Full Text Journal Articles by
Author Katsushige Ono

Advertisement

Find full text journal articles






Disruption of asparagine-linked glycosylation to rescue and alter gating of the NaV1.5-Na+ channel.

Pu Wang, Xiufang Zhu, Mengyan Wei, Yangong Liu, Kenshi Yoshimura, Mingqi Zheng, Gang Liu, Shinichiro Kume, Tatsuki Kurokawa, Katsushige Ono,

SCN5A gene encodes the voltage-gated sodium channel Na<sub>V</sub>1.5 which is composed of a pore-forming α subunit of the channel. Asparagine (N)-linked glycosylation is one of the common post-translational modifications in proteins. The aim of this study was to investigate impact of N-linked glycosylation disruption on the Na<sup>+</sup> channel, and the ... Read more >>

Heart Vessels (Heart and vessels)
[2021, :]

Cited: 0 times

View full text PDF listing >>



The impact of subclinical hypothyroidism on long-term outcomes in older patients undergoing percutaneous coronary intervention

Yong-Sheng Liu, Mei Wei, Le Wang, Gang Liu, Guo-Ping Ma, Katsushige Ono, Ze-Long Cao, Man Yang, Ming-Qi Zheng,

<h4>Background: </h4> Subclinical hypothyroidism (SCH) is reportedly associated with an increased risk of adverse events in patients undergoing percutaneous coronary intervention (PCI). The prognostic significance of SCH in the elderly was poorly defined. The purpose of this study was to evaluate the association between SCH and long-term outcomes in older ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

Binge Alcohol Exposure Triggers Atrial Fibrillation Through T-Type Ca2+ Channel Upregulation via Protein Kinase C (PKC) / Glycogen Synthesis Kinase 3β (GSK3β) / Nuclear Factor of Activated T-Cells (NFAT) Signaling - An Experimental Account of Holiday Heart Syndrome.

Yan Wang, Masaki Morishima, Dan Li, Naohiko Takahashi, Tetsunori Saikawa, Stanley Nattel, Katsushige Ono,

<h4>Background</h4>The association between binge alcohol ingestion and atrial fibrillation (AF), often termed "holiday heart syndrome", has long been recognized. However, the underlying cellular and molecular mechanisms are unknown.Methods and Results:An experimental model of binge alcohol-induced AF was developed to elucidate the mechanisms linking acute ethanol exposure to changes in ion channel transcription ... Read more >>

Circ J (Circulation journal : official journal of the Japanese Circulation Society)
[2020, 84(11):1931-1940]

Cited: 0 times

View full text PDF listing >>



Manifestations of gene expression profiles in human right atrial myocardium caused by mechanical stretch.

Ryusuke Suzuki, Masaki Morishima, Chisato Nakada, Shinji Miyamoto, Katsushige Ono,

This investigation was aimed to identify gene profiles in human atrial myocardium in response to chronic mechanical stretch. Right atrial appendages from 21 patients were divided into 2 groups based on the size of right atrial volume. The microarray DATA analyses differentially identified 335 genes (> 2.0-fold, corrected P < 0.05) including "functionally ... Read more >>

Heart Vessels (Heart and vessels)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Mitogen-activated protein kinase p38 modulates pacemaker ion channels differentiation in P19-derived pluripotent cells.

Mingqi Zheng, Lin Kang, Tomoko Uchino, Gang Liu, Yan Wang, Katsushige Ono,

Signal regulators during early cardiogenetic differentiation for the cellular automaticity are largely unknown. Our investigations were designed to clarify the role of transcription factors and their modulators in P19-derived cardiomyocytes to the expression of cardiac pacemaker ion channels. Transcription factors Csx/Nkx2.5 and GATA4 but not MEF2C were markedly inhibited by ... Read more >>

J Physiol Sci (The journal of physiological sciences : JPS)
[2020, 70(1):39]

Cited: 0 times

View full text PDF listing >>



Magnesium Deficiency Causes Transcriptional Downregulation of Kir2.1 and Kv4.2 Channels in Cardiomyocytes Resulting in QT Interval Prolongation.

