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Pretreatment Risk Stratification for Endoscopic Kidney-sparing Surgery in Upper Tract Urothelial Carcinoma: An International Collaborative Study.

Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Gautier Marcq, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Wassim Kassouf, Riccardo Autorino, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat,

<h4>Background</h4>Several groups have proposed features to identify low-risk patients who may benefit from endoscopic kidney-sparing surgery in upper tract urothelial carcinoma (UTUC).<h4>Objective</h4>To evaluate standard risk stratification features, develop an optimal model to identify ≥pT2/N+ stage at radical nephroureterectomy (RNU), and compare it with the existing unvalidated models.<h4>Design, setting, and participants</h4>This ... Read more >>

Eur Urol (European urology)
[2021, :]

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Novel Classification for Upper Tract Urothelial Carcinoma to Better Risk-stratify Patients Eligible for Kidney-sparing Strategies: An International Collaborative Study.

Gautier Marcq, Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Riccardo Autorino, Patricia John, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat, Wassim Kassouf,

<h4>Background</h4>The European Association of Urology risk stratification dichotomizes patients with upper tract urothelial carcinoma (UTUC) into two risk categories.<h4>Objective</h4>To evaluate the predictive value of a new classification to better risk stratify patients eligible for kidney-sparing surgery (KSS).<h4>Design, setting, and participants</h4>This was a retrospective study including 1214 patients from 21 centers ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Outcome after resection of occult and non-occult lymph node metastases at the time of nephrectomy.

Teele Kuusk, Tobias Klatte, Patricia Zondervan, Brunolf Lagerveld, Niels Graafland, Kees Hendricksen, Umberto Capitanio, Andrea Minervini, Grant D Stewart, Borje Ljungberg, Simon Horenblas, Axel Bex,

<h4>Purpose</h4>There is sparse evidence on outcomes of resected occult LN metastases at the time of nephrectomy (synchronous disease). We sought to analyse a large international cohort of patients and to identify clinico-pathological predictors of long-term survival.<h4>Materials and methods</h4>We collected data of consecutive patients who underwent nephrectomy and LND for T<sub>any</sub> ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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Staging 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Changes Treatment Recommendation in Invasive Bladder Cancer.

Charlotte S Voskuilen, Erik J van Gennep, Sarah M H Einerhand, Erik Vegt, Maarten L Donswijk, Annemarie Bruining, Henk G van der Poel, Simon Horenblas, Kees Hendricksen, Bas W G van Rhijn, Laura S Mertens,

Given the high risk of systemic relapse following initial therapy for muscle-invasive bladder cancer (MIBC), improved pretreatment staging is needed. We evaluated the incremental value of <sup>18</sup>F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) after standard conventional staging, in the largest cohort of MIBC patients to date. This is a retrospective analysis ... Read more >>

Eur Urol Oncol (European urology oncology)
[2021, :]

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Restaging Transurethral Resection of Bladder Tumours after BCG Immunotherapy Induction in Patients with T1 Non-Muscle-Invasive Bladder Cancer Might not Be Associated with Oncologic Benefit.

Wojciech Krajewski, Marco Moschini, Łukasz Nowak, Sławomir Poletajew, Andrzej Tukiendorf, Luca Afferi, Jeremy Teoh, Tim Muilwijk, Steven Joniau, Alessandro Tafuri, Alessandro Antonelli, Alessandra Gozzo, Andrea Mari, Ettore Di Trapani, Kees Hendricksen, Mario Alvarez-Maestro, Andrea Rodriguez Serrano, Giuseppe Simone, Stefania Zamboni, Claudio Simeone, Maria Cristina Marconi, Riccardo Mastroianni, Guillaume Ploussard, Paweł Rajwa, Ekaterina Laukhtina, Aleksandra Zdrojowy-Wełna, Anna Kołodziej, Andrzej Paradysz, Karl Tully, Joanna Krajewska, Radosław Piszczek, Evanguelos Xylinas, Romuald Zdrojowy,

<h4>Background and purpose</h4>The European Association of Urology guidelines recommend restaging transurethral resection of bladder tumours (reTURB) 2-6 weeks after primary TURB. However, in clinical practice some patients undergo a second TURB procedure after Bacillus Calmette-Guérin immunotherapy (BCG)induction. To date, there are no studies comparing post-BCG reTURB with the classic pre-BCG ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(10):]

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Sexual Satisfaction in Men Suffering From Erectile Dysfunction After Robot-Assisted Radical Prostatectomy for Prostate Cancer: An Observational Study.

