Full Text Journal Articles by
Author Katrin Reppe


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Neutralizing Complement C5a Protects Mice with Pneumococcal Pulmonary Sepsis.

Holger Müller-Redetzky, Ute Kellermann, Sandra-Maria Wienhold, Birgitt Gutbier, Jasmin Lienau, Katharina Hellwig, Katrin Reppe, Eleftheria Letsiou, Thomas Tschernig, Markus Scholz, Peter Ahnert, Christian Maasch, Kai Hoehlig, Sven Klussmann, Axel Vater, Theresa C Firsching, Judith Hoppe, Norbert Suttorp, Martin Witzenrath,

BACKGROUND:Community-acquired pneumonia and associated sepsis cause high mortality despite antibiotic treatment. Uncontrolled inflammatory host responses contribute to the unfavorable outcome by driving lung and extrapulmonary organ failure. The complement fragment C5a holds significant proinflammatory functions and is associated with tissue damage in various inflammatory conditions. The authors hypothesized that C5a ... Read more >>

Anesthesiology (Anesthesiology)
[2020, 132(4):795-807]

Cited: 2 times

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Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia.

Birgitt Gutbier, Anne-Kathrin Neuhauß, Katrin Reppe, Carolin Ehrler, Ansgar Santel, Jörg Kaufmann, Markus Scholz, Norbert Weissmann, Lars Morawietz, Timothy J Mitchell, Stefano Aliberti, Stefan Hippenstiel, Norbert Suttorp, Martin Witzenrath, ,

RATIONALE:During pneumonia, pathogen-host interaction evokes inflammation and lung barrier dysfunction. Tie2 activation by angiopoietin-1 reduces, whereas Tie2 blockade by angiopoietin-2 increases, inflammation and permeability during sepsis. The role of angiopoietin-1/-2 in pneumonia remains unidentified. OBJECTIVES:To investigate the prognostic and pathogenic impact of angiopoietins in regulating pulmonary vascular barrier function and ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2018, 198(2):220-231]

Cited: 15 times

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Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia.

Oliver H Robak, Markus M Heimesaat, Andrey A Kruglov, Sandra Prepens, Justus Ninnemann, Birgitt Gutbier, Katrin Reppe, Hubertus Hochrein, Mark Suter, Carsten J Kirschning, Veena Marathe, Jan Buer, Mathias W Hornef, Markus Schnare, Pascal Schneider, Martin Witzenrath, Stefan Bereswill, Ulrich Steinhoff, Norbert Suttorp, Leif E Sander, Catherine Chaput, Bastian Opitz,

Broad-spectrum antibiotics are widely used with patients in intensive care units (ICUs), many of whom develop hospital-acquired infections with Pseudomonas aeruginosa. Although preceding antimicrobial therapy is known as a major risk factor for P. aeruginosa-induced pneumonia, the underlying mechanisms remain incompletely understood. Here we demonstrate that depletion of the resident ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2018, 128(8):3535-3545]

Cited: 20 times

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Digital Image Analyses on Whole-Lung Slides in Mouse Models of Acute Pneumonia.

Kristina Dietert, Geraldine Nouailles, Birgitt Gutbier, Katrin Reppe, Sarah Berger, Xiaohui Jiang, Anja E Schauer, Andreas C Hocke, Susanne Herold, Hortense Slevogt, Martin Witzenrath, Norbert Suttorp, Achim D Gruber,

Descriptive histopathology of mouse models of pneumonia is essential in assessing the outcome of infections, molecular manipulations, or therapies in the context of whole lungs. Quantitative comparisons between experimental groups, however, have been limited to laborious stereology or ill-defined scoring systems that depend on the subjectivity of a more or ... Read more >>

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2018, 58(4):440-448]

Cited: 1 time

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Development of an Efficacious, Semisynthetic Glycoconjugate Vaccine Candidate against Streptococcus pneumoniae Serotype 1.

