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Prediction model for hepatocellular carcinoma occurrence in patients with hepatitis C in the era of direct-acting anti-virals.

Yuki Tahata, Ryotaro Sakamori, Ryoko Yamada, Takahiro Kodama, Hayato Hikita, Hideki Hagiwara, Yasuharu Imai, Naoki Hiramatsu, Shinji Tamura, Keiji Yamamoto, Masahide Oshita, Kazuyoshi Ohkawa, Taizo Hijioka, Hiroyuki Fukui, Toshifumi Ito, Yoshinori Doi, Yukinori Yamada, Takayuki Yakushijin, Yuichi Yoshida, Tomohide Tatsumi, Tetsuo Takehara, ,

<h4>Background</h4>Several factors associated with hepatocellular carcinoma (HCC) occurrence after sustained virological response (SVR) in patients with hepatitis C have been reported. However, few validation studies have been performed in the era of direct-acting anti-virals (DAAs).<h4>Aims</h4>To develop a prediction model for HCC occurrence after DAA-mediated SVR and validate its usefulness.<h4>Methods</h4>We analysed ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, :]

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The Survival Benefit of Chemoradiotherapy following Induction Chemotherapy with Gemcitabine Plus Nab-Paclitaxel for Unresectable Locally Advanced Pancreatic Cancer.

Ryoji Takada, Kenji Ikezawa, Kazuma Daiku, Shingo Maeda, Yutaro Abe, Makiko Urabe, Yugo Kai, Takuo Yamai, Nobuyasu Fukutake, Tasuku Nakabori, Hiroyuki Uehara, Reiko Ashida, Hirofumi Akita, Hidenori Takahashi, Teruki Teshima, Kazuyoshi Ohkawa,

An optimal therapeutic strategy for unresectable locally advanced pancreatic cancer (UR-LAPC) has not been established. This study investigated the therapeutic efficacy of chemoradiotherapy (CRT) following induction chemotherapy with gemcitabine plus nab-paclitaxel (GnP) (CRT group) compared with systemic chemotherapy alone (CTx group) in patients with UR-LAPC. This was a retrospective study ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(18):]

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Predictors of malignancy in main duct intraductal papillary mucinous neoplasm of the pancreas.

Hiroyuki Uehara, Yutaro Abe, Yugo Kai, Ryoji Takada, Takuo Yamai, Tasuku Nakabori, Kenji Ikezawa, Hidenori Takahashi, Kazuyoshi Ohkawa,

<h4>Background and aims</h4>The International Consensus Guidelines updated in 2017 recommended surgery to all main duct intraductal papillary mucinous neoplasms (MD-IPMNs) with the main pancreatic duct (MPD) of 10 mm or more and those with mural nodules regardless of size. The aim of the present study was to identify predictors of malignancy ... Read more >>

Gastrointest Endosc (Gastrointestinal endoscopy)
[2021, :]

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Success rate of microsatellite instability examination and complete response with pembrolizumab in biliary tract cancer.

Yugo Kai, Kenji Ikezawa, Ryoji Takada, Kazuma Daiku, Shingo Maeda, Yutaro Abe, Takuo Yamai, Nobuyasu Fukutake, Tasuku Nakabori, Hiroyuki Uehara, Shigenori Nagata, Hiroshi Wada, Kazuyoshi Ohkawa,

<h4>Background and aim</h4>The success rate of microsatellite instability (MSI) examination in biliary tract cancer (BTC) and the treatment outcomes of pembrolizumab in patients with MSI-high (MSI-H) BTC have not been fully investigated. We examined the success rate of MSI examination and the rate of MSI-H status in patients with BTC ... Read more >>

JGH Open (JGH open : an open access journal of gastroenterology and hepatology)
[2021, 5(6):712-716]

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Gallbladder neuroendocrine carcinoma: An important differential diagnosis of gallbladder adenocarcinoma.

