Full Text Journal Articles by
Author Kathylynn Saboda

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Analyzing outcomes of neoadjuvant and adjuvant treatment for borderline-resectable pancreatic adenocarcinoma in the perioperative period at an academic institution.

Alejandro Recio-Boiles, Jessica Vondrak, Summana Veeravelli, James J Mancuso, Kathylynn Saboda, Denise J Roe, Irbaz Bin Riaz, Aaron J Scott, Emad Elquza, Ali McBride, Hani M Babiker,

Background:Only 15-20% of pancreatic ductal adenocarcinoma (PDAC) patients are upfront surgical candidates at presentation, and for this cohort of patients, the 5-year survival is a mere 20% despite adjuvant therapy. Previous data indicate that in clinical practice most of these cases are "borderline-resectable," and there is currently no mature data ... Read more >>

Ann Pancreat Cancer (Annals of pancreatic cancer)
[2020, 3:]

Cited: 0 times

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Notch3 promotes prostate cancer-induced bone lesion development via MMP-3.

Sourik S Ganguly, Galen Hostetter, Lin Tang, Sander B Frank, Kathylynn Saboda, Rohit Mehra, Lisha Wang, Xiaohong Li, Evan T Keller, Cindy K Miranti,

Prostate cancer metastases primarily localize in the bone where they induce a unique osteoblastic response. Elevated Notch activity is associated with high-grade disease and metastasis. To address how Notch affects prostate cancer bone lesions, we manipulated Notch expression in mouse tibia xenografts and monitored tumor growth, lesion phenotype, and the ... Read more >>

Oncogene (Oncogene)
[2020, 39(1):204-218]

Cited: 2 times

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Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios inversely correlate to clinical and pathologic stage in patients with resectable pancreatic ductal adenocarcinoma.

Alejandro Recio-Boiles, Aparna Nallagangula, Summana Veeravelli, Jessica Vondrak, Kathylynn Saboda, Denise Roe, Emad Elquza, Ali McBride, Hani M Babiker,

Background:Post-surgical pathology (SP) staging correlates with long-term survival. Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) have been shown to predict prognosis and extent of tumor in patients with metastatic pancreatic ductal adenocarcinoma (PDAC). This study aimed to correlate NLR and PLR to radiological clinical staging (CS), carbohydrate antigen (CA) 19-9 ... Read more >>

Ann Pancreat Cancer (Annals of pancreatic cancer)
[2019, 2:]

Cited: 0 times

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Evaluation of the Number-Needed-to-Biopsy Metric for the Diagnosis of Cutaneous Melanoma: A Systematic Review and Meta-analysis.

Kelly C Nelson, Susan M Swetter, Kathylynn Saboda, Suephy C Chen, Clara Curiel-Lewandrowski,

Importance:To date, no concerted effort has been made to date to evaluate the literature on number-needed-to-biopsy (NNB) metrics, particularly to account for the differences in clinician type and melanoma prevalence in certain geographic locations. Objective:To review and synthesize worldwide data for NNB for the diagnosis of cutaneous melanoma. Data Source:MEDLINE, ... Read more >>

JAMA Dermatol (JAMA dermatology)
[2019, :]

Cited: 0 times

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Feasibility of a family-focused YMCA-based diabetes prevention program in youth: The E.P.I.C. Kids (Encourage, Practice, and Inspire Change) Study.

Melanie D Hingle, Tami Turner, Scott Going, Chris Ussery, Denise J Roe, Kathylynn Saboda, Randa Kutob, Craig Stump,

Efficacious lifestyle modification programs for children at risk of type 2 diabetes (T2D) have not been well established outside of clinical settings. In this study, the feasibility of a family-focused, YMCA-based prevention program for children at risk of T2D was evaluated between September 2015 and July 2016 in Tucson, Arizona. ... Read more >>

Prev Med Rep (Preventive medicine reports)
[2019, 14:100840]

Cited: 1 time

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Selenium supplementation and insulin resistance in a randomized, clinical trial.

