Full Text Journal Articles by
Author Kenichi Tanaka

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In Vitro Comparison of Recombinant and Plasma-Derived von Willebrand Factor Concentrate for Treatment of Acquired von Willebrand Syndrome in Adult Extracorporeal Membrane Oxygenation Patients.

Michael Mazzeffi, Reney Henderson, Eric Krause, Joseph Rabin, Ronson Madathil, Jonathan Chow, Alison Grazioli, Michael Meyer, Zhongjun Wu, Kenichi Tanaka,

<h4>Background</h4>Coagulopathic bleeding is common during adult extracorporeal membrane oxygenation (ECMO), and acquired von Willebrand syndrome is a contributing factor. We compared ECMO patient blood samples that were treated in vitro with recombinant von Willebrand Factor concentrate and plasma-derived von Willebrand Factor concentrate. Our hypothesis was that recombinant von Willebrand Factor ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2022, 134(2):312-321]

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Procalcitonin is associated with postnatal respiratory condition severity in preterm neonate: Conclusion: The serum PCT levels in preterm neonates were associated with postnatal respiratory condition severity.

Masanori Iwai, Hidetaka Yoshimatsu, Tetsuo Naramura, Hiroko Imamura, Tomomi Nakamura, Rieko Sakamoto, Takeshi Inoue, Kenichi Tanaka, Shiro Matsumoto, Kimitoshi Nakamura, Hiroshi Mitsubuchi,

<h4>Introduction</h4>Postnatal respiratory failure is common in preterm neonates and is difficult to distinguish from early-onset neonatal bacterial infection by clinical symptoms. Similar to C-reactive protein (CRP), procalcitonin (PCT) is used as a marker of bacterial infection. Recently, it has been reported that the serum PCT levels increase because of respiratory ... Read more >>

Pediatr Pulmonol (Pediatric pulmonology)
[2022, :]

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Technique of Augmenting Molecular Graph Data by Perturbating Hidden Features.

Takahiro Inoue, Kenichi Tanaka, Kimito Funatsu,

Quantitative structure-property relationship models are useful in efficiently searching for molecules with desired properties in drug discovery and materials development. In recent years, many such models based on graph neural networks, showing good prediction performance, have been reported. Training graph neural networks generally require many samples, but by using a ... Read more >>

Mol Inform (Molecular informatics)
[2022, :]

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Real-world effectiveness of liraglutide versus dulaglutide in Japanese patients with type 2 diabetes: a retrospective study.

Kenichi Tanaka, Yosuke Okada, Akemi Tokutsu, Yoshiya Tanaka,

Real-world data comparing the effectiveness of various glucagon-like peptide 1 receptor agonists (GLP-1 RAs) in type 2 diabetes mellitus (T2DM) are limited. We investigated the clinical effectiveness of liraglutide and dulaglutide in Japanese T2DM in a real-world setting. This retrospective study included 179 patients with T2DM who were treated with ... Read more >>

Sci Rep (Scientific reports)
[2022, 12(1):154]

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Relief of neuropathic pain by cell-specific manipulation of nucleus accumbens dopamine D1- and D2-receptor-expressing neurons.

Daisuke Sato, Michiko Narita, Yusuke Hamada, Tomohisa Mori, Kenichi Tanaka, Hideki Tamura, Akihiro Yamanaka, Ryosuke Matsui, Dai Watanabe, Yukari Suda, Emiko Senba, Moe Watanabe, Edita Navratilova, Frank Porreca, Naoko Kuzumaki, Minoru Narita,

Emerging evidence suggests that the mesolimbic dopaminergic network plays a role in the modulation of pain. As chronic pain conditions are associated with hypodopaminergic tone in the nucleus accumbens (NAc), we evaluated the effects of increasing signaling at dopamine D1/D2-expressing neurons in the NAc neurons in a model of neuropathic ... Read more >>

Mol Brain (Molecular brain)
[2022, 15(1):10]

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Case Report: Takotsubo Cardiomyopathy in Bickerstaff Brainstem Encephalitis Triggered by COVID-19.

Mizuki Kimura, Shunta Hashiguchi, Kenichi Tanaka, Manato Hagiwara, Keita Takahashi, Yosuke Miyaji, Hideto Joki, Hiroshi Doi, Michiaki Koga, Hideyuki Takeuchi, Fumiaki Tanaka,

Takotsubo cardiomyopathy (TCM) is a stress-induced cardiomyopathy triggered by critical illness including severe neurological disorders. However, an association between TCM and Bickerstaff brainstem encephalitis (BBE) has rarely been described. During the current coronavirus disease 2019 (COVID-19) pandemic, growing evidence indicates that COVID-19 often leads to various neurological disorders, but there ... Read more >>

Front Neurol (Frontiers in neurology)
[2021, 12:822247]

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Clinical profiles of Asians with NAFLD: A systematic review and meta-analysis.

