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Author Keisuke Shigeta

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Site-specific differences in survival among upper and lower tract urothelial carcinoma patients treated with radical surgery.

Tadatsugu Anno, Eiji Kikuchi, Keisuke Shigeta, Koichiro Ogihara, Keitaro Watanabe, Yoshinori Yanai, Kimiharu Takamatsu, Shintaro Hasegawa, Takeshi Masuda, Masafumi Oyama, Ryuichi Mizuno, Mototsugu Oya,

<h4>Background</h4>It currently remains unclear whether the location of primary tumours affects the clinical outcomes of patients with locally advanced urothelial carcinoma in the urinary tract. The aim of the present study was to compare prognostic differences between bladder urothelial carcinoma and upper tract urothelial carcinoma, particularly pT3 or higher tumours.<h4>Methods</h4>In ... Read more >>

Jpn J Clin Oncol (Japanese journal of clinical oncology)
[2021, 51(6):984-991]

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Guideline adherence for radical cystectomy significantly affects survival outcomes in non-muscle-invasive bladder cancer patients.

Emina Kayama, Keisuke Shigeta, Eiji Kikuchi, Koichiro Ogihara, Kyohei Hakozaki, Tomohiro Iwasawa, Ken Kamisawa, Kunimitsu Kanai, Hiroki Ide, Satoshi Hara, Ryuichi Mizuno, Mototsugu Oya,

<h4>Background</h4>The relationship between guideline adherence for radical cystectomy of non-muscle-invasive bladder cancer and patient prognoses currently remains unclear. We investigated whether guideline adherence at the time of non-muscle-invasive bladder cancer affects the oncological outcomes of bladder cancer patients who underwent radical cystectomy.<h4>Methods</h4>Among 267 cTa-4N0-2M0 bladder cancer patients, 70 who underwent ... Read more >>

Jpn J Clin Oncol (Japanese journal of clinical oncology)
[2021, :]

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Role of Previous Malignancy History in Clinical Outcomes in Patients with Initially Diagnosed Non-Muscle Invasive Bladder Cancer.

Ryohei Kufukihara, Eiji Kikuchi, Koichiro Ogihara, Keisuke Shigeta, Yoshinori Yanai, Kimiharu Takamatsu, Hiroki Ide, Masafumi Oyama, Hirotaka Asakura, Ryuichi Mizuno, Mototsugu Oya,

<h4>Introduction</h4>Our aim is to evaluate whether previous non-urothelial malignant history affects the clinical outcomes of patients with non-muscle invasive bladder cancer (NMIBC).<h4>Patients and methods</h4>We identified 1097 cases treated by transurethral resection of bladder tumors for initially diagnosed NMIBC at our four institutions between 1999 and 2017. We compared clinical characteristics ... Read more >>

Ann Surg Oncol (Annals of surgical oncology)
[2021, :]

Cited: 1 time

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ASO Author Reflections: Previous History of Non-urothelial Malignancy May Provide Predictive Information of Worse Clinical Outcome for Initially Diagnosed Non-Muscle Invasive Bladder Cancer.

Ryohei Kufukihara, Eiji Kikuchi, Koichiro Ogihara, Keisuke Shigeta, Mototsugu Oya,

Ann Surg Oncol (Annals of surgical oncology)
[2021, :]

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A comparison of perioperative outcomes of laparoscopic versus open nephroureterectomy for upper tract urothelial carcinoma: a propensity score matching analysis.

Luca Afferi, Mohammad Abufaraj, Francesco Soria, David D'Andrea, Evanguelos Xylinas, Thomas Seisen, Morgan Roupret, Chiara Lonati, Alexandre De la Taille, Benoit Peyronnet, Ekaterina Laukhtina, Benjamin Pradere, Andrea Mari, Wojciech Krajewski, Mario Alvarez-Maestro, Eiji Kikuchi, Keisuke Shigeta, Piotr Chlosta, Francesco Montorsi, Alberto Briganti, Giuseppe Simone, Paola I Ornaghi, Maria Angela Cerruto, Alessandro Antonelli, Kazumasa Matsumoto, Pierre I Karakiewicz, Livio Mordasini, Agostino Mattei, Shahrokh F Shariat, Marco Moschini,

<h4>Background</h4>Radical nephroureterectomy (RNU) with the concomitant excision of the distal ureter and bladder cuff is the current standard of care for the treatment of muscle invasive and/or high-risk upper tract urothelial carcinoma (UTUC). In small uncontrolled studies, laparoscopic RNU has been suggested to be associated with better perioperative outcomes compared ... Read more >>

Minerva Urol Nefrol (Minerva urologica e nefrologica = The Italian journal of urology and nephrology)
[2021, :]

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Significance of prophylactic urethrectomy at the time of radical cystectomy for bladder cancer.