Elizabeth Theresa Jacobs, Peter Lance, Lawrence J Mandarino, Nathan A Ellis, H-H Sherry Chow, Janet Foote, Jessica A Martinez, Chiu-Hsieh Paul Hsu, Ken Batai, Kathylynn Saboda, Patricia A Thompson,

Objective:While controversial, observational and randomized clinical trial data implicate the micronutrient selenium (Se) in the development of type 2 diabetes (T2D). The aim of this study was to test the hypothesis that Se supplementation adversely affects pancreatic β-cell function and insulin sensitivity. Research design and methods:In a subset of 400 ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2019, 7(1):e000613]

Cited: 1 time

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Selenium and Type 2 Diabetes: Systematic Review.

Lindsay N Kohler, Janet Foote, Connor P Kelley, Ana Florea, Colleen Shelly, H-H Sherry Chow, Paul Hsu, Ken Batai, Nathan Ellis, Kathylynn Saboda, Peter Lance, Elizabeth T Jacobs,

Several studies have investigated the potential role of selenium (Se) in the development of type 2 diabetes (T2D) with disparate findings. We conducted a systematic review and meta-analysis to synthesize the evidence of any association between Se and T2D. PubMed, Embase, and Scopus were searched following the Preferred Reporting Items ... Read more >>

Nutrients (Nutrients)
[2018, 10(12):]

Cited: 1 time

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Higher Plasma Selenium Concentrations Are Associated with Increased Odds of Prevalent Type 2 Diabetes.

Lindsay N Kohler, Ana Florea, Connor P Kelley, Sherry Chow, Paul Hsu, Ken Batai, Kathylynn Saboda, Peter Lance, Elizabeth T Jacobs,

Background:Selenium, an essential trace element, has been investigated as a potential cancer prevention agent. However, several studies have indicated that selenium supplementation may be associated with an increased risk of type 2 diabetes (T2D), although an equivocal relation of this nature requires confirmation. Objective:We examined the association between baseline plasma ... Read more >>

J. Nutr. (The Journal of nutrition)
[2018, 148(8):1333-1340]

Cited: 6 times

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Notch3 Promotes Prostate Cancer-Induced Bone Lesion Development via MMP-3

Sourik Ganguly, Galen Hostetter, Lin Tang, Sander Frank, Kathylynn Saboda, Rohit Mehra, Lisha Wang, Xiaohong Li, Evan Keller, Cindy Miranti,

ABSTRACT Prostate cancer metastases primarily localize in the bone where they induce a unique osteoblastic response. Elevated Notch activity is associated with high-grade disease and metastasis. To address how Notch affects prostate cancer bone lesions, we manipulated Notch expression in mouse tibia xenografts and monitored tumor growth, lesion phenotype, and ... Read more >>

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Pharmacological TLR4 Antagonism Using Topical Resatorvid Blocks Solar UV-Induced Skin Tumorigenesis in SKH-1 Mice.

Karen Blohm-Mangone, Nichole B Burkett, Shekha Tahsin, Paul B Myrdal, Alhassan Aodah, Brenda Ho, Jaroslav Janda, Michelle McComas, Kathylynn Saboda, Denise J Roe, Zigang Dong, Ann M Bode, Emanuel F Petricoin, Valerie S Calvert, Clara Curiel-Lewandrowski, David S Alberts, Georg T Wondrak, Sally E Dickinson,

An urgent need exists for the development of more efficacious molecular strategies targeting nonmelanoma skin cancer (NMSC), the most common malignancy worldwide. Inflammatory signaling downstream of Toll-like receptor 4 (TLR4) has been implicated in several forms of tumorigenesis, yet its role in solar UV-induced skin carcinogenesis remains undefined. We have ... Read more >>

Cancer Prev Res (Phila) (Cancer prevention research (Philadelphia, Pa.))
[2018, 11(5):265-278]

Cited: 0 times

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Protein activation mapping of human sun-protected epidermis after an acute dose of erythemic solar simulated light.