Kenji Ikezawa, Ryoji Takada, Nobuyasu Fukutake, Tomoyuki Otsuka, Shigenori Nagata, Kazuyoshi Ohkawa,

Gallbladder neuroendocrine carcinomas (NECs) are a rare but important differential diagnosis of gallbladder cancer. This case report highlights the importance of pathological diagnosis and the efficiency of endoscopic ultrasound-guided fine-needle aspiration. Pathological diagnosis should be attempted because the treatment of gallbladder NEC differs from that of gallbladder adenocarcinoma, especially in ... Read more >>

JGH Open (JGH open : an open access journal of gastroenterology and hepatology)
[2021, 5(6):717-719]

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Efficacy and safety of modified fluorouracil/leucovorin plus irinotecan and oxaliplatin (mFOLFIRINOX) compared with S-1 as second-line chemotherapy in metastatic pancreatic cancer.

Kenji Ikezawa, Ryosuke Kiyota, Ryoji Takada, Kazuma Daiku, Shingo Maeda, Toshihiro Imai, Yutaro Abe, Yugo Kai, Takuo Yamai, Nobuyasu Fukutake, Tasuku Nakabori, Reiko Ashida, Hiroyuki Uehara, Takahiro Tabuchi, Kazuhiro Katayama, Kazuyoshi Ohkawa,

<h4>Background and aim</h4>The optimal standard second-line chemotherapy for metastatic pancreatic cancer (MPC) remains unclear. Here, we evaluated the efficacy and safety of modified fluorouracil/leucovorin plus irinotecan and oxaliplatin (mFOLFIRINOX) compared with oral fluoropyrimidine S-1 as a second-line chemotherapy in patients with MPC.<h4>Methods</h4>We retrospectively reviewed 76 consecutive patients with metastatic pancreatic ... Read more >>

JGH Open (JGH open : an open access journal of gastroenterology and hepatology)
[2021, 5(6):679-685]

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Primary Pancreatic Mantle Cell Lymphoma Diagnosed via Endoscopic Ultrasound-Guided Fine-Needle Aspiration.

Takuo Yamai, Kenji Ikezawa, Kazuma Daiku, Shingo Maeda, Yutaro Abe, Yugo Kai, Ryoji Takada, Tasuku Nakabori, Nobuyasu Fukutake, Hiroyuki Uehara, Hiroaki Masaie, Kaori Ishida, Chiaki Kubo, Kazuyoshi Ohkawa,

Primary pancreatic lymphomas (PPLs) are rare, and the histological classification of these tumors is difficult. To accurately diagnose and determine the appropriate treatment for PPLs, sufficient sample amounts are necessary. Here, we report a 73-year-old man with a primary pancreatic mantle cell lymphoma. Histological samples were obtained via endoscopic ultrasound-guided ... Read more >>

Case Rep Gastroenterol (Case reports in gastroenterology)
[2021, 15(2):482-487]

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Clinical characteristics of immunoglobulin IgG4-related sclerosing cholangitis: Comparison of cases with and without autoimmune pancreatitis in a large cohort.

Itaru Naitoh, Terumi Kamisawa, Atsushi Tanaka, Takahiro Nakazawa, Kensuke Kubota, Hajime Takikawa, Michiaki Unno, Atsushi Masamune, Shigeyuki Kawa, Seiji Nakamura, Kazuichi Okazaki, ,

<h4>Background</h4>The clinical characteristics of IgG4-related sclerosing cholangitis (IgG4-SC) especially without autoimmune pancreatitis (AIP) have not been investigated in a large cohort.<h4>Aims</h4>To clarify the clinical characteristics of IgG4-SC and IgG4-SC without AIP.<h4>Methods</h4>We retrospectively reviewed imaging, serology, other organ involvement (OOI) and histology of 872 patients with IgG4-SC who participated in a ... Read more >>

Dig Liver Dis (Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver)
[2021, 53(10):1308-1314]

Cited: 1 time

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Efficacy of Ramucirumab Versus Sorafenib as Subsequent Treatment for Hepatocellular Carcinoma.