Benjamin Schumann, Katrin Reppe, Paulina Kaplonek, Annette Wahlbrink, Chakkumkal Anish, Martin Witzenrath, Claney L Pereira, Peter H Seeberger,

Infections with Streptococcus pneumoniae are a major health burden. Glycoconjugate vaccines based on capsular polysaccharides (CPSs) successfully protect from infection, but not all pneumococcal serotypes are covered with equal potency. Marketed glycoconjugate vaccines induce low levels of functional antibodies against the highly invasive serotype 1 (ST1), presumably due to the ... Read more >>

ACS Cent Sci (ACS central science)
[2018, 4(3):357-361]

Cited: 8 times

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Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.

Kristina Dietert, Birgitt Gutbier, Sandra M Wienhold, Katrin Reppe, Xiaohui Jiang, Ling Yao, Catherine Chaput, Jan Naujoks, Markus Brack, Alexandra Kupke, Christin Peteranderl, Stephan Becker, Carolin von Lachner, Nelli Baal, Hortense Slevogt, Andreas C Hocke, Martin Witzenrath, Bastian Opitz, Susanne Herold, Holger Hackstein, Leif E Sander, Norbert Suttorp, Achim D Gruber,

Pneumonia may be caused by a wide range of pathogens and is considered the most common infectious cause of death in humans. Murine acute lung infection models mirror human pathologies in many aspects and contribute to our understanding of the disease and the development of novel treatment strategies. Despite progress ... Read more >>

PLoS One (PloS one)
[2017, 12(11):e0188251]

Cited: 13 times

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A Semi-Synthetic Glycoconjugate Vaccine Candidate for Carbapenem-Resistant Klebsiella pneumoniae.

Peter H Seeberger, Claney L Pereira, Naeem Khan, Guozhi Xiao, Elizabeth Diago-Navarro, Katrin Reppe, Bastian Opitz, Bettina C Fries, Martin Witzenrath,

Hospital-acquired infections are an increasingly serious health concern. Infections caused by carpabenem-resistant Klebsiella pneumoniae (CR-Kp) are especially problematic, with a 50 % average survival rate. CR-Kp are isolated from patients with ever greater frequency, 7 % within the EU but 62 % in Greece. At a time when antibiotics are becoming less effective, ... Read more >>

Angew Chem Int Ed Engl (Angewandte Chemie (International ed. in English))
[2017, 56(45):13973-13978]

Cited: 15 times

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A Streptococcus pneumoniae Type 2 Oligosaccharide Glycoconjugate Elicits Opsonic Antibodies and Is Protective in an Animal Model of Invasive Pneumococcal Disease.

Madhu Emmadi, Naeem Khan, Lennart Lykke, Katrin Reppe, Sharavathi G Parameswarappa, Marilda P Lisboa, Sandra-Maria Wienhold, Martin Witzenrath, Claney L Pereira, Peter H Seeberger,

Invasive pneumococcal diseases (IPDs) remain the leading cause of vaccine-preventable childhood death, even though highly effective pneumococcal conjugate vaccines (PCVs) are used in national immunization programs in many developing countries. Licensed PCVs currently cover only 13 of the over 90 serotypes of Streptococcus pneumoniae (Sp), so nonvaccine serotypes are a ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2017, 139(41):14783-14791]

Cited: 13 times

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Semisynthetic glycoconjugate vaccine candidate against Streptococcus pneumoniae serotype 5.

Marilda P Lisboa, Naeem Khan, Christopher Martin, Fei-Fei Xu, Katrin Reppe, Andreas Geissner, Subramanian Govindan, Martin Witzenrath, Claney L Pereira, Peter H Seeberger,

Glycoconjugate vaccines based on isolated capsular polysaccharide (CPS) save millions of lives annually by preventing invasive pneumococcal disease caused by <i>Streptococcus pneumoniae</i> Some components of the <i>S. pneumoniae</i> glycoconjugate vaccine Prevnar13 that contains CPS antigens from 13 serotypes undergo modifications or degradation during isolation and conjugation, resulting in production problems ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2017, 114(42):11063-11068]

Cited: 11 times

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Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury.

