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Surface-topology-controlled mechanical characteristics of triply periodic carbon Schwarzite foams.

Hao Gong, Jinjie Liu, Ke Xu, Jianyang Wu, Yang Li,

Bulky sp2-carbon Schwarzites with negative Gaussian curvature are promising structures for practical applications due to their unique properties such as high surface area, large porosity, and stability against graphitization. Herein, a comprehensive study on the tension, compression and shear mechanical characteristics of seven triply periodic carbon Schwarzite foams with distinct ... Read more >>

Soft Matter (Soft matter)
[2020, 16(17):4324-4338]

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From a blue to white to yellow emitter: a hexanuclear copper iodide nanocluster.

Ke Xu, Bu-Lin Chen, Rui Zhang, Li Liu, Xin-Xin Zhong, Lei Wang, Feng-Yan Li, Guang-Hua Li, Khalid A Alamry, Fa-Bao Li, Wai-Yeung Wong, Hai-Mei Qin,

Highly emissive copper(i) halide nanoclusters showing thermally activated delayed fluorescence (TADF) have been paid much attention, but rarely reported so far. Herein, a hexanuclear copper(i) iodide cluster containing a tridentate N∧P∧N ligand, [Cu6I6(ppda)2] {ppda = 2-[2-(dimethylamino)phenyl(phenyl)phosphino]-N,N-dimethylaniline}, was synthesized. All six copper atoms are four-coordinate, including four CuPNI2 and two CuI4 ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2020, 49(18):5859-5868]

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Atomic-scale investigation of enhanced lithium, sodium and magnesium storage performance from defects in MoS2/graphene heterostructures.

Ke Xu, Ningbo Liao, Miao Zhang, Wei Xue,

MoS2 is of great interest as an anode material of batteries due to its high theoretical reversible capacity; in particular, a defective MoS2/graphene heterostructure exhibits excellent cycling stability. However, very little is known about the diffusion and ion storage mechanism at the atomistic level. To provide insights into the issue, ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(13):7098-7108]

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ddPCR: a more accurate tool for SARS-CoV-2 detection in low viral load specimens.

Tao Suo, Xinjin Liu, Jiangpeng Feng, Ming Guo, Wenjia Hu, Dong Guo, Hafiz Ullah, Yang Yang, Qiuhan Zhang, Xin Wang, Muhanmmad Sajid, Zhixiang Huang, Liping Deng, Tielong Chen, Fang Liu, Ke Xu, Yuan Liu, Qi Zhang, Yingle Liu, Yong Xiong, Guozhong Chen, Ke Lan, Yu Chen,

Quantitative real time PCR (RT-PCR) is widely used as the gold standard for clinical detection of SARS-CoV-2. However, due to the low viral load specimens and the limitations of RT-PCR, significant numbers of false negative reports are inevitable, which results in failure to timely diagnose, early treat, cut off transmission, ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, :1-30]

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Early warning signs for severe patients with Coronavirus Disease 2019 and its epidemical significance

Hong Ji, Qigang Dai, Hui Jin, Ke Xu, Jing Ai, Xinyu Fang, Naiyang Shi, Haodi Huang, Ying Wu, Zhihang Peng, Jianli Hu, Liguo Zhu, Ming Wu, Changjun Bao,

Abstract Background Since December 2019 coronavirus disease 2019 (COVID-19) emerged in Wuhan city and rapidly spread throughout China. However, early warning signs for severe patients with COVID-19 were not fully known.Methods Information on admission was collected through a standard questionnaire. We described the epidemiological characteristics of the patients with COVID-19, ... Read more >>

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Wearable Sensing and Telehealth Technology with Potential Applications in the Coronavirus Pandemic.

Xiao-Rong Ding, David Clifton, Nan Ji, Nigel Hamilton Lovell, Paolo Bonato, Wei Chen, Xinge Yu, Zhong Xue, Ting Xiang, Xi Long, Ke Xu, Xinyu Jiang, Qi Wang, Bin Yin, Guodong Feng, Yuanting Zhang,

Coronavirus disease 2019 (COVID-19) has emerged as a pandemic with serious clinical manifestations including death. A pandemic at the large-scale like COVID-19 places extraordinary demands on the world's health systems, dramatically devastates vulnerable populations, and critically threatens the global communities in an unprecedented way. While tremendous efforts at the frontline ... Read more >>

IEEE Rev Biomed Eng (IEEE reviews in biomedical engineering)
[2020, :]

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DNA methylation mediates the effect of cocaine use on HIV severity

Chang Shu, Amy Justice, Xinyu Zhang, Zuoheng Wang, Dana Hancock, Eric Johnson, Ke Xu,

Background: Cocaine use accelerates HIV progression and worsens HIV outcomes. We assessed whether DNA methylation (DNAm) in blood mediates the association between cocaine use and HIV severity in a veteran population. Methods: We analyzed 1,435 HIV-positive participants from the Veterans Aging Cohort Study Biomarker Cohort. HIV severity was measured by ... Read more >>

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Correction to: Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy.