Leonore F Albers, Corinne N Tillier, Erik van Muilekom, Erik van Werkhoven, Henk W Elzevier, Bas W G van Rhijn, Henk G van der Poel, Kees Hendricksen,

<h4>Background</h4>Preservation of erectile function is an important postoperative quality of life concern for patients after robot-assisted radical prostatectomy (RARP) for prostate cancer. Although erectile function may recover, many men continue to suffer from erectile dysfunction (ED).<h4>Aim</h4>This study aims to determine whether satisfaction with sexual life improves in patients with ED ... Read more >>

J Sex Med (The journal of sexual medicine)
[2021, 18(2):339-346]

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Delaying BCG immunotherapy onset after transurethral resection of non-muscle-invasive bladder cancer is associated with adverse survival outcomes.

Wojciech Krajewski, Marco Moschini, Joanna Chorbińska, Łukasz Nowak, Sławomir Poletajew, Andrzej Tukiendorf, Luca Afferi, Jeremy Yuen-Chun Teoh, Tim Muilwijk, Steven Joniau, Alessandro Tafuri, Alessandro Antonelli, Francesco Cianflone, Andrea Mari, Ettore Di Trapani, Kees Hendricksen, Mario Alvarez-Maestro, Andrea Rodríguez-Serrano, Giuseppe Simone, Stefania Zamboni, Claudio Simeone, Maria Cristina Marconi, Riccardo Mastroianni, Guillaume Ploussard, Ekaterina Laukhtina, Karl Tully, Anna Kołodziej, Joanna Krajewska, Radosław Piszczek, Evanguelos Xylinas, Romuald Zdrojowy, ,

<h4>Purpose</h4>This study was carried out to assess whether a prolonged time between primary transurethral resection of non-muscle-invasive bladder cancer (TURB) and implementation of bacillus Calmette-Guerin (BCG) immunotherapy (time to BCG; TTBCG) is associated with adverse oncological survival in patients with T1 high-grade (HG) non-muscle-invasive bladder cancer (NMIBC).<h4>Materials and methods</h4>Data on 429 ... Read more >>

World J Urol (World journal of urology)
[2020, :]

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Postoperative Chemotherapy Bladder Instillation After Radical Nephroureterectomy: Results of a European Survey from the Young Academic Urologist Urothelial Cancer Group.

Tom-Régis Dobé, Gianluigi Califano, Friedrich-Carl von Rundstedt, Idir Ouzaid, Simone Albisinni, Atiqullah Aziz, Ettore Di Trapani, Kees Hendricksen, Wojciech Krajewski, Andrea Mari, Marco Moschini, Andrea Necchi, Aidan P Noon, Cedric Poyet, Benjamin Pradère, Michael Rink, Florian Roghmann, Paul Sargos, Roland Seiler, Francesco Soria, Malte W Vetterlein, Evanguelos Xylinas,

<h4>Background</h4>Level 1 evidence supports the administration of single postoperative intravesical chemotherapy (pIVC) following radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC), in order to decrease intravesical recurrence risk.<h4>Objective</h4>The Young Academic Urologist Urothelial Cancer Group aimed to investigate the use of pIVC in daily practice among European colleagues.<h4>Design setting and ... Read more >>

Eur Urol Open Sci (European urology open science)
[2020, 22:45-50]

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Pre-therapy serum albumin-to-globulin ratio in patients treated with neoadjuvant chemotherapy and radical nephroureterectomy for upper tract urothelial carcinoma.

