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Author Katri Kaukinen

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Editorial: coeliac disease-it's a family affair. Authors' reply.

Saana Paavola, Katri Kaukinen, Kalle Kurppa,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(7):969]

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Persistent Skin Symptoms after Diagnosis and on a Long-term Gluten-free Diet in Dermatitis Herpetiformis.

Camilla Pasternack, Kaisa Hervonen, Eriika Mansikka, Timo Reunala, Pekka Collin, Katri Kaukinen, Teea Salmi,

Dermatitis herpetiformis is a cutaneous manifestation of coeliac disease treated with a gluten-free diet. However, the itching and blistering rash alleviates slowly after gluten withdrawal and occasionally persists despite a long-term gluten-free diet. This study investigated the prevalence and factors associated with prolonged (i.e. >2 years) and ongoing skin symptoms ... Read more >>

Acta Derm Venereol (Acta dermato-venereologica)
[2021, 101(9):adv00555]

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Lifetime risk of rheumatoid arthritis-associated interstitial lung disease in MUC5B mutation carriers.

Antti Palomäki, , Aarno Palotie, Jukka Koskela, Kari K Eklund, Matti Pirinen, , Samuli Ripatti, Tarja Laitinen, Nina Mars,

<h4>Objectives</h4>To estimate lifetime risk of developing rheumatoid arthritis-associated interstitial lung disease (RA-ILD) with respect to the strongest known risk factor for pulmonary fibrosis, a <i>MUC5B</i> promoter variant.<h4>Methods</h4>FinnGen is a collection of epidemiological cohorts and hospital biobank samples, integrating genetic data with up to 50 years of follow-up within nationwide registries ... Read more >>

Ann Rheum Dis (Annals of the rheumatic diseases)
[2021, :]

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Presence of high-risk HLA genotype is the most important individual risk factor for coeliac disease among at-risk relatives.

Saana Paavola, Katri Lindfors, Laura Kivelä, Juliana Cerqueira, Heini Huhtala, Päivi Saavalainen, Riku Tauschi, Katri Kaukinen, Kalle Kurppa,

<h4>Background</h4>Family screening has been advocated as a means to reduce the major underdiagnosis of coeliac disease. However, the precise risk of the disease in relatives and the impact of patient- and relative-related individual factors remain obscure.<h4>Aims</h4>To investigate the individual risk of coeliac disease among patients' relatives.<h4>Methods</h4>Altogether 2943 relatives of 624 ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(6):805-813]

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Uncertain Diagnosis of Celiac Disease and Implications for Management.

James O'Connell, Joseph A Murray, Katri Kaukinen,

N Engl J Med (The New England journal of medicine)
[2021, 384(24):2346-2348]

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Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection.

Seyedeh M Zekavat, Shu-Hong Lin, Alexander G Bick, Aoxing Liu, Kaavya Paruchuri, Chen Wang, Md Mesbah Uddin, Yixuan Ye, Zhaolong Yu, Xiaoxi Liu, Yoichiro Kamatani, Romit Bhattacharya, James P Pirruccello, Akhil Pampana, Po-Ru Loh, Puja Kohli, Steven A McCarroll, Krzysztof Kiryluk, Benjamin Neale, Iuliana Ionita-Laza, Eric A Engels, Derek W Brown, Jordan W Smoller, Robert Green, Elizabeth W Karlson, Matthew Lebo, Patrick T Ellinor, Scott T Weiss, Mark J Daly, , , Chikashi Terao, Hongyu Zhao, Benjamin L Ebert, Muredach P Reilly, Andrea Ganna, Mitchell J Machiela, Giulio Genovese, Pradeep Natarajan,

Age is the dominant risk factor for infectious diseases, but the mechanisms linking age to infectious disease risk are incompletely understood. Age-related mosaic chromosomal alterations (mCAs) detected from genotyping of blood-derived DNA, are structural somatic variants indicative of clonal hematopoiesis, and are associated with aberrant leukocyte cell counts, hematological malignancy, ... Read more >>

Nat Med (Nature medicine)
[2021, 27(6):1012-1024]

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Celiac Disease-Type Tissue Transglutaminase Autoantibody Deposits in Kidney Biopsies of Patients with IgA Nephropathy.

