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Correction to: Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2.

Rui Xiong, Leike Zhang, Shiliang Li, Yuan Sun, Minyi Ding, Yong Wang, Yongliang Zhao, Yan Wu, Weijuan Shang, Xiaming Jiang, Jiwei Shan, Zihao Shen, Yi Tong, Liuxin Xu, Yu Chen, Yingle Liu, Gang Zou, Dimitri Lavillete, Zhenjiang Zhao, Rui Wang, Lili Zhu, Gengfu Xiao, Ke Lan, Honglin Li, Ke Xu,

Protein Cell (Protein & cell)
[2021, 12(1):76-80]

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Nanobodies targeting immune checkpoint molecules for tumor immunotherapy and immunoimaging (Review).

Sheng Yu, Gui Xiong, Shimei Zhao, Yanbo Tang, Hua Tang, Kaili Wang, Hongjing Liu, Ke Lan, Xiongjie Bi, Siliang Duan,

The immune checkpoint blockade is an effective strategy to enhance the anti‑tumor T cell effector activity, thus becoming one of the most promising immunotherapeutic strategies in the history of cancer treatment. Several immune checkpoint inhibitor have been approved by the FDA, such as anti‑CTLA‑4, anti‑PD‑1, anti‑PD‑L1 monoclonal antibodies. Most tumor ... Read more >>

Int J Mol Med (International journal of molecular medicine)
[2021, 47(2):444-454]

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AnnoLnc: A One-Stop Portal to Systematically Annotate Novel Human Long Noncoding RNAs.

De-Chang Yang, Lan Ke, Yang Ding, Ge Gao,

While more than a hundred thousand long noncoding RNAs (lncRNAs) have been identified in human genome, their biological functions and regulation are largely elusive. Here we present AnnoLnc, a one-stop online annotation portal for human lncRNAs ( http://annolnc1.gao-lab.org/ ). As the first (and the most comprehensive) Web server to provide ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2021, 2254:111-131]

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Development of a risk scoring system for prognostication in HIV-related toxoplasma encephalitis.

Yao Li, Yan-Ming Zeng, Min Liu, Yan-Qiu Lu, Xue-Yan Liu, Yu-Lin Zhang, Zhong-Sheng Jiang, Tong-Tong Yang, Yan Sun, Ke Lan, Yao-Kai Chen,

<h4>Background</h4>This study aims to evaluate specific risk factors influencing prognosis of HIV-infected patients with toxoplasma encephalitis (TE) in order to develop a prognostic risk scoring system for them.<h4>Methods</h4>This is a six-center retrospective study of hospitalized HIV/TE patients. Data including six-week mortality after diagnosis, baseline characteristics, clinical features, laboratory tests and ... Read more >>

BMC Infect Dis (BMC infectious diseases)
[2020, 20(1):923]

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ddPCR: a more accurate tool for SARS-CoV-2 detection in low viral load specimens.

Tao Suo, Xinjin Liu, Jiangpeng Feng, Ming Guo, Wenjia Hu, Dong Guo, Hafiz Ullah, Yang Yang, Qiuhan Zhang, Xin Wang, Muhanmmad Sajid, Zhixiang Huang, Liping Deng, Tielong Chen, Fang Liu, Ke Xu, Yuan Liu, Qi Zhang, Yingle Liu, Yong Xiong, Guozhong Chen, Ke Lan, Yu Chen,

Quantitative real time PCR (RT-PCR) is widely used as the gold standard for clinical detection of SARS-CoV-2. However, due to the low viral load specimens and the limitations of RT-PCR, significant numbers of false negative reports are inevitable, which results in failure to timely diagnose, cut off transmission, and assess ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1259-1268]

Cited: 25 times

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Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism.

Xiaojiao Zheng, Tianlu Chen, Runqiu Jiang, Aihua Zhao, Qing Wu, Junliang Kuang, Dongnan Sun, Zhenxing Ren, Mengci Li, Mingliang Zhao, Shouli Wang, Yuqian Bao, Huating Li, Cheng Hu, Bing Dong, Defa Li, Jiayu Wu, Jialin Xia, Xuemei Wang, Ke Lan, Cynthia Rajani, Guoxiang Xie, Aiping Lu, Weiping Jia, Changtao Jiang, Wei Jia,

Hyocholic acid (HCA) and its derivatives are found in trace amounts in human blood but constitute approximately 76% of the bile acid (BA) pool in pigs, a species known for its exceptional resistance to type 2 diabetes. Here, we show that BA depletion in pigs suppressed secretion of glucagon-like peptide-1 ... Read more >>

Cell Metab (Cell metabolism)
[2020, :]

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Development of a risk scoring system for prognostication in HIV-related toxoplasma encephalitis

Yao Li, Yanming Zeng, Min Liu, Yanqiu Lu, Xueyan Liu, Yulin Zhang, Zhongsheng Jiang, Tongtong Yang, Yan Sun, Ke Lan, Yaokai Chen,

<h4>Background: </h4> This study aims to evaluate specific risk factors influencing prognosis of HIV-infected patients with toxoplasma encephalitis (TE) in order to develop a prognostic risk scoring system for them. <h4>Methods: </h4> This is a six-center retrospective study of hospitalized HIV/TE patients. Data including six-week mortality after diagnosis, baseline characteristics, ... Read more >>

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Analytical comparisons of SARS-COV-2 detection by qRT-PCR and ddPCR with multiple primer/probe sets.