Kazuki Maesaka, Ryotaro Sakamori, Ryoko Yamada, Yuki Tahata, Kazuyoshi Ohkawa, Masahide Oshita, Shinji Tamura, Hideki Hagiwara, Eiji Mita, Takayuki Yakushijin, Masami Inada, Takahiro Kodama, Hayato Hikita, Tomohide Tatsumi, Tetsuo Takehara,

<h4>Background/aim</h4>The present study aimed to examine the therapeutic efficacy of ramucirumab compared with that of sorafenib as subsequent systemic therapy for patients with hepatocellular carcinoma (HCC) and serum α-fetoprotein (AFP) levels ≥400 ng/ml.<h4>Patients and methods</h4>In our prospectively registered, real-world cohort, 13 and 11 patients treated with ramucirumab or sorafenib, respectively, ... Read more >>

Anticancer Res (Anticancer research)
[2021, 41(4):2187-2192]

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Predictive Factors for Pancreatic Cancer and Its Early Detection Using Special Pancreatic Ultrasonography in High-Risk Individuals.

Junko Fukuda, Kenji Ikezawa, Miho Nakao, Suetsumi Okagaki, Reiko Ashida, Tatsuya Ioka, Ryoji Takada, Takuo Yamai, Nobuyasu Fukutake, Hiroyuki Uehara, Shigenori Nagata, Hidenori Takahashi, Takahiro Tabuchi, Sachiko Tanaka, Kazuyoshi Ohkawa, Kazuhiro Katayama,

Because pancreatic cancer has a dismal prognosis, a strategy for early diagnosis is required. This study aimed to identify predictive factors of neoplastic progression in patients at high risk for pancreatic cancer and examined the efficiency of surveillance using transabdominal special ultrasonography focusing on the pancreas (special pancreatic US). Patients ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(3):]

Cited: 1 time

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ST6GAL1 Is a Novel Serum Biomarker for Lenvatinib-Susceptible FGF19-Driven Hepatocellular Carcinoma.

Yuta Myojin, Takahiro Kodama, Kazuki Maesaka, Daisuke Motooka, Yu Sato, Satoshi Tanaka, Yuichi Abe, Kazuyoshi Ohkawa, Eiji Mita, Yoshito Hayashi, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Ayumu Taguchi, Hidetoshi Eguchi, Tetsuo Takehara,

<h4>Purpose</h4>Hepatocellular carcinoma (HCC) is characterized by high intertumor heterogeneity of genetic drivers. Two multitarget tyrosine kinase inhibitors (TKI), lenvatinib and sorafenib, are used as standard-of-care chemotherapeutics in patients with advanced HCC, but a stratification strategy has not been established because of a lack of efficacious biomarkers. Therefore, we sought biomarkers ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2021, 27(4):1150-1161]

Cited: 3 times

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Clinical Utility of Pancreatic Cancer Circulating Tumor DNA in Predicting Disease Progression, Prognosis, and Response to Chemotherapy.

Ryoji Takada, Kazuyoshi Ohkawa, Yoji Kukita, Kenji Ikezawa, Nobuyasu Fukutake, Yutaro Abe, Toshihiro Imai, Ryosuke Kiyota, Takatoshi Nawa, Takuo Yamai, Reiko Ashida, Kikuya Kato, Kazuhiro Katayama,

Pancreas (Pancreas)
[2020, 49(9):e93-e95]

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Clinical outcomes of direct-acting antiviral treatments for patients with hepatitis C after hepatocellular carcinoma are equivalent to interferon treatment.

