alerts ... Read more >>

Heart Rhythm (Heart rhythm)
[2021, :]

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Case Report: Interventricular Septal Hematoma Complicating Left Bundle Branch Pacing Lead Implantation.

Rujie Zheng, Shengjie Wu, Songjie Wang, Lan Su, Kenneth A Ellenbogen, Weijian Huang,

<b>Background:</b> Left bundle branch pacing (LBBP) is a novel physiological pacing and previous studies have confirmed the feasibility and safety of it. The incidence of complications in LBBP is relatively low as reported. Here we present a case of interventricular septal hematoma complicating LBBP lead implantation. <b>Case summary:</b> LBBP was ... Read more >>

Front Cardiovasc Med (Frontiers in cardiovascular medicine)
[2021, 8:744079]

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Pacing of Specialized Conduction System.

Santosh K Padala, Kenneth A Ellenbogen,

Right ventricular pacing for bradycardia remains the mainstay of pacing therapy. Chronic right ventricular pacing may lead to pacing-induced cardiomyopathy. We focus on the anatomy of the conduction system and the clinical feasibility of pacing the His bundle and/or left bundle conduction system. We review the hemodynamics of conduction system ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, 13(4):755-784]

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Autonomic Modulation for Treatment of Repolarization Alternans and Refractory Ventricular Electrical Storm.

Ajay Pillai, Jayanthi N Koneru, Kenneth A Ellenbogen, Santosh K Padala,

Macroscopic T-wave alternans (TWA) is a rare finding on surface electrocardiogram and has been associated with an increased risk of impending sudden cardiac death. We highlight a case of macroscopic TWA in a patient with markedly prolonged QTc interval preceding ventricular electrical storm, which was refractory to medical management. Autonomic ... Read more >>

JACC Case Rep (JACC. Case reports)
[2021, 3(12):1438-1443]

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Electrocardiographic characteristics and ablation of ventricular arrhythmias originating from the basal inferoseptal area.

Timothy R Larsen, Richard K Shepard, Jayanthi N Koneru, José-Angel Cabrera, Kenneth A Ellenbogen, Santosh K Padala,

<h4>Aims </h4>Ventricular arrhythmias (VAs) from the basal inferoseptal (BIS) area are rare and can pose unique challenges during catheter ablation (CA) due to the anatomic complexity. The study sought to describe the electrocardiographic and clinical characteristics of VAs originating from the BIS area.<h4>Methods and results </h4>Patients with VAs and successful ablation at ... Read more >>

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2021, :]

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To the Editor-High subthreshold pacing impedance from device-lead connection issues.

Charles D Swerdlow, Kenneth A Ellenbogen,

Heart Rhythm (Heart rhythm)
[2021, 18(12):2225]

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Using Machine-Learning for Prediction of the Response to Cardiac Resynchronization Therapy: The SMART-AV Study.

Stacey J Howell, Tim Stivland, Kenneth Stein, Kenneth A Ellenbogen, Larisa G Tereshchenko,

<h4>Objectives</h4>This study aimed to apply machine learning (ML) to develop a prediction model for short-term cardiac resynchronization therapy (CRT) response to identifying CRT candidates for early multidisciplinary CRT heart failure (HF) care.<h4>Background</h4>Multidisciplinary optimization of cardiac resynchronization therapy (CRT) delivery can improve long-term CRT outcomes but requires substantial staff resources.<h4>Methods</h4>Participants from ... Read more >>

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2021, :]

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His-purkinje conduction system pacing in atrial fibrillation and heart failure: A virtual dream coming true.

Xueying Chen, Songjie Wang, Kenneth A Ellenbogen, Weijian Huang,

Pacing Clin Electrophysiol (Pacing and clinical electrophysiology : PACE)
[2021, 44(9):1481-1484]

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Cardiac Resynchronization Therapy in Patients With LVADs: Boon or Bust?

Kenneth A Ellenbogen, Santosh Padala,

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2021, 7(8):1010-1012]

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Safety and feasibility of left bundle branch area pacing following valvular interventions: Multicenter study.

Enes Elvin Gul, Rajiv A Kabadi, Santosh K Padala, Paula Sanchez Somonte, Jordana Kron, Richard K Shepard, Jayanthi N Koneru, Gautham Kalahasty, Maria Terricabras, Bernice Tsang, Yaariv Khaykin, Zaev Wulffhart, Alfredo Pantano, Kenneth A Ellenbogen, Atul Verma,

<h4>Objectives</h4>To evaluate the safety and feasibility of left bundle branch area pacing (LBBAP) in patients with valvular interventions.<h4>Methods</h4>Eighty-four patients were included in this study. All patients underwent recent surgical or percutaneous valvular interventions. LBBAP was attempted in all patients. Implant success rates, peri- and postprocedure electrocardiogram, pacing parameters, and complications ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2021, 32(9):2515-2521]

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Taking the Heat Out of Cardiac Resynchronization Therapy and Conduction System Pacing: Whither Simple CRT?

Kenneth A Ellenbogen, Santosh K Padala,

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2021, 7(7):893-895]

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The Hidden Value of a CHA2DS2-VASc Score.

Kenneth A Ellenbogen, Phoebe Ashley,

Cardiovasc Revasc Med (Cardiovascular revascularization medicine : including molecular interventions)
[2021, 29:69-70]

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Feasibility and Outcomes of Upgrading to Left Bundle Branch Pacing in Patients With Pacing-Induced Cardiomyopathy and Infranodal Atrioventricular Block.

