Full Text Journal Articles by
Author Katy Bell

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Katy Bell, Jenny Doust, Kevin McGeechan, Andrea R Horvath, Alexandra Barratt, Andrew Hayen, Christopher Semsarian, Les Irwig,

J Hypertens (Journal of hypertension)
[2021, 39(5):1045-1046]

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Benefits and Harms of Hypertension and High-Normal Labels: A Randomized Experiment.

Danielle Marie Muscat, Georgina May Morris, Katy Bell, Erin Cvejic, Jenna Smith, Jesse Jansen, Rae Thomas, Carissa Bonner, Jenny Doust, Kirsten McCaffery,

<h4>Background</h4>Recent US guidelines lowered the threshold for diagnosing hypertension while other international guidelines use alternative/no labels for the same group (blood pressure [BP], <140/90 mm Hg). We investigated potential benefits and harms of hypertension and high-normal BP labels, compared with control, among people at lower risk of cardiovascular disease.<h4>Methods</h4>We conducted ... Read more >>

Circ Cardiovasc Qual Outcomes (Circulation. Cardiovascular quality and outcomes)
[2021, :CIRCOUTCOMES120007160]

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Comparison of seroprevalence of SARS-CoV-2 infections with cumulative and imputed COVID-19 cases: Systematic review.

Oyungerel Byambasuren, Claudia C Dobler, Katy Bell, Diana Patricia Rojas, Justin Clark, Mary-Louise McLaws, Paul Glasziou,

<h4>Background</h4>Accurate seroprevalence estimates of SARS-CoV-2 in different populations could clarify the extent to which current testing strategies are identifying all active infection, and hence the true magnitude and spread of the infection. Our primary objective was to identify valid seroprevalence studies of SARS-CoV-2 infection and compare their estimates with the ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0248946]

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Overdiagnosis of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents: A Systematic Scoping Review.

Luise Kazda, Katy Bell, Rae Thomas, Kevin McGeechan, Rebecca Sims, Alexandra Barratt,

<h4>Importance</h4>Reported increases in attention-deficit/hyperactivity disorder (ADHD) diagnoses are accompanied by growing debate about the underlying factors. Although overdiagnosis is often suggested, no comprehensive evaluation of evidence for or against overdiagnosis has ever been undertaken and is urgently needed to enable evidence-based, patient-centered diagnosis and treatment of ADHD in contemporary health ... Read more >>

JAMA Netw Open (JAMA network open)
[2021, 4(4):e215335]

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Guidance for the design and reporting of studies evaluating the clinical performance of tests for present or past SARS-CoV-2 infection.

Jenny A Doust, Katy J L Bell, Mariska M G Leeflang, Jacqueline Dinnes, Sally J Lord, Sue Mallett, Janneke H H M van de Wijgert, Sverre Sandberg, Khosrow Adeli, Jonathan J Deeks, Patrick M Bossuyt, Andrea R Horvath,

BMJ (BMJ (Clinical research ed.))
[2021, 372:n568]

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Can Patient-Led Surveillance Detect Subsequent New Primary or Recurrent Melanomas and Reduce the Need for Routinely Scheduled Follow Up? A Protocol for the MEL-SELF Randomised Controlled Trial.

Deonna Ackermann, Amelia Smit, Monika Janda, Cathelijne van Kemenade, Mbathio Dieng, Rachael Morton, Robin Turner, Anne Cust, Les Irwig, Jolyn Hersch, Pascale Guitera, Peter Soyer, Victoria Mar, Robyn P.M. Saw, Donald Low, Cynthia Low, Dorothy Drabarek, David Espinoza, Jon Emery, Peter Murchie, John Thompson, Richard Scolyer, Anthony Azzi, Alister Lilleyman, Katy Bell,

<h4>Background: </h4> Most subsequent new primary or recurrent melanomas might be self-detected if patients are trained to systematically self-examine their skin and have access to timely medical review (patient-led surveillance). Routinely scheduled clinic visits (clinician-led surveillance) is resource-intensive and has not been shown to improve health outcomes; fewer visits may ... Read more >>

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Equity and evidence during vaccine rollout: stepped wedge cluster randomised trials could help.

Katy J L Bell, Paul Glasziou, Fiona Stanaway, Patrick Bossuyt, Les Irwig,

BMJ (BMJ (Clinical research ed.))
[2021, 372:n435]

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The potential for overdiagnosis and underdiagnosis because of blood pressure variability: a comparison of the 2017 ACC/AHA, 2018 ESC/ESH and 2019 NICE hypertension guidelines.

