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Recombinant Thrombomodulin Attenuates Preeclamptic Symptoms by Inhibiting High-Mobility Group Box 1 in Mice.

Hiroko Oda, Takeshi Nagamatsu, Danny J Schust, Horacio Cabral, Takuya Miyazaki, Takayuki Iriyama, Kei Kawana, Yutaka Osuga, Tomoyuki Fujii,

Preeclampsia (PE) is a common gestational complication that involves systemic endothelial dysfunction and inflammatory responses primarily due to placental damage. Recombinant thrombomodulin (rTM), a novel anticoagulant clinically used for disseminated intravascular coagulation, is reported to have a unique anti-inflammatory endothelial repair function by inhibiting proinflammatory mediator high-mobility group box 1 ... Read more >>

Endocrinology (Endocrinology)
[2021, 162(4):]

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The 2020 Japan Society of Gynecologic Oncology guidelines for the treatment of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer.

Hideki Tokunaga, Mikio Mikami, Satoru Nagase, Yoichi Kobayashi, Tsutomu Tabata, Masanori Kaneuchi, Toyomi Satoh, Yasuyuki Hirashima, Noriomi Matsumura, Yoshihito Yokoyama, Kei Kawana, Satoru Kyo, Daisuke Aoki, Hidetaka Katabuchi,

The fifth edition of the Japan Society of Gynecologic Oncology guidelines for the treatment of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer was published in 2020. The guidelines contain 6 chapters-namely, (1) overview of the guidelines; (2) epithelial ovarian cancer, fallopian tube cancer, and primary peritoneal cancer; (3) ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e49]

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Haplotype-based, case-control study of myosin phosphatase target subunit 1 (PPP1R12A) gene and hypertensive disorders of pregnancy.

Ai Kono, Kaori Shinya, Tomohiro Nakayama, Elisa Shikata, Tatsuo Yamamoto, Kei Kawana,

<b>Objective</b>: Hypertensive disorders of pregnancy (HDP) are thought to be a multifactorial genetic disease. Myosin light chain phosphorylation, which is involved in the regulation of vascular smooth muscle contraction and relaxation and thus contributes to the maintenance of blood pressure, is related to HDP. The official symbol of the gene ... Read more >>

Hypertens Pregnancy (Hypertension in pregnancy)
[2021, 40(1):88-96]

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Successful treatment of intractable chronic spontaneous urticaria with omalizumab in a patient with ovarian cancer.

Koremasa Hayama, Hideki Fujita, Mikiko Asai-Sato, Kei Kawana, Tadashi Terui,

Eur J Dermatol (European journal of dermatology : EJD)
[2021, 31(1):100-101]

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Nutrient management in the intrapartum period in maternal maple syrup urine disease.

Chika Takano, Mika Ishige, Erika Ogawa, Nobuhiko Nagano, Tamaki Morohashi, Aya Okahashi, Kaori Kawakami, Atsushi Komatsu, Kei Kawana, Tatsuhiko Urakami, Ichiro Morioka,

Women with congenital amino acid disorders, including maple syrup urine disease (MSUD), are at risk of metabolic crisis at delivery. There are still only a few case reports of maternal MSUD globally, and we are the first to report the successful perinatal management of a woman with classical MSUD in ... Read more >>

Mol Genet Metab Rep (Molecular genetics and metabolism reports)
[2021, 26:100711]

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A low preoperative albumin-to-globulin ratio is a negative prognostic factor in patients with surgically treated cervical cancer.

Akira Kawata, Ayumi Taguchi, Satoshi Baba, Yuichiro Miyamoto, Michihiro Tanikawa, Kenbun Sone, Tetsushi Tsuruga, Mayuyo Mori, Katsutoshi Oda, Kei Kawana, Yutaka Osuga, Tomoyuki Fujii,

<h4>Background</h4>The albumin-to-globulin ratio reflects both the nutrition and inflammation and predicts prognosis in patients with various malignancies. However, in cervical cancer patients who undergo surgery, its significance has yet to be established.<h4>Methods</h4>A total of 247 cervical cancer patients who received surgical treatment at our institution between 2005 and 2017 were ... Read more >>

Int J Clin Oncol (International journal of clinical oncology)
[2021, :]

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Use of Cap Analysis Gene Expression to detect human papillomavirus promoter activity patterns at different disease stages.

