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Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients.

Yong Xiong, Yuan Liu, Liu Cao, Dehe Wang, Ming Guo, Ao Jiang, Dong Guo, Wenjia Hu, Jiayi Yang, Zhidong Tang, Honglong Wu, Yongquan Lin, Meiyuan Zhang, Qi Zhang, Mang Shi, Yingle Liu, Yu Zhou, Ke Lan, Yu Chen,

Circulating in China and 158 other countries and areas, the ongoing COVID-19 outbreak has caused devastating mortality and posed a great threat to public health. However, efforts to identify effectively supportive therapeutic drugs and treatments has been hampered by our limited understanding of host immune response for this fatal disease. ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):761-770]

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ddPCR: a more accurate tool for SARS-CoV-2 detection in low viral load specimens.

Tao Suo, Xinjin Liu, Jiangpeng Feng, Ming Guo, Wenjia Hu, Dong Guo, Hafiz Ullah, Yang Yang, Qiuhan Zhang, Xin Wang, Muhanmmad Sajid, Zhixiang Huang, Liping Deng, Tielong Chen, Fang Liu, Ke Xu, Yuan Liu, Qi Zhang, Yingle Liu, Yong Xiong, Guozhong Chen, Ke Lan, Yu Chen,

Quantitative real time PCR (RT-PCR) is widely used as the gold standard for clinical detection of SARS-CoV-2. However, due to the low viral load specimens and the limitations of RT-PCR, significant numbers of false negative reports are inevitable, which results in failure to timely diagnose, early treat, cut off transmission, ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, :1-30]

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Analytical comparisons of SARS-COV-2 detection by qRT-PCR and ddPCR with multiple primer/probe sets.

Xinjin Liu, Jiangpeng Feng, Qiuhan Zhang, Dong Guo, Lu Zhang, Tao Suo, Wenjia Hu, Ming Guo, Xin Wang, Zhixiang Huang, Yong Xiong, Guozhong Chen, Yu Chen, Ke Lan,

Different primers/probes sets have been developed all over the world for the nucleic acid detection of SARS-CoV-2 by quantitative real time polymerase chain reaction (qRT-PCR) as a standard method. In our recent study, we explored the feasibility of droplet digital PCR (ddPCR) for clinical SARS-CoV-2 nucleic acid detection compared with ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, :1-12]

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Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals.

Yuan Liu, Zhi Ning, Yu Chen, Ming Guo, Yingle Liu, Nirmal Kumar Gali, Li Sun, Yusen Duan, Jing Cai, Dane Westerdahl, Xinjin Liu, Ke Xu, Kin-Fai Ho, Haidong Kan, Qingyan Fu, Ke Lan,

The ongoing outbreak of coronavirus disease (COVID)-19 has spread rapidly on a global scale. Although it is clear that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted through human respiratory droplets and direct contact, the potential for aerosol transmission is poorly understood1-3. Here we investigated the aerodynamic nature of ... Read more >>

Nature (Nature)
[2020, :]

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AnnoLnc2: the one-stop portal to systematically annotate novel lncRNAs for human and mouse.

Lan Ke, De-Chang Yang, Yu Wang, Yang Ding, Ge Gao,

With the abundant mammalian lncRNAs identified recently, a comprehensive annotation resource for these novel lncRNAs is an urgent need. Since its first release in November 2016, AnnoLnc has been the only online server for comprehensively annotating novel human lncRNAs on-the-fly. Here, with significant updates to multiple annotation modules, backend datasets ... Read more >>

Nucleic Acids Res. (Nucleic acids research)
[2020, :]

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Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity.