Katy Bell, Jenny Doust, Kevin McGeechan, Andrea Rita Horvath, Alexandra Barratt, Andrew Hayen, Christopher Semsarian, Les Irwig,

<h4>Objective</h4>To estimate the extent that BP measurement variability may drive over- and underdiagnosis of 'hypertension' when measurements are made according to current guidelines.<h4>Methods</h4>Using data from the National Health and Nutrition Examination Survey and empirical estimates of within-person variability, we simulated annual SBP measurement sets for 1 000 000 patients over 5 years. ... Read more >>

J Hypertens (Journal of hypertension)
[2021, 39(2):236-242]

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Widening Disease Definitions: What Can Physicians Do?

Jenny A Doust, Julian Treadwell, Katy J L Bell,

Am Fam Physician (American family physician)
[2021, 103(3):138-140]

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How to use imperfect tests for COVID-19 (SARS-CoV-2) to make clinical decisions.

Katy Jl Bell, Fiona F Stanaway, Les M Irwig, Andrea R Horvath, Armando Teixeira-Pinto, Clement Loy,

Med J Aust (The Medical journal of Australia)
[2021, 214(2):69-73.e1]

Cited: 1 time

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Active surveillance as a management option for cervical intraepithelial neoplasia 2: An online experimental study.

Rachael H Dodd, Erin Cvejic, Katy Bell, Kirsten Black, Deborah Bateson, Megan A Smith, Olivia A Mac, Kirsten J McCaffery,

<h4>Objective</h4>To investigate framing of active surveillance as a management option for cervical intraepithelial neoplasia (CIN)2 in women of childbearing age.<h4>Methods</h4>We conducted a between-subjects factorial (2 × 2) randomised experiment. Women aged 25-40 living in Australia were presented with the same hypothetical pathway of testing human papillomavirus (HPV)-positive, high-grade cytology and a diagnosis ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, 161(1):179-187]

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COVID-19: estimated number of deaths if Australia had experienced a similar outbreak to England and Wales.

Fiona Stanaway, Les M Irwig, Armando Teixeira-Pinto, Katy Jl Bell,

Med J Aust (The Medical journal of Australia)
[2021, 214(2):95-95.e1]

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Mendelian Randomization in Cardiovascular Research: Establishing Causality When There Are Unmeasured Confounders.

Katy J L Bell, Clement Loy, Anne E Cust, Armando Teixeira-Pinto,

Mendelian randomization is an epidemiological approach to making causal inferences using observational data. It makes use of the natural randomization that occurs in the generation of an individual's genetic makeup in a way that is analogous to the study design of a randomized controlled trial and uses instrumental variable analysis ... Read more >>

Circ Cardiovasc Qual Outcomes (Circulation. Cardiovascular quality and outcomes)
[2021, 14(1):e005623]

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Impact of Full-Field Digital Mammography Versus Film-Screen Mammography in Population Screening: A Meta-Analysis.

Rachel Farber, Nehmat Houssami, Sally Wortley, Gemma Jacklyn, Michael L Marinovich, Kevin McGeechan, Alexandra Barratt, Katy Bell,

<h4>Background</h4>Breast screening programs replaced film mammography with digital mammography, and the effects of this practice shift in population screening on health outcomes can be measured through examination of cancer detection and interval cancer rates.<h4>Methods</h4>A systematic review and random effects meta-analysis were undertaken. Seven databases were searched for publications that compared ... Read more >>

J Natl Cancer Inst (Journal of the National Cancer Institute)
[2021, 113(1):16-26]

Cited: 1 time

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A methods review of posttrial follow-up studies of cardiovascular prevention finds potential biases in estimating legacy effects.

Lin Zhu, Katy J L Bell, Agnish Nayak, Andrew Hayen,

<h4>Objectives</h4>The objective of the study was to assess the methods used, and potential for bias, in posttrial studies of cardiovascular disease (CVD) where legacy effects may be estimated.<h4>Study design and setting</h4>We undertook a methods review of posttrial studies after randomized controlled trials (RCTs) of interventions to prevent CVD. For each ... Read more >>

J Clin Epidemiol (Journal of clinical epidemiology)
[2021, 131:51-58]

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Why clinicians overtest: development of a thematic framework.

Justin H Lam, Kristen Pickles, Fiona F Stanaway, Katy J L Bell,

<h4>Background</h4>Medical tests provide important information to guide clinical management. Overtesting, however, may cause harm to patients and the healthcare system, including through misdiagnosis, false positives, false negatives and overdiagnosis. Clinicians are ultimately responsible for test requests, and are therefore ideally positioned to prevent overtesting and its unintended consequences. Through this ... Read more >>

BMC Health Serv Res (BMC health services research)
[2020, 20(1):1011]

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Why clinicians overtest: development of a thematic framework

Justin Lam, Kristen Pickles, Fiona Stanaway, Katy JL Bell,

<h4>Background: </h4> Medical tests provide important information to guide clinical management. Overtesting, however, may cause harm to patients and the healthcare system, including through misdiagnosis, false positives, false negatives and overdiagnosis. Clinicians are ultimately responsible for test requests, and are therefore ideally positioned to prevent overtesting and its unintended consequences. ... Read more >>

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Setting minimum clinical performance specifications for tests based on disease prevalence and minimum acceptable positive and negative predictive values: Practical considerations applied to COVID-19 testing.