Ayumi Taguchi, Kazunori Nagasaka, Charles Plessy, Hiroe Nakamura, Yoshiko Kawata, Sachi Kato, Kosuke Hashimoto, Takeshi Nagamatsu, Katsutoshi Oda, Iwao Kukimoto, Kei Kawana, Piero Carninci, Yutaka Osuga, Tomoyuki Fujii,

Transcription of human papillomavirus (HPV) genes proceeds unidirectionally from multiple promoters. Direct profiling of transcription start sites (TSSs) by Cap Analysis Gene Expression (CAGE) is a powerful strategy for examining individual HPV promoter activity. The objective of this study was to evaluate alterations of viral promoter activity during infection using ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):17991]

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Secretory leukocyte protease inhibitor and progranulin as possible regulators of cervical remodeling in pregnancy.

Taiki Samejima, Takeshi Nagamatsu, Naoya Akiba, Tatsuya Fujii, Seisuke Sayama, Kei Kawana, Ayumi Taguchi, Keiichi Kumasawa, Takayuki Iriyama, Yutaka Osuga, Tomoyuki Fujii,

Secretory leukocyte protease inhibitor (SLPI) and progranulin (PGRN) are secretory proteins with an anti-inflammatory property. Their involvement in cervical remodeling in pregnant uterus is not yet elucidated. Thus, this study aimed to explore the significance of SLPI and PGRN in the maintenance of pregnancy by investigating the factors associated with ... Read more >>

J Reprod Immunol (Journal of reproductive immunology)
[2021, 143:103241]

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Is routine X-ray pelvimetry of value to decide on mode of delivery for women with labor dystocia?

Kaori Kawakami, Yuria Tanaka, Yuji Ikeda, Atsushi Komatsu, Osamu Kobayashi, Takahiro Nakajima, Takehiro Nakao, Chiaki Takeya, Mikiko Asai-Sato, Fumihisa Chishima, Misako Iwata, Kei Kawana,

<h4>Background: </h4> X-ray pelvimetry is used for evaluation of pelvic inlet generally to diagnose cephalopelvic disproportion (CPD) or contracted inlet. Cesarean section delivery (C/S) is often performed for labor dystocia without CPD or contracted inlet. Here, we examined whether X-ray pelvimetry is useful to decide on mode of delivery in ... Read more >>

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Survey on the use of personal protective equipment and COVID-19 testing of pregnant women in Japan.

Takeshi Umazume, Etsuko Miyagi, Yasuo Haruyama, Gen Kobashi, Shigeru Saito, Satoshi Hayakawa, Kei Kawana, Satoru Ikenoue, Ichiro Morioka, Hideto Yamada,

<h4>Aim</h4>To clarify the status of personal protective equipment (PPE) and coronavirus disease 2019 (COVID-19) tests for pregnant women, we conducted an urgent survey.<h4>Methods</h4>The survey was conducted online from April 27 to May 1, 2020. Questionnaires were sent to core facilities and affiliated hospitals of the obstetrics and gynecology training program ... Read more >>

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2020, 46(10):1933-1939]

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Effectiveness and Tolerability of Oral Amoxicillin in Pregnant Women with Active Syphilis, Japan, 2010-2018.

Takeshi Nishijima, Kei Kawana, Ichio Fukasawa, Naoko Ishikawa, Melanie M Taylor, Hiroshige Mikamo, Kiyoko Kato, Jo Kitawaki, Tomoyuki Fujii, , ,

We conducted a nationwide retrospective study in Japan to evaluate the effectiveness of oral amoxicillin or ampicillin as alternatives to injectable benzathine penicillin G for treating pregnant women with syphilis and preventing congenital syphilis (CS). We investigated 80 pregnant women with active syphilis treated with amoxicillin or ampicillin during 2010-2018. ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2020, 26(6):1192-1200]

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Comparison of survival between primary debulking surgery and neoadjuvant chemotherapy for stage III/IV ovarian, tubal and peritoneal cancers in phase III randomised trial.