Yang Ye, Shengjie Wu, Lan Su, Xia Sheng, Jiefang Zhang, Bei Wang, Parikshit S Sharma, Kenneth A Ellenbogen, Yangang Su, Xueying Chen, Guosheng Fu, Weijian Huang,

His bundle pacing (HBP) can reverse left ventricular (LV) remodeling in patients with right ventricular (RV) pacing-induced cardimyopathy (PICM) but may be unable to correct infranodal atrioventricular block (AVB). Left bundle branch pacing (LBBP) results in rapid LV activation and may be able to reliably pace beyond the site of ... Read more >>

Front Cardiovasc Med (Frontiers in cardiovascular medicine)
[2021, 8:674452]

Cited: 2 times

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Pursue physiological pacing therapy: A better understanding of left bundle branch pacing and left ventricular septal myocardial pacing.

Weijian Huang, Xiaohong Zhou, Kenneth A Ellenbogen,

Heart Rhythm (Heart rhythm)
[2021, 18(8):1290-1291]

Cited: 2 times

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Impact of His bundle pacing on right ventricular performance in patients undergoing permanent pacemaker implantation.

Domenico Grieco, Edoardo Bressi, Karol Curila, Santosh K Padala, Kamil Sedlacek, Jordana Kron, Elisa Fedele, Oana Ionita, Sara Giannuzzi, Alessandro Fagagnini, Germana Panattoni, Ermenegildo De Ruvo, Kenneth A Ellenbogen, Leonardo Calò,

<h4>Background</h4>His-Bundle pacing (HBP) is an emerging technique for physiological pacing. However, its effects on right ventricle (RV) performance are still unknown.<h4>Methods</h4>We enrolled consecutive patients with an indication for pacemaker (PM) implantation to compare HBP versus RV pacing (RVP) effects on RV performance. Patients were evaluated before implantation and after 6 ... Read more >>

Pacing Clin Electrophysiol (Pacing and clinical electrophysiology : PACE)
[2021, 44(6):986-994]

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Spectrum of arrhythmogenic substrate post minimally invasive maze surgery in patients with recurrent.

Timothy R Larsen, Jayanthi N Koneru, Santosh K Padala, Vigneshwar Kasirajan, Kenneth A Ellenbogen,

<h4>Background</h4>Advancements in minimally invasive surgical ablation (MISA) have focused on improving pulmonary vein isolation. Additional ablation targets have been developed (such as posterior wall isolation). The mid- and long-term effects of current techniques (including electrophysiologic findings and recurrent arrhythmia mechanisms) have not previously been reported.<h4>Methods</h4>Twenty eight patients with recurrent atrial ... Read more >>

Pacing Clin Electrophysiol (Pacing and clinical electrophysiology : PACE)
[2021, 44(6):1054-1061]

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Clinical and translational insights on premature ventricular contractions and PVC-induced cardiomyopathy.

Jose F Huizar, Alex Y Tan, Karoly Kaszala, Kenneth A Ellenbogen,

The medical community's understanding of the consequences of premature ventricular contractions (PVCs) and PVC-induced cardiomyopathy has been derived mostly from observational and large population-based studies. Due to the difficulty of predicting the development of PVC-cardiomyopathy, the acute and chronic cardiac effects of PVCs and the mechanism of PVC-cardiomyopathy have been ... Read more >>

Prog Cardiovasc Dis (Progress in cardiovascular diseases)
[2021, 66:17-27]

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A Tale of 2 Blocks.

Ajay Pillai, Kenneth A Ellenbogen, Santosh K Padala,

Circulation (Circulation)
[2021, 143(10):1062-1065]

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Arrhythmias in Cardiac Sarcoidosis Bench to Bedside: A Case-Based Review.

Lynda E Rosenfeld, Mina K Chung, Clifford V Harding, Paolo Spagnolo, Johan Grunewald, Jason Appelbaum, William H Sauer, Daniel A Culver, Jose A Joglar, Ben A Lin, Christine L Jellis, Timm-Michael Dickfeld, Deborah H Kwon, Edward J Miller, Paul C Cremer, Frank Bogun, Jordana Kron, Ashley Bock, Davendra Mehta, Paul Leis, Konstantinos C Siontis, Elizabeth S Kaufman, Thomas Crawford, Peter Zimetbaum, Edwin T Zishiri, Jagmeet P Singh, Kenneth A Ellenbogen, Jonathan Chrispin, Syed Quadri, Logan L Vincent, Kristen K Patton, Steven Kalbfleish, Thomas D Callahan, Francis Murgatroyd, Marc A Judson, David Birnie, David R Okada, Christopher Maulion, Pavan Bhat, Lavanya Bellumkonda, Ron Blankstein, Richard K Cheng, Maryjane A Farr, Jerry D Estep,

Cardiac sarcoidosis is a component of an often multiorgan granulomatous disease of still uncertain cause. It is being recognized with increasing frequency, mainly as the result of heightened awareness and new diagnostic tests, specifically cardiac magnetic resonance imaging and <sup>18</sup>F-fluorodeoxyglucose positron emission tomography scans. The purpose of this case-based review ... Read more >>

Circ Arrhythm Electrophysiol (Circulation. Arrhythmia and electrophysiology)
[2021, 14(2):e009203]

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