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New insights into atypical Alzheimer's disease in the era of biomarkers.

Jonathan Graff-Radford, Keir X X Yong, Liana G Apostolova, Femke H Bouwman, Maria Carrillo, Bradford C Dickerson, Gil D Rabinovici, Jonathan M Schott, David T Jones, Melissa E Murray,

Most patients with Alzheimer's disease present with amnestic problems; however, a substantial proportion, over-represented in young-onset cases, have atypical phenotypes including predominant visual, language, executive, behavioural, or motor dysfunction. In the past, these individuals often received a late diagnosis; however, availability of CSF and PET biomarkers of Alzheimer's disease pathologies ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):222-234]

Cited: 0 times

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Augmenting Dementia Cognitive Assessment With Instruction-Less Eye-Tracking Tests.

Kyriaki Mengoudi, Daniele Ravi, Keir X X Yong, Silvia Primativo, Ivanna M Pavisic, Emilie Brotherhood, Kirsty Lu, Jonathan M Schott, Sebastian J Crutch, Daniel C Alexander,

Eye-tracking technology is an innovative tool that holds promise for enhancing dementia screening. In this work, we introduce a novel way of extracting salient features directly from the raw eye-tracking data of a mixed sample of dementia patients during a novel instruction-less cognitive test. Our approach is based on self-supervised ... Read more >>

IEEE J Biomed Health Inform (IEEE journal of biomedical and health informatics)
[2020, 24(11):3066-3075]

Cited: 1 time

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Analyzing large Alzheimer's disease cognitive datasets: Considerations and challenges.

Maura Bellio, Neil P Oxtoby, Zuzana Walker, Susie Henley, Annemie Ribbens, Ann Blandford, Daniel C Alexander, Keir X X Yong,

Recent data-sharing initiatives of clinical and preclinical Alzheimer's disease (AD) have led to a growing number of non-clinical researchers analyzing these datasets using modern data-driven computational methods. Cognitive tests are key components of such datasets, representing the principal clinical tool to establish phenotypes and monitor symptomatic progression. Despite the potential ... Read more >>

Alzheimers Dement (Amst) (Alzheimer's & dementia (Amsterdam, Netherlands))
[2020, 12(1):e12135]

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Effects of lighting variability on locomotion in posterior cortical atrophy.

Keir X X Yong, Ian D McCarthy, Teresa Poole, Dilek Ocal, Ayako Suzuki, Tatsuto Suzuki, Kyriaki Mengoudi, Nikolaos Papadosifos, Derrick Boampong, Nick Tyler, Chris Frost, Sebastian J Crutch,

<h4>Introduction</h4>Clinical reports describe patients with Alzheimer's disease (AD) exhibiting atypical adaptive walking responses to the visual environment; however, there is limited empirical investigation of such behaviors or factors modulating their expression. We aim to evaluate effects of lighting-based interventions and clinical presentation (visual- vs memory-led) on walking function in participants ... Read more >>

Alzheimers Dement (N Y) (Alzheimer's & dementia (New York, N. Y.))
[2020, 6(1):e12077]

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Impairments of auditory scene analysis in posterior cortical atrophy.

Chris J D Hardy, Keir X X Yong, Johanna C Goll, Sebastian J Crutch, Jason D Warren,

Although posterior cortical atrophy is often regarded as the canonical 'visual dementia', auditory symptoms may also be salient in this disorder. Patients often report particular difficulty hearing in busy environments; however, the core cognitive process-parsing of the auditory environment ('auditory scene analysis')-has been poorly characterized. In this cross-sectional study, we ... Read more >>

Brain (Brain : a journal of neurology)
[2020, 143(9):2689-2695]

Cited: 1 time

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Sequences of cognitive decline in typical Alzheimer's disease and posterior cortical atrophy estimated using a novel event-based model of disease progression.