Janine G Einspahr, Clara Curiel-Lewandrowski, Valerie S Calvert, Steven P Stratton, David S Alberts, James Warneke, Chengcheng Hu, Kathylynn Saboda, Elisabeth L Wagener, Sally Dickinson, Zigang Dong, Ann M Bode, Emanuel F PetricoinIII,

Ultraviolet radiation is an important etiologic factor in skin cancer and a better understanding of how solar stimulated light (SSL) affects signal transduction pathways in human skin which is needed in further understanding activated networks that could be targeted for skin cancer prevention. We utilized Reverse Phase Protein Microarray Analysis ... Read more >>

NPJ Precis Oncol (NPJ precision oncology)
[2017, 1:]

Cited: 0 times

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Multispectral fluorescence imaging of human ovarian and fallopian tube tissue for early-stage cancer detection.

Tyler H Tate, Brenda Baggett, Photini F S Rice, Jennifer Watson Koevary, Gabriel V Orsinger, Ariel C Nymeyer, Weston A Welge, Kathylynn Saboda, Denise J Roe, Kenneth D Hatch, Setsuko K Chambers, Urs Utzinger, Jennifer Kehlet Barton,

With early detection, 5-year survival rates for ovarian cancer exceed 90%, yet no effective early screening method exists. Emerging consensus suggests over 50% of the most lethal form of the disease originates in the fallopian tube. Twenty-eight women undergoing oophorectomy or debulking surgery provided informed consent for the use of ... Read more >>

J Biomed Opt (Journal of biomedical optics)
[2016, 21(5):56005]

Cited: 5 times

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Cancer Screening on the Hopi Reservation: A Model for Success in a Native American Community.

Sylvia R Brown, Lori Joshweseoma, Kathylynn Saboda, Priscilla Sanderson, Delores Ami, Robin Harris,

American Indian women have lower cancer survival rates compared to non-Hispanic White women. Increased cancer screening fostered by culturally sensitive education and community programs may help decrease this disparity. This study assesses the effectiveness of Hopi Cancer Support Services (HCSS) in maintaining high rates of breast and cervical cancer screening ... Read more >>

J Community Health (Journal of community health)
[2015, 40(6):1165-1172]

Cited: 5 times

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Inhibition of Akt Enhances the Chemopreventive Effects of Topical Rapamycin in Mouse Skin.

Sally E Dickinson, Jaroslav Janda, Jane Criswell, Karen Blohm-Mangone, Erik R Olson, Zhonglin Liu, Christy Barber, Emanuel F Petricoin, Valerie S Calvert, Janine Einspahr, Jesse E Dickinson, Steven P Stratton, Clara Curiel-Lewandrowski, Kathylynn Saboda, Chengcheng Hu, Ann M Bode, Zigang Dong, David S Alberts, G Timothy Bowden,

The PI3Kinase/Akt/mTOR pathway has important roles in cancer development for multiple tumor types, including UV-induced nonmelanoma skin cancer. Immunosuppressed populations are at increased risk of aggressive cutaneous squamous cell carcinoma (SCC). Individuals who are treated with rapamycin (sirolimus, a classical mTOR inhibitor) have significantly decreased rates of developing new cutaneous ... Read more >>

Cancer Prev Res (Phila) (Cancer prevention research (Philadelphia, Pa.))
[2016, 9(3):215-224]

Cited: 5 times

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Activation of the PI3K/Akt/mTOR and MAPK Signaling Pathways in Response to Acute Solar-Simulated Light Exposure of Human Skin.

Yira Bermudez, Steven P Stratton, Clara Curiel-Lewandrowski, James Warneke, Chengcheng Hu, George T Bowden, Sally E Dickinson, Zigang Dong, Ann M Bode, Kathylynn Saboda, Christine A Brooks, Emanuel F Petricoin, Craig A Hurst, David S Alberts, Janine G Einspahr,

The incidence of skin cancer is higher than all other cancers and continues to increase, with an average annual cost over $8 billion in the United States. As a result, identifying molecular pathway alterations that occur with UV exposure to strategize more effective preventive and therapeutic approaches is essential. To ... Read more >>

Cancer Prev Res (Phila) (Cancer prevention research (Philadelphia, Pa.))
[2015, 8(8):720-728]

Cited: 11 times

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Topical analgesia treats pain and decreases propofol use during lumbar punctures in a randomized pediatric leukemia trial.