Kyohei Hakozaki, Eiji Kikuchi, Koichiro Ogihara, Keisuke Shigeta, Takayuki Abe, Yasumasa Miyazaki, Gou Kaneko, Takahiro Maeda, Shunsuke Yoshimine, Kunimitsu Kanai, Hiroki Ide, Suguru Shirotake, Masafumi Oyama, Ryuichi Mizuno, Mototsugu Oya,

<h4>Background</h4>Prophylactic urethrectomy at the time of radical cystectomy is frequently recommended for patients with bladder cancer at a high risk of urethral recurrence without definitive evidence. The present study attempted to clarify the survival benefits of performing prophylactic urethrectomy.<h4>Methods</h4>We identified 214 male patients who were treated by radical cystectomy with ... Read more >>

Jpn J Clin Oncol (Japanese journal of clinical oncology)
[2021, 51(2):287-295]

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The clinicopathological characteristics of muscle-invasive bladder recurrence in upper tract urothelial carcinoma.

Keisuke Shigeta, Kazuhiro Matsumoto, Koichiro Ogihara, Tetsushi Murakami, Tadatsugu Anno, Kota Umeda, Mizuki Izawa, Yuto Baba, Tansei Sanjo, Kazunori Shojo, Nobuyuki Tanaka, Toshikazu Takeda, Takeo Kosaka, Ryuichi Mizuno, Shuji Mikami, Eiji Kikuchi, Mototsugu Oya,

This study aimed to clarify the clinical characteristics and oncological outcomes of patients with upper tract urothelial carcinoma (UTUC) who developed muscle-invasive bladder cancer (MIBC) after radical nephroureterectomy (RNU). We identified 966 pTa-4N0-2M0 patients with UTUC who underwent RNU and clarified the risk factors for MIBC progression after initial intravesical ... Read more >>

Cancer Sci (Cancer science)
[2021, 112(3):1084-1094]

Cited: 1 time

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Evaluating the Oncological Outcomes of Pure Laparoscopic Radical Nephroureterectomy Performed for Upper-Tract Urothelial Carcinoma Patients: A Multicenter Cohort Study Adjusted by Propensity Score Matching.

Keisuke Shigeta, Kazuhiro Matsumoto, Toshikazu Takeda, Seiya Hattori, Gou Kaneko, Masashi Matsushima, Takayuki Abe, Nobuyuki Tanaka, Ryuichi Mizuno, Hiroshi Asanuma, Eiji Kikuchi, Mototsugu Oya,

<h4>Purpose</h4>To evaluate the oncological feasibility of pure laparoscopic radical nephroureterectomy (p-LRNU) for upper tract urothelial carcinoma (UTUC) compared with conventional LRNU (c-LRNU) using a propensity-adjusted multi-institutional collaboration dataset.<h4>Methods</h4>Among the 503 UTUC patients who underwent RNU, we identified 219 who underwent c-LRNU (laparoscopic nephrectomy with open bladder cuff resection) and 72 ... Read more >>

Ann Surg Oncol (Annals of surgical oncology)
[2021, 28(1):465-473]

Cited: 2 times

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Conditional Survival and Time of Biochemical Recurrence of Localized Prostate Cancer in Japanese Patients Undergoing Laparoscopic Radical Prostatectomies.

Masayoshi Kawakami, Masanori Hasegawa, Koichiro Yamada, Keisuke Shigeta, Izumi Hanada, Tatsuya Otaki, Kentaro Nagao, Tatsuya Umemoto, Yuuki Shimizu, Hakushi Kim, Nobuyuki Nakajima, Masahiro Nitta, Kazuya Hanai, Yoshiaki Kawamura, Sunao Shoji, Akira Miyajima,

<h4>Purpose</h4>Using conditional survival (CS) analysis, we investigated whether the duration of survival without biochemical recurrence (BCR) of prostate cancer after laparoscopic radical prostatectomies (LRP) affected the BCR rate. We also investigated the impact of well-known risk factors for BCR.<h4>Methods</h4>Between 2002 and 2014, 627 consecutive patients underwent LRPs at our institution. ... Read more >>

Ann Surg Oncol (Annals of surgical oncology)
[2021, 28(2):1247-1253]

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Clinical utility of the Vesical Imaging-Reporting and Data System for muscle-invasive bladder cancer between radiologists and urologists based on multiparametric MRI including 3D FSE T2-weighted acquisitions.

