Full Text Journal Articles by
Author Kelly Smith

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Effect of Subject-Specific, Spatially Reduced, and Idealized Boundary Conditions on the Predicted Hemodynamic Environment in the Murine Aorta.

Kelly A Smith, Samer S Merchant, Edward W Hsu, Lucas H Timmins,

Mouse models of atherosclerosis have become effective resources to study atherogenesis, including the relationship between hemodynamics and lesion development. Computational methods aid the prediction of the in vivo hemodynamic environment in the mouse vasculature, but careful selection of inflow and outflow boundary conditions (BCs) is warranted to promote model accuracy. ... Read more >>

Ann Biomed Eng (Annals of biomedical engineering)
[2021, :]

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Digital Spatial Profiling of Collapsing Glomerulopathy

Kelly Smith, Kammi Henriksen, Roberto Nicosia, Charles Alpers, Shreeram Akilesh,

<h4>ABSTRACT</h4> Collapsing glomerulopathy is a histologically distinct variant of focal and segmental glomerulosclerosis that presents with heavy proteinuria and portends a poor prognosis. Collapsing glomerulopathy can be triggered by viral infections such as HIV and SARS-CoV-2. Transcriptional profiling of collapsing glomerulopathy lesions is difficult since only a few glomeruli may ... Read more >>

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Granulomatosis with polyangiitis: A case report and brief review of literature.

Dhairya A Lakhani, Aneri B Balar, Ayodele Adelanwa, Alexander Gross, Rehab Mohamed, Kelly T Smith, Cathy Kim,

Granulomatosis with polyangiitis formerly known as Wegener's granulomatosis was first described by German pathologist Friedrich Wegener in 1936. It is a multi-system necrotizing noncaseating granulomatous vasculitis which affects small to medium-sized vessels. It can involve any organ system, most commonly the lungs and kidneys. American College of Rheumatology requires 2 ... Read more >>

Radiol Case Rep (Radiology case reports)
[2021, 16(11):3445-3450]

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Elys deficiency constrains Kras-driven tumour burden by amplifying oncogenic stress

Kimberly Morgan, Karen Doggett, Fan-Suo Geng, Lachlan Whitehead, Kelly Smith, Benjamin Hogan, Cas Simons, Gregory Baillie, Ramyar Molania, Anthony Papenfuss, Thomas Hall, Elke Ober, Didier Stainier, Zhiyuan Gong, Joan Heath,

<h4>ABSTRACT</h4> The nucleoporin ELYS, encoded by AHCTF1 , is a large multifunctional protein with essential roles in nuclear pore assembly and mitosis. Using a zebrafish model of hepatocellular carcinoma, in which the expression of an inducible mutant kras transgene (kras G12V ) drives hepatocyte-specific hyperplasia and liver enlargement, we show ... Read more >>

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Phase I/II trial of a long peptide vaccine (LPV7) plus toll-like receptor (TLR) agonists with or without incomplete Freund's adjuvant (IFA) for resected high-risk melanoma.

Sapna P Patel, Gina R Petroni, Jason Roszik, Walter C Olson, Nolan A Wages, Kimberly A Chianese-Bullock, Mark Smolkin, Nikole Varhegyi, Elizabeth Gaughan, Kelly T Smith, Kathleen Haden, Emily H Hall, Sacha Gnjatic, Patrick Hwu, Craig L Slingluff,

<h4>Background</h4>We performed a clinical trial to evaluate safety and immunogenicity of a novel long peptide vaccine administered in combinations of incomplete Freund's adjuvant (IFA) and agonists for TLR3 (polyICLC) and TLR7/8 (resiquimod). We hypothesized that T cell responses to minimal epitope peptides (MEPs) within the long peptides would be enhanced ... Read more >>

J Immunother Cancer (Journal for immunotherapy of cancer)
[2021, 9(8):]

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Diversity of inhibitory and excitatory parvalbumin interneuron circuits in the dorsal horn.