Chun Zhou, Xia Chen, Rosa Planells-Cases, Jiachen Chu, Li Wang, Limin Cao, Zhihong Li, Karen I López-Cayuqueo, Yadong Xie, Shiwei Ye, Xiang Wang, Florian Ullrich, Shixin Ma, Yiyuan Fang, Xiaoming Zhang, Zhikang Qian, Xiaozheng Liang, Shi-Qing Cai, Zhengfan Jiang, Dongming Zhou, Qibin Leng, Tsan S Xiao, Ke Lan, Jinbo Yang, Huabin Li, Chao Peng, Zhaozhu Qiu, Thomas J Jentsch, Hui Xiao,

The enzyme cyclic GMP-AMP synthase (cGAS) senses cytosolic DNA in infected and malignant cells and catalyzes the formation of 2'3'cGMP-AMP (cGAMP), which in turn triggers interferon (IFN) production via the STING pathway. Here, we examined the contribution of anion channels to cGAMP transfer and anti-viral defense. A candidate screen revealed ... Read more >>

Immunity (Immunity)
[2020, 52(5):767-781.e6]

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Species Differences of Bile Acid Redox Metabolism: Tertiary Oxidation of Deoxycholate is Conserved in Preclinical Animals.

Qiu-Hong Lin, Xian-Wen Tan, Wen-Xia Wang, Wu-Shuang Zeng, Lan-Lan Gui, Ming-Ming Su, Chang-Xiao Liu, Wei Jia, Liang Xu, Ke Lan,

It was recently disclosed that CYP3A is responsible for the tertiary stereoselective oxidations of deoxycholic acid (DCA), which becomes a continuum mechanism of the host-gut microbial co-metabolism of bile acids (BAs) in human. This work aims to investigate the species difference of BA redox metabolism and clarify whether the tertiary ... Read more >>

Drug Metab. Dispos. (Drug metabolism and disposition: the biological fate of chemicals)
[2020, :]

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Detection of Covid-19 in Children in Early January 2020 in Wuhan, China.

Weiyong Liu, Qi Zhang, Junbo Chen, Rong Xiang, Huijuan Song, Sainan Shu, Ling Chen, Lu Liang, Jiaxin Zhou, Lei You, Peng Wu, Bo Zhang, Yanjun Lu, Liming Xia, Lu Huang, Yang Yang, Fang Liu, Malcolm G Semple, Benjamin J Cowling, Ke Lan, Ziyong Sun, Hongjie Yu, Yingle Liu,

N. Engl. J. Med. (The New England journal of medicine)
[2020, 382(14):1370-1371]

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Novel and potent inhibitors targeting DHODH, a rate-limiting enzyme in de novo pyrimidine biosynthesis, are broad-spectrum antiviral against RNA viruses including newly emerged coronavirus SARS-CoV-2

Rui Xiong, Leike Zhang, Shiliang Li, Yuan Sun, Minyi Ding, Yong Wang, Yongliang Zhao, Yan Wu, Weijuan Shang, Xiaming Jiang, Jiwei Shan, Zihao Shen, Yi Tong, Liuxin Xu, Chen Yu, Yingle Liu, Gang Zou, Dimitri Lavillete, Zhenjiang Zhao, Rui Wang, Lili Zhu, Gengfu Xiao, Ke Lan, Honglin Li, Ke Xu,

Abstract Emerging and re-emerging RNA viruses occasionally cause epidemics and pandemics worldwide, such as the on-going outbreak of coronavirus SARS-CoV-2. Existing direct-acting antiviral (DAA) drugs cannot be applied immediately to new viruses because of virus-specificity, and the development of new DAA drugs from the beginning is not timely for outbreaks. ... Read more >>

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ddPCR: a more sensitive and accurate tool for SARS-CoV-2 detection in low viral load specimens

Tao Suo, Xinjin Liu, Jiangpeng Feng, Ming Guo, Wenjia Hu, Dong Guo, Hafiz Ullah, Yang Yang, Qiuhan Zhang, Xin Wang, Muhanmmad Sajid, Zhixiang Huang, Liping Deng, Tielong Chen, Fang Liu, Ke Xu, Yuan Liu, Qi Zhang, Yingle Liu, Yong Xiong, Guozhong Chen, Ke Lan, Yu Chen,

Real time fluorescent quantitative PCR (RT-PCR) is widely used as the gold standard for clinical detection of SARS-CoV-2. However, due to the low viral load in patient throats and the limitations of RT-PCR, significant numbers of false negative reports are inevitable, which results in failure to timely diagnose, early treat, ... Read more >>

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Lamellar Keratoplasty Combined with Amniotic Membrane Transplantation for the Treatment of Corneal Perforations: A Clinical and In Vivo Confocal Microscopy Study.