Yuki Arita, Keisuke Shigeta, Hirotaka Akita, Tatsuya Suzuki, Ryohei Kufukihara, Thomas C Kwee, Ryota Ishii, Shuji Mikami, Shigeo Okuda, Eiji Kikuchi, Mototsugu Oya, Masahiro Jinzaki,

<h4>Objectives</h4>To investigate the clinical utility of the Vesical Imaging-Reporting and Data System (VI-RADS) by comparing its diagnostic performance for muscle-invasive bladder cancer (MIBC) between radiologists and urologists based on multiparametric MRI, including three-dimensional (3D) fast spin-echo (FSE) T2-weighted acquisitions.<h4>Methods</h4>This study included 66 treatment-naïve patients (60 men, 6 women; mean age ... Read more >>

Eur Radiol (European radiology)
[2021, 31(2):875-883]

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Relationship between radiation doses and erectile function deterioration in patients with localized prostate cancer treated with permanent prostate brachytherapy.

Keisuke Shigeta, Eiji Kikuchi, Masashi Matsushima, Koichiro Ogihara, Takeo Kosaka, Ryuichi Mizuno, Tomoki Tanaka, Naoyuki Shigematsu, Mototsugu Oya,

<h4>Objectives</h4>To investigate the relationship between radiation doses in prostate brachytherapy and deterioration of erectile function in patients with localized prostate cancer.<h4>Methods</h4>A longitudinal survey study was carried out among 261 prostate cancer patients who received prostate brachytherapy. A total of 48 patients were potent at baseline and they did not receive ... Read more >>

Int J Urol (International journal of urology : official journal of the Japanese Urological Association)
[2020, 27(12):1087-1093]

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ASO Author Reflections: Discussing the Oncological Feasibility of Performing Pure Laparoscopic Radical Nephroureterectomy for Upper-Tract Urothelial Carcinoma Patients: Results from a Multi-institution Collaborative Study Adjusted by Propensity Score Matching.

Keisuke Shigeta, Kazuhiro Matsumoto, Mototsugu Oya,

Ann Surg Oncol (Annals of surgical oncology)
[2021, 28(1):474-475]

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Role of the MUC1-C oncoprotein in the acquisition of cisplatin resistance by urothelial carcinoma.

Keisuke Shigeta, Masanori Hasegawa, Eiji Kikuchi, Yota Yasumizu, Takeo Kosaka, Ryuichi Mizuno, Shuji Mikami, Akira Miyajima, Donald Kufe, Mototsugu Oya,

Mucin 1 C-terminal subunit (MUC1-C) has been introduced as a key regulator for acquiring drug resistance in various cancers, but the functional role of MUC1-C in urothelial carcinoma (UC) cells remains unknown. We aimed to elucidate the molecular mechanisms underlying the acquisition of cisplatin (CDDP) resistance through MUC1-C oncoprotein in ... Read more >>

Cancer Sci (Cancer science)
[2020, 111(10):3639-3652]

Cited: 2 times

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Risk for intravesical recurrence of bladder cancer stratified by the results on two consecutive UroVysion fluorescence in situ hybridization tests: a prospective follow-up study in Japan.

Atsushi Ikeda, Takahiro Kojima, Koji Kawai, Shiro Hinotsu, Naoto Keino, Kenichiro Shiga, Hideaki Miyake, Yasuyoshi Miyata, Yutaka Enomoto, Fumitaka Shimizu, Satoshi Anai, Hideyasu Matsuyama, Chieko Suzuki, Yusuke Kanimoto, Keisuke Shigeta, Seiji Naito, Hideyuki Akaza, Hiroyuki Nishiyama,

<h4>Background</h4>A previous comparative study in Japan has demonstrated that the two consecutive UroVysion tests are useful tools to detect the presence of bladder cancer during follow-up after transurethral resection, but they also presented their high rates of false-positive results. Here, we aimed to evaluate the relationship between the UroVysion tests ... Read more >>

Int J Clin Oncol (International journal of clinical oncology)
[2020, 25(6):1163-1169]

Cited: 3 times

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The pretreatment neutrophil-to-lymphocyte ratio is a novel biomarker for predicting clinical responses to pembrolizumab in platinum-resistant metastatic urothelial carcinoma patients.