Mark A Gradwell, Kieran A Boyle, Tyler J Browne, Andrew M Bell, Jacklyn Leonardo, Fernanda S Peralta Reyes, Allen C Dickie, Kelly M Smith, Robert J Callister, Christopher V Dayas, David I Hughes, Brett A Graham,

<h4>Abstract</h4>Parvalbumin-expressing interneurons (PVINs) in the spinal dorsal horn are found primarily in laminae II inner and III. Inhibitory PVINs (iPVINs) play an important role in segregating innocuous tactile input from pain-processing circuits through presynaptic inhibition of myelinated low-threshold mechanoreceptors and postsynaptic inhibition of distinct spinal circuits. By comparison, relatively little ... Read more >>

Pain (Pain)
[2021, :]

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Deafness in Australian Cattle Dogs associated to QTL on chromosome 20 in genome-wide association study analyses.

J M Seddon, M Fortes, M Kelly-Smith, S F Sommerlad, J J Hayward, L Burmeister, L De Risio, C Mellersh, J Freeman, G M Strain,

Pigment-associated deafness is a common hereditary condition in a range of dog breeds. The aim of this study was to perform a genome-wide association analysis to investigate the genetic architecture of deafness in Australian Cattle Dogs. Genotypes for 104 757 polymorphisms in 216 dogs were available for analyses after quality control. ... Read more >>

Anim Genet (Animal genetics)
[2021, 52(5):694-702]

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A New Normal.

Renee J Hinojosa, Deana Benefield, Amanda Dunn, Ashley Harper, Jennifer Lieb, Donna Paver, Karen Reay, Kelly Smith, Jade Hewlett,

Plast Surg Nurs (Plastic surgical nursing : official journal of the American Society of Plastic and Reconstructive Surgical Nurses)
[2021, 41(3):128-129]

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MrgprdCre lineage neurons mediate optogenetic allodynia through an emergent polysynaptic circuit.

Charles Warwick, Colleen Cassidy, Junichi Hachisuka, Margaret C Wright, Kyle M Baumbauer, Peter C Adelman, Kuan H Lee, Kelly M Smith, Tayler D Sheahan, Sarah E Ross, H Richard Koerber,

<h4>Abstract</h4>Most cutaneous C fibers, including both peptidergic and nonpeptidergic subtypes, are presumed to be nociceptors and respond to noxious input in a graded manner. However, mechanically sensitive, nonpeptidergic C fibers also respond to mechanical input in the innocuous range, so the degree to which they contribute to nociception remains unclear. ... Read more >>

Pain (Pain)
[2021, 162(7):2120-2131]

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Early intervention for inhibited young children: a randomized controlled trial comparing the Turtle Program and Cool Little Kids.

Andrea Chronis-Tuscano, Danielle R Novick, Christina M Danko, Kelly A Smith, Nicholas J Wagner, Christine H Wang, Lindsay Druskin, Lea R Dougherty, Kenneth H Rubin,

<h4>Background</h4>Children classified as behaviorally inhibited (BI) are at risk for social anxiety. Risk for anxiety is moderated by both parental behavior and social-emotional competence. Grounded in developmental-transactional theory, the Turtle Program involves both parent and child treatment components delivered within the peer context. Our pilot work demonstrated beneficial effects of ... Read more >>

J Child Psychol Psychiatry (Journal of child psychology and psychiatry, and allied disciplines)
[2021, :]

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Club, country and clinicians united: ensuring collaborative care in elite sport medical handovers.

Richard Weiler, Richard Collinge, Josh Ewens, Vincent Gouttebarge, Andrew Massey, Pippa Bennett, Kelly Smith, Osman Hassan Ahmed,

Br J Sports Med (British journal of sports medicine)
[2021, :]

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Spinoparabrachial projection neurons form distinct classes in the mouse dorsal horn.

Tyler J Browne, Kelly M Smith, Mark A Gradwell, Jacqueline A Iredale, Christopher V Dayas, Robert J Callister, David I Hughes, Brett A Graham,

<h4>Abstract</h4>Projection neurons in the spinal dorsal horn relay sensory information to higher brain centres. The activation of these populations is shaped by afferent input from the periphery, descending input from the brain, and input from local interneuron circuits. Much of our recent understanding of dorsal horn circuitry comes from studies ... Read more >>

Pain (Pain)
[2021, 162(7):1977-1994]

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Utility of abdominal skin punch biopsy for detecting systemic amyloidosis.