Yuki Tahata, Ryotaro Sakamori, Ayako Urabe, Ryoko Yamada, Kazuyoshi Ohkawa, Naoki Hiramatsu, Hideki Hagiwara, Masahide Oshita, Yasuharu Imai, Takahiro Kodama, Hayato Hikita, Tomohide Tatsumi, Tetsuo Takehara,

<h4>Aim</h4>It remains unclear how direct-acting antiviral (DAA) treatments influence hepatocellular carcinoma (HCC) recurrence and survival in comparison with interferon (IFN).<h4>Methods</h4>In total, 338 patients with chronic hepatitis C virus (HCV) infection and previous HCC treatments who initiated IFN (N = 88, IFN group) or DAA treatment (N = 250, DAA group) from January 2005 to ... Read more >>

Hepatol Res (Hepatology research : the official journal of the Japan Society of Hepatology)
[2020, 50(10):1118-1127]

Cited: 1 time

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Initial treatment response to transarterial chemoembolization as a predictive factor for Child-Pugh class deterioration prior to refractoriness in hepatocellular carcinoma.

Kazuki Maesaka, Ryotaro Sakamori, Ryoko Yamada, Yuki Tahata, Yasuharu Imai, Masahide Oshita, Kazuyoshi Ohkawa, Takahiro Kodama, Hayato Hikita, Tomohide Tatsumi, Tetsuo Takehara,

AIM:Repeated transarterial chemoembolization (TACE) for intermediate-stage hepatocellular carcinoma (HCC) eventually leads to either deteriorated hepatic reserve or TACE refractoriness. Switching to molecular targeted agents after TACE requires preservation of hepatic reserve. This study aimed to investigate the predictive factors associated with early deterioration of hepatic reserve by repeated TACE prior ... Read more >>

Hepatol Res (Hepatology research : the official journal of the Japan Society of Hepatology)
[2020, 50(11):1275-1283]

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Therapeutic efficacy of lenvatinib in hepatocellular carcinoma patients with portal hypertension.

Kazuki Maesaka, Ryotaro Sakamori, Ryoko Yamada, Ayako Urabe, Yuki Tahata, Masahide Oshita, Kazuyoshi Ohkawa, Eiji Mita, Hideki Hagiwara, Shinji Tamura, Toshifumi Ito, Takayuki Yakushijin, Sadaharu Iio, Takahiro Kodama, Hayato Hikita, Tomohide Tatsumi, Tetsuo Takehara,

<h4>Aim</h4>Preserved liver function may be an important factor affecting therapeutic efficacy in hepatocellular carcinoma patients treated with lenvatinib, but not all patients can be treated while preserving liver function. This study evaluated the therapeutic efficacy of lenvatinib in patients with poor liver function with and without portal hypertension.<h4>Methods</h4>This prospectively registered ... Read more >>

Hepatol Res (Hepatology research : the official journal of the Japan Society of Hepatology)
[2020, 50(9):1091-1100]

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Lower Serum Sodium Levels Are Associated with the Therapeutic Effect of Sorafenib on Hepatocellular Carcinoma.

Tadashi Kegasawa, Ryotaro Sakamori, Kazuki Maesaka, Ryoko Yamada, Yuki Tahata, Ayako Urabe, Takahiro Kodama, Hayato Hikita, Kazuho Imanaka, Kazuyoshi Ohkawa, Naoki Hiramatsu, Masahide Oshita, Yukinori Yamada, Masami Inada, Takayuki Yakushijin, Yasuharu Imai, Tomohide Tatsumi, Tetsuo Takehara,

<h4>Background and aim</h4>Although the serum sodium level has been reported to be a prognostic and predictive marker for the therapeutic effects of lung cancer and renal cell carcinoma treated with molecular targeted therapy, the serum sodium level has not been investigated in hepatocellular carcinoma (HCC) patients treated with sorafenib. The ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2021, 66(5):1720-1729]

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Self-expandable metallic stent placement above the papilla without endoscopic sphincterotomy in patients with distal malignant biliary obstruction.

Ryoji Takada, Kenji Ikezawa, Ryosuke Kiyota, Toshihiro Imai, Yutaro Abe, Nobuyasu Fukutake, Reiko Ashida, Takatoshi Nawa, Takahiro Tabuchi, Kazuhiro Katayama, Kazuyoshi Ohkawa,

Background and study aims  The best method for endoscopic placement of self-expandable metallic stents (SEMS) for distal malignant biliary obstruction (MBO) has not yet been determined. The aim of this study was to evaluate how SEMS placement above the papilla and without endoscopic sphincterotomy (EST) impacts the time to recurrent ... Read more >>

Endosc Int Open (Endoscopy international open)
[2020, 8(6):E753-E760]

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Effectiveness of Contrast-Enhanced Ultrasonography for the Characterization of Small and Early Stage Pancreatic Adenocarcinoma.