Benjamin Pradere, David D'Andrea, Victor M Schuettfort, Beat Foerster, Fahad Quhal, Keiichiro Mori, Mohammad Abufaraj, Vitaly Margulis, Marine Deuker, Alberto Briganti, Tim Muilwijk, Kees Hendricksen, Yair Lotan, Pierre Karakiewic, Shahrokh F Shariat, ,

<h4>Purpose</h4>The accurate selection of patients who are most likely to benefit from neoadjuvant chemotherapy is an important challenge in oncology. Serum AGR has been found to be associated with oncological outcomes in various malignancies. We assessed the association of pre-therapy serum albumin-to-globulin ratio (AGR) with pathologic response and oncological outcomes ... Read more >>

World J Urol (World journal of urology)
[2020, :]

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The clonal relation of primary upper urinary tract urothelial carcinoma and paired urothelial carcinoma of the bladder.

Thomas van Doeveren, Jose A Nakauma-Gonzalez, Jose A Nakauma-Gonzalez, Andrew S Mason, Geert J L H van Leenders, Tahlita C M Zuiverloon, Ellen C Zwarthoff, Isabelle C Meijssen, Angelique C van der Made, Antoine G van der Heijden, Kees Hendricksen, Bas W G van Rhijn, Charlotte S Voskuilen, Job van Riet, Winand N M Dinjens, Hendrikus J Dubbink, Harmen J G van de Werken, Joost L Boormans,

The risk of developing urothelial carcinoma of the bladder (UCB) in patients treated by radical nephroureterectomy (RNU) for an upper urinary tract urothelial carcinoma (UTUC) is 22% to 47% in the 2 years after surgery. Subject of debate remains whether UTUC and the subsequent UCB are clonally related or represent separate ... Read more >>

Int J Cancer (International journal of cancer)
[2021, 148(4):981-987]

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Preoperative ipilimumab plus nivolumab in locoregionally advanced urothelial cancer: the NABUCCO trial.

Nick van Dijk, Alberto Gil-Jimenez, Karina Silina, Kees Hendricksen, Laura A Smit, Jeantine M de Feijter, Maurits L van Montfoort, Charlotte van Rooijen, Dennis Peters, Annegien Broeks, Henk G van der Poel, Annemarie Bruining, Yoni Lubeck, Karolina Sikorska, Thierry N Boellaard, Pia Kvistborg, Daniel J Vis, Erik Hooijberg, Ton N Schumacher, Maries van den Broek, Lodewyk F A Wessels, Christian U Blank, Bas W van Rhijn, Michiel S van der Heijden,

Preoperative immunotherapy with anti-PD1 plus anti-CTLA4 antibodies has shown remarkable pathological responses in melanoma<sup>1</sup> and colorectal cancer<sup>2</sup>. In NABUCCO (ClinicalTrials.gov: NCT03387761 ), a single-arm feasibility trial, 24 patients with stage III urothelial cancer (UC) received two doses of ipilimumab and two doses of nivolumab, followed by resection. The primary endpoint ... Read more >>

Nat Med (Nature medicine)
[2020, 26(12):1839-1844]

Cited: 15 times

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The Performance of Tumor Size as Risk Stratification Parameter in Upper Tract Urothelial Carcinoma (UTUC).

Beat Foerster, Mohammad Abufaraj, Andrea Mari, Thomas Seisen, Marco Bandini, Donald Schweitzer, Anna K Czech, Marco Moschini, David D'Andrea, Marco Bianchi, Kees Hendricksen, Morgan Rouprêt, Alberto Briganti, Bas W G van Rhijn, Piotr Chłosta, Pierre Colin, Hubert John, Shahrokh F Shariat,

<h4>Introduction</h4>The objective of this study was to evaluate the performance of different tumor diameters for identifying ≥ pT2 upper tract urothelial carcinoma (UTUC) at radical nephroureterectomy.<h4>Patients and methods</h4>This was a multi-institutional retrospective study that included 932 patients who underwent radical nephroureterectomy for nonmetastatic UTUC between 2000 and 2016. Tumor sizes were ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, 19(3):272.e1-272.e7]

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18F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography in muscle-invasive bladder cancer.

Sarah M H Einerhand, Erik J van Gennep, Laura S Mertens, Kees Hendricksen, Maarten L Donswijk, Henk G van der Poel, Bas W G van Rhijn,

<h4>Purpose of review</h4>In this narrative review, we assessed the role of F-fluoro-2-deoxy-D-glucose-positron emission tomography/CT (FDG-PET/CT) in preoperative staging and response evaluation of neoadjuvant chemotherapy in muscle-invasive bladder carcinoma (MIBC), and to assess its incremental value to contrast-enhanced (CE)CT and MRI in terms of patient management at initial diagnosis and detection ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2020, 30(5):654-664]

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Adjuvant chemotherapy is ineffective in patients with bladder cancer and variant histology treated with radical cystectomy with curative intent.