Bicong Wu, Daniel M Pak, Kelly D Smith, Michi M Shinohara,

<h4>Background</h4>Early and accurate diagnosis of systemic amyloidosis (SA) is critical for optimal patient outcomes. Biopsy of clinically uninvolved skin and subcutaneous tissue including abdominal skin punch biopsy (ASPB) is often used as a surrogate for affected organ sampling. There is a lack of published data on the sensitivity and specificity ... Read more >>

J Cutan Pathol (Journal of cutaneous pathology)
[2021, :]

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Getting to the Heart of Left-Right Asymmetry: Contributions from the Zebrafish Model.

Kelly A Smith, Veronica Uribe,

The heart is laterally asymmetric. Not only is it positioned on the left side of the body but the organ itself is asymmetric. This patterning occurs across scales: at the organism level, through left-right axis patterning; at the organ level, where the heart itself exhibits left-right asymmetry; at the cellular ... Read more >>

J Cardiovasc Dev Dis (Journal of cardiovascular development and disease)
[2021, 8(6):]

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Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial.

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<h4>Background</h4>Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19.<h4>Methods</h4>This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised ... Read more >>

Lancet (Lancet (London, England))
[2021, 397(10289):2049-2059]

Cited: 27 times

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Early Transplant Arteriopathy in Kidney Transplantation.

Carrie Minnelli, Maziar Riazy, Ryuji Ohashi, Jolanta Kowalewska, Nicolae Leca, Behzad Najafian, Kelly D Smith, Roberto F Nicosia, Charles E Alpers, Shreeram Akilesh,

<h4>Background</h4>Early dysfunction of renal allografts may be associated with vascular injury, which raises the specter of active rejection processes that require medical intervention. In our practice, we have encountered patients who present with delayed graft function and demonstrate a unique pattern of endothelial cell injury that raises concern for rejection ... Read more >>

Transplant Proc (Transplantation proceedings)
[2021, 53(5):1554-1561]

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Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.

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<h4>Background</h4>In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation.<h4>Methods</h4>This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. Those ... Read more >>

Lancet (Lancet (London, England))
[2021, 397(10285):1637-1645]

Cited: 107 times

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Pathogenesis of coronavirus disease 2019-associated kidney injury.

Kelly D Smith, Shreeram Akilesh,

<h4>Purpose of review</h4>The current review summarizes the pathologic findings in kidneys from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients who have had autopsies or undergone biopsy, and the pathogenic mechanisms implicated in coronavirus disease 2019 (COVID-19)-associated kidney diseases.<h4>Recent findings</h4>Direct infection of the kidney by SARS-CoV-2 is not common, and ... Read more >>

Curr Opin Nephrol Hypertens (Current opinion in nephrology and hypertension)
[2021, 30(3):324-331]

Cited: 1 time

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Peer Influence during Adolescence: The Moderating Role of Parental Support.

Mazneen Havewala, Julie C Bowker, Kelly A Smith, Linda Rose-Krasnor, Cathryn Booth-LaForce, Brett Laursen, Julia W Felton, Kenneth H Rubin,

Although many studies show that peers influence the development of adolescent internalizing and externalizing difficulties, few have considered both internalizing and externalizing difficulties in the same study, and fewer have considered the contributions of parents. Using a longitudinal sample of 385 adolescents, the contributions of best friends' internalizing and externalizing ... Read more >>

Children (Basel) (Children (Basel, Switzerland))
[2021, 8(4):]

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Operational Impacts of the Coronavirus Disease 2019 (COVID-19) Pandemic and Early Recovery Trends: University of Washington Anatomic Pathology Experience.

Timothy Isaac Miller, Kelly D Smith, Luis Francisco Gonzalez-Cuyar, Paul E Swanson,

<h4>Context.—</h4>The coronavirus disease 2019 pandemic, caused by the novel coronavirus severe acute respiratory syndrome coronavirus 2, has resulted in worldwide disruption to the delivery of patient care. The Seattle, Washington metropolitan area was one of the first in the United States affected by the pandemic. As a result, the anatomic ... Read more >>

Arch Pathol Lab Med (Archives of pathology & laboratory medicine)
[2021, 145(4):399-406]

Cited: 2 times

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The zebrafish grime mutant uncovers an evolutionarily conserved role for Tmem161b in the control of cardiac rhythm.