Malgorzata Wygrecka, Djuro Kosanovic, Lukasz Wujak, Katrin Reppe, Ingrid Henneke, Helena Frey, Miroslava Didiasova, Grazyna Kwapiszewska, Leigh M Marsh, Nelli Baal, Holger Hackstein, Dariusz Zakrzewicz, Holger C Müller-Redetzky, Steven de Maat, Coen Maas, Marc W Nolte, Con Panousis, Ralph T Schermuly, Werner Seeger, Martin Witzenrath, Liliana Schaefer, Philipp Markart,

<h4>Rationale</h4>Acute respiratory distress syndrome is characterized by alveolar epithelial cell injury, edema formation, and intraalveolar contact phase activation.<h4>Objectives</h4>To explore whether C1 esterase inhibitor (C1INH), an endogenous inhibitor of the contact phase, may protect from lung injury in vivo and to decipher the possible underlying mechanisms mediating protection.<h4>Methods</h4>The ability of C1INH ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2017, 196(2):186-199]

Cited: 14 times

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A Semi-synthetic Oligosaccharide Conjugate Vaccine Candidate Confers Protection against Streptococcus pneumoniae Serotype 3 Infection.

Sharavathi Guddehalli Parameswarappa, Katrin Reppe, Andreas Geissner, Petra Ménová, Subramanian Govindan, Adam D J Calow, Annette Wahlbrink, Markus W Weishaupt, Bopanna Ponnappa Monnanda, Roland Lawrence Bell, Liise-Anne Pirofski, Norbert Suttorp, Leif Erik Sander, Martin Witzenrath, Claney Lebev Pereira, Chakkumkal Anish, Peter H Seeberger,

The identification of immunogenic glycotopes that render glycoconjugate vaccines protective is key to improving vaccine efficacy. Synthetic oligosaccharides are an attractive alternative to the heterogeneous preparations of purified polysaccharides that most marketed glycoconjugate vaccines are based on. To investigate the potency of semi-synthetic glycoconjugates, we chose the least-efficient serotype in the current pneumococcal ... Read more >>

Cell Chem Biol (Cell chemical biology)
[2016, 23(11):1407-1416]

Cited: 14 times

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Pulmonary immunostimulation with MALP-2 in influenza virus-infected mice increases survival after pneumococcal superinfection.

Katrin Reppe, Peter Radünzel, Kristina Dietert, Thomas Tschernig, Thorsten Wolff, Sven Hammerschmidt, Achim D Gruber, Norbert Suttorp, Martin Witzenrath,

Pulmonary infection with influenza virus is frequently complicated by bacterial superinfection, with Streptococcus pneumoniae being the most prevalent causal pathogen and hence often associated with high morbidity and mortality rates. Local immunosuppression due to pulmonary influenza virus infection has been identified as a major cause of the pathogenesis of secondary ... Read more >>

Infect Immun (Infection and immunity)
[2015, 83(12):4617-4629]

Cited: 14 times

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Murine CLCA5 is uniquely expressed in distinct niches of airway epithelial cells.

Kristina Dietert, Lars Mundhenk, Nancy A Erickson, Katrin Reppe, Andreas C Hocke, Wolfgang Kummer, Martin Witzenrath, Achim D Gruber,

The murine mCLCA5 protein is a member of the chloride channel regulators, calcium-activated (CLCA) family and is suspected to play a role in airway mucus cell differentiation. Although mCLCA5 mRNA was previously found in total lung extracts, the expressing cells and functions in the naive murine respiratory tract are unknown. ... Read more >>

Histochem Cell Biol (Histochemistry and cell biology)
[2015, 143(3):277-287]

Cited: 10 times

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Miniaturized bronchoscopy enables unilateral investigation, application, and sampling in mice.

Claudia Dames, Levent Akyüz, Katrin Reppe, Christoph Tabeling, Kristina Dietert, Olivia Kershaw, Achim D Gruber, Christian Meisel, Andreas Meisel, Martin Witzenrath, Odilo Engel,

Lung diseases, including pneumonia and asthma, are among the most prevalent human disorders, and murine models have been established to investigate their pathobiology and develop novel treatment approaches. Whereas bronchoscopy is valuable for diagnostic and therapeutic procedures in patients, no equivalent for small rodents has been established. Here, we introduce ... Read more >>

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2014, 51(6):730-737]

Cited: 10 times

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NF-κB2/p100 deficiency impairs immune responses to T-cell-independent type 2 antigens.