Stefania Zamboni, Luca Afferi, Francesco Soria, Atiqullah Aziz, Mohammad Abufaraj, Cedric Poyet, Andrea Necchi, David D'Andrea, Giuseppe Simone, Mariaconsiglia Ferriero, Ettore Di Trapani, Claudio Simeone, Alessandro Antonelli, Andrea Gallina, Francesco Montorsi, Alberto Briganti, Renzo Colombo, Giorgio Gandaglia, Agostino Mattei, Philipp Baumeister, Livio Mordasini, Kees Hendricksen, Charlotte S Voskuilen, Michael Rink, Shahrokh F Shariat, Evanguelous Xylinas, Marco Moschini,

<h4>Objectives</h4>Adjuvant chemotherapy (ACT) is recommended for non-organ-confined bladder cancer (BCa) after radical cystectomy (RC) and pelvic lymph node dissection (PLND), but there are sparse data regarding its specific efficacy in patients with histological variants. The aim of our study was to evaluate the role of ACT on survival outcomes in ... Read more >>

World J Urol (World journal of urology)
[2021, 39(6):1947-1953]

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Impact of tumor size on the oncological outcome of high-grade nonmuscle invasive bladder cancer - examining the utility of classifying Ta bladder cancer based on size.

Karl H Tully, Marco Moschini, Friedrich-Carl E von Rundstedt, Atiqullah Aziz, Luis A Kluth, Andrea Necchi, Michael Rink, Kees Hendricksen, Paul Sargos, Malte W Vetterlein, Roland Seiler, Cedric Poyet, Wojciech Krajewski, Harun Fajkovic, Shahrokh F Shariat, Evanguelos Xylinas, Florian Roghmann,

<h4>Purpose</h4>To examine survival rates and to calculate the risk of disease recurrence, progression, overall, and cancer-specific mortality in patients diagnosed with high-risk NMIBC using a multi-institutional dataset to evaluate differences between the guidelines of the European Association of Urology and the guidelines of the National Comprehensive Cancer Network (NCCN) with ... Read more >>

Urol Oncol (Urologic oncology)
[2020, 38(11):851.e19-851.e25]

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The association of cigarette smoking and pathological response to neoadjuvant platinum-based chemotherapy in patients undergoing treatment for urinary bladder cancer - A prospective European multicenter observational study of the EAU Young Academic Urologists (YAU) urothelial carcinoma working group.

Philipp Gild, Malte W Vetterlein, Roland Seiler, Andrea Necchi, Kees Hendricksen, Laura S Mertens, Florian Roghmann, Nicolas V Landenberg, Paolo Gontero, Marcus Cumberbatch, Jakub Dobruch, Thomas Seisen, Pietro Grande, David D'Andrea, Julien Anract, Evi Comploj, Armin Pycha, Karim Saba, Cedric Poyet, Bas W van Rhijn, Aidan P Noon, Morgan Roupret, Shahrokh F Shariat, Margit Fisch, Evanguelos Xylinas, Michael Rink,

<h4>Objective</h4>To prospectively study the impact of smoking on pathological response to neoadjuvant chemotherapy (NAC) in patients undergoing radical cystectomy (RC) for urothelial carcinoma of the bladder (UCB).<h4>Materials & methods</h4>We collected standard clinicopathological variables, including smoking status (never, former, current) in patients undergoing NAC and RC for UCB at 12 European ... Read more >>

Surg Oncol (Surgical oncology)
[2020, 34:312-317]

Cited: 1 time

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Impact of Sex on Response to Neoadjuvant Chemotherapy in Patients with Upper-tract Urothelial Cancer.