Takashi Onda, Toyomi Satoh, Gakuto Ogawa, Toshiaki Saito, Takahiro Kasamatsu, Toru Nakanishi, Tomonori Mizutani, Kazuhiro Takehara, Aikou Okamoto, Kimio Ushijima, Hiroaki Kobayashi, Kei Kawana, Harushige Yokota, Masashi Takano, Hiroyuki Kanao, Yoh Watanabe, Kaichiro Yamamoto, Nobuo Yaegashi, Toshiharu Kamura, Hiroyuki Yoshikawa, ,

BACKGROUND:Regarding the comparison between primary debulking surgery (PDS) and neoadjuvant chemotherapy (NACT) for stage III/IV ovarian, tubal and peritoneal cancers, EORTC55971 and CHORUS studies demonstrated noninferiority of NACT. Previously, we reported reduced invasiveness of NACT in JCOG0602. This is a final analysis including the primary endpoint of overall survival (OS). METHODS:Patients ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2020, 130:114-125]

Cited: 12 times

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Successful surgical treatment of cardiac metastasis from uterine leiomyosarcoma: A case report and literature review.

Aki Maebayashi, Masaji Nagaishi, Takahiro Nakajima, Mitsumasa Hata, Tang Xiaoyan, Kei Kawana,

Uterine leiomyosarcoma is a malignant soft tissue tumor resembling uterine fibroma clinically and is difficult to diagnose preoperatively. Since metastatic cardiac tumors are very rare and asymptomatic, most cardiac metastases are detected at autopsy after death due to other diseases. A 49-year-old woman presented with menorrhagia and anemia, and a ... Read more >>

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2020, 46(5):795-800]

Cited: 1 time

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Differential expression of human papillomavirus 16-, 18-, 52-, and 58-derived transcripts in cervical intraepithelial neoplasia

Satoshi Baba, Ayumi Taguchi, Akira Kawata, Konan Hara, Satoko Eguchi, Mayuyo Mori, Katsuyuki Adachi, Seiichiro Mori, Takashi Iwata, Akira Mitsuhashi, Daichi Maeda, Atsushi Komatsu, Takeshi Nagamatsu, Katsutoshi Oda, Iwao Kukimoto, Yutaka Osuga, Tomoyuki Fujii, Kei Kawana,

<h4>Background: </h4> Human papillomavirus (HPV) infection is a primary cause of cervical cancer. Although epidemiologic study revealed that carcinogenic risk differs according to HPV genotypes, the expression patterns of HPV-derived transcripts and their dependence on HPV genotypes have not yet been fully elucidated. Methods In this study, 382 ... Read more >>

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Differential expression of human papillomavirus 16-, 18-, 52-, and 58-derived transcripts in cervical intraepithelial neoplasia.

Satoshi Baba, Ayumi Taguchi, Akira Kawata, Konan Hara, Satoko Eguchi, Mayuyo Mori, Katsuyuki Adachi, Seiichiro Mori, Takashi Iwata, Akira Mitsuhashi, Daichi Maeda, Atsushi Komatsu, Takeshi Nagamatsu, Katsutoshi Oda, Iwao Kukimoto, Yutaka Osuga, Tomoyuki Fujii, Kei Kawana,

<h4>Background</h4>Human papillomavirus (HPV) infection is a primary cause of cervical cancer. Although epidemiologic study revealed that carcinogenic risk differs according to HPV genotypes, the expression patterns of HPV-derived transcripts and their dependence on HPV genotypes have not yet been fully elucidated.<h4>Methods</h4>In this study, 382 patients with abnormal cervical cytology were ... Read more >>

Virol J (Virology journal)
[2020, 17(1):32]

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Impact of additional risk factors on the incidence of preterm delivery among pregnant women diagnosed with short cervix.

Taiki Samejima, Takeshi Nagamatsu, Takayuki Iriyama, Toshio Nakayama, Takahiro Seyama, Seisuke Sayama, Keiichi Kumasawa, Atsushi Komatsu, Kei Kawana, Yutaka Osuga, Tomoyuki Fujii,

<h4>Objective</h4>Additional risk factors for preterm delivery in pregnant women with cervical shortening are not fully understood; however, mid-trimester cervical shortening is accepted as a risk factor for preterm delivery. This study aimed to identify risk factors associated with subsequent preterm delivery among patients with short cervix detected after late mid-trimester.<h4>Materials ... Read more >>

Taiwan J Obstet Gynecol (Taiwanese journal of obstetrics & gynecology)
[2020, 59(2):195-199]

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Reconstructed uterine length is critical for the prevention of cervical stenosis following abdominal trachelectomy in cervical cancer patients.