Ke Xu, Dongkyoo Park, Andrew T Magis, Jun Zhang, Wei Zhou, Gabriel L Sica, Suresh S Ramalingam, Walter J Curran, Xingming Deng,

An amendment to this paper has been published and can be accessed via the original article. ... Read more >>

Mol. Cancer (Molecular cancer)
[2020, 19(1):93]

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Case report: a Chinese girl with dent disease 1 and turner syndrome due to a hemizygous CLCN5 gene mutation and Isochromosome (Xq).

Yuhong Ye, Jingjing Wang, Xiaofang Quan, Ke Xu, Haidong Fu, Weiyue Gu, Jianhua Mao,

BACKGROUND:Female Dent disease 1 patients with low-molecular-weight proteinuria (LMWP) due to CLCN5 gene mutation were rarely reported, and these cases that the people were also with Turner syndrome (TS) were even hardly documented before. CASE PRESENTATION:Here we report a 3-year and 11-month old Chinese girl with short stature who had ... Read more >>

BMC Nephrol (BMC nephrology)
[2020, 21(1):171]

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Cytotoxic Heptaketides from the Endolichenic Fungus Ulospora bilgramii.

Fei Xie, Xiao-Yi Luan, Yun Gao, Ke Xu, Hong-Xiang Lou,

Eleven new metabolites including nine heptaketides, ulosporin A-G (1a-7b), one diphenyl compound, ulophenol (8), and one spirobisnaphthalene, palmarumycin P5 (9), were isolated from the endolichenic fungus Ulospora bilgramii, which inhabits the lichen Umbilicaria sp. The structures of these compounds were elucidated based on comprehensive analysis of their spectroscopic, electronic circular ... Read more >>

J. Nat. Prod. (Journal of natural products)
[2020, 83(5):1623-1633]

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A Population-Based Analysis of Distant Metastasis in Stage IV Gastric Cancer.

Yiran Zhang, Yile Lin, Jincai Duan, Ke Xu, Min Mao, Xin Wang,

BACKGROUND Distant metastasis (DM) is a crucial problem in management of patients with gastric cancer. Identification of the risk factors for development of DM and the prognostic factors for patients with DM is essential in development of individualized treatment of patients at the advanced stage with specific metastasis. MATERIAL AND ... Read more >>

Med. Sci. Monit. (Medical science monitor : international medical journal of experimental and clinical research)
[2020, 26:e923867]

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Direct Observation of the Exciton Self-Trapping Process in CsCu2I3 Thin Films.

Robin Kentsch, Marius Morgenroth, Mirko Scholz, Ke Xu, Jörn Schmedt Auf der Günne, Thomas Lenzer, Kawon Oum,

Low-dimensional copper halides, such as CsCu2I3, have emerged as promising LED materials featuring strongly Stokes-shifted photoluminescence with high quantum yield. Previous calculations suggest an exciton self-trapping mechanism; however, direct experimental evidence for this process is still lacking. Here, we present femtosecond UV-vis transient absorption experiments of CsCu2I3 thin films. The ... Read more >>

J Phys Chem Lett (The journal of physical chemistry letters)
[2020, :4286-4291]

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Refining Risk Prediction for Recurrent Venous Thromboembolism: Can We Do Better?

Ke Xu, Noel C Chan,

Thromb. Haemost. (Thrombosis and haemostasis)
[2020, 120(5):725-727]

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A mode of cell adhesion and migration facilitated by CD44-dependent microtentacles.

Kayla J Wolf, Poojan Shukla, Kelsey Springer, Stacey Lee, Jason D Coombes, Caleb J Choy, Samuel J Kenny, Ke Xu, Sanjay Kumar,

The structure and mechanics of many connective tissues are dictated by a collagen-rich extracellular matrix (ECM), where collagen fibers provide topological cues that direct cell migration. However, comparatively little is known about how cells navigate the hyaluronic acid (HA)-rich, nanoporous ECM of the brain, a problem with fundamental implications for ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2020, 117(21):11432-11443]

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Hippocampal Resting State Functional Connectivity in Patients With Schizophrenia and Unaffected Family Members.