Branislav Krljanac, Debra Weih, Ilse D Jacobsen, Desheng Hu, Ievgen Koliesnik, Katrin Reppe, Martin Witzenrath, Falk Weih,

Formation of the splenic marginal zone (MZ) depends on the alternative NF-κB signaling pathway. Recently, we reported that unrestricted activation of this pathway in NF-κB2/p100-deficient (p100(-/-) ) knock-in mice alters the phenotype of MZ stroma and B cells. Here, we show that lack of the p100 inhibitor resulted in an ... Read more >>

Eur J Immunol (European journal of immunology)
[2014, 44(3):662-672]

Cited: 5 times

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Delivery of the endolysin Cpl-1 by inhalation rescues mice with fatal pneumococcal pneumonia.

Jan M Doehn, Katja Fischer, Katrin Reppe, Birgitt Gutbier, Thomas Tschernig, Andreas C Hocke, Vincent A Fischetti, Jutta Löffler, Norbert Suttorp, Stefan Hippenstiel, Martin Witzenrath,

<h4>Objectives</h4>Pneumonia is associated with a high morbidity and mortality worldwide. Streptococcus pneumoniae remains the most common cause of pneumonia, and pneumococcal antibiotic resistance is increasing. The purified bacteriophage endolysin Cpl-1 rapidly and specifically kills pneumococci. We tested the hypothesis that a single dose of recombinant aerosolized Cpl-1 would rescue mice ... Read more >>

J Antimicrob Chemother (The Journal of antimicrobial chemotherapy)
[2013, 68(9):2111-2117]

Cited: 25 times

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The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia.

Martin Witzenrath, Florence Pache, Daniel Lorenz, Uwe Koppe, Birgitt Gutbier, Christoph Tabeling, Katrin Reppe, Karolin Meixenberger, Anca Dorhoi, Jiangtao Ma, Ashleigh Holmes, George Trendelenburg, Markus M Heimesaat, Stefan Bereswill, Mark van der Linden, Jürg Tschopp, Timothy J Mitchell, Norbert Suttorp, Bastian Opitz,

Streptococcus pneumoniae is a leading cause of pneumonia, meningitis, and sepsis. Pneumococci can be divided into >90 serotypes that show differences in the pathogenicity and invasiveness. We tested the hypotheses that the innate immune inflammasome pathway is involved in fighting pneumococcal pneumonia and that some invasive pneumococcal types are not ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2011, 187(1):434-440]

Cited: 134 times

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RNAi-mediated suppression of constitutive pulmonary gene expression by small interfering RNA in mice.

Birgitt Gutbier, Stefanie M Kube, Katrin Reppe, Ansgar Santel, Christian Lange, Jörg Kaufmann, Norbert Suttorp, Martin Witzenrath,

The ability of synthetic small interfering RNA (siRNA) to silence gene expression makes it a useful tool in biomedical research. However, effective and non-toxic functional siRNA delivery to mouse lungs in vivo is still a key challenge, and regulation of constitutively expressed genes is poorly characterized. Following in vitro validation ... Read more >>

Pulm Pharmacol Ther (Pulmonary pharmacology & therapeutics)
[2010, 23(4):334-344]

Cited: 22 times

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Immunostimulation with macrophage-activating lipopeptide-2 increased survival in murine pneumonia.

Katrin Reppe, Thomas Tschernig, Anke Lührmann, Vincent van Laak, Karsten Grote, Maren V Zemlin, Birgitt Gutbier, Holger C Müller, Mischo Kursar, Hartwig Schütte, Simone Rosseau, Reinhard Pabst, Norbert Suttorp, Martin Witzenrath,

Community-acquired pneumonia (CAP) is associated with high morbidity and mortality, and Streptococcus pneumoniae is the most prevalent causal pathogen identified in CAP. Impaired pulmonary host defense increases susceptibility to pneumococcal pneumonia. S. pneumoniae may up-regulate Toll-like receptor (TLR)-2 expression and activate TLR-2, contributing to pneumococcus-induced immune responses. In the current ... Read more >>

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2009, 40(4):474-481]

Cited: 26 times

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