David D'Andrea, Beat Foerster, Surena F Matin, Ja H Ku, Tim Muilwijk, Leonardo L Monteiro, Ross Liao, Firas G Petros, Philippe E Spiess, Trinity J Bivalacqua, Kees Hendricksen, Bas W G van Rhijn, Ahmad Shabsigh, Alberto Briganti, Steven Joniau, Wassim Kassouf, Phillip M Pierorazio, Vitaly Margulis, Andrea Necchi, Shahrokh F Shariat, ,

Eur Urol Open Sci (European urology open science)
[2020, 19:16-19]

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Efficacy of Preoperative Chemotherapy for High Risk Upper Tract Urothelial Carcinoma.

Beat Foerster, Mohammad Abufaraj, Firas Petros, Mounsif Azizi, Mohit Gupta, Donald Schweitzer, Vitaly Margulis, Takehiro Iwata, Shoji Kimura, Ahmad Shabsigh, Alberto Briganti, Ja H Ku, Tim Muilwijk, Wassim Kassouf, Surena F Matin, Philippe E Spiess, Phillip M Pierorazio, Kees Hendricksen, Shahrokh F Shariat, ,

PURPOSE:The impact of preoperative chemotherapy in patients with upper urinary tract urothelial carcinoma remains poorly investigated. We assessed the rates of pathological complete response (pT0N0/X) and downstaging (pT1N0/X or less) at radical nephroureterectomy after preoperative chemotherapy and evaluated their impact on survival. MATERIALS AND METHODS:This was an international observational study ... Read more >>

J Urol (The Journal of urology)
[2020, 203(6):1101-1108]

Cited: 2 times

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The impact of treatment modality on survival in patients with clinical node-positive bladder cancer: results from a multicenter collaboration.

Luca Afferi, Stefania Zamboni, R Jeffrey Karnes, Florian Roghmann, Paul Sargos, Francesco Montorsi, Alberto Briganti, Andrea Gallina, Agostino Mattei, Gerald Bastian Schulz, Kees Hendricksen, Charlotte S Voskuilen, Michael Rink, Cedric Poyet, Ottavio De Cobelli, Ettore di Trapani, Claudio Simeone, Matteo Soligo, Giuseppe Simone, Gabriele Tuderti, Mario Alvarez-Maestro, Luis Martínez-Piñeiro, Atiqullah Aziz, Shahrokh F Shariat, Mohammad Abufaraj, Evanguelos Xylinas, Marco Moschini, ,

<h4>Purpose</h4>To assess the impact of perioperative chemotherapy on survival in cN+ BCa patients and analyze it according to the pN status.<h4>Methods</h4>A retrospective analysis was conducted on 639 BCa patients with cTanyN1-3M0 BCa treated with radical cystectomy (RC) and bilateral lymph node dissection (LND) with or without perioperative chemotherapy in ten tertiary referral ... Read more >>

World J Urol (World journal of urology)
[2021, 39(2):443-451]

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Topographic distribution of first landing sites of lymphatic metastases from patients with renal cancer.

Teele Kuusk, Patricia Zondervan, Brunolf Lagerveld, Barak Rosenzweig, Avi Raman, Joost M Blok, Roderick de Bruijn, Niels Graafland, Kees Hendricksen, Umberto Capitanio, Andrea Minervini, Borje Ljungberg, Simon Horenblas, Axel Bex,

<h4>Introduction and objective</h4>Adjuvant studies with checkpoint inhibitors have attracted new interest in accurate pathological lymph node (LN) staging in renal cell carcinoma. Sentinel lymph node (SN) studies in cN0 patients revealed the pattern of lymphatic radiotracer drainage from renal tumors. The aim of this study was to describe the location ... Read more >>

Urol Oncol (Urologic oncology)
[2020, 38(5):521-525]

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Diagnostic Laparoscopy and Abdominal Cytology Reliably Detect Peritoneal Metastases in Patients with Urachal Adenocarcinoma.

Laura E Stokkel, Akash M Mehta, Mark A Behrendt, Jeroen de Jong, Elise M Bekers, Kees Hendricksen, Arend G J Aalbers, Niels F M Kok, Wim Meinhardt, Laura S Mertens, Bas W G van Rhijn,

<h4>Background</h4>Urachal adenocarcinoma (UrAC) is a rare malignancy that can cause peritoneal metastases (PM). Analogous to other enteric malignancies, selected patients with limited PM of UrAC can be treated by cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC).<h4>Objective</h4>The aim of this study was to address the value of diagnostic laparoscopy (DLS) and ... Read more >>

Ann Surg Oncol (Annals of surgical oncology)
[2020, 27(7):2468-2475]

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Multicenter Validation of Histopathologic Tumor Regression Grade After Neoadjuvant Chemotherapy in Muscle-invasive Bladder Carcinoma.