Toru Shimaoka, Yan Wang, Masaki Morishima, Shinji Miyamoto, Katsushige Ono,

<h4>Background</h4>Mechanisms for QT interval prolongation and cardiac arrhythmogenesis in hypomagnesemia are poorly understood. This study investigated the potential molecular mechanism for QT prolongation caused by magnesium (Mg) deficiency in rats by using the patch clamp technique and molecular biology.Methods and Results:Male Wistar rats were fed an Mg-free diet or a normal diet ... Read more >>

Circ J (Circulation journal : official journal of the Japanese Circulation Society)
[2020, 84(8):1244-1253]

Cited: 0 times

View full text PDF listing >>



Cardiac specific transcription factor Csx/Nkx2.5 regulates transient-outward K+ channel expression in pluripotent P19 cell-derived cardiomyocytes.

Tomoko Uchino, Ming-Qi Zheng, Yan Wang, Katsushige Ono,

The homeobox-containing gene Csx/Nkx2.5 codes several cardiac transcription factors and plays a critical role in early cardiogenesis. We investigated the effect of Csx/Nkx2.5 on the expression of cardiac ion channels using P19-derived cardiomyocytes. P19CL6 cells and P19CL6 cells with Csx/Nkx2.5 overexpression (P19CL6-Csx cells) were induced to differentiate into cardiomyocytes by ... Read more >>

J Physiol Sci (The journal of physiological sciences : JPS)
[2020, 70(1):20]

Cited: 0 times

View full text PDF listing >>



How Is Uric Acid Related to Atrial Fibrillation?

Katsushige Ono,

Circ J (Circulation journal : official journal of the Japanese Circulation Society)
[2019, 83(4):705-706]

Cited: 0 times

View full text PDF listing >>



Asparagine-linked glycosylation modifies voltage-dependent gating properties of CaV3.1-T-type Ca2+ channel.

Yangong Liu, Pu Wang, Fangfang Ma, Mingqi Zheng, Gang Liu, Shinichiro Kume, Tatsuki Kurokawa, Katsushige Ono,

T-type channels are low-voltage-activated channels that play a role in the cardiovascular system particularly for pacemaker activity. Glycosylation is one of the most prevalent post-translational modifications in protein. Among various glycosylation types, the most common one is asparagine-linked (N-linked) glycosylation. The aim of this study was to elucidate the roles ... Read more >>

J Physiol Sci (The journal of physiological sciences : JPS)
[2019, 69(2):335-343]

Cited: 1 time

View full text PDF listing >>



The necessity of implantable cardioverter defibrillators in patients with Kearns-Sayre syndrome - systematic review of the articles.

Tomohiko Imamura, Naokata Sumitomo, Shota Muraji, Hitoshi Mori, Yousuke Osada, Takayuki Oyanagi, Takuro Kojima, Shigeki Yoshiba, Toshiki Kobayashi, Katsushige Ono,

The most common cardiac feature of Kearns-Sayre syndrome (KSS) is atrioventricular block (AVB), and pacemaker implantations (PMIs) are recommended for KSS patients with advanced AVB. However, some KSS patients develop fatal arrhythmias such as polymorphic ventricular tachycardia (PMVT) and ventricular fibrillation (VF) and die suddenly even after PMIs. We report ... Read more >>

Int J Cardiol (International journal of cardiology)
[2019, 279:105-111]

Cited: 1 time

View full text PDF listing >>



Short- and long-term roles of phosphatidylinositol 4,5-bisphosphate PIP2 on Cav3.1- and Cav3.2-T-type calcium channel current.

