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Author Ken Uchida

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Dose-response relationships of accelerometer-measured sedentary behaviour and physical activity with non-alcoholic fatty liver disease.

Kenji Tsunoda, Naruki Kitano, Yuko Kai, Takashi Jindo, Ken Uchida, Takashi Arao,

<h4>Background</h4>Although a few studies have confirmed the association of accelerometer-measured sedentary behaviour (SB) and physical activity (PA) with non-alcoholic fatty liver disease (NAFLD), PA intensity and co-dependent daily time-use of movement behaviours are yet to be studied.<h4>Aims</h4>To cross-sectionally examine the dose-response relationship between accelerometer-measured SB or PA and NAFLD using ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, :]

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Perfect isolation of π-conjugated molecules on inorganic surfaces with [1]rotaxane structure for enhancing electrical properties

Sheng-Ying Chou, Hiroshi Masai, Masaya Otani, Gentaro Sakamoto, Yusuke Yamada, Yusuke Kinoshita, Hitoshi Tamiaki, Takayoshi Katase, Hiromichi Ohta, Tomoki Kondo, Akinobu Nakada, Ryu Abe, Takahisa Tanaka, Ken Uchida, Jun Terao,

π-Conjugated molecules have been utilized to functionalize inorganic surfaces to form organic–inorganic hybrid materials. However, the intrinsically strong π–π interaction results in undesirable aggregations on the inorganic surface, thereby disturbing the charge transfer through the organic–inorganic interface. In this study, a new strategy was developed using insulated π-conjugated molecules bearing ... Read more >>

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In situ AP-XPS analysis of a Pt thin-film sensor for highly sensitive H2 detection.

Ryo Toyoshima, Takahisa Tanaka, Taro Kato, Ken Uchida, Hiroshi Kondoh,

In situ ambient-pressure X-ray photoelectron spectroscopy (AP-XPS) combined with resistivity measurement was performed for a Pt thin-film H2 gas sensor. We experimentally demonstrate that the chemical state of the Pt surface changes under working conditions, and it directly links to the sensing performance. Moreover, the operating principle is discussed at ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2020, 56(70):10147-10150]

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Preservation of the nipple-areola complex in skin-sparing mastectomy for early breast cancer.

Ryo Miyake, Satoki Kinoshita, Naoko Shimada, Ken Uchida, Hiroshi Takeyama, Toshiaki Morikawa,

<h4>Purpose</h4>Skin-sparing mastectomy (SSM) enables a radical cure of breast cancer while overcoming the cosmetic issues related to surgery. We review our experience of performing SSMs and assess whether preservation of the nipple-areola complex (NAC) could have been an option for some patients who underwent SSM.<h4>Methods</h4>The subjects of this retrospective study ... Read more >>

Surg Today (Surgery today)
[2018, 48(6):591-597]

Cited: 1 time

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Triple-negative breast cancer exhibits a favorable response to neoadjuvant chemotherapy independent of the expression of topoisomerase IIα.

Hiroko Nogi, Ken Uchida, Makiko Kamio, Kumiko Kato, Yasuo Toriumi, Tadashi Akiba, Toshiaki Morikawa, Masaaki Suzuki, Tadashi Kobayashi, Hiroshi Takeyama,

The present study retrospectively analyzed the utility of topoisomerase IIα expression as a prognostic marker to predict the neoadjuvant chemotherapeutic response and survival among different breast cancer subtypes. The patients were subtyped and the expression of topoisomerase IIα was determined using immunohistochemistry. All patients (n=147) received an anthracycline-containing regimen preoperatively, ... Read more >>

Mol Clin Oncol (Molecular and clinical oncology)
[2016, 4(3):383-389]

Cited: 2 times

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Long-Term Follow-Up of Node-Negative Breast Cancer Patients Evaluated via Sentinel Node Biopsy After Neoadjuvant Chemotherapy.