Xinjin Liu, Jiangpeng Feng, Qiuhan Zhang, Dong Guo, Lu Zhang, Tao Suo, Wenjia Hu, Ming Guo, Xin Wang, Zhixiang Huang, Yong Xiong, Guozhong Chen, Yu Chen, Ke Lan,

Different primers/probes sets have been developed all over the world for the nucleic acid detection of SARS-CoV-2 by quantitative real time polymerase chain reaction (qRT-PCR) as a standard method. In our recent study, we explored the feasibility of droplet digital PCR (ddPCR) for clinical SARS-CoV-2 nucleic acid detection compared with ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1175-1179]

Cited: 4 times

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Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients.

Yong Xiong, Yuan Liu, Liu Cao, Dehe Wang, Ming Guo, Ao Jiang, Dong Guo, Wenjia Hu, Jiayi Yang, Zhidong Tang, Honglong Wu, Yongquan Lin, Meiyuan Zhang, Qi Zhang, Mang Shi, Yingle Liu, Yu Zhou, Ke Lan, Yu Chen,

Circulating in China and 158 other countries and areas, the ongoing COVID-19 outbreak has caused devastating mortality and posed a great threat to public health. However, efforts to identify effectively supportive therapeutic drugs and treatments has been hampered by our limited understanding of host immune response for this fatal disease. ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):761-770]

Cited: 151 times

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Adverse Events of Intense Pulsed Light Combined With Meibomian Gland Expression Versus Meibomian Gland Expression in the Treatment of Meibomian Gland Dysfunction.

Chen Qiao, Liping Li, Haoyu Wang, Cong Zhao, Lan Ke, Dan Sen, Mengying Qi, Shaowei Li, Mingwu Wang, Qingyan Zeng,

<h4>Background and objective</h4>To analyze the occurrence and causes of adverse events (AEs) in intense pulsed light (IPL) combined with meibomian gland expression (MGX) and MGX treatment alone for meibomian gland dysfunction (MGD).<h4>Study design/materials and methods</h4>A retrospective study was conducted on MGD patients treated in Wuhan Aier Hankou Eye Hospital from ... Read more >>

Lasers Surg Med (Lasers in surgery and medicine)
[2020, :]

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Correction to: Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2.

Rui Xiong, Leike Zhang, Shiliang Li, Yuan Sun, Minyi Ding, Yong Wang, Yongliang Zhao, Yan Wu, Weijuan Shang, Xiaming Jiang, Jiwei Shan, Zihao Shen, Yi Tong, Liuxin Xu, Yu Chen, Yingle Liu, Gang Zou, Dimitri Lavillette, Zhenjiang Zhao, Rui Wang, Lili Zhu, Gengfu Xiao, Ke Lan, Honglin Li, Ke Xu,

In the original publication the author's name 'Dimitri Lavillete' is published incorrectly. The correct author name should be spelt as 'Dimitri Lavillette' is provided in this correction. ... Read more >>

Protein Cell (Protein & cell)
[2020, :]

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A Study of Two Cases Co-Infected with SARS-CoV-2 and Human Immunodeficiency Virus.

Rong Zhang, Xiaohua Chen, Yuqing Huang, Qi Zhang, Yan Cheng, Nan Zhang, Haibo Zhang, Bo Yang, Fang Liu, Yingle Liu, Ke Lan,

Virol Sin (Virologica Sinica)
[2020, 35(6):849-852]

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Many bat species are not potential hosts of SARS-CoV and SARS-CoV-2: Evidence from ACE2 receptor usage

Huan Yan, Hengwu Jiao, Qianyun Liu, Zhen Zhang, Xin Wang, Ming Guo, Bing-Jun Wang, Ke Lan, Yu Chen, Huabin Zhao,

Bats are the suggested natural hosts for severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2, the latter of which caused the coronavirus disease 2019 (COVID-19) pandemic. The interaction of viral Spike proteins with their host receptor angiotensin-converting enzyme 2 (ACE2) is a critical determinant of potential hosts and cross-species transmission. ... Read more >>

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Identification of dibucaine derivatives as novel potent enterovirus 2C helicase inhibitors: In vitro, in vivo, and combination therapy study.