Yangong Liu, Tomohiro Iwano, Fangfang Ma, Pu Wang, Yan Wang, Mingqi Zheng, Gang Liu, Katsushige Ono,

T-type calcium (Ca<sup>2+</sup>) channels play important physiological functions in excitable cells including cardiomyocyte. Phosphatidylinositol-4,5-bisphosphate (PIP<sub>2</sub>) has recently been reported to modulate various ion channels' function. However the actions of PIP<sub>2</sub> on the T-type Ca<sup>2+</sup> channel remain unclear. To elucidate possible effects of PIP<sub>2</sub> on the T-type Ca<sup>2+</sup> channel, we applied ... Read more >>

Pathophysiology (Pathophysiology : the official journal of the International Society for Pathophysiology)
[2019, 26(1):31-38]

Cited: 0 times

View full text PDF listing >>



Direct free radical scavenging effects of water-soluble HMG-CoA reductase inhibitors.

Ryohei Umeda, Hiroki Takanari, Kazue Ogata, Shigekiyo Matsumoto, Takaaki Kitano, Katsushige Ono, Osamu Tokumaru,

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, statins, are widely used for preventing cardiovascular and cerebrovascular diseases by controlling blood cholesterol level. Additionally, previous studies revealed the scavenging effects of statins on free radicals. We assessed direct scavenging activities of two water-soluble statins, fluvastatin and pravastatin, on multiple free radicals using electron ... Read more >>

J Clin Biochem Nutr (Journal of clinical biochemistry and nutrition)
[2019, 64(1):20-26]

Cited: 0 times

View full text PDF listing >>



Testosterone-mediated upregulation of delayed rectifier potassium channel in cardiomyocytes causes abbreviation of QT intervals in rats.

Kimiko Masuda, Hiroki Takanari, Masaki Morishima, FangFang Ma, Yan Wang, Naohiko Takahashi, Katsushige Ono,

Men have shorter rate-corrected QT intervals (QTc) than women, especially at the period of adolescence or later. The aim of this study was to elucidate the long-term effects of testosterone on cardiac excitability parameters including electrocardiogram (ECG) and potassium channel current. Testosterone shortened QT intervals in ECG in castrated male ... Read more >>

J Physiol Sci (The journal of physiological sciences : JPS)
[2018, 68(6):759-767]

Cited: 4 times

View full text PDF listing >>



Erratum to: Short- and long-term inhibition of cardiac inward-rectifier potassium channel current by an antiarrhythmic drug bepridil.

Fangfang Ma, Hiroki Takanari, Kimiko Masuda, Masaki Morishima, Katsushige Ono,

Heart Vessels (Heart and vessels)
[2016, 31(7):1185]

Cited: 1 time

View full text PDF listing >>



Atrial Fibrillation-Mediated Upregulation of miR-30d Regulates Myocardial Electrical Remodeling of the G-Protein-Gated K(+) Channel, IK.ACh.

Masaki Morishima, Eriko Iwata, Chisato Nakada, Yoshiyuki Tsukamoto, Hiroki Takanari, Shinji Miyamoto, Masatsugu Moriyama, Katsushige Ono,

<h4>Background</h4>Atrial fibrillation (AF) begets AF in part due to atrial remodeling, the molecular mechanisms of which have not been completely elucidated. This study was conducted to identify microRNA(s) responsible for electrical remodeling in AF.<h4>Methods and results</h4>The expression profiles of 1205 microRNAs, in cardiomyocytes from patients with persistent AF and from age-, gender-, ... Read more >>

Circ J (Circulation journal : official journal of the Japanese Circulation Society)
[2016, 80(6):1346-1355]

Cited: 10 times

View full text PDF listing >>



Short- and long-term inhibition of cardiac inward-rectifier potassium channel current by an antiarrhythmic drug bepridil.

Fangfang Ma, Hiroki Takanari, Kimiko Masuda, Masaki Morishima, Katsushige Ono,

Bepridil is an effective antiarrhythmic drug on supraventricular and ventricular arrhythmias, and inhibitor of calmodulin. Recent investigations have been elucidating that bepridil exerts antiarrhythmic effects through its acute and chronic application for patients. The aim of this study was to identify the efficacy and the potential mechanism of bepridil on ... Read more >>

Heart Vessels (Heart and vessels)
[2016, 31(7):1176-1184]

Cited: 2 times

View full text PDF listing >>



Hypomagnesemic down-regulation of L-type Ca(2+) channel in cardiomyocyte as an arrhythmogenic substrate in rats.