Koichiro Ogihara, Eiji Kikuchi, Keisuke Shigeta, Takashi Okabe, Seiya Hattori, Ryo Yamashita, Shunsuke Yoshimine, Suguru Shirotake, Ryuto Nakazawa, Kazuhiro Matsumoto, Ryuichi Mizuno, Satoshi Hara, Masafumi Oyama, Takeshi Masuda, Masashi Niwakawa, Mototsugu Oya,

<h4>Purpose</h4>We investigated the relationship between pretreatment neutrophil-to-lymphocyte ratio (pre-NLR) levels just before the initiation of treatment with pembrolizumab and clinical outcomes in platinum-resistant metastatic urothelial carcinoma (UC) patients treated with pembrolizumab.<h4>Methods</h4>Our study population comprised 78 patients diagnosed with metastatic UC and treated with pembrolizumab after platinum-based chemotherapy at our institutions ... Read more >>

Urol Oncol (Urologic oncology)
[2020, 38(6):602.e1-602.e10]

Cited: 3 times

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The efficacy of the TachoSil binding suturing technique in laparoscopic partial nephrectomy to prevent the development of pseudoaneurysm.

Keisuke Shigeta, Kazuhiro Matsumoto, Takayuki Abe, Akari Komatsuda, Toshikazu Takeda, Ryuichi Mizuno, Eiji Kikuchi, Hiroshi Asanuma, Yuki Arita, Hirotaka Akita, Masahiro Jinzaki, Akira Miyajima, Mototsugu Oya,

OBJECTIVE:Our specific aim was to introduce the TachoSil binding suturing technique for renal cell carcinoma (RCC) patients when closing the parenchymal defect after tumor excision during laparoscopic partial nephrectomy (LPN), which is a novel technique for reducing the risk of developing subsequent pseudoaneurysm (PA). METHODS:We identified 113 pT1aN0M0 RCC patients ... Read more >>

Asian J Surg (Asian journal of surgery)
[2020, 43(6):668-675]

Cited: 1 time

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Bacillus Calmette-Guérin-unresponsive non-muscle-invasive bladder cancer: Its definition and future therapeutic strategies.

Eiji Kikuchi, Nozomi Hayakawa, Keishiro Fukumoto, Keisuke Shigeta, Kazuhiro Matsumoto,

Bacillus Calmette-Guérin induction with or without maintenance is the gold standard therapy for intermediate-/high-risk non-muscle-invasive bladder cancer; however, one-third of patients treated with adequate bacillus Calmette-Guérin therapy do not achieve sufficient responses, and this is referred to as "bacillus Calmette-Guérin failure." The term, bacillus Calmette-Guérin failure, is ambiguous and includes ... Read more >>

Int J Urol (International journal of urology : official journal of the Japanese Urological Association)
[2020, 27(2):108-116]

Cited: 2 times

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Long-Term Oncologic Outcomes of Laparoscopic Versus Open Radical Nephroureterectomy for Patients with T3N0M0 Upper Tract Urothelial Carcinoma: A Multicenter Cohort Study with Adjustment by Propensity Score Matching.

Keisuke Shigeta, Eiji Kikuchi, Takayuki Abe, Masayuki Hagiwara, Koichiro Ogihara, Tadanori Anno, Kota Umeda, Yuto Baba, Tansei Sanjo, Kazunori Shojo, Ryuichi Mizuno, Mototsugu Oya,

<h4>Background</h4>This study aimed to investigate the long-term oncologic outcomes of laparoscopic radical nephroureterectomy (LRNU) and open radical nephroureterectomy (ORNU) for patients with clinical and pathologic T3N0M0 upper tract urothelial carcinoma (UTUC).<h4>Methods</h4>Among 375 UTUC patients who underwent radical nephroureterectomy, this study identified 144 pT3N0M0 patients as cohort 1 after propensity score ... Read more >>

Ann Surg Oncol (Annals of surgical oncology)
[2019, 26(11):3774-3781]

Cited: 1 time

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ASO Author Reflections: Could Laparoscopic Surgery Have the Same Long-Term Oncological Outcomes as Open Radical Nephroureterectomy in T3N0M0 Upper Tract Urothelial Carcinoma? A Multicenter Cohort Study Adjusted by Propensity Score Matching.