Rakel Nurmi, Ilma Korponay-Szabó, Kaija Laurila, Heini Huhtala, Onni Niemelä, Jukka Mustonen, Satu Mäkelä, Katri Kaukinen, Katri Lindfors,

An association between celiac disease and IgA nephropathy (IgAN) has been suggested. In celiac disease, in addition to circulating in serum, IgA-class tissue transglutaminase (tTG) autoantibodies are deposited in the small bowel mucosa and extraintestinal organs. In this case series of IgAN patients with or without celiac disease, we studied ... Read more >>

Nutrients (Nutrients)
[2021, 13(5):]

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Anaemia in Dermatitis Herpetiformis: Prevalence and Associated Factors at Diagnosis and One-year Follow-up.

Anna Alakoski, Camilla Pasternack, Timo Reunala, Katri Kaukinen, Heini Huhtala, Eriika Mansikka, Juha Jernman, Kaisa Hervonen, Teea Salmi,

Dermatitis herpetiformis is a cutaneous manifestation of coeliac disease. Anaemia is a common finding in patients with untreated coeliac disease, but little is known about the occurrence of anaemia in those with dermatitis herpetiformis. This study investigated the prevalence of anaemia and factors associated with anaemia in 250 patients with ... Read more >>

Acta Derm Venereol (Acta dermato-venereologica)
[2021, 101(4):adv00443]

Cited: 1 time

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Clustering based approach for population level identification of condition-associated T-cell receptor β-chain CDR3 sequences.

Dawit A Yohannes, Katri Kaukinen, Kalle Kurppa, Päivi Saavalainen, Dario Greco,

<h4>Background</h4>Deep immune receptor sequencing, RepSeq, provides unprecedented opportunities for identifying and studying condition-associated T-cell clonotypes, represented by T-cell receptor (TCR) CDR3 sequences. However, due to the immense diversity of the immune repertoire, identification of condition relevant TCR CDR3s from total repertoires has mostly been limited to either "public" CDR3 sequences ... Read more >>

BMC Bioinformatics (BMC bioinformatics)
[2021, 22(1):159]

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Celiac disease antibody levels reflect duodenal mucosal damage but not clinical symptoms.

Aki J Käräjämäki, Juha Taavela, Christian Nielsen, Mårten Lönnqvist, Marcus Svartbäck, Katri Kaukinen, Risto Tertti,

<h4>Objectives</h4>This study aimed to investigate, in a real-world population, whether the histological and clinical phenotype differ at baseline and during follow-up in patients with high and low CD (celiac disease) antibody titers.<h4>Materials and methods</h4>The study cohort consisted of 96 consecutive patients diagnosed to have CD during the years 2010-2018. The ... Read more >>

Scand J Gastroenterol (Scandinavian journal of gastroenterology)
[2021, 56(5):514-519]

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Iron Transporter Protein Expressions in Children with Celiac Disease.

Marleena Repo, Markus Hannula, Juha Taavela, Jari Hyttinen, Jorma Isola, Pauliina Hiltunen, Alina Popp, Katri Kaukinen, Kalle Kurppa, Katri Lindfors,

Anemia is a frequent finding in children with celiac disease but the detailed pathophysiological mechanisms in the intestine remain obscure. One possible explanation could be an abnormal expression of duodenal iron transport proteins. However, the results have so far been inconsistent. We investigated this issue by comparing immunohistochemical stainings of ... Read more >>

Nutrients (Nutrients)
[2021, 13(3):]

Cited: 1 time

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Independent and cumulative coeliac disease-susceptibility loci are associated with distinct disease phenotypes.

Juliana X M Cerqueira, Päivi Saavalainen, Kalle Kurppa, Pilvi Laurikka, Heini Huhtala, Matti Nykter, Lotta L E Koskinen, Dawit A Yohannes, Elina Kilpeläinen, Anastasia Shcherban, Aarno Palotie, Katri Kaukinen, Katri Lindfors,

The phenotype of coeliac disease varies considerably for incompletely understood reasons. We investigated whether established coeliac disease susceptibility variants (SNPs) are individually or cumulatively associated with distinct phenotypes. We also tested whether a polygenic risk score (PRS) based on genome-wide associated (GWA) data could explain the phenotypic variation. The phenotypic ... Read more >>

J Hum Genet (Journal of human genetics)
[2021, 66(6):613-623]

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Updates on systemic consequences of coeliac disease.