Toru Shimaoka, Yan Wang, Masaki Morishima, Shinji Miyamoto, Katsushige Ono,

The present study was designed to investigate the effect of magnesium (Mg) depletion on the expression of voltage-gated calcium (Ca(2+)) channels and Ca(2+) currents in the heart and thereby on hypomagnesemic arrhythmogenesis in adult male rats. Male Wistar rats were fed an Mg-free diet or a normal diet for up ... Read more >>

Pathophysiology (Pathophysiology : the official journal of the International Society for Pathophysiology)
[2015, 22(2):87-93]

Cited: 0 times

View full text PDF listing >>



Commensal microbiota contributes to chronic endocarditis in TAX1BP1 deficient mice.

Satoko Nakano, Emi Ikebe, Yoshiyuki Tsukamoto, Yan Wang, Takashi Matsumoto, Takahiro Mitsui, Takaaki Yahiro, Kunimitsu Inoue, Hiroaki Kawazato, Aiko Yasuda, Kanako Ito, Shigeo Yokoyama, Naohiko Takahashi, Mitsuo Hori, Tatsuo Shimada, Masatsugu Moriyama, Toshiaki Kubota, Katsushige Ono, Wataru Fujibuchi, Kuan-Teh Jeang, Hidekatsu Iha, Akira Nishizono,

Tax1-binding protein 1 (Tax1bp1) negatively regulates NF-κB by editing the ubiquitylation of target molecules by its catalytic partner A20. Genetically engineered TAX1BP1-deficient (KO) mice develop age-dependent inflammatory constitutions in multiple organs manifested as valvulitis or dermatitis and succumb to premature death. Laser capture dissection and gene expression microarray analysis on ... Read more >>

PLoS One (PloS one)
[2013, 8(9):e73205]

Cited: 7 times

View full text PDF listing >>



Association between obstructive sleep apnea and premature supraventricular contractions.

Yoshiyuki Kawano, Akira Tamura, Katsushige Ono, Junichi Kadota,

<h4>Objective</h4>The exact association between obstructive sleep apnea (OSA) and premature supraventricular contractions (PSVCs) has not been established.<h4>Methods</h4>We prospectively performed polysomnography together with 24-hour Holter electrocardiography in 431 patients who were clinically suspected of having OSA and examined the association between OSA severity and PSVCs during wakefulness and sleep. The patients ... Read more >>

J Cardiol (Journal of cardiology)
[2014, 63(1):69-72]

Cited: 4 times

View full text PDF listing >>



Window current through the T-type Ca2+ channel triggers the mechanism for cellular apoptosis via mitochondrial pathways.

Tomoko Uchino, Shojiro Isomoto, Takayuki Noguchi, Katsushige Ono,

We hypothesized that Ca(2+) entry through the window T-type Ca(2+) current causes apoptosis. To test this hypothesis, we transfected human embryonic kidney (HEK) 293 cells to express recombinant Cav3.2 T-type Ca(2+) channels (hereafter called HEK-Cav3.2 cells). After incubation in media containing a high concentration (7.2 mM) of Ca(2+), intracellular Ca(2+) levels ... Read more >>

Heart Vessels (Heart and vessels)
[2013, 28(5):658-666]

Cited: 3 times

View full text PDF listing >>



Synaptic degradation of cardiac autonomic nerves in streptozotocin-induced diabetic rats.