Sachiko Tanaka, Junko Fukuda, Miho Nakao, Tatsuya Ioka, Reiko Ashida, Rena Takakura, Suetsumi Okagaki, Kazuhiro Katayama, Kazuyoshi Ohkawa, Kenji Ikezawa, Shigenori Nagata,

The purpose of this retrospective study is to evaluate the effectiveness of contrast-enhanced ultrasonography for the characterization of small and early stage pancreatic adenocarcinoma. Contrast-enhanced ultrasonography and contrast-enhanced computed tomography (CT) were performed in 200 cases, with pancreatic hypoechoic regions detected with ultrasonography. Assuming that hypo-enhancement was indicative of pancreatic ... Read more >>

Ultrasound Med Biol (Ultrasound in medicine & biology)
[2020, 46(9):2245-2253]

Cited: 2 times

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Decreased CT-number in the pancreatic parenchyma is a reliable imaging biomarker of the presence of malignancies in patients with high-risk intraductal papillary mucinous neoplasm.

Tomoki Abe, Daisaku Yamada, Kei Asukai, Shinichiro Hasegawa, Akira Tomokuni, Hiroshi Wada, Wataru Fujii, Kenji Ikezawa, Nobuyasu Fukutake, Kazuyoshi Ohkawa, Naoki Shinno, Hisashi Hara, Yoshitomo Yanagimoto, Yusuke Takahashi, Keijiro Sugimura, Kazuyoshi Yamamoto, Hajime Ushigome, Naotsugu Haraguchi, Junichi Nishimura, Masayoshi Yasui, Takeshi Omori, Hiroshi Miyata, Masayuki Ohue, Masahiko Yano, Masato Sakon, Hidenori Takahashi,

<h4>Background</h4>Intraductal papillary mucinous neoplasm (IPMN) is a premalignant cystic neoplasm of the pancreas and is frequently detected in imaging investigations. A proportion of the patients with IPMN develop malignancies including high-grade dysplasia and invasive carcinoma. To predict the presence of malignancies in IPMN, constant imaging follow-up is usually required. Pancreatic ... Read more >>

Pancreatology (Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.])
[2020, 20(3):442-447]

Cited: 1 time

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Ramucirumab after prior sorafenib in patients with advanced hepatocellular carcinoma and elevated alpha-fetoprotein: Japanese subgroup analysis of the REACH-2 trial.

Masatoshi Kudo, Takuji Okusaka, Kenta Motomura, Izumi Ohno, Manabu Morimoto, Satoru Seo, Yoshiyuki Wada, Shinpei Sato, Tatsuya Yamashita, Masayuki Furukawa, Takeshi Aramaki, Seijin Nadano, Kazuyoshi Ohkawa, Hirofumi Fujii, Toshihiro Kudo, Junji Furuse, Hiroki Takai, Gosuke Homma, Reigetsu Yoshikawa, Andrew X Zhu,

<h4>Background</h4>The global, randomized, phase 3 REACH-2 study (ClinicalTrials.gov identifier: NCT02435433) found significantly longer overall survival (OS) for second-line ramucirumab versus placebo (hazard ratio [HR]: 0.710, 95% confidence interval [CI] 0.531-0.949, P = 0.0199) in patients with advanced hepatocellular carcinoma (HCC) and alpha-fetoprotein (AFP) ≥ 400 ng/mL. This prespecified subgroup analysis evaluated the efficacy and safety ... Read more >>

J Gastroenterol (Journal of gastroenterology)
[2020, 55(6):627-639]

Cited: 4 times

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Efficacy of Larger-Diameter Plastic Stent Placement for Preoperative Biliary Drainage in Patients Receiving Neoadjuvant Chemoradiation for Pancreatic Cancer.