Lan Ke, Dan Shen, Haoyu Wang, Chen Qiao, Qingyan Zeng,

Purpose:To evaluate the clinical and in vivo confocal microscopy outcome of lamellar keratoplasty combined with amniotic membrane transplantation for the treatment of corneal perforations. Methods:In this retrospective, noncomparative, and interventional case series, 13 eyes of 13 patients with corneal perforation were included. All eyes were treated with lamellar keratoplasty combined ... Read more >>

Biomed Res Int (BioMed research international)
[2020, 2020:7403842]

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RNA based mNGS approach identifies a novel human coronavirus from two individual pneumonia cases in 2019 Wuhan outbreak.

Liangjun Chen, Weiyong Liu, Qi Zhang, Ke Xu, Guangming Ye, Weichen Wu, Ziyong Sun, Fang Liu, Kailang Wu, Bo Zhong, Yi Mei, Wenxia Zhang, Yu Chen, Yirong Li, Mang Shi, Ke Lan, Yingle Liu,

From December 2019, an outbreak of unusual pneumonia was reported in Wuhan with many cases linked to Huanan Seafood Market that sells seafood as well as live exotic animals. We investigated two patients who developed acute respiratory syndromes after independent contact history with this market. The two patients shared common ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):313-319]

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A quite sensitive fluorescent loop-mediated isothermal amplification for rapid detection of respiratory syncytial virus.

Yihong Hu, Zhenzhou Wan, Yonglin Mu, Yi Zhou, Jia Liu, Ke Lan, Chiyu Zhang,

INTRODUCTION:Human respiratory syncytial virus (hRSV) is a common respiratory virus closely related to respiratory tract infection (RTI). Rapid and accurate detection of hRSV is urgently needed to reduce the high morbidity and mortality due to hRSV infection. METHODOLOGY:Here, we established a highly sensitive and specific reverse-transcription loop-mediated isothermal amplification (RT-LAMP) ... Read more >>

J Infect Dev Ctries (Journal of infection in developing countries)
[2019, 13(12):1135-1141]

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Emetine protects mice from enterovirus infection by inhibiting viral translation.

Qi Tang, Siliang Li, Liaoqi Du, Shihua Chen, Jingyi Gao, Yang Cai, Zhichao Xu, Zixuan Zhao, Ke Lan, Shuwen Wu,

IRES-driven translation plays an essential role in picornavirus infection. However, there are seldom reports of compounds targeting this pathway with effective protection in animal models. Here, we identified emetine, an antiprotozoal drug, which inhibits EV-A71 with an EC50 value of 0.04 μM and a CC50 value of 10 μM in RD cell ... Read more >>

Antiviral Res. (Antiviral research)
[2020, 173:104650]

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A chimpanzee adenoviral vector-based rabies vaccine protects beagle dogs from lethal rabies virus challenge.

Xiang Wang, Zihao Fang, Jun Xiong, Kaiyan Yang, Yudan Chi, Xinying Tang, Li Ma, Renhuai Zhang, Fei Deng, Ke Lan, Dongming Zhou,

Rabies continues to poses serious threats to the public health in many countries. The development of novel inexpensive, safe and effective vaccines has become a high priority for rabies control worldwide. We previously generated a novel recombinant rabies vaccine by cloning rabies virus glycoprotein into a chimpanzee adenoviral vector, termed ... Read more >>

Virology (Virology)
[2019, 536:32-38]

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Altered respiratory virome and serum cytokine profile associated with recurrent respiratory tract infections in children.