Hiroko Nogi, Ken Uchida, Rei Mimoto, Makiko Kamio, Hisashi Shioya, Yasuo Toriumi, Masafumii Suzuki, Eijiro Nagasaki, Tadashi Kobayashi, Hiroshi Takeyama,

<h4>Background</h4>Sentinel node biopsy (SNB) is used to accurately assess axillary lymph node status in patients with node-negative breast cancer. However, its use after neoadjuvant chemotherapy (NAC) is controversial. We retrospectively assessed the usefulness of SNB after NAC by comparing axillary recurrence rates and other parameters in patients with clinically node-negative ... Read more >>

Clin Breast Cancer (Clinical breast cancer)
[2017, 17(8):644-649]

Cited: 3 times

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Impact of physical activity on nonalcoholic steatohepatitis in people with nonalcoholic simple fatty liver: A prospective cohort study.

Kenji Tsunoda, Yuko Kai, Naruki Kitano, Ken Uchida, Tsutomu Kuchiki, Toshiya Nagamatsu,

Preventing nonalcoholic simple fatty liver (NASFL) from progressing to nonalcoholic steatohepatitis (NASH) is a key to avoiding cirrhosis. Physical activity (PA) may help manage fatty liver; however, there is a lack of prospective studies showing an association between PA and NASH. Our current prospective study investigated whether PA prevents NASFL ... Read more >>

Prev Med (Preventive medicine)
[2016, 88:237-240]

Cited: 8 times

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Deionization of Dopants in Silicon Nanofilms Even with Donor Concentration of Greater than 10(19) cm(-3).

Takahisa Tanaka, Yuya Kurosawa, Naotoshi Kadotani, Tsunaki Takahashi, Shunri Oda, Ken Uchida,

Understanding the dopant properties in heavily doped nanoscale semiconductors is essential to design nanoscale devices. We report the deionization or finite ionization energy of dopants in silicon (Si) nanofilms with dopant concentration (ND) of greater than 10(19) cm(-3), which is in contrast to the zero ionization energy (ED) in bulk ... Read more >>

Nano Lett (Nano letters)
[2016, 16(2):1143-1149]

Cited: 1 time

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Prospective study of physical activity and sleep in middle-aged and older adults.

Kenji Tsunoda, Naruki Kitano, Yuko Kai, Ken Uchida, Tsutomu Kuchiki, Tomohiro Okura, Toshiya Nagamatsu,

<h4>Introduction</h4>Few prospective cohort studies have examined the association between physical activity (PA) and insomnia prevention, and the effective PA intensity remains unclear. This prospective study explores how PA intensity prevents incident short sleep duration and subjective insufficient sleep in middle-aged and older adults.<h4>Methods</h4>A self-reported questionnaire gathered data on sleep and ... Read more >>

Am J Prev Med (American journal of preventive medicine)
[2015, 48(6):662-673]

Cited: 18 times

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Effects of the oriental herbal medicine Bofu-tsusho-san in obesity hypertension: a multicenter, randomized, parallel-group controlled trial (ATH-D-14-01021.R2).

Kengo Azushima, Kouichi Tamura, Sona Haku, Hiromichi Wakui, Tomohiko Kanaoka, Masato Ohsawa, Kazushi Uneda, Ryu Kobayashi, Kohji Ohki, Toru Dejima, Akinobu Maeda, Tatsuo Hashimoto, Jin Oshikawa, Yusuke Kobayashi, Koichiro Nomura, Chieko Azushima, Yasuyo Takeshita, Ryota Fujino, Ken Uchida, Ken Shibuya, Daisaku Ando, Yasuo Tokita, Tetsuya Fujikawa, Yoshiyuki Toya, Satoshi Umemura,

<h4>Objective</h4>There is no clinical evidence that supports the benefit of integrative medicine, defined as combination therapy of oriental and western medicine, on obesity-related hypertension. This study evaluates the efficacy of Bofu-tsusho-san (BOF), an oriental herbal medicine, on the ambulatory blood pressure (BP) profile in hypertensive patients with obesity.<h4>Methods</h4>The study design ... Read more >>

Atherosclerosis (Atherosclerosis)
[2015, 240(1):297-304]

Cited: 15 times

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Clinical relevance and low tumor-initiating properties of oligometastatic breast cancer in pulmonary metastasectomy.