Nicholas C Firth, Silvia Primativo, Emilie Brotherhood, Alexandra L Young, Keir X X Yong, Sebastian J Crutch, Daniel C Alexander, Neil P Oxtoby,

<h4>Introduction</h4>This work aims to characterize the sequence in which cognitive deficits appear in two dementia syndromes.<h4>Methods</h4>Event-based modeling estimated fine-grained sequences of cognitive decline in clinically-diagnosed posterior cortical atrophy (PCA) ( n=94 ) and typical Alzheimer's disease (tAD) ( n=61 ) at the UCL Dementia Research Centre. Our neuropsychological battery assessed memory, ... Read more >>

Alzheimers Dement (Alzheimer's & dementia : the journal of the Alzheimer's Association)
[2020, 16(7):965-973]

Cited: 1 time

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Longitudinal neuroanatomical and cognitive progression of posterior cortical atrophy.

Nicholas C Firth, Silvia Primativo, Razvan-Valentin Marinescu, Timothy J Shakespeare, Aida Suarez-Gonzalez, Manja Lehmann, Amelia Carton, Dilek Ocal, Ivanna Pavisic, Ross W Paterson, Catherine F Slattery, Alexander J M Foulkes, Basil H Ridha, Eulogio Gil-Néciga, Neil P Oxtoby, Alexandra L Young, Marc Modat, M Jorge Cardoso, Sebastien Ourselin, Natalie S Ryan, Bruce L Miller, Gil D Rabinovici, Elizabeth K Warrington, Martin N Rossor, Nick C Fox, Jason D Warren, Daniel C Alexander, Jonathan M Schott, Keir X X Yong, Sebastian J Crutch,

Posterior cortical atrophy is a clinico-radiological syndrome characterized by progressive decline in visual processing and atrophy of posterior brain regions. With the majority of cases attributable to Alzheimer's disease and recent evidence for genetic risk factors specifically related to posterior cortical atrophy, the syndrome can provide important insights into selective ... Read more >>

Brain (Brain : a journal of neurology)
[2019, 142(7):2082-2095]

Cited: 9 times

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Retinal thickness as potential biomarker in posterior cortical atrophy and typical Alzheimer's disease.

Jurre den Haan, Lajos Csinscik, Tom Parker, Ross W Paterson, Catherine F Slattery, Alexander Foulkes, Femke H Bouwman, Frank D Verbraak, Philip Scheltens, Tunde Peto, Imre Lengyel, Jonathan M Schott, Sebastian J Crutch, Timothy J Shakespeare, Keir X X Yong,

<h4>Background</h4>Retinal thickness can be measured non-invasively with optical coherence tomography (OCT) and may offer compelling potential as a biomarker for Alzheimer's disease (AD). Retinal thinning is hypothesized to be a result of retrograde atrophy and/or parallel neurodegenerative processes. Changes in the visual pathway are of particular interest in posterior cortical ... Read more >>

Alzheimers Res Ther (Alzheimer's research & therapy)
[2019, 11(1):62]

Cited: 6 times

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Unusual Pattern of Reading Errors in a Patient with Posterior Cortical Atrophy.

Ivanna M Pavisic, Keir X X Yong, Silvia Primativo, Sebastian J Crutch, Aida Suarez Gonzalez,

Posterior cortical atrophy (PCA) is a degenerative condition characterized by a progressive deterioration of visual processing. Dyslexia constitutes an early and frequent visual symptom of the disease and previous comprehensive investigations in series of individuals have extensively documented a characteristic abundance of visual errors as the most prevalent error category ... Read more >>

Case Rep Neurol (Case reports in neurology)
[2019, 11(2):157-166]

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Health and social care practitioners' understanding of the problems of people with dementia-related visual processing impairment.

