Full Text Journal Articles by
Author Ken C Walls

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Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer's disease-like pathology.

David Baglietto-Vargas, Stefania Forner, Lena Cai, Alessandra C Martini, Laura Trujillo-Estrada, Vivek Swarup, Marie Minh Thu Nguyen, Kelly Do Huynh, Dominic I Javonillo, Kristine Minh Tran, Jimmy Phan, Shan Jiang, Enikö A Kramár, Cristina Nuñez-Diaz, Gabriela Balderrama-Gutierrez, Franklin Garcia, Jessica Childs, Carlos J Rodriguez-Ortiz, Juan Antonio Garcia-Leon, Masashi Kitazawa, Mohammad Shahnawaz, Dina P Matheos, Xinyi Ma, Celia Da Cunha, Ken C Walls, Rahasson R Ager, Claudio Soto, Antonia Gutierrez, Ines Moreno-Gonzalez, Ali Mortazavi, Andrea J Tenner, Grant R MacGregor, Marcelo Wood, Kim N Green, Frank M LaFerla,

The majority of Alzheimer's disease (AD) cases are late-onset and occur sporadically, however most mouse models of the disease harbor pathogenic mutations, rendering them better representations of familial autosomal-dominant forms of the disease. Here, we generated knock-in mice that express wildtype human Aβ under control of the mouse App locus. ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):2421]

Cited: 0 times

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p-Tau immunotherapy reduces soluble and insoluble tau in aged 3xTg-AD mice.

Ken C Walls, Rahasson R Ager, Vitaly Vasilevko, Dave Cheng, Rodrigo Medeiros, Frank M LaFerla,

Alzheimer's disease (AD) is a proteinopathy characterized by the accumulation of β-amyloid (Aβ) and tau. To date, clinical trials indicate that Aβ immunotherapy does not improve cognition. Consequently, it is critical to modulate other aspects of AD pathology. As such, tau represents an excellent target, as its accumulation better correlates ... Read more >>

Neurosci Lett (Neuroscience letters)
[2014, 575:96-100]

Cited: 26 times

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Presenilin-null cells have altered two-pore calcium channel expression and lysosomal calcium: implications for lysosomal function.

Kara M Neely Kayala, George D Dickinson, Anet Minassian, Ken C Walls, Kim N Green, Frank M Laferla,

Presenilins are necessary for calcium homeostasis and also for efficient proteolysis through the autophagy/lysosome system. Presenilin regulates both endoplasmic reticulum calcium stores and autophagic proteolysis in a γ-secretase independent fashion. The endo-lysosome system can also act as a calcium store, with calcium efflux channels being recently identified as two-pore channels ... Read more >>

Brain Res (Brain research)
[2012, 1489:8-16]

Cited: 30 times

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A highly toxic cellular prion protein induces a novel, nonapoptotic form of neuronal death.

Heather M Christensen, Krikor Dikranian, Aimin Li, Kathleen C Baysac, Ken C Walls, John W Olney, Kevin A Roth, David A Harris,

Several different deletions within the N-terminal tail of the prion protein (PrP) induce massive neuronal death when expressed in transgenic mice. This toxicity is dose-dependently suppressed by coexpression of full-length PrP, suggesting that it results from subversion of a normal physiological activity of cellular PrP. We performed a combined biochemical ... Read more >>

Am J Pathol (The American journal of pathology)
[2010, 176(6):2695-2706]

Cited: 14 times

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Lysosome dysfunction triggers Atg7-dependent neural apoptosis.

Ken C Walls, Arindam P Ghosh, Aimee V Franklin, Barbara J Klocke, Mary Ballestas, John J Shacka, Jianhua Zhang, Kevin A Roth,

Macroautophagy (autophagy) is a process wherein bulk cytosolic proteins and damaged organelles are sequestered and degraded via the lysosome. Alterations in autophagy-associated proteins have been shown to cause neural tube closure defects, neurodegeneration, and tumor formation. Normal lysosome function is critical for autophagy completion and when altered may lead to ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2010, 285(14):10497-10507]

Cited: 47 times

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The proapoptotic BH3-only, Bcl-2 family member, Puma is critical for acute ethanol-induced neuronal apoptosis.

Arindam P Ghosh, Ken C Walls, Barbara J Klocke, Rune Toms, Andreas Strasser, Kevin A Roth,

Synaptogenesis in humans occurs in the last trimester of gestation and in the first few years of life, whereas it occurs in the postnatal period in rodents. A single exposure of neonatal rodents to ethanol during this period evokes extensive neuronal apoptosis. Previous studies indicate that ethanol triggers the intrinsic ... Read more >>

J Neuropathol Exp Neurol (Journal of neuropathology and experimental neurology)
[2009, 68(7):747-756]

Cited: 20 times

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Differential methylation hybridization array of endometrial cancers reveals two novel cancer-specific methylation markers.

Israel Zighelboim, Paul J Goodfellow, Amy P Schmidt, Ken C Walls, Mary Ann Mallon, David G Mutch, Pearlly S Yan, Tim Hui-Ming Huang, Matthew A Powell,

<h4>Purpose</h4>To identify novel endometrial cancer-specific methylation markers and to determine their association with clinicopathologic variables and survival outcomes.<h4>Experimental design</h4>Differential methylation hybridization analysis (DMH) was done for 20 endometrioid endometrial cancers using normal endometrial DNA as a reference control. Combined bisulfite restriction analysis (COBRA) was used to verify methylation of sequences ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2007, 13(10):2882-2889]

Cited: 21 times

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Altered regulation of phosphatidylinositol 3-kinase signaling in cathepsin D-deficient brain.

Ken C Walls, Barbara J Klocke, Paul Saftig, Masahiro Shibata, Yasuo Uchiyama, Kevin A Roth, John J Shacka,

Cathepsin D (CD) is an essential lysosomal protease and mice lacking this enzyme exhibit neuropathology similar to that observed in brains of patients with neuronal ceroid lipofuscinosces (NCL/Batten disease), a group of autosomal recessive pediatric neurodegenerative diseases. CD-deficient (CD-/-) brains exhibit a dramatic induction of autophagic stress as defined by ... Read more >>

Autophagy (Autophagy)
[2007, 3(3):222-229]

Cited: 19 times

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Prevalence of defective DNA mismatch repair and MSH6 mutation in an unselected series of endometrial cancers.

Paul J Goodfellow, Barbara M Buttin, Thomas J Herzog, Janet S Rader, Randall K Gibb, Elizabeth Swisher, Katherine Look, Ken C Walls, Ming-Yu Fan, David G Mutch,

Endometrial cancer is the most common gynecologic malignancy in the United States and the most frequent extracolonic tumor in hereditary nonpolyposis colorectal cancer (HNPCC). HNPCC patients have inherited defects in DNA mismatch repair and the microsatellite instability (MSI) tumor phenotype. Sporadic endometrial cancers also exhibit MSI, usually associated with methylation ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2003, 100(10):5908-5913]

Cited: 133 times

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