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Author Katja Steiger

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Morphology Matters: A Critical Reappraisal of the Clinical Relevance of Morphologic Criteria From the 2019 WHO Classification in a Large Colorectal Cancer Cohort Comprising 1004 Cases.

Moritz Jesinghaus, Maxime Schmitt, Corinna Lang, Marianne Reiser, Alexander Scheiter, Björn Konukiewitz, Katja Steiger, Miguel Silva, Markus Tschurtschenthaler, Sebastian Lange, Sebastian Foersch, Karl F Becker, Dieter Saur, Helmut Friess, Kathrin Halfter, Jutta Engel, Melanie Boxberg, Nicole Pfarr, Dirk Wilhelm, Wilko Weichert,

The 2019 World Health Organization (WHO) classification of colorectal carcinoma (CRC) profoundly reclassified CRC subtypes and introduces tumor budding as a second major grading criterion, while condensing conventional grade into a 2-tiered system. So far it remains largely unexplored how these parameters interact with each other and whether they truly ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2021, 45(7):969-978]

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Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia.

Veronika Ecker, Martina Stumpf, Lisa Brandmeier, Tanja Neumayer, Lisa Pfeuffer, Thomas Engleitner, Ingo Ringshausen, Nina Nelson, Manfred Jücker, Stefan Wanninger, Thorsten Zenz, Clemens Wendtner, Katrin Manske, Katja Steiger, Roland Rad, Markus Müschen, Jürgen Ruland, Maike Buchner,

Current therapeutic approaches for chronic lymphocytic leukemia (CLL) focus on the suppression of oncogenic kinase signaling. Here, we test the hypothesis that targeted hyperactivation of the phosphatidylinositol-3-phosphate/AKT (PI3K/AKT)-signaling pathway may be leveraged to trigger CLL cell death. Though counterintuitive, our data show that genetic hyperactivation of PI3K/AKT-signaling or blocking the ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):3526]

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Author Correction: Hyperpolarized 13C pyruvate magnetic resonance spectroscopy for in vivo metabolic phenotyping of rat HCC.

Elisabeth Bliemsrieder, Georgios Kaissis, Martin Grashei, Geoffrey Topping, Jennifer Altomonte, Christian Hundshammer, Fabian Lohöfer, Irina Heid, Dominik Keim, Selamawit Gebrekidan, Marija Trajkovic-Arsic, A M Winkelkotte, Katja Steiger, Roman Nawroth, Jens Siveke, Markus Schwaiger, Marcus Makowski, Franz Schilling, Rickmer Braren,

Sci Rep (Scientific reports)
[2021, 11(1):11705]

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Response to letter regarding "ACVIM consensus statement on pancreatitis in cats".

Marnin A Forman, Joerg M Steiner, P Jane Armstrong, Melinda S Camus, Lorrie Gaschen, Steve L Hill, Caroline S Mansfield, Katja Steiger,

J Vet Intern Med (Journal of veterinary internal medicine)
[2021, :]

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Anti-CD20 Depletes Meningeal B Cells but Does Not Halt the Formation of Meningeal Ectopic Lymphoid Tissue.

Rosa Margareta Brand, Verena Friedrich, Jolien Diddens, Monika Pfaller, Francesca Romana de Franchis, Helena Radbruch, Bernhard Hemmer, Katja Steiger, Klaus Lehmann-Horn,

<h4>Objective</h4>To investigate whether anti-CD20 B-cell-depleting monoclonal antibodies (ɑCD20 mAbs) inhibit the formation or retention of meningeal ectopic lymphoid tissue (mELT) in a murine model of multiple sclerosis (MS).<h4>Methods</h4>We used a spontaneous chronic experimental autoimmune encephalomyelitis (EAE) model of mice with mutant T-cell and B-cell receptors specific for myelin oligodendrocyte glycoprotein ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2021, 8(4):]

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Response to letter regarding "ACVIM consensus statement on pancreatitis in cats".