Anne McIntyre, Emma Harding, Keir X X Yong, Mary Pat Sullivan, Mary Gilhooly, Kenneth Gilhooly, Rachel Woodbridge, Sebastian Crutch,

It has been highlighted that health and social care staff need a greater awareness of the needs and problems of those people with young onset dementia in the UK. Symptoms of Alzheimer's disease are relatively well known (memory loss, disorientation, language difficulties and behavioural problems). However, there is less awareness ... Read more >>

Health Soc Care Community (Health & social care in the community)
[2019, 27(4):982-990]

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Differences in hippocampal subfield volume are seen in phenotypic variants of early onset Alzheimer's disease.

Thomas D Parker, Catherine F Slattery, Keir X X Yong, Jennifer M Nicholas, Ross W Paterson, Alexander J M Foulkes, Ian B Malone, David L Thomas, David M Cash, Sebastian J Crutch, Nick C Fox, Jonathan M Schott,

The most common presentation of early onset Alzheimer's disease (EOAD - defined as symptom onset <65 years) is with progressive episodic memory impairment - amnestic or typical Alzheimer's disease (tAD). However, EOAD is notable for its phenotypic heterogeneity, with posterior cortical atrophy (PCA) - characterised by prominent higher-order visual processing deficits ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2019, 21:101632]

Cited: 3 times

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ReadClear: An Assistive Reading Tool for People Living with Posterior Cortical Atrophy.

Aida Suarez-Gonzalez, Dilek Ocal, Ivanna Pavisic, Ashley Peacock, Michelle Naessens, Samrah Ahmed, Christopher R Butler, Alexander P Leff, Keir X X Yong, Sebastian J Crutch,

<h4>Background</h4>Progressive reading impairment is an early and debilitating symptom of posterior cortical atrophy (PCA) arising from the progressive deterioration of visual processing skills.<h4>Objective</h4>The goal of this study was to test the effectiveness of a purpose-built reading app (ReadClear) co-produced with people living with PCA and designed to reduce the reading ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2019, 71(4):1285-1295]

Cited: 0 times

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Navigational cue effects in Alzheimer's disease and posterior cortical atrophy.

Keir X X Yong, Ian D McCarthy, Teresa Poole, Tatsuto Suzuki, Biao Yang, Amelia M Carton, Catherine Holloway, Catherine Holloway, Nikolaos Papadosifos, Derrick Boampong, Julia Langham, Catherine F Slattery, Ross W Paterson, Alexander J M Foulkes, Jonathan M Schott, Chris Frost, Nick Tyler, Sebastian J Crutch,

<h4>Objective</h4>Deficits in spatial navigation are characteristic and disabling features of typical Alzheimer's disease (tAD) and posterior cortical atrophy (PCA). Visual cues have been proposed to mitigate such deficits; however, there is currently little empirical evidence for their use.<h4>Methods</h4>The effect of visual cues on visually guided navigation was assessed within a ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2018, 5(6):697-709]

Cited: 4 times

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'Because my brain isn't as active as it should be, my eyes don't always see': a qualitative exploration of the stress process for those living with posterior cortical atrophy.

Emma Harding, Mary Pat Sullivan, Rachel Woodbridge, Keir X X Yong, Anne McIntyre, Mary L Gilhooly, Kenneth J Gilhooly, Sebastian J Crutch,

OBJECTIVES:To explore the stress process for individuals living with posterior cortical atrophy (PCA) and their families. DESIGN:A qualitative study using in-depth semi-structured dyadic and individual interviews with people living with a diagnosis of PCA and a family carer. Interview transcripts were thematically analysed. SETTING:Participants' homes. PARTICIPANTS:20 individuals in the mild ... Read more >>

BMJ Open (BMJ open)
[2018, 8(2):e018663]

Cited: 2 times

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Eyetracking metrics reveal impaired spatial anticipation in behavioural variant frontotemporal dementia.