Leslie Kam, Daniel Q Huang, Margaret L P Teng, Hirokazu Takahashi, Kenichi Tanaka, Satoshi Yasuda, James Fung, Teng-Yu Lee, Hideyuki Hyogo, Masafumi Ono, Junji Saruwatari, Kentaro Oniki, Yee Hui Yeo, Scott Barnett, Linda Henry, Jie Li, Biyao Zou, Ramsey C Cheung, Takashi Kumada, Man-Fung Yuen, Yuichiro Eguchi, Hidenori Toyoda, Mindie H Nguyen,

<h4>Introduction</h4>NAFLD is increasingly prevalent in Asia, where people suffer more metabolic comorbidities at a lower body mass index (BMI), suggesting potential differences in their clinical profile. Therefore, we attempted to characterize the clinical profile of Asians with NAFLD via a meta-analytic approach.<h4>Methods</h4>We searched Pubmed, EMBASE, and Cochrane databases from January ... Read more >>

Dig Dis (Digestive diseases (Basel, Switzerland))
[2021, :]

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Hereditary Antithrombin Deficiency: A Balancing Act of Perioperative Hemostasis and Thromboprophylaxis-A Case Report.

Kofi VanDyck, Ian F Dunn, Cooper Yates, Christopher Robbs, Kenichi A Tanaka,

Hereditary deficiency of antithrombin (AT) is associated with increased risk of venous thromboembolism (VTE), especially under the circumstances of stress, vascular injury, and immobilization associated with surgery. To date, there is no consensus on the use of perioperative anticoagulant bridging in the setting of hereditary thrombophilia. Balancing hemorrhagic and thrombotic ... Read more >>

A A Pract (A&A practice)
[2021, 15(12):e01550]

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Hypoglycemia Induces Vascular Endothelial Dysfunction in Subjects With Normal Glucose Tolerance

Kenichi Tanaka, Yosuke Okada, Keiichi Torimoto, Kosuke Nishio, Manabu Narisawa, Yoshiya Tanaka,

This prospective study determined the effects of hypoglycemic stimulation on vascular endothelial function in non-diabetic patients using reactive hyperemia peripheral arterial tonometry (RH-PAT). The study included non-diabetic patients who were hospitalized for an insulin tolerance test (ITT) for the diagnosis of hypoadrenocorticism or hypopituitarism. Vascular endothelial function was assessed using ... Read more >>

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Association between Serum Inorganic Phosphorus Levels and Adverse Outcomes in Chronic Kidney Disease: The Fukushima CKD Cohort Study.

Akira Oda, Kenichi Tanaka, Hirotaka Saito, Tsuyoshi Iwasaki, Shuhei Watanabe, Hiroshi Kimura, Sakumi Kazama, Michio Shimabukuro, Koichi Asahi, Tsuyoshi Watanabe, Junichiro James Kazama,

Objective Although an association between serum inorganic phosphorus levels and a poor prognosis has been noted in dialysis patients, these associations have been insufficiently reported in non-dialysis-dependent chronic kidney disease (NDD-CKD) patients. This study attempted to determine the association between serum inorganic phosphorus levels and adverse outcomes in Japanese NDD-CKD ... Read more >>

Intern Med (Internal medicine (Tokyo, Japan))
[2021, :]

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Management of Patients With Hemophilia Undergoing Cardiac Surgery.

Daniel Bolliger, Kofi Vandyck, Kenichi A Tanaka,

J Cardiothorac Vasc Anesth (Journal of cardiothoracic and vascular anesthesia)
[2022, 36(2):539-541]

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Efficacy of sonorheometry point of the care device in determining low fibrinogen levels in pregnant blood: an invitro dilution and reconstitution study.

Bhavani Shankar Kodali, Arun Karuppiah, Shobana Bharadwaj, Jonathan Chow, Kenichi Tanaka,

Quantra® Hemostasis Analyzer is a Point of the care device that uses ultrasound technology to assess clot formation. In this study, we establish how Quantra® system performs compared to conventional coagulation tests at low levels of fibrinogen in the blood obtained from pregnant women. 24 mL blood was obtained from each ... Read more >>

J Clin Monit Comput (Journal of clinical monitoring and computing)
[2021, :]

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Red Blood Cell Transfusion and Postoperative Delirium in Hip Fracture Surgery Patients: A Retrospective Observational Cohort Study.