Marnin A Forman, Joerg M Steiner, P Jane Armstrong, Melinda S Camus, Lorrie Gaschen, Steve L Hill, Caroline S Mansfield, Katja Steiger,

J Vet Intern Med (Journal of veterinary internal medicine)
[2021, :]

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Proof of Concept of a Multimodal Intravital Molecular Imaging System for Tumour Transpathology Investigation

Zhen Liu, Tao Cheng, Stephan Düwel, Ziying Jian, Geoffrey Topping, Katja Steiger, Qian Wang, Rickmer Braren, Sybille Reder, Markus Mittelhäuser, Christian Hundshammer, Benedikt Feuerecker, Sung-Cheng Huang, Markus Schwaiger, Franz Schilling, Sibylle Ziegler, Kuangyu Shi,

<h4>Background: </h4> Transpathology highlights the interpretation of underlying physiology behind molecular imaging. However, it remains challenging due to the discrepancies between in vivo and in vitro measurements and difficulties of precise co-registration between multi-scaled images. This study aims to develop a multimodal intravital molecular imaging (MIMI) system as a tool ... Read more >>

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uPA-PAI-1 heteromerization promotes breast cancer progression by attracting tumorigenic neutrophils.

Bernd Uhl, Laura A Mittmann, Julian Dominik, Roman Hennel, Bojan Smiljanov, Florian Haring, Johanna B Schaubächer, Constanze Braun, Lena Padovan, Robert Pick, Martin Canis, Christian Schulz, Matthias Mack, Ewgenija Gutjahr, Peter Sinn, Jörg Heil, Katja Steiger, Sandip M Kanse, Wilko Weichert, Markus Sperandio, Kirsten Lauber, Fritz Krombach, Christoph A Reichel,

High intratumoral levels of urokinase-type plasminogen activator (uPA)-plasminogen activator inhibitor-1 (PAI-1) heteromers predict impaired survival and treatment response in early breast cancer. The pathogenetic role of this protein complex remains obscure. Here, we demonstrate that heteromerization of uPA and PAI-1 multiplies the potential of the single proteins to attract pro-tumorigenic ... Read more >>

EMBO Mol Med (EMBO molecular medicine)
[2021, 13(6):e13110]

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TIMP-1 triggers neutrophil extracellular trap formation in pancreatic cancer.

Benjamin Schoeps, Celina Eckfeld, Olga Prokopchuk, Jan P Böttcher, Daniel Häußler, Katja Steiger, Ihsan Ekin Demir, Percy Knolle, Oliver Soehnlein, Dieter E Jenne, Chris D Hermann, Achim Krüger,

Tumor-derived protein tissue inhibitor of metalloproteinases-1 (TIMP-1) correlates with poor prognosis in many cancers, including highly lethal pancreatic ductal adenocarcinoma (PDAC). The non-canonical signaling activity of TIMP-1 is emerging as one basis for its contribution to cancer progression. However, TIMP-1-triggered progression-related biological processes are largely unknown. Formation of neutrophil extracellular ... Read more >>

Cancer Res (Cancer research)
[2021, :]

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Prediction of Tumor Cellularity in Resectable PDAC from Preoperative Computed Tomography Imaging.

Friederike Jungmann, Georgios A Kaissis, Sebastian Ziegelmayer, Felix Harder, Clara Schilling, Hsi-Yu Yen, Katja Steiger, Wilko Weichert, Rebekka Schirren, Ishan Ekin Demir, Helmut Friess, Markus R Makowski, Rickmer F Braren, Fabian K Lohöfer,

<h4>Background</h4>PDAC remains a tumor entity with poor prognosis and a 5-year survival rate below 10%. Recent research has revealed invasive biomarkers, such as distinct molecular subtypes, predictive for therapy response and patient survival. Non-invasive prediction of individual patient outcome however remains an unresolved task.<h4>Methods</h4>Discrete cellularity regions of PDAC resection specimen ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(9):]

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Bcl3 Couples Cancer Stem Cell Enrichment With Pancreatic Cancer Molecular Subtypes.

Jiaoyu Ai, Sonja M Wörmann, Kıvanç Görgülü, Mireia Vallespinos, Sladjana Zagorac, Sonia Alcala, Nan Wu, Derya Kabacaoglu, Alexandra Berninger, Diego Navarro, Ezgi Kaya-Aksoy, Dietrich A Ruess, Katrin J Ciecielski, Marlena Kowalska, Ekin I Demir, Güralp O Ceyhan, Irina Heid, Rickmer Braren, Marc Riemann, Sabrina Schreiner, Samuel Hofmann, Maria Kutschke, Martin Jastroch, Julia Slotta-Huspenina, Alexander Muckenhuber, Anna Melissa Schlitter, Roland M Schmid, Katja Steiger, Kalliope N Diakopoulos, Marina Lesina, Bruno Sainz, Hana Algül,

<h4>Background & aims</h4>The existence of different subtypes of pancreatic ductal adenocarcinoma (PDAC) and their correlation with patient outcome have shifted the emphasis on patient classification for better decision-making algorithms and personalized therapy. The contribution of mechanisms regulating the cancer stem cell (CSC) population in different subtypes remains unknown.<h4>Methods</h4>Using RNA-seq, we ... Read more >>

Gastroenterology (Gastroenterology)
[2021, :]

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PSMA Expression in Glioblastoma as a Basis for Theranostic Approaches: A Retrospective, Correlational Panel Study Including Immunohistochemistry, Clinical Parameters and PET Imaging.