Takahiro Nakajima, Akiko Kasuga, Aki Hara-Yamashita, Yuji Ikeda, Mikiko Asai-Sato, Takehiro Nakao, Chuyu Hayashi, Chiaki Takeya, Katsuyuki Adachi, Tetsushi Tsuruga, Yoko Matsumoto, Takahide Arimoto, Takeshi Nagamatsu, Katsutoshi Oda, Atsushi Komatsu, Fumihisa Chishima, Yutaka Osuga, Tomoyuki Fujii, Kei Kawana,

AIM:Although the procedure of abdominal trachelectomy has been remarkably improved, preventing subsequent cervical stenosis remains challenging. In this study, we analyzed the clinicopathological risk factors for cervical stenosis to explore the appropriate surgical procedures for the prevention of cervical stenosis following trachelectomy. METHODS:Thirty-two patients who underwent abdominal extended and radical ... Read more >>

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2020, 46(2):328-336]

Cited: 1 time

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Interleukin-17 is associated with expression of programmed cell death 1 ligand 1 in ovarian carcinoma.

Aeri Aotsuka, Yoko Matsumoto, Takahide Arimoto, Akira Kawata, Juri Ogishima, Ayumi Taguchi, Michihiro Tanikawa, Kenbun Sone, Mayuyo Mori-Uchino, Tetsushi Tsuruga, Katsutoshi Oda, Kei Kawana, Yutaka Osuga, Tomoyuki Fujii,

The programmed cell death 1/programmed cell death 1 ligand 1 pathway was successfully targeted in cancer immunotherapy. Elevated interleukin-17 (IL-17), which is known in autoimmune diseases, has recently been recognized in cancer patients. We investigated the role of IL-17 in the regulation of expression of programmed cell death 1 ligand ... Read more >>

Cancer Sci (Cancer science)
[2019, 110(10):3068-3078]

Cited: 6 times

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Anti-tumor activity of dual inhibition of phosphatidylinositol 3-kinase and MDM2 against clear cell ovarian carcinoma.

Chinami Makii, Yuji Ikeda, Katsutoshi Oda, Yuriko Uehara, Akira Nishijima, Takahiro Koso, Yoshiko Kawata, Tomoko Kashiyama, Aki Miyasaka, Kenbun Sone, Michihiro Tanikawa, Tetsushi Tsuruga, Mayuyo Mori-Uchino, Kazunori Nagasaka, Yoko Matsumoto, Osamu Wada-Hiraike, Kei Kawana, Kosei Hasegawa, Keiichi Fujiwara, Hiroyuki Aburatani, Yutaka Osuga, Tomoyuki Fujii,

INTRODUCTION:PI3K pathway signaling has received attention as a molecular target in clear cell ovarian carcinoma (CCOC). MDM2 is one of the AKT effectors in the PI3K pathway, which binds to and degrades p53. In this study, we aimed to clarify the prognostic significance of PIK3CA and MDM2 expression, and potential ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2019, 155(2):331-339]

Cited: 3 times

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Safety and efficacy of mucosal immunotherapy using human papillomavirus (HPV) type 16 E7-expressing Lactobacillus-based vaccine for the treatment of high-grade squamous intraepithelial lesion (HSIL): the study protocol of a randomized placebo-controlled clinical trial (MILACLE study).

Yuji Ikeda, Yukari Uemura, Mikiko Asai-Sato, Takehiro Nakao, Takahiro Nakajima, Takashi Iwata, Azusa Akiyama, Toyomi Satoh, Hideaki Yahata, Kiyoko Kato, Daichi Maeda, Daisuke Aoki, Kei Kawana,

We developed an HPV16 E7-expressing Lactobacillus-based therapeutic vaccine, IGMKK16E7, to elicit mucosal E7-specific TH1 cellular immune responses. This study aims to examine the safety and clinical efficacy of IGMKK16E7 on HPV16-positive high-grade squamous intraepithelial lesion (HSIL). This is a multicenter, placebo-controlled, double-blind randomized phase I/II trial to test the safety ... Read more >>

Jpn J Clin Oncol (Japanese journal of clinical oncology)
[2019, 49(9):877-880]

Cited: 2 times

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Radiation therapy for vaginal cancer in complete uterine prolapse with intrauterine adhesion: a case report.