Qi Tang, Zhichao Xu, Mengyu Jin, Ting Shu, Yinuo Chen, Leilei Feng, Qiuhan Zhang, Ke Lan, Shuwen Wu, Hai-Bing Zhou,

Enterovirus A71 (EV-A71) is a human pathogen causing hand, foot and mouth disease (HFMD) which seriously threatened the safety and lives of infants and young children. However, there are no licensed direct antiviral agents to cure the HFMD. In this study, a series of quinoline formamide analogues as effective enterovirus ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2020, 202:112310]

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A Small-Scale Medication of Leflunomide as a Treatment of COVID-19 in an Open-Label Blank-Controlled Clinical Trial.

Ke Hu, Mengmei Wang, Yang Zhao, Yunting Zhang, Tao Wang, Zhishui Zheng, Xiaochen Li, Shaolin Zeng, Dong Zhao, Honglin Li, Ke Xu, Ke Lan,

We recently reported that inhibitors against human dihydroorotate dehydrogenase (DHODH) have broad-spectrum antiviral activities including their inhibitory efficacies on SARS-CoV-2 replication in infected cells. However, there are limited data from clinical studies to prove the application of DHODH inhibitors in Coronavirus disease 2019 (COVID-19) patients. In the present study, we evaluated ... Read more >>

Virol Sin (Virologica Sinica)
[2020, 35(6):725-733]

Cited: 2 times

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Urinary Bile Acid Profile of Newborns Born by Cesarean Section Is Characterized by Oxidative Metabolism of Primary Bile Acids: Limited Roles of Fetal-Specific CYP3A7 in Cholate Oxidations.

Wen-Xia Wang, Li Chen, Guo-Yu Wang, Jin-Ling Zhang, Xian-Wen Tan, Qiu-Hong Lin, Yu-Jie Chen, Jian Zhang, Ping-Ping Zhu, Jia Miao, Ming-Ming Su, Chang-Xiao Liu, Wei Jia, Ke Lan,

This work aims to investigate how the bile acid metabolism of newborns differs from that of adults along the axis of primary, secondary, and tertiary bile acids (BAs). The total unconjugated BA profiles were quantitatively determined by enzyme digestion techniques in urine of 21 newborns born by cesarean section, 29 ... Read more >>

Drug Metab Dispos (Drug metabolism and disposition: the biological fate of chemicals)
[2020, 48(8):662-672]

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AnnoLnc2: the one-stop portal to systematically annotate novel lncRNAs for human and mouse.

Lan Ke, De-Chang Yang, Yu Wang, Yang Ding, Ge Gao,

With the abundant mammalian lncRNAs identified recently, a comprehensive annotation resource for these novel lncRNAs is an urgent need. Since its first release in November 2016, AnnoLnc has been the only online server for comprehensively annotating novel human lncRNAs on-the-fly. Here, with significant updates to multiple annotation modules, backend datasets ... Read more >>

Nucleic Acids Res (Nucleic acids research)
[2020, 48(W1):W230-W238]

Cited: 1 time

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Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals.

Yuan Liu, Zhi Ning, Yu Chen, Ming Guo, Yingle Liu, Nirmal Kumar Gali, Li Sun, Yusen Duan, Jing Cai, Dane Westerdahl, Xinjin Liu, Ke Xu, Kin-Fai Ho, Haidong Kan, Qingyan Fu, Ke Lan,

The ongoing outbreak of coronavirus disease 2019 (COVID-19) has spread rapidly on a global scale. Although it is clear that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted through human respiratory droplets and direct contact, the potential for aerosol transmission is poorly understood<sup>1-3</sup>. Here we investigated the aerodynamic nature of ... Read more >>

Nature (Nature)
[2020, 582(7813):557-560]

Cited: 157 times

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Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity.

Chun Zhou, Xia Chen, Rosa Planells-Cases, Jiachen Chu, Li Wang, Limin Cao, Zhihong Li, Karen I López-Cayuqueo, Yadong Xie, Shiwei Ye, Xiang Wang, Florian Ullrich, Shixin Ma, Yiyuan Fang, Xiaoming Zhang, Zhikang Qian, Xiaozheng Liang, Shi-Qing Cai, Zhengfan Jiang, Dongming Zhou, Qibin Leng, Tsan S Xiao, Ke Lan, Jinbo Yang, Huabin Li, Chao Peng, Zhaozhu Qiu, Thomas J Jentsch, Hui Xiao,

The enzyme cyclic GMP-AMP synthase (cGAS) senses cytosolic DNA in infected and malignant cells and catalyzes the formation of 2'3'cGMP-AMP (cGAMP), which in turn triggers interferon (IFN) production via the STING pathway. Here, we examined the contribution of anion channels to cGAMP transfer and anti-viral defense. A candidate screen revealed ... Read more >>

Immunity (Immunity)
[2020, 52(5):767-781.e6]

Cited: 4 times

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Species Differences of Bile Acid Redox Metabolism: Tertiary Oxidation of Deoxycholate is Conserved in Preclinical Animals.