Yanpeng Li, Xuemin Fu, Jinmin Ma, Jianhui Zhang, Yihong Hu, Wei Dong, Zhenzhou Wan, Qiongfang Li, Yi-Qun Kuang, Ke Lan, Xia Jin, Jian-Hua Wang, Chiyu Zhang,

Recurrent acute respiratory tract infections (ARTIs) affect a large population, yet the specific decisive factors are largely unknown. Here we study a population of 4407 children diagnosed with ARTI, comparing respiratory virome and serum cytokine profiles associated with multiple ARTIs and single ARTI during a six-year period. The relative abundance ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):2288]

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Co-Delivery of Paclitaxel and PLK1-Targeted siRNA Using Aptamer-Functionalized Cationic Liposome for Synergistic Anti-Breast Cancer Effects In Vivo.

Sheng Yu, Xiongjie Bi, Lei Yang, Shanguang Wu, Yating Yu, Bojin Jiang, Anwen Zhang, Ke Lan, Siliang Duan,

Cancer cells can develop in several ways to escape from death induced by chemotherapeutic agents, thereby weakening the anti-tumor efficacy of single-target chemotherapy. Therefore, the efficacy of conventional chemotherapy hits a single target in tumor cells subject to strict limits. In this article, an AS1411 aptamer-functionalized liposome is prepared, which ... Read more >>

J Biomed Nanotechnol (Journal of biomedical nanotechnology)
[2019, 15(6):1135-1148]

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First exploration of radiation temperatures of the laser spot, re-emitting wall and entire hohlraum drive source.

Kuan Ren, Shenye Liu, Xufei Xie, Huabing Du, Lifei Hou, Longfei Jing, Dong Yang, Yang Zhao, Ji Yan, Zhiwen Yang, Zhichao Li, Jianjun Dong, Guohong Yang, Sanwei Li, Zhurong Cao, Ke Lan, Wenyi Huo, Jie Liu, Guoli Ren, Yongkun Ding, Shaoen Jiang,

This study explores the radiation field temperatures introduced by the laser spot, the re-emitting wall in a hohlraum and the entire hohlraum drive source. This investigation, which is the first of its kind, is based on the radiation fluxes from the laser spot and the re-emitting wall, which have been ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):5050]

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Modulation of Corneal FAK/PI3K/Akt Signaling Expression and of Metalloproteinase-2 and Metalloproteinase-9 during the Development of Herpes Simplex Keratitis.

Lan Ke, Yanning Yang, Jing Wei Li, Bo Wang, Yujing Wang, Wanju Yang, Jiangbo Yan,

To observe the expression of MMP-2 and MMP-9 and of the FAK/PI3K/Akt signaling pathway in HSK. Fifty BALB/c mice were infected to establish the model and killed on days 0, 2, 7, 14, and 28. The cornea samples were prepared, respectively. Slit lamp examination, immunofluorescence staining, reverse transcription PCR, and ... Read more >>

Biomed Res Int (BioMed research international)
[2019, 2019:4143981]

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Hyocholic acid species and the risk of type 2 diabetes

Xiaojiao Zheng, Tianlu Chen, Runqiu Jiang, Aihua Zhao, Fengjie Huang, Yunjing Zhang, Xiaolong Han, Mengci Li, Meilin Wei, Yijun You, Shouli Wang, Xiaojing Ma, Yuqian Bao, Miao Jiang, Jiajian Liu, Qing Zhao, Kun Ge, Bing Dong, Defa Li, Dandan Liang, Sha Lei, Yitao Li, Ke Lan, Aiping Lu, Weituo Zhang, Congrong Wang, Haoyong Yu, Cynthia Rajani, Jun Panee, Guoxiang Xie, Weiping Jia, Wei Jia,

ABSTRACT Hyocholic acid (HCA) and its derivatives are found in only trace amounts in human blood, but constitute approximately 76 % of the bile acid (BA) pool in the pig, a species known for its exceptional resistance to type 2 diabetes mellitus (T2DM). Here we show that HCA species play ... Read more >>

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Spectrum of Enterovirus Serotypes Causing Uncomplicated Hand, Foot, and Mouth Disease and Enteroviral Diagnostic Yield of Different Clinical Samples.