Puja G Whitlow, Kathylynn Saboda, Denise J Roe, Susan Bazzell, Cera Wilson,

Lumbar punctures are frequently performed in pediatric leukemia for central nervous system leukemic prophylaxis. The contribution of local anesthetic with deep sedation is unknown. The objective was to evaluate EMLA (eutectic mixture of local anesthetics) cream as a pain reliever in conjunction with propofol in the setting of routine lumbar ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2015, 62(1):85-90]

Cited: 3 times

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Self-reported physical activity patterns among low-income Latina women in Arizona.

Lisa L Smith, Linda K Larkey, Denise J Roe, Julie A Bucho-Gonzalez, Kathylynn Saboda, Barbara E Ainsworth,

Adherence to recommendations for physical activity (PA) among adults in the United States is reported as poor, particularly among low-income Latinos. In particular, Latina women are at increased risk for inactivity and chronic illness, but national health survey reports aggregate data across demographic strata, limiting descriptive information that could guide ... Read more >>

Womens Health Issues (Women's health issues : official publication of the Jacobs Institute of Women's Health)
[2014, 24(3):e353-61]

Cited: 2 times

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Primary cilia are lost in preinvasive and invasive prostate cancer.

Nadia B Hassounah, Ray Nagle, Kathylynn Saboda, Denise J Roe, Bruce L Dalkin, Kimberly M McDermott,

Prostate cancer is the second most commonly diagnosed cancer in men worldwide. Little is known about the role of primary cilia in preinvasive and invasive prostate cancer. However, reduced cilia expression has been observed in human cancers including pancreatic cancer, renal cell carcinoma, breast cancer, cholangiocarcinoma, and melanoma. The aim ... Read more >>

PLoS ONE (PloS one)
[2013, 8(7):e68521]

Cited: 44 times

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A cancer screening intervention for underserved Latina women by lay educators.

Linda K Larkey, Patricia M Herman, Denise J Roe, Francisco Garcia, A M Lopez, J Gonzalez, Prasadini N Perera, Kathylynn Saboda,

OBJECTIVES: Inadequate screening adherence for breast, cervical, and colorectal cancer among Latinas places them at greater risk for poor survival rates, once diagnosed. The purpose of this study was to examine two delivery methods of lay health educators (promotoras de salud) to increase screening behavior and evaluate costs. METHODS: This ... Read more >>

J Womens Health (Larchmt) (Journal of women's health (2002))
[2012, 21(5):557-566]

Cited: 28 times

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Development of a photographic scale for consistency and guidance in dermatologic assessment of forearm sun damage.

Naja E McKenzie, Kathylynn Saboda, Laura D Duckett, Rayna Goldman, Chengcheng Hu, Clara N Curiel-Lewandrowski,

To develop a photographic sun damage assessment scale for forearm skin and test its feasibility and utility for consistent classification of sun damage.For a blinded comparison, 96 standardized 8 × 10 digital photographs of participants' forearms were taken. Photographs were graded by an expert dermatologist using an existing 9-category dermatologic ... Read more >>

Arch Dermatol (Archives of dermatology)
[2011, 147(1):31-36]

Cited: 12 times

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p38 MAP kinase plays a functional role in UVB-induced mouse skin carcinogenesis.