Qiuhong Lin, Xianwen Tan, Wenxia Wang, Wushuang Zeng, Lanlan Gui, Mingming Su, Changxiao Liu, Wei Jia, Liang Xu, Ke Lan,

It was recently disclosed that CYP3A is responsible for the tertiary stereoselective oxidations of deoxycholic acid (DCA), which becomes a continuum mechanism of the host-gut microbial cometabolism of bile acids (BAs) in humans. This work aims to investigate the species differences of BA redox metabolism and clarify whether the tertiary ... Read more >>

Drug Metab Dispos (Drug metabolism and disposition: the biological fate of chemicals)
[2020, 48(6):499-507]

Cited: 1 time

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Detection of Covid-19 in Children in Early January 2020 in Wuhan, China.

Weiyong Liu, Qi Zhang, Junbo Chen, Rong Xiang, Huijuan Song, Sainan Shu, Ling Chen, Lu Liang, Jiaxin Zhou, Lei You, Peng Wu, Bo Zhang, Yanjun Lu, Liming Xia, Lu Huang, Yang Yang, Fang Liu, Malcolm G Semple, Benjamin J Cowling, Ke Lan, Ziyong Sun, Hongjie Yu, Yingle Liu,

N Engl J Med (The New England journal of medicine)
[2020, 382(14):1370-1371]

Cited: 130 times

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Lamellar Keratoplasty Combined with Amniotic Membrane Transplantation for the Treatment of Corneal Perforations: A Clinical and In Vivo Confocal Microscopy Study.

Lan Ke, Dan Shen, Haoyu Wang, Chen Qiao, Qingyan Zeng,

<h4>Purpose</h4>To evaluate the clinical and in vivo confocal microscopy outcome of lamellar keratoplasty combined with amniotic membrane transplantation for the treatment of corneal perforations.<h4>Methods</h4>In this retrospective, noncomparative, and interventional case series, 13 eyes of 13 patients with corneal perforation were included. All eyes were treated with lamellar keratoplasty combined with ... Read more >>

Biomed Res Int (BioMed research international)
[2020, 2020:7403842]

Cited: 0 times

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ddPCR: a more sensitive and accurate tool for SARS-CoV-2 detection in low viral load specimens

Tao Suo, Xinjin Liu, Jiangpeng Feng, Ming Guo, Wenjia Hu, Dong Guo, Hafiz Ullah, Yang Yang, Qiuhan Zhang, Xin Wang, Muhanmmad Sajid, Zhixiang Huang, Liping Deng, Tielong Chen, Fang Liu, Xu Ke, Yuan Liu, Qi Zhang, Yingle Liu, Yong Xiong, Guozhong Chen, Ke Lan, Yu Chen,

Real time fluorescent quantitative PCR (RT-PCR) is widely used as the gold standard for clinical detection of SARS-CoV-2. However, due to the low viral load in patient throats and the limitations of RT-PCR, significant numbers of false negative reports are inevitable, which results in failure to timely diagnose, early treat, ... Read more >>

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RNA based mNGS approach identifies a novel human coronavirus from two individual pneumonia cases in 2019 Wuhan outbreak.

Liangjun Chen, Weiyong Liu, Qi Zhang, Ke Xu, Guangming Ye, Weichen Wu, Ziyong Sun, Fang Liu, Kailang Wu, Bo Zhong, Yi Mei, Wenxia Zhang, Yu Chen, Yirong Li, Mang Shi, Ke Lan, Yingle Liu,

From December 2019, an outbreak of unusual pneumonia was reported in Wuhan with many cases linked to Huanan Seafood Market that sells seafood as well as live exotic animals. We investigated two patients who developed acute respiratory syndromes after independent contact history with this market. The two patients shared common ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):313-319]

Cited: 88 times

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A quite sensitive fluorescent loop-mediated isothermal amplification for rapid detection of respiratory syncytial virus.

Yihong Hu, Zhenzhou Wan, Yonglin Mu, Yi Zhou, Jia Liu, Ke Lan, Chiyu Zhang,

INTRODUCTION:Human respiratory syncytial virus (hRSV) is a common respiratory virus closely related to respiratory tract infection (RTI). Rapid and accurate detection of hRSV is urgently needed to reduce the high morbidity and mortality due to hRSV infection. METHODOLOGY:Here, we established a highly sensitive and specific reverse-transcription loop-mediated isothermal amplification (RT-LAMP) ... Read more >>

J Infect Dev Ctries (Journal of infection in developing countries)
[2019, 13(12):1135-1141]

Cited: 2 times

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