Naoya Ishibashi, Toshiya Maebayashi, Mikiko Asai-Sato, Kei Kawana, Masahiro Okada,

<h4>Background</h4>We encountered a woman with vaginal cancer that was associated with complete uterine prolapse and complicated by severe intrauterine adhesions. In this case report, we describe the clinical course and successful treatment of this rare condition.<h4>Case presentation</h4>A 78-year-old woman (gravida 10, para 2, abortion 8) with a 10-year history of ... Read more >>

BMC Womens Health (BMC women's health)
[2019, 19(1):69]

Cited: 2 times

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Development and evaluation of a cervical cancer screening system in Cambodia: A collaborative project of the Cambodian Society of Gynecology and Obstetrics and Japan Society of Obstetrics and Gynecology.

Yutaka Ueda, Kei Kawana, Nozomu Yanaihara, Kouji Banno, Maryan Chhit, Kyna Uy, Leangsim Kruy, Chan S Sann, Miwa Ishioka-Kanda, Hiroki Akaba, Yasuyo Matsumoto, Noriko Fujita, Testu Yano, Kanal Koum, Aikou Okamoto, Tadashi Kimura,

<h4>Aim</h4>In Cambodia, the Japan Society of Obstetrics and Gynecology and the Cambodian Society of Gynecology and Obstetrics have an on-going project, started in 2015, for cervical cancer prevention and treatment. The project, currently aimed at factory workers, includes a women's health education program that leads into cervical cancer prevention by ... Read more >>

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2019, 45(7):1260-1267]

Cited: 0 times

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Neoadjuvant Chemotherapy with Taxane and Platinum Followed by Radical Hysterectomy for Stage IB2-IIB Cervical Cancer: Impact of Histology Type on Survival.

Koji Matsuo, Muneaki Shimada, Satoshi Yamaguchi, Junzo Kigawa, Hideki Tokunaga, Tsutomu Tabata, Junichi Kodama, Kei Kawana, Mikio Mikami, Toru Sugiyama,

The current study examined the histology-specific impact of neoadjuvant chemotherapy (NACT) with a taxane/platinum regimen on survival in women with locally-advanced cervical cancer who underwent radical hysterectomy. This nation-wide retrospective cohort study examined women with clinical stage IB2-IIB cervical cancer who received NACT prior to radical hysterectomy from 2004⁻2008 (n ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 8(2):]

Cited: 3 times

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Enhancing T Cell Receptor Stability in Rejuvenated iPSC-Derived T Cells Improves Their Use in Cancer Immunotherapy.

Atsutaka Minagawa, Toshiaki Yoshikawa, Masaki Yasukawa, Akitsu Hotta, Mihoko Kunitomo, Shoichi Iriguchi, Maiko Takiguchi, Yoshiaki Kassai, Eri Imai, Yutaka Yasui, Yohei Kawai, Rong Zhang, Yasushi Uemura, Hiroyuki Miyoshi, Mahito Nakanishi, Akira Watanabe, Akira Hayashi, Kei Kawana, Tomoyuki Fujii, Tetsuya Nakatsura, Shin Kaneko,

Limited T cell availability and proliferative exhaustion present major barriers to successful T cell-based immunotherapies and may potentially be overcome through the use of "rejuvenated" induced pluripotent stem cells derived from antigen-specific T cells (T-iPSCs). However, strict antigen specificity is essential for safe and efficient T cell immunotherapy. Here, we report that CD8αβ T cells ... Read more >>

Cell Stem Cell (Cell stem cell)
[2018, 23(6):850-858.e4]

Cited: 26 times

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Kaempferol, a natural dietary flavonoid, suppresses 17β-estradiol-induced survivin expression and causes apoptotic cell death in endometrial cancer.

Agapiti Hipoliti Chuwa, Kenbun Sone, Katsutoshi Oda, Michihiro Tanikawa, Asako Kukita, Machiko Kojima, Shinya Oki, Tomohiko Fukuda, Makoto Takeuchi, Aki Miyasaka, Tomoko Kashiyama, Yuji Ikeda, Kazunori Nagasaka, Mayuyo Mori-Uchino, Yoko Matsumoto, Osamu Wada-Hiraike, Hiroyuki Kuramoto, Kei Kawana, Yutaka Osuga, Tomoyuki Fujii,

Endometrioid endometrial carcinoma, commonly known as type 1 endometrial cancer, accounts for >80% of endometrial carcinomas and is dependent on estrogen. We recently reported on the prognostic significance of the <i>BIRC5</i> survivin gene in endometrial cancer. Estradiol induces survivin expression in estrogen receptor-positive, but not in estrogen receptor-negative, cancer cells. ... Read more >>

Oncol Lett (Oncology letters)
[2018, 16(5):6195-6201]

Cited: 5 times

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