Adrien Holzgreve, Annamaria Biczok, Viktoria C Ruf, Friederike Liesche-Starnecker, Katja Steiger, Maximilian A Kirchner, Marcus Unterrainer, Lena Mittlmeier, Jochen Herms, Jürgen Schlegel, Peter Bartenstein, Jörg-Christian Tonn, Nathalie L Albert, Bogdana Suchorska,

<h4>Aim</h4>The aim of the current study was to enlighten the evolution of prostate-specific membrane antigen (PSMA) expression in glioblastoma between initial diagnosis and recurrence in order to provide preliminary insight for further clinical investigations into innovative PSMA-directed treatment concepts in neuro-oncology.<h4>Methods</h4>Patients who underwent resection for de-novo glioblastoma (GBM) and had ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:646387]

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Important role of Nfkb2 in the KrasG12D-driven carcinogenesis in the pancreas.

Zonera Hassan, Christian Schneeweis, Matthias Wirth, Sebastian Müller, Claudia Geismann, Thorsten Neuß, Katja Steiger, Oliver H Krämer, Roland M Schmid, Roland Rad, Alexander Arlt, Maximilian Reichert, Dieter Saur, Günter Schneider,

<h4>Background</h4>Oncogenic Kras initiates and drives carcinogenesis in the pancreas by complex signaling networks, including activation of the NFκB pathway. Although recent evidence has shown that oncogenic gains in Nfκb2 collaborate with Kras in the carcinogenesis, no data at the level of genetics for the contribution of Nfκb2 is available so ... Read more >>

Pancreatology (Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.])
[2021, :]

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Stroma composition and proliferative activity are related to therapy response in neoadjuvant treated pancreatic ductal adenocarcinoma.

Lena Haeberle, Andrea Cacciato Insilla, Anne-Christine Kapp, Katja Steiger, Anna Melissa Schlitter, Björn Konukiewitz, Ihsan Ekin Demir, Helmut Friess, Irene Esposito,

<h4>Background</h4>Tumor regression grading (TRG) based on histopathology is the main tool to assess therapy effects after neoadjuvant therapy (NAT) of pancreatic ductal adenocarcinoma (PDAC). However, reliable markers to distinguish therapy effects from pre-existing tumor features are lacking. The aim of this study was the characterization of PDAC after NAT, focusing ... Read more >>

Histol Histopathol (Histology and histopathology)
[2021, :18332]

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PALLD mutation in a European family conveys a stromal predisposition for familial pancreatic cancer.

Lucia Liotta, Sebastian Lange, H Carlo Maurer, Kenneth P Olive, Rickmer Braren, Nicole Pfarr, Sebastian Burger, Alexander Muckenhuber, Moritz Jesinghaus, Katja Steiger, Wilko Weichert, Helmut Friess, Roland Schmid, Hana Algül, Philipp J Jost, Juliane Ramser, Christine Fischer, Anne S Quante, Maximilian Reichert, Michael Quante,

BACKGROUNDPancreatic cancer is one of the deadliest cancers, with low long-term survival rates. Despite recent advances in treatment, it is important to identify and screen high-risk individuals for cancer prevention. Familial pancreatic cancer (FPC) accounts for 4%-10% of pancreatic cancers. Several germline mutations are related to an increased risk and ... Read more >>

JCI Insight (JCI insight)
[2021, 6(8):]

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Toll-like receptor 3 expression in myeloid cells is essential for efficient regeneration after acute pancreatitis in mice.