Rei Mimoto, Tadashi Kobayashi, Yoshimi Imawari, Makiko Kamio, Kumiko Kato, Hiroko Nogi, Yasuo Toriumi, Shinichi Hirooka, Ken Uchida, Hiroshi Takeyama,

Metastatic breast cancer is a systemic disease. However, certain subsets of patients, such as those with oligometastatic breast cancer (OMBC), have long-term survival prospects. Our aim was to evaluate the clinical relevance of OMBC in pulmonary metastasectomy of recurrent breast cancer. We also investigated lung metastases for the prevalence of ... Read more >>

Breast Cancer Res Treat (Breast cancer research and treatment)
[2014, 147(2):317-324]

Cited: 3 times

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Modulation of thermoelectric power factor via radial dopant inhomogeneity in B-doped Si nanowires.

Fuwei Zhuge, Takeshi Yanagida, Naoki Fukata, Ken Uchida, Masaki Kanai, Kazuki Nagashima, Gang Meng, Yong He, Sakon Rahong, Xiaomin Li, Tomoji Kawai,

We demonstrate a modulation of thermoelectric power factor via a radial dopant inhomogeneity in B-doped Si nanowires. These nanowires grown via vapor-liquid-solid (VLS) method were naturally composed of a heavily doped outer shell layer and a lightly doped inner core. The thermopower measurements for a single nanowire demonstrated that the ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2014, 136(40):14100-14106]

Cited: 1 time

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Physical activity and risk of fatty liver in people with different levels of alcohol consumption: a prospective cohort study.

Kenji Tsunoda, Yuko Kai, Ken Uchida, Tsutomu Kuchiki, Toshiya Nagamatsu,

<h4>Objective</h4>To investigate whether physical activity affects the future incidence of fatty liver in people with never-moderate and heavy alcohol consumption.<h4>Design</h4>Prospective cohort study.<h4>Setting</h4>Health check-up programme at Meiji Yasuda Shinjuku Medical Center in Shinjuku Ward, Tokyo, Japan.<h4>Population</h4>A total of 10,146 people aged 18 years or older without fatty liver enrolled through baseline surveys ... Read more >>

BMJ Open (BMJ open)
[2014, 4(8):e005824]

Cited: 6 times

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Usefulness of contrast-enhanced ultrasonography for intracystic breast tumors: a report of three cases.

Kumiko Kato, Hiroko Nogi, Tomoyuki Ohta, Makiko Kamio, Yasuo Toriumi, Norio Nakata, Ken Uchida, Yukio Miyamoto, Hiroshi Takeyama,

Cystic breast lesions are caused by a wide spectrum of breast diseases and can range from simple cysts to malignant tumors. Ultrasonography is a good tool for evaluation of the morphology and vascularity of cystic breast lesions. We report three patients in whom contrast-enhanced ultrasonography (CEUS) was used to evaluate ... Read more >>

J Med Ultrason (2001) (Journal of medical ultrasonics (2001))
[2014, 41(3):389-396]

Cited: 0 times

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An Extracellular Matrix Molecule, Secreted by the Epithelial-Mesenchymal Transition is Associated With Lymph Node Metastasis of Thyroid Papillary Carcinoma.

Hiroshi Takeyama, Yoshinobu Manome, Kouki Fujioka, Isao Tabei, Hiroko Nogi, Yasuo Toriumi, Kumiko Kato, Makiko Kamio, Yoshimi Imawari, Satoki Kinoshita, Naoshi Akiba, Ken Uchida, Toshiaki Morikawa,

BACKGROUND:Papillary thyroid carcinoma often has lymph node metastasis, compared with follicular thyroid carcinoma. The study showed that epithelial-mesenchymal transition occurs in carcinoma cells during the first stage of metastasis, where some extracellular matrix molecules are secreted in large quantities. Sialic acid carried by fibronectin as the antigen of the monoclonal ... Read more >>

Int J Endocrinol Metab (International journal of endocrinology and metabolism)
[2014, 12(1):e10748]

Cited: 3 times

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Clinical comparison of four types of skin incisions for skin-sparing mastectomy and immediate breast reconstruction.

