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The impact of subclinical hypothyroidism on long-term outcomes in older patients undergoing percutaneous coronary intervention

Yong-Sheng Liu, Mei Wei, Le Wang, Gang Liu, Guo-Ping Ma, Katsushige Ono, Ze-Long Cao, Man Yang, Ming-Qi Zheng,

Abstract Background Subclinical hypothyroidism (SCH) is reportedly associated with an increased risk of adverse events in patients undergoing percutaneous coronary intervention (PCI). The prognostic significance of SCH in the elderly was poorly defined. The purpose of this study was to evaluate the association between SCH and long-term outcomes in older ... Read more >>

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Magnesium Deficiency Causes Transcriptional Downregulation of Kir2.1 and Kv4.2 Channels in Cardiomyocytes Resulting in QT Interval Prolongation.

Toru Shimaoka, Yan Wang, Masaki Morishima, Shinji Miyamoto, Katsushige Ono,

BACKGROUND:Mechanisms for QT interval prolongation and cardiac arrhythmogenesis in hypomagnesemia are poorly understood. This study investigated the potential molecular mechanism for QT prolongation caused by magnesium (Mg) deficiency in rats by using the patch clamp technique and molecular biology.Methods and Results:Male Wistar rats were fed an Mg-free diet or a normal diet ... Read more >>

Circ. J. (Circulation journal : official journal of the Japanese Circulation Society)
[2020, :]

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Cardiac specific transcription factor Csx/Nkx2.5 regulates transient-outward K+ channel expression in pluripotent P19 cell-derived cardiomyocytes.

Tomoko Uchino, Ming-Qi Zheng, Yan Wang, Katsushige Ono,

The homeobox-containing gene Csx/Nkx2.5 codes several cardiac transcription factors and plays a critical role in early cardiogenesis. We investigated the effect of Csx/Nkx2.5 on the expression of cardiac ion channels using P19-derived cardiomyocytes. P19CL6 cells and P19CL6 cells with Csx/Nkx2.5 overexpression (P19CL6-Csx cells) were induced to differentiate into cardiomyocytes by ... Read more >>

J Physiol Sci (The journal of physiological sciences : JPS)
[2020, 70(1):20]

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How Is Uric Acid Related to Atrial Fibrillation?

Katsushige Ono,

Circ. J. (Circulation journal : official journal of the Japanese Circulation Society)
[2019, 83(4):705-706]

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Asparagine-linked glycosylation modifies voltage-dependent gating properties of CaV3.1-T-type Ca2+ channel.

Yangong Liu, Pu Wang, Fangfang Ma, Mingqi Zheng, Gang Liu, Shinichiro Kume, Tatsuki Kurokawa, Katsushige Ono,

T-type channels are low-voltage-activated channels that play a role in the cardiovascular system particularly for pacemaker activity. Glycosylation is one of the most prevalent post-translational modifications in protein. Among various glycosylation types, the most common one is asparagine-linked (N-linked) glycosylation. The aim of this study was to elucidate the roles ... Read more >>

J Physiol Sci (The journal of physiological sciences : JPS)
[2019, 69(2):335-343]

Cited: 1 time

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The necessity of implantable cardioverter defibrillators in patients with Kearns-Sayre syndrome - systematic review of the articles.

Tomohiko Imamura, Naokata Sumitomo, Shota Muraji, Hitoshi Mori, Yousuke Osada, Takayuki Oyanagi, Takuro Kojima, Shigeki Yoshiba, Toshiki Kobayashi, Katsushige Ono,

The most common cardiac feature of Kearns-Sayre syndrome (KSS) is atrioventricular block (AVB), and pacemaker implantations (PMIs) are recommended for KSS patients with advanced AVB. However, some KSS patients develop fatal arrhythmias such as polymorphic ventricular tachycardia (PMVT) and ventricular fibrillation (VF) and die suddenly even after PMIs. We report ... Read more >>

Int. J. Cardiol. (International journal of cardiology)
[2019, 279:105-111]

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Short- and long-term roles of phosphatidylinositol 4,5-bisphosphate PIP2 on Cav3.1- and Cav3.2-T-type calcium channel current.

Yangong Liu, Tomohiro Iwano, Fangfang Ma, Pu Wang, Yan Wang, Mingqi Zheng, Gang Liu, Katsushige Ono,

T-type calcium (Ca2+) channels play important physiological functions in excitable cells including cardiomyocyte. Phosphatidylinositol-4,5-bisphosphate (PIP2) has recently been reported to modulate various ion channels' function. However the actions of PIP2 on the T-type Ca2+ channel remain unclear. To elucidate possible effects of PIP2 on the T-type Ca2+ channel, we applied ... Read more >>

Pathophysiology (Pathophysiology : the official journal of the International Society for Pathophysiology)
[2019, 26(1):31-38]

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Direct free radical scavenging effects of water-soluble HMG-CoA reductase inhibitors.