Jacob Raphael, Nadia B Hensley, Jonathan Chow, K Gage Parr, John S McNeil, Steven B Porter, Monica Taneja, Kenichi Tanaka, Michael Mazzeffi,

<h4>Background</h4>Patients having hip fracture surgery are at high risk for postoperative delirium. Red blood cell (RBC) transfusion may increase postoperative delirium risk by causing neuroinflammation. We hypothesized that RBC transfusion would be associated with postoperative delirium in patients having hip fracture surgery.<h4>Methods</h4>An observational cohort study was performed using the United ... Read more >>

Anesthesiol Res Pract (Anesthesiology research and practice)
[2021, 2021:8593257]

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Association of Polypharmacy with Kidney Disease Progression in Adults with CKD.

Hiroshi Kimura, Kenichi Tanaka, Hirotaka Saito, Tsuyoshi Iwasaki, Akira Oda, Shuhei Watanabe, Makoto Kanno, Michio Shimabukuro, Koichi Asahi, Tsuyoshi Watanabe, Junichiro James Kazama,

<h4>Background and objective</h4>Polypharmacy is common in patients with CKD and reportedly associated with adverse outcomes. However, its effect on kidney outcomes among patients with CKD has not been adequately elucidated. Hence, this investigation was aimed at exploring the association between polypharmacy and kidney failure requiring KRT.<h4>Design, setting, participants, and measurements</h4>We ... Read more >>

Clin J Am Soc Nephrol (Clinical journal of the American Society of Nephrology : CJASN)
[2021, 16(12):1797-1804]

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"COVID arm" detected by MR neurography.

Hiroyasu Komiya, Kohei Harada, Ryoji Morishita, Shunta Hashiguchi, Mikiko Tada, Kenichi Tanaka, Hiroshi Doi, Hideyuki Takeuchi, Fumiaki Tanaka,

eNeurologicalSci (eNeurologicalSci)
[2021, 25:100377]

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Survey of Practice Pattern in Patients With Heparin-Induced Thrombocytopenia Requiring Cardiopulmonary Bypass.

Alycia Wanat-Hawthorne, Kenichi Tanaka, Ronald Angona, Changyong Feng, Michael Eaton,

<h4>Background</h4>Heparin-induced thrombocytopenia (HIT) is an immune-mediated adverse reaction to heparin. Patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) are routinely anticoagulated with heparin before the initiation of bypass. Heparin is contraindicated, however, in patients with acute HIT, and alternatives to routine practice are often used. While guidelines have recently been ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 133(5):1180-1186]

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In vitro effects of emicizumab on activated clotting time in blood samples from cardiac surgical patients.

Kenichi A Tanaka, Reney Henderson, Kiruphagaran Thangaraju, Yoshihisa Morita, Michael A Mazzeffi, Erik Strauss, Upendra Katneni, Paul W Buehler,

<h4>Background</h4>Heparin management in hemophilia A (HA) patients with a factor VIII (FVIII) inhibitor can be challenging due to severe activated clotting time (ACT) prolongations. It is important to better understand the impact of emicizumab, a FVIII mimetic on ACT, and tissue factor (TF)-based coagulation assays.<h4>Methods</h4>Whole blood from 18 patients undergoing ... Read more >>

Haemophilia (Haemophilia : the official journal of the World Federation of Hemophilia)
[2022, 28(1):183-190]

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Seen by a Glance, But Not by a Stare-A Case Study of a Patient With Simultanagnosia.

Keisuke Morihara, Yuichi Higashiyama, Shiori Asano, Yuki Matsunaga, Keita Takahashi, Ryoko Miyake, Kenichi Tanaka, Hideto Joki, Hiroshi Doi, Hideyuki Takeuchi, Fumiaki Tanaka,

<h4>Objective</h4>Simultanagnosia is a rare neuropsychological symptom characterized by difficulty recognizing global structures while preserving perception of local detail. The condition is classified into ventral and dorsal types. Clinical presentation of ventral simultanagnosia includes a reduced ability to recognize multiple visual stimuli rapidly, that is, part-by-part recognition. Here, we report a ... Read more >>

Arch Clin Neuropsychol (Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists)
[2021, :]

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The Algorithm Examining the Risk of Massive Transfusion (ALERT) Score Accurately Predicts Massive Transfusion at the Scene of Injury and on Arrival to the Trauma Bay: A Retrospective Analysis.