Tze Ping Loh, Sarah J Lord, Katy Bell, Mary Kathryn Bohn, Chun Yee Lim, Corey Markus, Hernan Fares Taie, Khosrow Adeli, Giuseppe Lippi, Sverre Sandberg, Andrea Horvath,

<h4>Objectives</h4>Several guidelines for the evaluation of laboratory tests for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection have recommended establishing an a priori definition of minimum clinical performance specifications before test selection and method evaluation.<h4>Methods</h4>Using positive (PPV) and negative predictive values (NPV), we constructed a spreadsheet tool for determining the minimum clinical ... Read more >>

Clin Biochem (Clinical biochemistry)
[2021, 88:18-22]

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Mammography screening for breast cancer-the UK Age trial.

Katy J L Bell, Les Irwig, Brooke Nickel, Jolyn Hersch, Andrew Hayen, Alexandra Barratt,

Lancet Oncol (The Lancet. Oncology)
[2020, 21(11):e504]

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Future directions in cardiovascular disease risk prediction.

Jenny A Doust, Carissa Bonner, Katy JL Bell,

<h4>Background</h4>Although the National Vascular Disease Prevention Alliance (NVDPA) guidelines were published in 2012, many individuals at high risk of cardiovascular disease (CVD) are not prescribed preventive medication or have CVD risk factors recorded. Better use of CVD risk prediction tools and targeting of medication could reduce CVD.<h4>Objective</h4>The aim of this ... Read more >>

Aust J Gen Pract (Australian journal of general practice)
[2020, 49(8):488-494]

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Estimating the seroprevalence of SARS-CoV-2 infections: systematic review

Oyungerel Byambasuren, Claudia Dobler, Katy Bell, Diana Patricia Rojas, Justin Clark, Mary-Louise McLaws, Paul Glasziou,

<h4>Background</h4> Accurate seroprevalence estimates of SARS-CoV-2 in different populations could help gauge the true magnitude and spread of the infection seroprevalence. Reported estimates have varied greatly, but many have derived from biased samples, and inadequate testing methods. <h4>Objective</h4> To estimate the range of valid seroprevalence rates of SARS-CoV-2 in different ... Read more >>

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The carbon footprint of pathology testing.

Scott McAlister, Alexandra L Barratt, Katy Jl Bell, Forbes McGain,

<h4>Objectives</h4>To estimate the carbon footprint of five common hospital pathology tests: full blood examination; urea and electrolyte levels; coagulation profile; C-reactive protein concentration; and arterial blood gases.<h4>Design, setting</h4>Prospective life cycle assessment of five pathology tests in two university-affiliated health services in Melbourne. We included all consumables and associated waste for ... Read more >>

Med J Aust (The Medical journal of Australia)
[2020, 212(8):377-382]

Cited: 1 time

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Estimating the extent of asymptomatic COVID-19 and its potential for community transmission: systematic review and meta-analysis

Oyungerel Byambasuren, Magnolia Cardona, Katy Bell, Justin Clark, Mary-Louise McLaws, Paul Glasziou,

<h4>Background</h4> The prevalence of true asymptomatic COVID-19 cases is critical to policy makers considering the effectiveness of mitigation measures against the SARS-CoV-2 pandemic. We aimed to synthesize all available research on the asymptomatic rates and transmission rates where possible. <h4>Methods</h4> We searched PubMed, Embase, Cochrane COVID-19 trials, and Europe PMC ... Read more >>

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Estimating the magnitude of cancer overdiagnosis in Australia.

Paul P Glasziou, Katy Jl Bell, Alexandra L Barratt,

Med J Aust (The Medical journal of Australia)
[2020, 213(4):189-189.e1]

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Age specific trends in prostate cancer tests, incidence and mortality in Australia since the introduction of the Prostate Specific Antigen (PSA) test

Thanya Pathirana, Rehan Sequeira, Chris Del Mar, James Dickinson, Katy Bell, Paul Glasziou,

<h4>Background: </h4> Population trends in PSA screening and prostate cancer incidence do not perfectly correspond. We aimed to better understand relationships between trends in PSA screening, prostate cancer incidence and mortality in Australia. <h4>Methods: </h4> Description of age standardised time trends in PSA tests, prostate biopsies, cancer incidence and mortality ... Read more >>

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