Satoki Kinoshita, Shigeya Kyoda, Akio Hirano, Tadashi Akiba, Kimihiro Nojima, Ken Uchida, Hiroshi Takeyama, Toshiaki Morikawa,

<h4>Purpose</h4>Skin-sparing mastectomy (SSM) and immediate breast reconstruction (IBR) has become popular as an effective procedure for patients with early breast cancer. We herein report an overview of the four types of skin incisions used for SSM.<h4>Methods</h4>The records of 111 consecutive breast cancer patients, who received SSM and IBR from 2003 ... Read more >>

Surg Today (Surgery today)
[2014, 44(8):1470-1475]

Cited: 3 times

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Breast cancer screening and the changing population pyramid of Japan.

Ken Uchida, Hitoshi Ohashi, Satoki Kinoshita, Hiroko Nogi, Kumiko Kato, Yasuo Toriumi, Akinori Yamashita, Makiko Kamio, Rei Mimoto, Hiroshi Takeyama,

<h4>Background</h4>Breast cancer has been the most prevalent cancer in Japan since the 1990s. The mortality from breast cancer is increasing in Japan, whereas in other industrialized countries it has been decreasing since 1990. On the other hand, Japan faces unparalleled growth in its aging population. The aim of this study ... Read more >>

Breast Cancer (Breast cancer (Tokyo, Japan))
[2015, 22(2):172-176]

Cited: 13 times

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DYRK2 controls the epithelial-mesenchymal transition in breast cancer by degrading Snail.

Rei Mimoto, Naoe Taira, Hiroyuki Takahashi, Tomoko Yamaguchi, Masataka Okabe, Ken Uchida, Yoshio Miki, Kiyotsugu Yoshida,

The epithelial-mesenchymal transition (EMT) plays a fundamental role in the early stages of breast cancer invasion. Snail, a zinc finger transcriptional repressor, is an important regulator of EMT. Snail is phosphorylated by GSK3β and is subsequently degraded by βTrCP-mediated ubiquitination. We identified an additional kinase, DYRK2, that regulates Snail stability. ... Read more >>

Cancer Lett (Cancer letters)
[2013, 339(2):214-225]

Cited: 36 times

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Phase II clinical trial of high-dose toremifene as primary hormone therapy in aromatase inhibitor-resistant breast cancer.

Hideaki Ogata, Yasushi Okamoto, Youichi Arima, Hisaki Fukushima, Hiroshi Takeyama, Akinori Yamashita, Masao Kinoshita, Noriyuki Suzuki, Terumasa Sawada, Yoshitomo Koshida, Akira Matsui, Akihiko Tachibana, Hiroshi Nakayama, Yoko Oishi, Hiroko Nogi, Ken Uchida,

<h4>Background</h4>Third-generation aromatase inhibitors(AIs)are now common in adjuvant hormone therapy for breast cancer in postmenopausal women. However, a suitable treatment has yet to be established for patients who develop cancer recurrence during or after adjuvant AI therapy.<h4>Patients and methods</h4>This prospective study evaluated the efficacy and safety of 120mg/day toremifene citrate(TOR-120)administered orally ... Read more >>

Gan To Kagaku Ryoho (Gan to kagaku ryoho. Cancer & chemotherapy)
[2013, 40(6):749-753]

Cited: 4 times

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[Which biomarkers can we use?].