Jonathan H Chow, Justin E Richards, Samuel M Galvagno, Patrick J Coleman, Allison S Lankford, Cheralyn Hendrix, Jackson Dunitz, Ikeoluwapo Ibrahim, Mira Ghneim, Kenichi A Tanaka, Thomas M Scalea, Michael A Mazzeffi, Peter Hu,

<h4>Background</h4>Massive transfusion (MT) is required to resuscitate traumatically injured patients with complex derangements. Scoring systems for MT typically require laboratory values and radiological imaging that may delay the prediction of MT.<h4>Study design</h4>The Trauma ALgorithm Examining the Risk of massive Transfusion (Trauma ALERT) study was an observational cohort study. Prehospital and ... Read more >>

Shock (Shock (Augusta, Ga.))
[2021, 56(4):529-536]

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Histone modification of pain-related gene expression in spinal cord neurons under a persistent postsurgical pain-like state by electrocautery.

Yosuke Katsuda, Kenichi Tanaka, Tomohisa Mori, Michiko Narita, Hideyuki Takeshima, Takashige Kondo, Yoshiyuki Yamabe, Misa Matsufuji, Daisuke Sato, Yusuke Hamada, Keisuke Yamaguchi, Toshikazu Ushijima, Eiichi Inada, Naoko Kuzumaki, Masako Iseki, Minoru Narita,

Chronic postsurgical pain (CPSP) is a serious problem. We developed a mouse model of CPSP induced by electrocautery and examined the mechanism of CPSP. In this mouse model, while both incision and electrocautery each produced acute allodynia, persistent allodynia was only observed after electrocautery. Under these conditions, we found that ... Read more >>

Mol Brain (Molecular brain)
[2021, 14(1):146]

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Can We Use Viscoelastic Testing to Evaluate Microvascular Dysfunction in Acute Myocardial Infarction?

Jerrold H Levy, Kenichi A Tanaka,

JACC Basic Transl Sci (JACC. Basic to translational science)
[2021, 6(9-10):762-764]

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Roles of Four-Factor Prothrombin Complex Concentrate in the Management of Critical Bleeding.

Kenichi A Tanaka, Shashank Shettar, Kofi Vandyck, Susan M Shea, Ezeldeen Abuelkasem,

Four-factor prothrombin complex concentrate (4F-PCC) is the term used to describe a pathogen-reduced, lyophilized concentrate that contains therapeutic amounts of at least 4 coagulation factors: Factor II (FII), Factor VII (FVII), Factor IX (FIX), and Factor X (FX). 4F-PCC has proven to be an effective hemostatic agent compared to plasma ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2021, 35(4):96-103]

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A case of peripancreatic plexiform schwannoma.

Kenji Fukushima, Makoto Shinzeki, Kentaro Tai, Masaki Omori, Natsuko Yamauchi, Tomoko Tanaka, Yasunori Matsuda, Hiroshi Ashitani, Kenichi Tanaka,

<h4>Background</h4>Plexiform schwannoma is one of the least common variants of schwannoma, accounting for only 5% of all schwannoma cases. It generally occurs in the skin and subcutaneous tissues and is uncommon in deep soft tissue or viscera. We present an extremely rare case of plexiform schwannoma arising from the peripancreatic ... Read more >>

Surg Case Rep (Surgical case reports)
[2021, 7(1):199]

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Effect of skin-capsular distance on controlled attenuation parameter for diagnosing liver steatosis in patients with nonalcoholic fatty liver disease.

Syunichiro Kimura, Kenichi Tanaka, Satoshi Oeda, Kaori Inoue, Chika Inadomi, Yoshihito Kubotsu, Wataru Yoshioka, Michiaki Okada, Hiroshi Isoda, Takuya Kuwashiro, Takumi Akiyama, Aya Kurashige, Ayaka Oshima, Mayumi Oshima, Yasue Matsumoto, Atsushi Kawaguchi, Keizo Anzai, Eisaburo Sueoka, Shinichi Aishima, Hirokazu Takahashi,

The effect of the skin-capsular distance (SCD) on the controlled attenuation parameter (CAP) for diagnosis of liver steatosis in patients with nonalcoholic fatty liver disease (NAFLD) remains unclear. The SCD was measured using B-mode ultrasound, and the CAP was measured using the M probe of FibroScan<sup>®</sup>. According to the indications ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):15641]

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Real-World Effectiveness of Liraglutide Versus Dulaglutide In Japanese Patients With Type 2 Diabetes: A Retrospective Study

Kenichi Tanaka, Yosuke Okada, Akemi Tokutsu, Yoshiya Tanaka,

Real-world data comparing the effectiveness of various glucagon-like peptide 1 receptor agonists (GLP-1 RAs) in type 2 diabetes mellitus (T2DM) are limited. We investigated the clinical effectiveness of liraglutide and dulaglutide in Japanese T2DM in a real-world setting. This retrospective study included 179 patients with T2DM who were treated with ... Read more >>

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