Silvia Primativo, Camilla Clark, Keir X X Yong, Nicholas C Firth, Jennifer Nicholas, Daniel Alexander, Jason D Warren, Jonathan D Rohrer, Sebastian J Crutch,

Eyetracking technology has had limited application in the dementia field to date, with most studies attempting to discriminate syndrome subgroups on the basis of basic oculomotor functions rather than higher-order cognitive abilities. Eyetracking-based tasks may also offer opportunities to reduce or ameliorate problems associated with standard paper-and-pencil cognitive tests such ... Read more >>

Neuropsychologia (Neuropsychologia)
[2017, 106:328-340]

Cited: 2 times

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Eyetracking Metrics in Young Onset Alzheimer's Disease: A Window into Cognitive Visual Functions.

Ivanna M Pavisic, Nicholas C Firth, Samuel Parsons, David Martinez Rego, Timothy J Shakespeare, Keir X X Yong, Catherine F Slattery, Ross W Paterson, Alexander J M Foulkes, Kirsty Macpherson, Amelia M Carton, Daniel C Alexander, John Shawe-Taylor, Nick C Fox, Jonathan M Schott, Sebastian J Crutch, Silvia Primativo,

Young onset Alzheimer's disease (YOAD) is defined as symptom onset before the age of 65 years and is particularly associated with phenotypic heterogeneity. Atypical presentations, such as the clinic-radiological visual syndrome posterior cortical atrophy (PCA), often lead to delays in accurate diagnosis. Eyetracking has been used to demonstrate basic oculomotor impairments ... Read more >>

Front Neurol (Frontiers in neurology)
[2017, 8:377]

Cited: 4 times

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Consensus classification of posterior cortical atrophy.

Sebastian J Crutch, Jonathan M Schott, Gil D Rabinovici, Melissa Murray, Julie S Snowden, Wiesje M van der Flier, Bradford C Dickerson, Rik Vandenberghe, Samrah Ahmed, Thomas H Bak, Bradley F Boeve, Christopher Butler, Stefano F Cappa, Mathieu Ceccaldi, Leonardo Cruz de Souza, Bruno Dubois, Olivier Felician, Douglas Galasko, Jonathan Graff-Radford, Neill R Graff-Radford, Patrick R Hof, Pierre Krolak-Salmon, Manja Lehmann, Eloi Magnin, Mario F Mendez, Peter J Nestor, Chiadi U Onyike, Victoria S Pelak, Yolande Pijnenburg, Silvia Primativo, Martin N Rossor, Natalie S Ryan, Philip Scheltens, Timothy J Shakespeare, Aida Suárez González, David F Tang-Wai, Keir X X Yong, Maria Carrillo, Nick C Fox, ,

<h4>Introduction</h4>A classification framework for posterior cortical atrophy (PCA) is proposed to improve the uniformity of definition of the syndrome in a variety of research settings.<h4>Methods</h4>Consensus statements about PCA were developed through a detailed literature review, the formation of an international multidisciplinary working party which convened on four occasions, and a ... Read more >>

Alzheimers Dement (Alzheimer's & dementia : the journal of the Alzheimer's Association)
[2017, 13(8):870-884]

Cited: 82 times

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The oral spelling profile of posterior cortical atrophy and the nature of the graphemic representation.

Silvia Primativo, Keir X X Yong, Timothy J Shakespeare, Sebastian J Crutch,

Spelling is a complex cognitive task where central and peripheral components are involved in engaging resources from many different cognitive processes. The present paper aims to both characterize the oral spelling deficit in a population of patients affected by a neurodegenerative condition and to clarify the nature of the graphemic ... Read more >>

Neuropsychologia (Neuropsychologia)
[2017, 94:61-74]

Cited: 3 times

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Corrigendum to "Intact reading in patients with profound early visual dysfunction" [Cortex 49 (9) (2013) 2294-2306].

Keir X X Yong, Jason D Warren, Elizabeth K Warrington, Sebastian J Crutch,

Cortex (Cortex; a journal devoted to the study of the nervous system and behavior)
[2016, :]

Cited: 0 times

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Effect of age at onset on cortical thickness and cognition in posterior cortical atrophy.