Charlotte D Koopman, Jessica De Angelis, Swati P Iyer, Arie O Verkerk, Jason Da Silva, Geza Berecki, Angela Jeanes, Gregory J Baillie, Scott Paterson, Veronica Uribe, Ophelia V Ehrlich, Samuel D Robinson, Laurence Garric, Steven Petrou, Cas Simons, Irina Vetter, Benjamin M Hogan, Teun P de Boer, Jeroen Bakkers, Kelly A Smith,

The establishment of cardiac function in the developing embryo is essential to ensure blood flow and, therefore, growth and survival of the animal. The molecular mechanisms controlling normal cardiac rhythm remain to be fully elucidated. From a forward genetic screen, we identified a unique mutant, <i>grime,</i> that displayed a specific ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(9):]

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A phase 1 study of NY-ESO-1 vaccine + anti-CTLA4 antibody Ipilimumab (IPI) in patients with unresectable or metastatic melanoma.

Craig L Slingluff, Hassane M Zarour, Hussein Abdul-Hassan Tawbi, John M Kirkwood, Michael A Postow, Philip Friedlander, Craig E Devoe, Elizabeth M Gaughan, Ileana S Mauldin, Walter C Olson, Kelly T Smith, Mary J Macri, Toni Ricciardi, Aileen Ryan, Ralph Venhaus, Jedd D Wolchok,

Ipilimumab (IPI) can enhance immunity to the cancer-testis antigen NY-ESO-1. A clinical trial was designed to assess safety, immunogenicity, and clinical responses with IPI + NY-ESO-1 vaccines and effects on the tumor microenvironment (TME). Patients with measurable NY-ESO-1<sup>+</sup> tumors were enrolled among three arms: A) IPI + NY-ESO-1 protein + ... Read more >>

Oncoimmunology (Oncoimmunology)
[2021, 10(1):1898105]

Cited: 1 time

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Routine Use of Tenecteplase for Thrombolysis in Acute Ischemic Stroke.

Cathy S Zhong, James Beharry, Daniel Salazar, Kelly Smith, Stephen Withington, Bruce C V Campbell, Duncan Wilson, Campbell Le Heron, Deborah Mason, Roderick Duncan, Jon Reimers, Frances Mein-Smith, William K Diprose, P Alan Barber, Annemarei Ranta, John N Fink, Teddy Y Wu,

<h4>Background and purpose</h4>In ischemic stroke, intravenous tenecteplase is noninferior to alteplase in selected patients and has some practical advantages. Several stroke centers in New Zealand changed to routine off-label intravenous tenecteplase due to improved early recanalization in large vessel occlusion, inconsistent access to thrombectomy within stroke networks, and for consistency ... Read more >>

Stroke (Stroke)
[2021, 52(3):1087-1090]

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Muscle-specific Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle

Harriet Lo, Ye-Wheen Lim, Zherui Xiong, Nick Martel, Charles Ferguson, Nicholas Ariotti, Jean Giacomotto, James Rae, Matthias Floetenmeyer, Shayli Varasteh Moradi, Ya Gao, Vikas Tillu, Di Xia, Huang Wang, Samira Rahnama, Susan Nixon, Michele Bastiani, Ryan Day, Kelly Smith, Nathan Palpant, Wayne Johnston, Kirill Alexandrov, Brett Collins, Thomas Hall, Robert Parton,

<h4>Summary</h4> The cavin proteins are essential for caveola biogenesis and function. Here, we identify a role for the muscle-specific component, Cavin4, in skeletal muscle T-tubule development by analyzing two vertebrate systems: mouse and zebrafish. In both models Cavin4 localized to T-tubules and loss of Cavin4 resulted in aberrant T-tubule maturation. ... Read more >>

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Altered Mental Status After Esophagogastroduodenoscopy.

Joshua D Lee, Daniel F Gallego, James Malleis, Kelly D Smith, Andrew M Luks, Desiree A Marshall,

<h4>Case presentation</h4>A 79-year-old man with medical history of atrial fibrillation and esophageal cancer status post trans-hiatal esophageal resection and chemotherapy presented with altered mental status after outpatient esophagogastroduodenoscopy (EGD). One month before presentation, the patient was seen at another hospital with severe anemia and melena requiring transfusion of multiple units ... Read more >>

Chest (Chest)
[2021, 159(2):e75-e79]

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