Katri Kaukinen,

Nat Rev Gastroenterol Hepatol (Nature reviews. Gastroenterology & hepatology)
[2021, 18(2):87-88]

Cited: 1 time

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Letter: no-biopsy pathway for diagnosing adult coeliac disease-authors' reply.

Kalle Kurppa, Laura Kivelä, Katri Kaukinen,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 53(2):359]

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Influence of HLA-DQ2.5 Dose on Clinical Picture of Unrelated Celiac Disease Patients.

Laura Airaksinen, Pilvi Laurikka, Heini Huhtala, Kalle Kurppa, Teea Salmi, Päivi Saavalainen, Katri Kaukinen, Katri Lindfors,

The clinical phenotype of celiac disease varies considerably among patients and the dosage of HLA-DQ2.5 alleles has been suggested to be a contributing factor. We investigated whether HLA-DQ2.5 allele dosage is associated with distinct clinical parameters at the time of diagnosis and with patients' response to a gluten-free diet. The ... Read more >>

Nutrients (Nutrients)
[2020, 12(12):]

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Prevalence of Inflammatory Bowel Disease and Celiac Disease in Patients with IgA Nephropathy over Time.

Rakel Nurmi, Jussi Pohjonen, Martti Metso, Ilkka Pörsti, Onni Niemelä, Heini Huhtala, Jukka Mustonen, Katri Kaukinen, Satu Mäkelä,

<h4>Introduction</h4>IgA nephropathy (IgAN) has been connected with increased intestinal permeability and subclinical intestinal mucosal inflammation as well as with inflammatory bowel disease (IBD) and celiac disease - nevertheless, the results are controversial. The prevalence of bowel diseases has increased over time in Western populations. Whether similar trend is seen among ... Read more >>

Nephron (Nephron)
[2021, 145(1):78-84]

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Effects of In Vivo Gluten Challenge on PBMC Gene Expression Profiles in Diet Treated Celiac Disease.

Dawit A Yohannes, Andrea de Kauwe, Katri Kaukinen, Kalle Kurppa, Markku Mäki, Robert P Anderson, Sten Linnarsson, Dario Greco, Päivi Saavalainen,

The pathological mechanisms that lead to the onset and reactivation of celiac disease (CD) remain largely unknown. While gluten free diet (GFD) improves the intestinal damage and associated clinical symptoms in majority of cases, it falls short of providing full recovery. Additionally, late or misdiagnosis is also common as CD ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:594243]

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The use of peripheral blood mononuclear cells in celiac disease diagnosis and treatment.

Alma Kurki, Esko Kemppainen, Pilvi Laurikka, Katri Kaukinen, Katri Lindfors,

<b>Introduction</b>: Celiac disease is characterized by an abnormal immune activation driven by the ingestion of gluten from wheat, barley, and rye. Gluten-specific CD4<sup>+</sup> T cells play an important role in disease pathogenesis and are detectable among peripheral blood mononuclear cells (PBMCs). <b>Areas covered</b>: This review summarizes the use of celiac ... Read more >>

Expert Rev Gastroenterol Hepatol (Expert review of gastroenterology & hepatology)
[2021, 15(3):305-316]

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Autoantibodies Against the Immunodominant Bullous Pemphigoid Epitopes Are Rare in Patients With Dermatitis Herpetiformis and Coeliac Disease.

Antti Nätynki, Jussi Tuusa, Kaisa Hervonen, Katri Kaukinen, Outi Lindgren, Laura Huilaja, Nina Kokkonen, Teea Salmi, Kaisa Tasanen,

Dermatitis herpetiformis (DH) is an extraintestinal manifestation of coeliac disease (CD). Patients with DH have an elevated risk of development of another autoimmune blistering skin disease, bullous pemphigoid (BP). In this study we investigated whether patients with DH and CD (mean age for both 49 years) have circulating autoantibodies against ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:575805]

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Non-Biopsy Serology-Based Diagnosis of Celiac Disease in Adults Is Accurate with Different Commercial Kits and Pre-Test Probabilities.