Hiroko Nogi, Ken Uchida, Tadashi Kobayashi,

Gene array testing defined the intrinsic biological subtypes including"luminal A", "luminal B", "HER2-enriched" and "basal" within breast cancer. These subtypes may be approximated using clinicopathological immunochemistry rather than gene expression array criteria. These subtypes have different epidemiological risk factors, different natural histories, and different response to systemic and local therapies. ... Read more >>

Nihon Rinsho (Nihon rinsho. Japanese journal of clinical medicine)
[2012, 70(5):816-820]

Cited: 0 times

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Possible clinical cure of metastatic breast cancer: lessons from our 30-year experience with oligometastatic breast cancer patients and literature review.

Tadashi Kobayashi, Tamotsu Ichiba, Toshikazu Sakuyama, Yasuhiro Arakawa, Eijiroh Nagasaki, Keisuke Aiba, Hiroko Nogi, Kazumi Kawase, Hiroshi Takeyama, Yasuo Toriumi, Ken Uchida, Masao Kobayashi, Chihiro Kanehira, Masafumi Suzuki, Naomi Ando, Kazuhiko Natori, Yasunobu Kuraishi,

<h4>Background</h4>Metastatic breast cancer (MBC) is generally incurable. However, 10-20-year relapse-free survival of MBC is approximately 2%, implying that at least a small subset of MBC patients achieve prolonged survival. We therefore analyzed long-term outcome in a particular subset, i.e., oligometastatic breast cancer (OMBC).<h4>Methods</h4>Data of OMBC subjects (N = 75) treated in our ... Read more >>

Breast Cancer (Breast cancer (Tokyo, Japan))
[2012, 19(3):218-237]

Cited: 40 times

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[A case of repeated bone metastases of breast carcinoma successfully treated by S-1 chemotherapy].

Hiroshi Takeyama, Shigeya Kyoda, Akinori Yamashita, Satoki Kinoshita, Tomoyoshi Okamoto, Ken Uchida, Toshiaki Morikawa,

We report a case of breast carcinoma with repeated recurrences in the right bone. The recurrent site of the bone was treated by radiation therapy with a total of 3 7. 5 Gy irradiation, and chemotherapy with the CMF regimen. After 2 years, recurrence was suspected in the same region ... Read more >>

Gan To Kagaku Ryoho (Gan to kagaku ryoho. Cancer & chemotherapy)
[2011, 38(11):1873-1875]

Cited: 0 times

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Retrospective comparison of non-skin-sparing mastectomy and skin-sparing mastectomy with immediate breast reconstruction.

Satoki Kinoshita, Kimihiro Nojima, Meisei Takeishi, Yoshimi Imawari, Shigeya Kyoda, Akio Hirano, Tadashi Akiba, Susumu Kobayashi, Hiroshi Takeyama, Ken Uchida, Toshiaki Morikawa,

Background. We compared Skin-sparing mastectomy (SSM) with immediate breast reconstruction and Non-skin-sparing mastectomy (NSSM), various types of incision in SSM. Method. Records of 202 consecutive breast cancer patients were reviewed retrospectively. Also in the SSM, three types of skin incision were used. Type A was a periareolar incision with a ... Read more >>

Int J Surg Oncol (International journal of surgical oncology)
[2011, 2011:876520]

Cited: 8 times

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Detection of micrometastatic cells in peripheral blood and bone marrow fluid of stage I-III Japanese breast cancer patients and transition following anti-cancer drug treatment.

Hiroshi Takeyama, Takaki Shimada, Yoshinobu Manome, Ken Uchida, Toshiaki Morikawa,

Breast J (The breast journal)
[2012, 18(1):85-87]

Cited: 0 times

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Germanium nanowires with 3-nm-diameter prepared by low temperature vapour-liquid-solid chemical vapour deposition.

Marolop Simanullang, Koichi Usami, Tetsuo Kodera, Ken Uchida, Shunri Oda,

We report the growth of germanium nanowires (Ge NWs) with single-step temperature method via vapour-liquid-solid (VLS) mechanism in the low pressure chemical vapour deposition (CVD) reactor at 300 degrees C, 280 degrees C, and 260 degrees C. The catalyst used in our experiment was Au nanoparticles with equivalent thicknesses of ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2011, 11(9):8163-8168]

Cited: 0 times

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