Shamarendra N Sanyal, Tomoyuki Wada, Motoko Yamabe, Hirofumi Anai, Shinji Miyamoto, Tatsuo Shimada, Katsushige Ono,

<h4>Background</h4>Cardiac autonomic neuropathy (CAN) is a common complication in type I diabetes mellitus (DM). Nevertheless, the relationship between functional and structural disturbances of cardiac autonomic nerves remains unclear.<h4>Methods and results</h4>To clarify this relationship, we studied heart rate variability (HRV) and ultrastructural changes of cardiac autonomic nerves in streptozotocin (STZ)-induced DM ... Read more >>

Pathophysiology (Pathophysiology : the official journal of the International Society for Pathophysiology)
[2012, 19(4):299-307]

Cited: 3 times

View full text PDF listing >>



Cardiac autonomic nerve abnormalities in chronic heart failure are associated with presynaptic vagal nerve degeneration.

Shamarendra N Sanyal, Tomoyuki Wada, Motoko Yamabe, Hirofumi Anai, Shinji Miyamoto, Tatsuo Shimada, Katsushige Ono,

<h4>Background</h4>Understanding of the functional and structural disturbances of cardiac autonomic nerves in ventricular hypertrophy and eventual chronic heart failure (CHF) remains unclear.<h4>Methods and results</h4>ECG signals were obtained by a radio transmitter from male Wistar rats that received monocrotaline (MCT) via subcutaneous injection. Heart rate (HR) and HR variability (HRV) were ... Read more >>

Pathophysiology (Pathophysiology : the official journal of the International Society for Pathophysiology)
[2012, 19(4):253-260]

Cited: 3 times

View full text PDF listing >>



Intracellular Ca(2+)- and PKC-dependent upregulation of T-type Ca(2+) channels in LPC-stimulated cardiomyocytes.

Mingqi Zheng, Yan Wang, Lin Kang, Toru Shimaoka, Farzana Marni, Katsushige Ono,

Lysophosphatidylcholine (LPC) accumulation in intracellular and/or interstitial space in cardiomyocytes may underlie as a mechanism for tachycardia and various arrhythmias during cardiac ischemia, which is usually accompanied by elevation of intracellular Ca(2+) concentration ([Ca(2+)](i)). The present study was therefore designed to investigate possible mechanisms responsible for [Ca(2+)](i) elevation by LPC ... Read more >>

J Mol Cell Cardiol (Journal of molecular and cellular cardiology)
[2010, 48(1):131-139]

Cited: 9 times

View full text PDF listing >>



Beta-adrenergic-AMPK pathway phosphorylates acetyl-CoA carboxylase in a high-epinephrine rat model, SPORTS.

Atsushi Hattori, Kazuaki Mawatari, Satomi Tsuzuki, Emiko Yoshioka, Satomi Toda, Masaki Yoshida, Sonoko Yasui, Hiroko Furukawa, Masaki Morishima, Katsushige Ono, Takamasa Ohnishi, Masayuki Nakano, Nagakatsu Harada, Akira Takahashi, Yutaka Nakaya,

We established a new animal model called SPORTS (Spontaneously-Running Tokushima-Shikoku) rats, which show high-epinephrine (Epi) levels. Recent reports show that Epi activates adenosine monophosphate (AMP)-activated protein kinase (AMPK) in adipocytes. Acetyl-CoA carboxylase (ACC) is the rate-limiting enzyme in fatty acid synthesis, and the enzymatic activity is suppressed when its Ser-79 ... Read more >>

Obesity (Silver Spring) (Obesity (Silver Spring, Md.))
[2010, 18(1):48-54]

Cited: 9 times

View full text PDF listing >>



Telmisartan, an angiotensin II type 1 receptor antagonist, attenuates T-type Ca2+ channel expression in neonatal rat cardiomyocytes.

Masaki Morishima, Yan Wang, Yuko Akiyoshi, Shinji Miyamoto, Katsushige Ono,

Recently, it has been revealed that angiotensin II type 1 receptor (AT(1)) antagonists act as antiarrhythmic agents and that the T-type Ca2+ channel plays an important role in arrhythmia. However, it remains unclear how the T-type Ca2+ channel expression system is involved in angiotensin II-mediated arrhythmogenesis in cardiomyocytes. In this ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2009, 609(1-3):105-112]

Cited: 12 times

View full text PDF listing >>



Advertisement

Disclaimer
1.0764 s