Sally E Dickinson, Erik R Olson, Jack Zhang, Simon J Cooper, Tania Melton, P Jane Criswell, Ana Casanova, Zigang Dong, Chengcheng Hu, Kathylynn Saboda, Elizabeth T Jacobs, David S Alberts, G Tim Bowden,

UVB irradiation of epidermal keratinocytes results in the activation of the p38 mitogen-activated protein kinase (MAPK) pathway and subsequently activator protein-1 (AP-1) transcription factor activation and cyclooxygenase-2 (COX-2) expression. AP-1 and COX-2 have been shown to play functional roles in UVB-induced mouse skin carcinogenesis. In this study, the experimental approach ... Read more >>

Mol. Carcinog. (Molecular carcinogenesis)
[2011, 50(6):469-478]

Cited: 30 times

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A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer.

Steven P Stratton, David S Alberts, Janine G Einspahr, Paul M Sagerman, James A Warneke, Clara Curiel-Lewandrowski, Paul B Myrdal, Kelly L Karlage, Brian J Nickoloff, Chris Brooks, Kathylynn Saboda, Michael L Yozwiak, Mary F Krutzsch, Chengcheng Hu, Maria Lluria-Prevatt, Zigang Dong, G Timothy Bowden, Peter H Bartels,

The chemopreventive and antitumor properties of perillyl alcohol (POH) that were studied preclinically indicate that topical POH inhibits both UVB-induced murine skin carcinogenesis (squamous cell tumor models) and 7,12-dimethylbenz(a)anthracene-induced murine melanoma (transgenic models involving tyrosinase-driven Ras). A previous phase 1 clinical trial in participants with normal-appearing skin showed that topical ... Read more >>

Cancer Prev Res (Phila) (Cancer prevention research (Philadelphia, Pa.))
[2010, 3(2):160-169]

Cited: 14 times

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Chemopreventive efficacy of topical difluoromethylornithine and/or triamcinolone in the treatment of actinic keratoses analyzed by karyometry.

Peter Bartels, Michael Yozwiak, Janine Einspahr, Kathylynn Saboda, Yun Liu, Christine Brooks, Hubert Bartels, David S Alberts,

To determine whether low-dose topical applications of difluoromethylornithine (DFMO) with or without Triamcinolone (Fougena, Melville, New York, U.S.A.) to moderately sun-damaged skin with actinic skin keratoses are efficacious.There were 4 topically administered, 6-month treatments, DFMO + Eucerin (Beiersdorf Inc., Hamburg, Germany), DFMO + Triamcinolone, Triamcinolone + Eucerin and Eucerin + ... Read more >>

Anal. Quant. Cytol. Histol. (Analytical and quantitative cytology and histology)
[2009, 31(6):355-366]

Cited: 3 times

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Inhibition of activator protein-1 by sulforaphane involves interaction with cysteine in the cFos DNA-binding domain: implications for chemoprevention of UVB-induced skin cancer.

Sally E Dickinson, Tania F Melton, Erik R Olson, Jian Zhang, Kathylynn Saboda, G Timothy Bowden,

Sulforaphane is an isothiocyanate derived from cruciferous vegetables that has been linked to decreased risk of certain cancers. Although the role of sulforaphane in the induction of the transcription factor Nrf2 has been studied extensively, there is also evidence that inhibition of the transcription factor activator protein-1 (AP-1) may contribute ... Read more >>

Cancer Res. (Cancer research)
[2009, 69(17):7103-7110]

Cited: 31 times

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Chemoprevention of human actinic keratoses by topical DL-alpha-tocopherol.

Janet A Foote, James R Ranger-Moore, Janine G Einspahr, Kathylynn Saboda, Jaime Kenyon, James Warneke, Richard C Miller, Rayna Goldman, Min-Jian Xu, Denise J Roe, David S Alberts,

Prior research shows that topical application of free, nonfatty acid-conjugated vitamin E (DL-alpha-tocopherol) prevents skin cancer in mice, as well as immunosuppression induced by UVB radiation. This study investigated the chemopreventive potential of DL-alpha-tocopherol in humans through monitoring surrogate end point biomarkers in sun-damaged skin. Contralateral arms of healthy human ... Read more >>

Cancer Prev Res (Phila) (Cancer prevention research (Philadelphia, Pa.))
[2009, 2(4):394-400]

Cited: 8 times

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