Keisuke Shigeta, Eiji Kikuchi, Mototsugu Oya,

Ann Surg Oncol (Annals of surgical oncology)
[2019, 26(Suppl 3):815-816]

Cited: 0 times

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A Novel Risk-based Approach Simulating Oncological Surveillance After Radical Nephroureterectomy in Patients with Upper Tract Urothelial Carcinoma.

Keisuke Shigeta, Eiji Kikuchi, Takayuki Abe, Masayuki Hagiwara, Koichiro Ogihara, Tadatsugu Anno, Kota Umeda, Yuto Baba, Tansei Sanjo, Kazunori Shojo, Shuji Mikami, Ryuichi Mizuno, Mototsugu Oya,

<h4>Background</h4>The current guideline lacks evidence for creating individualized surveillance strategies for upper tract urothelial carcinoma (UTUC) patients after radical nephroureterectomy (RNU).<h4>Objective</h4>To create a novel risk model and to simulate individualized surveillance duration that dynamically illustrates the changing risk relationship of UTUC-related death and non-UTUC death, considering the impact of cigarette ... Read more >>

Eur Urol Oncol (European urology oncology)
[2020, 3(6):756-763]

Cited: 1 time

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Accidental Hypothermia Treated by Hemodialysis in the Acute Phase: Three Case Reports and a Review of the Literature.

Tetsushi Murakami, Tadashi Yoshida, Arata Kurokochi, Kimiharu Takamatsu, Yu Teranishi, Keisuke Shigeta, Satoshi Tamaki, Shinya Morita, Ryuichi Mizuno, Mototsugu Oya,

Accidental hypothermia is defined as a core body temperature <35°C. Even with the use of multiple active rewarming methods, it has a high mortality rate. No standard treatment strategy for moderate or severe hypothermia in the absence of cardiac arrest has yet been established. We herein report three patients with ... Read more >>

Intern Med (Internal medicine (Tokyo, Japan))
[2019, 58(18):2743-2748]

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Correction to: Castration-resistant prostate cancer patients who had poor response on first androgen deprivation therapy would obtain certain clinical benefit from early docetaxel administration.

Keisuke Shigeta, Takeo Kosaka, Hiroshi Hongo, Yoshinori Yanai, Kazuhiro Matsumoto, Shinya Morita, Ryuichi Mizuno, Toshiaki Shinojima, Eiji Kikuchi, Mototsugu Oya,

The original article can be found online. ... Read more >>

Int J Clin Oncol (International journal of clinical oncology)
[2019, 24(5):554-556]

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Castration-resistant prostate cancer patients who had poor response on first androgen deprivation therapy would obtain certain clinical benefit from early docetaxel administration.

Keisuke Shigeta, Takeo Kosaka, Hiroshi Hongo, Yoshinori Yanai, Kazuhiro Matsumoto, Shinya Morita, Ryuichi Mizuno, Toshiaki Shinojima, Eiji Kikuchi, Mototsugu Oya,

<h4>Background</h4>Our specific aim was to investigate the prognostic value of effective duration of first androgen deprivation therapy (ADT) and to evaluate the clinical impact on early docetaxel administration with oncological outcomes in castration-resistant prostate cancer (CRPC) patients treated with docetaxel.<h4>Methods</h4>We identified 148 mCRPC patients who were treated with 75 mg/m<sup>2</sup> docetaxel. ... Read more >>

Int J Clin Oncol (International journal of clinical oncology)
[2019, 24(5):546-553]

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Rare association of the anterior and posterior urethral valves.

Tetsushi Murakami, Hiroshi Asanuma, Keisuke Shigeta, Taisuke Ezaki, Mototsugu Oya,

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2018, 60(12):1090-1091]

Cited: 0 times

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The Conditional Survival with Time of Intravesical Recurrence of Upper Tract Urothelial Carcinoma.

Keisuke Shigeta, Eiji Kikuchi, Masayuki Hagiwara, Toshiyuki Ando, Ryuichi Mizuno, Takayuki Abe, Shuji Mikami, Akira Miyajima, Ken Nakagawa, Mototsugu Oya,

<h4>Purpose</h4>Since conditional survival analysis provides better estimates of survival time at each followup, we assessed changes in conditional intravesical recurrence-free survival rates after radical nephroureterectomy. We also sought to determine how the impact of well-known risk factors evolves with time, particularly in patients with localized upper tract urothelial carcinoma.<h4>Materials and ... Read more >>

J Urol (The Journal of urology)
[2017, 198(6):1278-1285]

Cited: 7 times

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