Ryohei Umeda, Hiroki Takanari, Kazue Ogata, Shigekiyo Matsumoto, Takaaki Kitano, Katsushige Ono, Osamu Tokumaru,

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, statins, are widely used for preventing cardiovascular and cerebrovascular diseases by controlling blood cholesterol level. Additionally, previous studies revealed the scavenging effects of statins on free radicals. We assessed direct scavenging activities of two water-soluble statins, fluvastatin and pravastatin, on multiple free radicals using electron ... Read more >>

J Clin Biochem Nutr (Journal of clinical biochemistry and nutrition)
[2019, 64(1):20-26]

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Testosterone-mediated upregulation of delayed rectifier potassium channel in cardiomyocytes causes abbreviation of QT intervals in rats.

Kimiko Masuda, Hiroki Takanari, Masaki Morishima, FangFang Ma, Yan Wang, Naohiko Takahashi, Katsushige Ono,

Men have shorter rate-corrected QT intervals (QTc) than women, especially at the period of adolescence or later. The aim of this study was to elucidate the long-term effects of testosterone on cardiac excitability parameters including electrocardiogram (ECG) and potassium channel current. Testosterone shortened QT intervals in ECG in castrated male ... Read more >>

J Physiol Sci (The journal of physiological sciences : JPS)
[2018, 68(6):759-767]

Cited: 2 times

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Erratum to: Short- and long-term inhibition of cardiac inward-rectifier potassium channel current by an antiarrhythmic drug bepridil.

Fangfang Ma, Hiroki Takanari, Kimiko Masuda, Masaki Morishima, Katsushige Ono,

Heart Vessels (Heart and vessels)
[2016, 31(7):1185]

Cited: 1 time

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Atrial Fibrillation-Mediated Upregulation of miR-30d Regulates Myocardial Electrical Remodeling of the G-Protein-Gated K(+) Channel, IK.ACh.

Masaki Morishima, Eriko Iwata, Chisato Nakada, Yoshiyuki Tsukamoto, Hiroki Takanari, Shinji Miyamoto, Masatsugu Moriyama, Katsushige Ono,

Atrial fibrillation (AF) begets AF in part due to atrial remodeling, the molecular mechanisms of which have not been completely elucidated. This study was conducted to identify microRNA(s) responsible for electrical remodeling in AF.The expression profiles of 1205 microRNAs, in cardiomyocytes from patients with persistent AF and from age-, gender-, ... Read more >>

Circ. J. (Circulation journal : official journal of the Japanese Circulation Society)
[2016, 80(6):1346-1355]

Cited: 7 times

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Short- and long-term inhibition of cardiac inward-rectifier potassium channel current by an antiarrhythmic drug bepridil.

Fangfang Ma, Hiroki Takanari, Kimiko Masuda, Masaki Morishima, Katsushige Ono,

Bepridil is an effective antiarrhythmic drug on supraventricular and ventricular arrhythmias, and inhibitor of calmodulin. Recent investigations have been elucidating that bepridil exerts antiarrhythmic effects through its acute and chronic application for patients. The aim of this study was to identify the efficacy and the potential mechanism of bepridil on ... Read more >>

Heart Vessels (Heart and vessels)
[2016, 31(7):1176-1184]

Cited: 2 times

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Hypomagnesemic down-regulation of L-type Ca(2+) channel in cardiomyocyte as an arrhythmogenic substrate in rats.

Toru Shimaoka, Yan Wang, Masaki Morishima, Shinji Miyamoto, Katsushige Ono,

The present study was designed to investigate the effect of magnesium (Mg) depletion on the expression of voltage-gated calcium (Ca(2+)) channels and Ca(2+) currents in the heart and thereby on hypomagnesemic arrhythmogenesis in adult male rats. Male Wistar rats were fed an Mg-free diet or a normal diet for up ... Read more >>

Pathophysiology (Pathophysiology : the official journal of the International Society for Pathophysiology)
[2015, 22(2):87-93]

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Commensal microbiota contributes to chronic endocarditis in TAX1BP1 deficient mice.