E Kale Edmiston, Yanzhuo Song, Miao Chang, Zhiyang Yin, Qian Zhou, Yifang Zhou, Xiaowei Jiang, Shengnan Wei, Ke Xu, Yanqing Tang, Fei Wang,

The hippocampus is an important candidate region in the study of functional connectivity alterations in schizophrenia (SZ) given its role as a functional hub for multiple brain networks. Although studies have implicated the hippocampus in SZ, no studies have compared hippocampal functional connectivity in healthy participants, patients with SZ, and ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2020, 11:278]

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GOLVEN peptide signalling through RGI receptors and MPK6 restricts asymmetric cell division during lateral root initiation.

Ana I Fernandez, Nick Vangheluwe, Ke Xu, Joris Jourquin, Lucas Alves Neubus Claus, Stefania Morales-Herrera, Boris Parizot, Hugues De Gernier, Qiaozhi Yu, Andrzej Drozdzecki, Takanori Maruta, Kurt Hoogewijs, Willem Vannecke, Brenda Peterson, Davy Opdenacker, Annemieke Madder, Zachary L Nimchuk, Eugenia Russinova, Tom Beeckman,

During lateral root initiation, lateral root founder cells undergo asymmetric cell divisions that generate daughter cells with different sizes and fates, a prerequisite for correct primordium organogenesis. An excess of the GLV6/RGF8 peptide disrupts these initial asymmetric cell divisions, resulting in more symmetric divisions and the failure to achieve lateral ... Read more >>

Nat Plants (Nature plants)
[2020, 6(5):533-543]

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The Functional Spatio-Temporal Statistical Model with Application to O3 Pollution in Beijing, China.

Yaqiong Wang, Ke Xu, Shaomin Li,

In recent years, with rapid industrialization and massive energy consumption, ground-level ozone ( O 3 ) has become one of the most severe air pollutants. In this paper, we propose a functional spatio-temporal statistical model to analyze air quality data. Firstly, since the pollutant data from the monitoring network usually ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(9):]

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Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals.

Yuan Liu, Zhi Ning, Yu Chen, Ming Guo, Yingle Liu, Nirmal Kumar Gali, Li Sun, Yusen Duan, Jing Cai, Dane Westerdahl, Xinjin Liu, Ke Xu, Kin-Fai Ho, Haidong Kan, Qingyan Fu, Ke Lan,

The ongoing outbreak of coronavirus disease (COVID)-19 has spread rapidly on a global scale. Although it is clear that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted through human respiratory droplets and direct contact, the potential for aerosol transmission is poorly understood1-3. Here we investigated the aerodynamic nature of ... Read more >>

Nature (Nature)
[2020, :]

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Bone marrow mesenchymal stem cells improve bone erosion in collagen-induced arthritis by inhibiting osteoclasia-related factors and differentiating into chondrocytes.

Jinfang Gao, Gailian Zhang, Ke Xu, Dan Ma, Limin Ren, Jingjing Fan, Jianwen Hou, Jian Han, Liyun Zhang,

BACKGROUND:Rheumatoid arthritis (RA) is characterized by joint inflammation and damage to the cartilage and bone in collagen-induced arthritis (CIA). Mesenchymal stem cells (MSCs) can improve articular symptoms and reduce bone erosion in CIA rats; however, the underlying mechanism remains unknown. This study aimed to investigate the mechanism underlying MSC-induced improvement ... Read more >>

Stem Cell Res Ther (Stem cell research & therapy)
[2020, 11(1):171]

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Knockdown of CTRP6 reduces the deposition of intramuscular and subcutaneous fat in pigs via different signaling pathways.

Wenjing Wu, Miao Ji, Ke Xu, Dawei Zhang, Yajun Yin, Xin Huang, Yongjia Peng, Jin Zhang,

The regulation of porcine subcutaneous (SC) and intramuscular (IM) fat deposition significantly affects pork quality and the lean meat percentage of the carcass, respectively. The adipokine C1q/tumor necrosis factor-related protein 6 (CTRP6), plays a significant role in regulating animal fat deposition. The purpose of this study was to understand the ... Read more >>

Biochim Biophys Acta Mol Cell Biol Lipids (Biochimica et biophysica acta. Molecular and cell biology of lipids)
[2020, 1865(8):158729]

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Carvacrol Induces Candida albicans Apoptosis Associated With Ca2+/Calcineurin Pathway.