Ana Hidalgo-Sastre, Ludwig A Kuebelsbeck, Leonie S Jochheim, Lina M Staufer, Felicitas Altmayr, Widya Johannes, Katja Steiger, Monica Ronderos, Daniel Hartmann, Norbert Hüser, Roland M Schmid, Bernhard Holzmann, Guido von Figura,

Stringent regulation of the inflammatory response is crucial for normal tissue regeneration. Here, we analyzed the role of Toll-like receptor 3 (TLR3) in pancreatic regeneration after acute pancreatitis (AP). AP was induced by caerulein treatment in mice with global TLR3 deficiency (TLR3<sup>OFF</sup> ) or in mice re-expressing TLR3 exclusively in ... Read more >>

Eur J Immunol (European journal of immunology)
[2021, 51(5):1182-1194]

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Notch signaling drives development of Barrett's metaplasia from Dclk1-positive epithelial tuft cells in the murine gastric mucosa.

Bettina Kunze, Moritz Middelhoff, H Carlo Maurer, Tatiana Agibalova, Akanksha Anand, Anne-Marie Bührer, Hsin-Yu Fang, Theresa Baumeister, Katja Steiger, Julia Strangmann, Roland M Schmid, Timothy C Wang, Michael Quante,

Barrett's esophagus (BE) is a precursor to esophageal adenocarcinoma (EAC), but its cellular origin and mechanism of neoplastic progression remain unresolved. Notch signaling, which plays a key role in regulating intestinal stem cell maintenance, has been implicated in a number of cancers. The kinase Dclk1 labels epithelial post-mitotic tuft cells ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):4509]

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ACVIM consensus statement on pancreatitis in cats.

Marnin A Forman, Joerg M Steiner, P Jane Armstrong, Melinda S Camus, Lorrie Gaschen, Steve L Hill, Caroline S Mansfield, Katja Steiger,

<h4>Background</h4>Pancreatitis in cats, although commonly diagnosed, still presents many diagnostic and management challenges.<h4>Objective</h4>To summarize the current literature as it relates to etiology, pathogenesis, diagnosis, and management of pancreatitis in cats and to arrive at clinically relevant suggestions for veterinary clinicians that are based on evidence, and where such evidence is ... Read more >>

J Vet Intern Med (Journal of veterinary internal medicine)
[2021, 35(2):703-723]

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Porcine model elucidates function of p53 isoform in carcinogenesis and reveals novel circTP53 RNA.

Guanglin Niu, Isabel Hellmuth, Tatiana Flisikowska, Hubert Pausch, Beate Rieblinger, Alexander Carrapeiro, Benjamin Schade, Brigitte Böhm, Eva Kappe, Konrad Fischer, Bernhard Klinger, Katja Steiger, Reiner Burgkart, Jean-Christophe Bourdon, Dieter Saur, Alexander Kind, Angelika Schnieke, Krzysztof Flisikowski,

Recent years have seen an increasing number of genetically engineered pig models of human diseases including cancer. We previously generated pigs with a modified TP53 allele that carries a Cre-removable transcriptional stop signal in intron 1, and an oncogenic mutation TP53<sup>R167H</sup> (orthologous to human TP53<sup>R175H</sup>) in exon 5. Pigs with ... Read more >>

Oncogene (Oncogene)
[2021, 40(10):1896-1908]

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Differential Effects of Trp53 Alterations in Murine Colorectal Cancer.

Alexander M Betzler, Lahiri K Nanduri, Barbara Hissa, Linda Blickensdörfer, Michael H Muders, Janine Roy, Moritz Jesinghaus, Katja Steiger, Wilko Weichert, Matthias Kloor, Barbara Klink, Michael Schroeder, Massimiliano Mazzone, Jürgen Weitz, Christoph Reissfelder, Nuh N Rahbari, Sebastian Schölch,

<h4>Background</h4>Colorectal cancer (CRC) development is a multi-step process resulting in the accumulation of genetic alterations. Despite its high incidence, there are currently no mouse models that accurately recapitulate this process and mimic sporadic CRC. We aimed to develop and characterize a genetically engineered mouse model (GEMM) of Apc/Kras/Trp53 mutant CRC, ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(4):]

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Synthesis and Preclinical Evaluation of 68Ga-labeled Adnectin, 68Ga-BMS-986192 as a PET Agent for Imaging PD-L1 Expression.