Satoko Nakano, Emi Ikebe, Yoshiyuki Tsukamoto, Yan Wang, Takashi Matsumoto, Takahiro Mitsui, Takaaki Yahiro, Kunimitsu Inoue, Hiroaki Kawazato, Aiko Yasuda, Kanako Ito, Shigeo Yokoyama, Naohiko Takahashi, Mitsuo Hori, Tatsuo Shimada, Masatsugu Moriyama, Toshiaki Kubota, Katsushige Ono, Wataru Fujibuchi, Kuan-Teh Jeang, Hidekatsu Iha, Akira Nishizono,

Tax1-binding protein 1 (Tax1bp1) negatively regulates NF-κB by editing the ubiquitylation of target molecules by its catalytic partner A20. Genetically engineered TAX1BP1-deficient (KO) mice develop age-dependent inflammatory constitutions in multiple organs manifested as valvulitis or dermatitis and succumb to premature death. Laser capture dissection and gene expression microarray analysis on ... Read more >>

PLoS ONE (PloS one)
[2013, 8(9):e73205]

Cited: 6 times

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Association between obstructive sleep apnea and premature supraventricular contractions.

Yoshiyuki Kawano, Akira Tamura, Katsushige Ono, Junichi Kadota,

OBJECTIVE: The exact association between obstructive sleep apnea (OSA) and premature supraventricular contractions (PSVCs) has not been established. METHODS: We prospectively performed polysomnography together with 24-hour Holter electrocardiography in 431 patients who were clinically suspected of having OSA and examined the association between OSA severity and PSVCs during wakefulness and ... Read more >>

J Cardiol (Journal of cardiology)
[2014, 63(1):69-72]

Cited: 4 times

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Window current through the T-type Ca2+ channel triggers the mechanism for cellular apoptosis via mitochondrial pathways.

Tomoko Uchino, Shojiro Isomoto, Takayuki Noguchi, Katsushige Ono,

We hypothesized that Ca(2+) entry through the window T-type Ca(2+) current causes apoptosis. To test this hypothesis, we transfected human embryonic kidney (HEK) 293 cells to express recombinant Cav3.2 T-type Ca(2+) channels (hereafter called HEK-Cav3.2 cells). After incubation in media containing a high concentration (7.2 mM) of Ca(2+), intracellular Ca(2+) levels ... Read more >>

Heart Vessels (Heart and vessels)
[2013, 28(5):658-666]

Cited: 3 times

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Synaptic degradation of cardiac autonomic nerves in streptozotocin-induced diabetic rats.

Shamarendra N Sanyal, Tomoyuki Wada, Motoko Yamabe, Hirofumi Anai, Shinji Miyamoto, Tatsuo Shimada, Katsushige Ono,

Cardiac autonomic neuropathy (CAN) is a common complication in type I diabetes mellitus (DM). Nevertheless, the relationship between functional and structural disturbances of cardiac autonomic nerves remains unclear.To clarify this relationship, we studied heart rate variability (HRV) and ultrastructural changes of cardiac autonomic nerves in streptozotocin (STZ)-induced DM in rats. ... Read more >>

Pathophysiology (Pathophysiology : the official journal of the International Society for Pathophysiology)
[2012, 19(4):299-307]

Cited: 3 times

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Cardiac autonomic nerve abnormalities in chronic heart failure are associated with presynaptic vagal nerve degeneration.

Shamarendra N Sanyal, Tomoyuki Wada, Motoko Yamabe, Hirofumi Anai, Shinji Miyamoto, Tatsuo Shimada, Katsushige Ono,

Understanding of the functional and structural disturbances of cardiac autonomic nerves in ventricular hypertrophy and eventual chronic heart failure (CHF) remains unclear.ECG signals were obtained by a radio transmitter from male Wistar rats that received monocrotaline (MCT) via subcutaneous injection. Heart rate (HR) and HR variability (HRV) were analyzed. The ... Read more >>

Pathophysiology (Pathophysiology : the official journal of the International Society for Pathophysiology)
[2012, 19(4):253-260]

Cited: 3 times

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Intracellular Ca(2+)- and PKC-dependent upregulation of T-type Ca(2+) channels in LPC-stimulated cardiomyocytes.

Mingqi Zheng, Yan Wang, Lin Kang, Toru Shimaoka, Farzana Marni, Katsushige Ono,

Lysophosphatidylcholine (LPC) accumulation in intracellular and/or interstitial space in cardiomyocytes may underlie as a mechanism for tachycardia and various arrhythmias during cardiac ischemia, which is usually accompanied by elevation of intracellular Ca(2+) concentration ([Ca(2+)](i)). The present study was therefore designed to investigate possible mechanisms responsible for [Ca(2+)](i) elevation by LPC ... Read more >>

J. Mol. Cell. Cardiol. (Journal of molecular and cellular cardiology)
[2010, 48(1):131-139]

Cited: 9 times

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Beta-adrenergic-AMPK pathway phosphorylates acetyl-CoA carboxylase in a high-epinephrine rat model, SPORTS.