Kenji Ikezawa, Ryoji Takada, Hidenori Takahashi, Ryosuke Kiyota, Toshihiro Imai, Yutaro Abe, Nobuyasu Fukutake, Takatoshi Nawa, Reiko Ashida, Kazuhiro Katayama, Kazuyoshi Ohkawa,

Pancreas (Pancreas)
[2020, 49(3):e20-e21]

Cited: 0 times

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Hepatocellular carcinoma occurrence does not differ between interferon-based and interferon-free treatment with liver histological assessment.

Yuki Tahata, Ryotaro Sakamori, Ayako Urabe, Ryoko Yamada, Kazuyoshi Ohkawa, Naoki Hiramatsu, Hideki Hagiwara, Masahide Oshita, Taizo Hijioka, Shinji Tamura, Yasuharu Imai, Takahiro Kodama, Hayato Hikita, Tomohide Tatsumi, Tetsuo Takehara,

<h4>Aim</h4>Several studies have recently reported that hepatocellular carcinoma (HCC) occurrence does not differ between hepatitis C virus patients receiving interferon (IFN)-based and IFN-free treatments considering the patients' backgrounds. However, liver fibrosis was not directly considered in these studies.<h4>Methods</h4>In total, 3972 patients without a history of HCC who started IFN-based or IFN-free ... Read more >>

Hepatol Res (Hepatology research : the official journal of the Japan Society of Hepatology)
[2020, 50(3):313-320]

Cited: 0 times

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Development of a thrombus in the superior mesenteric artery associated with sequential therapy with tyrosine kinase inhibitors for hepatocellular carcinoma.

Takatoshi Nawa, Kazuhiro Katayama, Ryosuke Kiyota, Toshihiro Imai, Yutaro Abe, Noriko Hasegawa, Ryoji Takada, Nobuyasu Fukutake, Kenji Ikezawa, Mitsuru Sakakibara, Masashi Fujita, Kazuyoshi Ohkawa,

Tyrosine kinase inhibitors (TKIs) are widely used for systemic chemotherapy of hepatocellular carcinoma (HCC). Arterial thromboembolism (ATE) has been reported to be an adverse event associated with TKI therapy, but its incidence is rare. Here, we report a case of an HCC patient who developed a thrombus in the superior ... Read more >>

Clin J Gastroenterol (Clinical journal of gastroenterology)
[2020, 13(2):247-251]

Cited: 0 times

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Chemotherapy-Induced Sclerosing Cholangitis Caused by Systemic Chemotherapy.

Akira Kusakabe, Kazuyoshi Ohkawa, Nobuyasu Fukutake, Mitsuru Sakakibara, Toshihiro Imai, Yutaro Abe, Ryoji Takada, Kenji Ikezawa, Takatoshi Nawa, Reiko Ashida, Toshihiro Kimura, Shigenori Nagata, Kazuhiro Katayama,

A 61-year-old woman diagnosed with cervical cancer received systemic chemotherapy using paclitaxel and bevacizumab. Marked elevation of liver enzyme levels was observed. Ultrasonography and computed tomography showed wall thickening of the extrahepatic and intrahepatic bile ducts accompanied by stricture and dilatation. According to these, she was diagnosed as chemotherapy-induced sclerosing ... Read more >>

ACG Case Rep J (ACG case reports journal)
[2019, 6(7):e00136]

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Clinical Features and Prognosis of Patients With the Bone Metastasis of Pancreatic Cancer: A Single-Institutional Cohort Study.

Hidetatsu Outani, Hirofumi Akita, Takaaki Nakai, Ryoji Takada, Yoshinori Imura, Takaaki Tanaka, Hironari Tamiya, Kazuya Oshima, Hidenori Takahashi, Kazuyoshi Ohkawa, Kazuhiro Katayama, Nobuhito Araki, Norifumi Naka,

Pancreas (Pancreas)
[2018, 47(7):e43-e46]

Cited: 2 times

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