Stephanie Robu, Antonia Richter, Dario Gosmann, Christof Seidl, David Leung, Wendy Hayes, Daniel Cohen, Paul Morin, David J Donnelly, Daša Lipovšek, Samuel J Bonacorsi, Adam Smith, Katja Steiger, Christina Aulehner, Angela M Krackhardt, Wolfgang A Weber,

Blocking the interaction of the immune checkpoint molecules programmed cell death protein-1 (PD-1) and its ligand, PD-L1, using specific antibodies has been a major breakthrough for immune oncology. Whole-body PD-L1 expression positron emission tomography (PET) imaging may potentially allow for a better prediction of response to PD-1 targeted therapies. Imaging ... Read more >>

J Nucl Med (Journal of nuclear medicine : official publication, Society of Nuclear Medicine)
[2021, :]

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Spatial and temporal plasticity of neoantigen-specific T-cell responses bases on characteristics associated to antigen and TCR

Eva Bräunlein, Gaia Lupoli, Esam Abualrous, Niklas de Andrade Krätzig, Dario Gosmann, Franziska Füchsl, Lukas Wietbrock, Sebastian Lange, Thomas Engleitner, Huan Lan, Stefan Audehm, Manuel Effenberger, Melanie Boxberg, Katja Steiger, Yinshui Chang, Kai Yu, Cigdem Atay, Florian Bassermann, Wilko Weichert, Dirk Busch, Roland Rad, Christian Freund, Iris Antes, Angela Krackhardt,

Neoantigens derived from somatic mutations have been demonstrated to correlate with therapeutic responses mediated by treatment with immune checkpoint inhibitors. Neoantigens are therefore highly attractive targets for the development of personalized medicine approaches although their quality and associated immune responses is not yet well understood. In a case study of ... Read more >>

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Hyperpolarized 13C pyruvate magnetic resonance spectroscopy for in vivo metabolic phenotyping of rat HCC.

Elisabeth Bliemsrieder, Georgios Kaissis, Martin Grashei, Geoffrey Topping, Jennifer Altomonte, Christian Hundshammer, Fabian Lohöfer, Irina Heid, Dominik Keim, Selamawit Gebrekidan, Marija Trajkovic-Arsic, A M Winkelkotte, Katja Steiger, Roman Nawroth, Jens Siveke, Markus Schwaiger, Marcus Makowski, Franz Schilling, Rickmer Braren,

The in vivo assessment of tissue metabolism represents a novel strategy for the evaluation of oncologic disease. Hepatocellular carcinoma (HCC) is a high-prevalence, high-mortality tumor entity often discovered at a late stage. Recent evidence indicates that survival differences depend on metabolic alterations in tumor tissue, with particular focus on glucose ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):1191]

Cited: 1 time

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Mutation of the Cell Cycle Regulator p27kip1 Drives Pseudohypoxic Pheochromocytoma Development.

Hermine Mohr, Simone Ballke, Nicole Bechmann, Sebastian Gulde, Jaber Malekzadeh-Najafabadi, Mirko Peitzsch, Vasilis Ntziachristos, Katja Steiger, Tobias Wiedemann, Natalia S Pellegata,

<h4>Background</h4>Pseudohypoxic tumors activate pro-oncogenic pathways typically associated with severe hypoxia even when sufficient oxygen is present, leading to highly aggressive tumors. Prime examples are pseudohypoxic pheochromocytomas and paragangliomas (p-PPGLs), neuroendendocrine tumors currently lacking effective therapy. Previous attempts to generate mouse models for p-PPGLs all failed. Here, we describe that the ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(1):]

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The immunologic tumor microenvironment in endometrioid endometrial cancer in the morphomolecular context: mutual correlations and prognostic impact depending on molecular alterations.

Barbara Willvonseder, Fabian Stögbauer, Katja Steiger, Moritz Jesinghaus, Peer-Hendrik Kuhn, Christine Brambs, Jutta Engel, Holger Bronger, Georg Philipp Schmidt, Bernhard Haller, Wilko Weichert, Gisela Keller, Aurelia Noske, Nicole Pfarr, Melanie Boxberg,

<h4>Objective</h4>POLE-mutant, microsatellite-instable (MSI), p53-mutant and non-specific molecular profile (NSMP) are TCGA-defined molecular subgroups of endometrial cancer (EC). Hypothesizing that morphology and tumor immunology might differ depending on molecular background concerning composition and prognostic impact, we aimed to comprehensively interconnect morphologic, immunologic and molecular data.<h4>Methods</h4>TCGA-defined molecular groups were determined by immunohistochemistry ... Read more >>

Cancer Immunol Immunother (Cancer immunology, immunotherapy : CII)
[2021, 70(6):1679-1689]

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