Atsushi Hattori, Kazuaki Mawatari, Satomi Tsuzuki, Emiko Yoshioka, Satomi Toda, Masaki Yoshida, Sonoko Yasui, Hiroko Furukawa, Masaki Morishima, Katsushige Ono, Takamasa Ohnishi, Masayuki Nakano, Nagakatsu Harada, Akira Takahashi, Yutaka Nakaya,

We established a new animal model called SPORTS (Spontaneously-Running Tokushima-Shikoku) rats, which show high-epinephrine (Epi) levels. Recent reports show that Epi activates adenosine monophosphate (AMP)-activated protein kinase (AMPK) in adipocytes. Acetyl-CoA carboxylase (ACC) is the rate-limiting enzyme in fatty acid synthesis, and the enzymatic activity is suppressed when its Ser-79 ... Read more >>

Obesity (Silver Spring) (Obesity (Silver Spring, Md.))
[2010, 18(1):48-54]

Cited: 8 times

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Telmisartan, an angiotensin II type 1 receptor antagonist, attenuates T-type Ca2+ channel expression in neonatal rat cardiomyocytes.

Masaki Morishima, Yan Wang, Yuko Akiyoshi, Shinji Miyamoto, Katsushige Ono,

Recently, it has been revealed that angiotensin II type 1 receptor (AT(1)) antagonists act as antiarrhythmic agents and that the T-type Ca2+ channel plays an important role in arrhythmia. However, it remains unclear how the T-type Ca2+ channel expression system is involved in angiotensin II-mediated arrhythmogenesis in cardiomyocytes. In this ... Read more >>

Eur. J. Pharmacol. (European journal of pharmacology)
[2009, 609(1-3):105-112]

Cited: 12 times

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17 beta-estradiol modulates expression of low-voltage-activated Ca(V)3.2 T-type calcium channel via extracellularly regulated kinase pathway in cardiomyocytes.

Farzana Marni, Yan Wang, Masaki Morishima, Toru Shimaoka, Tomoko Uchino, Mingqi Zheng, Toshihiko Kaku, Katsushige Ono,

T-type Ca(2+) channel current (I(Ca,T)) plays an important role for spontaneous pacemaker activity and is involved in the progression of structural heart diseases. Estrogens are of importance for the regulation of growth and differentiation and function in a wide array of target tissues, including those in the cardiovascular system. The ... Read more >>

Endocrinology (Endocrinology)
[2009, 150(2):879-888]

Cited: 15 times

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Rescue of pulmonary hypertension with an oral sulfonamide antibiotic sulfisoxazole by endothelin receptor antagonistic actions.

Tomoko Uchino, Shamarendra N Sanyal, Motoko Yamabe, Toshihiko Kaku, Satoshi Takebayashi, Toru Shimaoka, Tatsuo Shimada, Takayuki Noguchi, Katsushige Ono,

Pulmonary hypertension (PH) is a disease of unknown etiology that ultimately causes right ventricle heart failure with a lethal outcome. An increase in circulating endothelin (ET)-1 levels may contribute to disease progression. This study aimed to examine the possible effects of an orally active ET receptor antagonist, sulfisoxazole (SFX), for ... Read more >>

Hypertens. Res. (Hypertension research : official journal of the Japanese Society of Hypertension)
[2008, 31(9):1781-1790]

Cited: 5 times

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Beneficial effects of the dual L- and T-type Ca2+ channel blocker efonidipine on cardiomyopathic hamsters.

Shinsuke Suzuki, Tomoko Ohkusa, Katsushige Ono, Takashi Sato, Masa-aki Yoshida, Masafumi Yano, Satoshi Takebayashi, Masunori Matsuzaki,

BACKGROUND:The T-type Ca2+ channel (TCC) is activated, and abnormalities of the TCC may be related to the pathogenesis of Ca2+ overload, in cardiomyopathic hamster hearts. The aims of the present study were to investigate the alteration in expression of the TCC and to examine the effects of a dual L-and ... Read more >>

Circ. J. (Circulation journal : official journal of the Japanese Circulation Society)
[2007, 71(12):1970-1976]

Cited: 6 times

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Transcription factors Csx/Nkx2.5 and GATA4 distinctly regulate expression of Ca2+ channels in neonatal rat heart.

Yan Wang, Masaki Morishima, Mingqi Zheng, Tomoko Uchino, Kazuaki Mannen, Akira Takahashi, Yutaka Nakaya, Issei Komuro, Katsushige Ono,

The cardiac transcription factors Csx/Nkx2.5 and GATA4 play important roles in vertebrate heart development. Although mutations of Csx/Nkx2.5 or GATA4 are associated with various congenital heart diseases, their mechanism of action on cardiomyocyte function is not completely elucidated. In this study, we therefore investigated the actions of these transcription factors ... Read more >>

J. Mol. Cell. Cardiol. (Journal of molecular and cellular cardiology)
[2007, 42(6):1045-1053]

Cited: 20 times

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