Venla Ylönen, Katri Lindfors, Marleena Repo, Heini Huhtala, Valma Fuchs, Päivi Saavalainen, Alex Musikka, Kaija Laurila, Katri Kaukinen, Kalle Kurppa,

Non-biopsy diagnosis of celiac disease is possible in children with anti-transglutaminase 2 antibodies (TGA) > 10× the upper limit of normal (ULN) and positive anti-endomysial antibodies (EMA). Similar criteria have been suggested for adults, but evidence with different TGA assays is scarce. We compared the performance of four TGA tests ... Read more >>

Nutrients (Nutrients)
[2020, 12(9):]

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Clinical characteristics and long-term health in celiac disease patients diagnosed in early childhood: Large cohort study.

Sara Koskimaa, Laura Kivelä, Taina Arvola, Pauliina Hiltunen, Heini Huhtala, Katri Kaukinen, Kalle Kurppa,

<h4>Background</h4>Early detection of celiac disease could theoretically prevent most of the disease-associated complications, but long-term effects of this approach are unclear.<h4>Aims</h4>To investigate features at diagnosis and adulthood health in celiac disease patients diagnosed in early childhood in 1965-2014.<h4>Methods</h4>Medical data on 978 pediatric patients were collected and study questionnaires sent to ... Read more >>

Dig Liver Dis (Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver)
[2020, 52(11):1315-1322]

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X-ray microtomography is a novel method for accurate evaluation of small-bowel mucosal morphology and surface area.

Johannes Virta, Markus Hannula, Ilmari Tamminen, Katri Lindfors, Katri Kaukinen, Alina Popp, Juha Taavela, Päivi Saavalainen, Pauliina Hiltunen, Jari Hyttinen, Kalle Kurppa,

The often poorly orientated small-bowel mucosal biopsies taken for the diagnostics of celiac disease and other intestinal disorders are prone to misinterpretation. Furthermore, conventional histopathology has suboptimal sensitivity for early histopathological changes observed in short-term challenge studies. X-ray microtomography (micro-CT) is a promising new method for accurate imaging of human-derived ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):13164]

Cited: 3 times

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Severity of Villous Atrophy at Diagnosis in Childhood Does Not Predict Long-term Outcomes in Celiac Disease.

Sofia Kröger, Kalle Kurppa, Marleena Repo, Heini Huhtala, Katri Kaukinen, Katri Lindfors, Taina Arvola, Laura Kivelä,

<h4>Objectives</h4>Current pediatric guidelines allow noninvasive diagnosis of celiac disease in selected children. We investigated in a large cohort study whether the severity of villous atrophy at diagnosis is associated with clinical characteristics or long-term health outcomes, thus having a prognostic significance.<h4>Methods</h4>Comprehensive medical data on 906 children with celiac disease were ... Read more >>

J Pediatr Gastroenterol Nutr (Journal of pediatric gastroenterology and nutrition)
[2020, 71(1):71-77]

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Differences Between Familial and Sporadic Celiac Disease.

Laura Airaksinen, Lauri Myllymäki, Katri Kaukinen, Päivi Saavalainen, Heini Huhtala, Katri Lindfors, Kalle Kurppa,

<h4>Background</h4>It is not known if genetic background, characteristics at diagnosis, physical and psychological well-being, and adherence to a gluten-free diet are comparable between patients with familial or sporadic celiac disease. These issues were investigated in a follow-up study.<h4>Methods</h4>Altogether 1064 patients were analyzed for celiac disease-associated serology, predisposing HLA-DQ, and non-HLA ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2021, 66(6):1981-1988]

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Overall and Cause-Specific Mortality in Adult Celiac Disease and Dermatitis Herpetiformis Diagnosed in the 21st Century.

Inka Koskinen, Lauri J Virta, Heini Huhtala, Tuire Ilus, Katri Kaukinen, Pekka Collin,

INTRODUCTION:We assessed whether celiac disease-associated mortality is increased in Finland among patients diagnosed in the 21st century, given recent improvements in diagnostic and treatment facilities. METHODS:Biopsy-proven patients with celiac disease (Marsh III) and dermatitis herpetiformis aged 20-79 years (median 50 years) diagnosed 2005-2014 (n = 12,803) were identified from the ... Read more >>

Am J Gastroenterol (The American journal of gastroenterology)
[2020, 115(7):1117-1124]

Cited: 2 times

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