Chao Niu, Chenglu Wang, Yijia Yang, Ruiyao Chen, Jian Zhang, Haiyan Chen, Yingzhi Zhuge, Jingqi Li, Jianhua Cheng, Ke Xu, Maoping Chu, Chunhua Ren, Chunxiang Zhang, Chang Jia,

As the prevalence of systemic fungal infections caused by Candida albicans gradually increases, it is necessary to explore potential and effective antifungals. Carvacrol is reported to be lethally toxic to C. albicans, involving several potential mechanisms. However, the form and specific mechanism of cell death caused by this compound has ... Read more >>

Front Cell Infect Microbiol (Frontiers in cellular and infection microbiology)
[2020, 10:192]

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Cinobufacini Inhibits Colon Cancer Invasion and Metastasis via Suppressing Wnt/β-Catenin Signaling Pathway and EMT.

Jie Wang, Han Cai, Qiaoli Liu, Yue Xia, LiKai Xing, Qingsong Zuo, Yong Zhang, Cao Chen, Ke Xu, Peihao Yin, Teng Chen,

Cinobufacini is a well-known Chinese medicine extracted from Venenum Bufonis, also called Chan Su. It has been used clinically for various cancers, including colon cancer. However, the function of Cinobufacini on colon cancer invasion and metastasis, and its underlying molecular mechanism, is still not clear. In this study, we investigated ... Read more >>

Am. J. Chin. Med. (The American journal of Chinese medicine)
[2020, 48(3):703-718]

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Development of Novel Anti-influenza Thiazolides with Relatively Broad-spectrum Antiviral Potentials.

Lei Zhao, Yunzheng Yan, Qingsong Dai, Xingzhou Li, Ke Xu, Gang Zou, Keyu Yang, Wei Li, Xiaojia Guo, Jingjing Yang, Yuexiang Li, Qing Xia, Ruiyuan Cao, Wu Zhong,

Seasonal and pandemic influenza causes 650,000 deaths annually in the world. The emergence of drug-resistance to specific anti-influenza drugs such as oseltamivir and baloxavir marboxil highlights the urgency of novel anti-influenza chemical entity discovery. In this study, we report a series of novel thiazolides derived from an FDA-approved drug nitazoxanide ... Read more >>

Antimicrob. Agents Chemother. (Antimicrobial agents and chemotherapy)
[2020, :]

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Interpretation of Autosomal Recessive Kidney Diseases With "Presumed Homozygous" Pathogenic Variants Should Consider Technical Pitfalls.

Haiyue Deng, Yanqin Zhang, Yong Yao, Huijie Xiao, Baige Su, Ke Xu, Na Guan, Jie Ding, Fang Wang,

Background: A false interpretation of homozygosity for pathogenic variants causing autosomal recessive disorders can lead to improper genetic counseling. The aim of this study was to demonstrate the underlying etiologies of presumed homozygous disease-causing variants harbored in six unrelated children with five different genetic renal diseases when the same variant ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:165]

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Echocardiographic Results of Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients: The PARTNER 3 Trial.

Philippe Pibarot, Erwan Salaun, Abdellaziz Dahou, Eleonora Avenatti, Ezequiel Guzzetti, Mohamed-Salah Annabi, Oumhani Toubal, Mathieu Bernier, Jonathan Beaudoin, Géraldine Ong, Julien Ternacle, Laura Krapf, Vinod H Thourani, Raj Makkar, Susheel K Kodali, Mark Russo, Samir R Kapadia, S Chris Malaisrie, David J Cohen, Jonathon Leipsic, Philipp Blanke, Mathew R Williams, James M McCabe, David L Brown, Vasilis Babaliaros, Scott Goldman, Wilson Y Szeto, Philippe Généreux, Ashish Pershad, Maria C Alu, Ke Xu, Erin Rogers, John G Webb, Craig R Smith, Michael J Mack, Martin B Leon, Rebecca T Hahn, ,

BACKGROUND:This study aimed to compare echocardiographic findings in low-risk patients with severe aortic stenosis after surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR). METHODS:The PARTNER 3 trial (Placement of Aortic Transcatheter Valves) randomized 1000 patients with severe aortic stenosis and low surgical risk to undergo either transfemoral ... Read more >>

Circulation (Circulation)
[2020, 141(19):1527-1537]

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