Full Text Journal Articles by
Author Kathryn A Clausen


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Hepcidin regulation in prostate and its disruption in prostate cancer.

Lia Tesfay, Kathryn A Clausen, Jin Woo Kim, Poornima Hegde, Xiaohong Wang, Lance D Miller, Zhiyong Deng, Nicole Blanchette, Tara Arvedson, Cindy K Miranti, Jodie L Babitt, Herbert Y Lin, Donna M Peehl, Frank M Torti, Suzy V Torti,

Hepcidin is a circulating peptide hormone made by the liver that is a central regulator of systemic iron uptake and recycling. Here, we report that prostate epithelial cells also synthesize hepcidin, and that synthesis and secretion of hepcidin are markedly increased in prostate cancer cells and tissue. Prostatic hepcidin functions ... Read more >>

Cancer Res. (Cancer research)
[2015, 75(11):2254-2263]

Cited: 51 times

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SOSTDC1 differentially modulates Smad and beta-catenin activation and is down-regulated in breast cancer.

Kathryn A Clausen, Kimberly R Blish, Charles E Birse, Matthew A Triplette, Timothy E Kute, Gregory B Russell, Ralph B D'Agostino, Lance D Miller, Frank M Torti, Suzy V Torti,

Sclerostin domain containing 1 (SOSTDC1) protein regulates processes from development to cancer by modulating activity of bone morphogenetic protein (BMP) and wingless/int (Wnt) signaling pathways. As dysregulation of both BMP and Wnt signaling has been observed in breast cancer, we investigated whether disruption of SOSTDC1 signaling occurs in breast cancer. ... Read more >>

Breast Cancer Res. Treat. (Breast cancer research and treatment)
[2011, 129(3):737-746]

Cited: 22 times

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Loss of heterozygosity and SOSTDC1 in adult and pediatric renal tumors.

Kimberly R Blish, Kathryn A Clausen, Gregory A Hawkins, A Julian Garvin, Mark C Willingham, Julie C Turner, Frank M Torti, Suzy V Torti,

Deletions within the short arm of chromosome 7 are observed in approximately 25% of adult and 10% of Wilms pediatric renal tumors. Within Wilms tumors, the region of interest has been delineated to a 2-Mb minimal region that includes ten known genes. Two of these ten candidate genes, SOSTDC1 and ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2010, 29:147]

Cited: 11 times

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Cbl controls EGFR fate by regulating early endosome fusion.

Gina D Visser Smit, Trenton L Place, Sara L Cole, Kathryn A Clausen, Soumya Vemuganti, Guojuan Zhang, John G Koland, Nancy L Lill,

Amino acid residues 1 to 434 of the E3 ubiquitin ligase Cbl control signaling of the epidermal growth factor receptor (EGFR) by enhancing its ubiquitination, down-regulation, and lysosomal degradation. This region of Cbl comprises a tyrosine kinase-binding domain, a linker region, a really interesting new gene finger (RF), and a ... Read more >>

Sci Signal (Science signaling)
[2009, 2(102):ra86]

Cited: 21 times

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