Aida Suárez-González, Manja Lehmann, Timothy J Shakespeare, Keir X X Yong, Ross W Paterson, Catherine F Slattery, Alexander J M Foulkes, Gil D Rabinovici, Eulogio Gil-Néciga, Florinda Roldán-Lora, Jonathan M Schott, Nick C Fox, Sebastian J Crutch,

Age at onset (AAO) has been shown to influence the phenotype of Alzheimer's disease (AD), but how it affects atypical presentations of AD remains unknown. Posterior cortical atrophy (PCA) is the most common form of atypical AD. In this study, we aimed to investigate the effect of AAO on cortical ... Read more >>

Neurobiol Aging (Neurobiology of aging)
[2016, 44:108-113]

Cited: 4 times

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Reduced modulation of scanpaths in response to task demands in posterior cortical atrophy.

Timothy J Shakespeare, Yoni Pertzov, Keir X X Yong, Jennifer Nicholas, Sebastian J Crutch,

A difficulty in perceiving visual scenes is one of the most striking impairments experienced by patients with the clinico-radiological syndrome posterior cortical atrophy (PCA). However whilst a number of studies have investigated perception of relatively simple experimental stimuli in these individuals, little is known about multiple object and complex scene ... Read more >>

Neuropsychologia (Neuropsychologia)
[2015, 68:190-200]

Cited: 5 times

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Facilitating text reading in posterior cortical atrophy.

Keir X X Yong, Kishan Rajdev, Timothy J Shakespeare, Alexander P Leff, Sebastian J Crutch,

<h4>Objective</h4>We report (1) the quantitative investigation of text reading in posterior cortical atrophy (PCA), and (2) the effects of 2 novel software-based reading aids that result in dramatic improvements in the reading ability of patients with PCA.<h4>Methods</h4>Reading performance, eye movements, and fixations were assessed in patients with PCA and typical ... Read more >>

Neurology (Neurology)
[2015, 85(4):339-348]

Cited: 11 times

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Abnormalities of fixation, saccade and pursuit in posterior cortical atrophy.

Timothy J Shakespeare, Diego Kaski, Keir X X Yong, Ross W Paterson, Catherine F Slattery, Natalie S Ryan, Jonathan M Schott, Sebastian J Crutch,

The clinico-neuroradiological syndrome posterior cortical atrophy is the cardinal 'visual dementia' and most common atypical Alzheimer's disease phenotype, offering insights into mechanisms underlying clinical heterogeneity, pathological propagation and basic visual phenomena (e.g. visual crowding). Given the extensive attention paid to patients' (higher order) perceptual function, it is surprising that there ... Read more >>

Brain (Brain : a journal of neurology)
[2015, 138(Pt 7):1976-1991]

Cited: 19 times

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Pronounced impairment of everyday skills and self-care in posterior cortical atrophy.

Timothy J Shakespeare, Keir X X Yong, David Foxe, John Hodges, Sebastian J Crutch,

Posterior cortical atrophy (PCA) is a neurodegenerative syndrome characterized by progressive visual dysfunction and parietal, occipital, and occipitotemporal atrophy. The aim of this study was to compare the impact of PCA and typical Alzheimer's disease (tAD) on everyday functional abilities and neuropsychiatric status. The Cambridge Behavioural Inventory-Revised was given to ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2015, 43(2):381-384]

Cited: 11 times

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Auditory spatial processing in Alzheimer's disease.

Hannah L Golden, Jennifer M Nicholas, Keir X X Yong, Laura E Downey, Jonathan M Schott, Catherine J Mummery, Sebastian J Crutch, Jason D Warren,

The location and motion of sounds in space are important cues for encoding the auditory world. Spatial processing is a core component of auditory scene analysis, a cognitively demanding function that is vulnerable in Alzheimer's disease. Here we designed a novel neuropsychological battery based on a virtual space paradigm to ... Read more >>

Brain (Brain : a journal of neurology)
[2015, 138(Pt 1):189-202]

Cited: 19 times

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