Lidong Gao, Gang Zou, Qiaohong Liao, Yonghong Zhou, Fengfeng Liu, Bingbing Dai, Jia Liu, Zhiyong Chen, Weijia Xing, Le Yang, Hong Liang, Yi Zhang, Zhenhua Chen, Li Luo, Qing Li, Kaiwei Luo, Peng Wu, Xiaowei Mo, Lili Wang, Ke Lan, Peter W Horby, Benjamin J Cowling, Peter Simmonds, Ralf Altmeyer, H Rogier van Doorn, Hongjie Yu,

Background:Hand, foot, and mouth disease (HFMD) represents a substantial disease burden in the Western Pacific region. We investigated the spectrum of causative enteroviruses of HFMD, and evaluated different clinical samples' diagnostic yield for enteroviruses. Methods:We enrolled pediatric patients hospitalized for HFMD among 6 hospitals in Anhua County, Hunan Province, China ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2018, 67(11):1729-1735]

Cited: 3 times

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Animal Pharmacokinetic/Pharmacodynamic Studies (APPS) Reporting Guidelines.

Jasbir Singh, Fawzy Elbarbry, Ke Lan, Tomasz Grabowski,

Animal pharmacokinetic/pharmacodynamic studies are commonly used to provide meaningful preclinical information that can be utilized by the scientific community to conduct first-in-human studies. Poor presentation and interpretation of the data limit study reproducibility, and may result in rejection when the study is submitted to a journal, leading to loss of ... Read more >>

Eur J Drug Metab Pharmacokinet (European journal of drug metabolism and pharmacokinetics)
[2018, 43(5):483-494]

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Itraconazole inhibits the proliferation of gastric cancer cells in vitro and improves patient survival.

Ke Lan, Ron Yan, Kun Zhu, Wenhan Li, Zisen Xu, Chengxue Dang, Kang Li,

Itraconazole is a Food and Drug Administration-approved antifungal drug belonging to the azole family. Recent studies reported that itraconazole has potential anticancer activity. Whether combining itraconazole with other anticancer compounds such as 5-fluorouracil (5-FU), a potent drug used in the treatment of gastric cancer, is unknown and warrants further study. ... Read more >>

Oncol Lett (Oncology letters)
[2018, 16(3):3651-3657]

Cited: 1 time

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Application of the space-resolving flux detector for radiation measurements from an octahedral-aperture spherical hohlraum.

Xufei Xie, Huabing Du, Jinwen Chen, Shenye Liu, Zhichao Li, Dong Yang, Yunbao Huang, Kuan Ren, Lifei Hou, Sanwei Li, Liang Guo, Xiaohua Jiang, Wenyi Huo, Yaohua Chen, Guoli Ren, Ke Lan, Feng Wang, Shaoen Jiang, Yongkun Ding,

Space-resolving flux detection is an important technique for the diagnostic of the radiation field within the hohlraum in inertial confinement fusion, especially for the radiation field diagnostic in the novel spherical hohlraum with octahedral six laser entrance holes (LEHs), where localized measurements are necessary for the discrimination of the radiation ... Read more >>

Rev Sci Instrum (The Review of scientific instruments)
[2018, 89(6):063502]

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Homocysteine induces vascular inflammatory response via SMAD7 hypermethylation in human umbilical vein smooth muscle cells.

Li-Hua Wei, Nai-Xia Chao, Si Gao, Ya-Ting Yu, Lin Shi, Xin-Bo Ma, Na Liao, Ke Lan, Yu Luo, Zheng-Yi Xie, Yuan-Yuan Li,

Homocysteine (Hcy) can induce atherosclerosis through the inflammatory response and DNA methylation disorder. Our recent study has reported a novel epigenetic modified gene related to atherosclerosis -SMAD7. To further understand the pathogenesis of atherosclerosis, the current study was designed to investigate an inflammatory role of Hcy in human umbilical vein ... Read more >>

Microvasc. Res. (Microvascular research)
[2018, 120:8-12]

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