Charlotte S Voskuilen, Htoo Zarni Oo, Vera Genitsch, Laura A Smit, Alvaro Vidal, Manuel Meneses, Andrea Necchi, Maurizio Colecchia, Evanguelos Xylinas, Jacqueline Fontugne, Mathilde Sibony, Morgan Rouprêt, Louis Lenfant, Jean-François Côté, Lorenz Buser, Karim Saba, Marc A Furrer, Michiel S van der Heijden, Mads Daugaard, Peter C Black, Bas W G van Rhijn, Kees Hendricksen, Cédric Poyet, Roland Seiler,

Response classification after neoadjuvant chemotherapy in muscle-invasive bladder carcinoma is based on the TNM stage at radical cystectomy. We recently showed that histopathologic tumor regression grades (TRGs) add prognostic information to TNM. Our aim was to validate the prognostic significance of TRG in muscle-invasive bladder cancer in a multicenter setting. ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2019, 43(12):1600-1610]

Cited: 2 times

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Diagnostic Value of 18F-fluorodeoxyglucose Positron Emission Tomography with Computed Tomography for Lymph Node Staging in Patients with Upper Tract Urothelial Carcinoma.

Charlotte S Voskuilen, Donald Schweitzer, Jørgen Bjerggaard Jensen, Anna M Nielsen, Steven Joniau, Tim Muilwijk, Andrea Necchi, Mounsif Azizi, Philippe E Spiess, Alberto Briganti, Marco Bandini, Karolien Goffin, Kirsten Bouchelouche, Erik van Werkhoven, Shahrokh F Shariat, Evanguelos Xylinas, Nessn H Azawi, Ja Hyeon Ku, Beat Foerster, Bas W G van Rhijn, Erik Vegt, Kees Hendricksen,

<h4>Background</h4>Presence of lymph node metastases (LNM) is an important prognostic factor for cancer-specific survival (CSS) in patients with upper tract urothelial carcinoma (UTUC). In various neoplasms, <sup>18</sup>F-fluorodeoxyglucose positron emission tomography with computed tomography (FDG-PET/CT) is an established modality for preoperative lymph node (LN) staging. In UTUC, the diagnostic value of ... Read more >>

Eur Urol Oncol (European urology oncology)
[2020, 3(1):73-79]

Cited: 3 times

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Long-term survival and complications following bladder-preserving brachytherapy in patients with cT1-T2 bladder cancer.

Charlotte S Voskuilen, Judith Bosschieter, Erik van Werkhoven, Kees Hendricksen, André N Vis, Thelma Witteveen, Bradley R Pieters, Max Burger, Axel Bex, Henk G van der Poel, Luc M Moonen, Simon Horenblas, Jakko A Nieuwenhuijzen, Bas W G van Rhijn,

<h4>Background and purpose</h4>Radical cystectomy (RC) is considered standard treatment for muscle-invasive bladder cancer (BC) and high-risk non-muscle invasive BC. In selected cases, bladder-sparing treatment using brachytherapy can be offered. We examined the outcome after brachytherapy in comparison to RC in terms of survival, complications and bladder preservation in patients with ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2019, 141:130-136]

Cited: 2 times

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Sentinel Lymph Node Biopsy in Renal Tumors: Surgical Technique and Safety.

Teele Kuusk, Oscar Brouwer, Niels Graafland, Kees Hendricksen, Maarten Donswijk, Axel Bex,

<h4>Objective</h4>To understand uncertainties and knowledge gaps regarding lymphatic drainage in renal tumors, we performed 2 prospective studies to demonstrate regional lymph node (LN) drainage with sentinel lymph node (SN) imaging and biopsy. Here, we report the technique and perioperative safety of retroperitoneal SN dissection with different surgical approaches.<h4>Methods</h4>Seventy three patients ... Read more >>

Urology (Urology)
[2019, 130:186-190]

Cited: 0 times

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