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Author Kathrin Halfter

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Morphology Matters: A Critical Reappraisal of the Clinical Relevance of Morphologic Criteria From the 2019 WHO Classification in a Large Colorectal Cancer Cohort Comprising 1004 Cases.

Moritz Jesinghaus, Maxime Schmitt, Corinna Lang, Marianne Reiser, Alexander Scheiter, Björn Konukiewitz, Katja Steiger, Miguel Silva, Markus Tschurtschenthaler, Sebastian Lange, Sebastian Foersch, Karl F Becker, Dieter Saur, Helmut Friess, Kathrin Halfter, Jutta Engel, Melanie Boxberg, Nicole Pfarr, Dirk Wilhelm, Wilko Weichert,

The 2019 World Health Organization (WHO) classification of colorectal carcinoma (CRC) profoundly reclassified CRC subtypes and introduces tumor budding as a second major grading criterion, while condensing conventional grade into a 2-tiered system. So far it remains largely unexplored how these parameters interact with each other and whether they truly ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2021, 45(7):969-978]

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Evaluating the interreader agreement and intrareader reproducibility of Visual Field Defects in Thyroid Eye Disease- Compressive Optic Neuropathy.

Aylin Garip Kuebler, Kathrin Halfter, Lukas Reznicek, Annemarie Klingenstein, Siegfried Priglinger, Christoph Hintschich,

<h4>Purpose</h4>To categorize visual field (VF) defects according to Freitag and Tanking's (FT) classification in Thyroid Eye Disease-Compressive Optic Neuropathy (TED-CON) and evaluate the interreader agreement and intrareader reproducibility of the classification.<h4>Subjects and methods</h4>In this retrospective, observational study we included medical reports of 96 eyes (51 patients), who underwent VF testing ... Read more >>

Eye (Lond) (Eye (London, England))
[2021, :]

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Colonoscopy and polypectomy: beside age, size of polyps main factor for long-term risk of colorectal cancer in a screening population.

Kathrin Halfter, Lea Bauerfeind, Anne Schlesinger-Raab, Michael Schmidt, Gabriele Schubert-Fritschle, Dieter Hölzel, Jutta Engel,

<h4>Purpose</h4>Despite national and international guideline recommendations, few studies have been conducted to estimate the impact of colonoscopy screening on long-term colorectal cancer incidence. Aim of this study was to determine the long-term impact of a full colonoscopy with polypectomy on colorectal cancer incidence in a large screening population.<h4>Methods</h4>In this prospective ... Read more >>

J Cancer Res Clin Oncol (Journal of cancer research and clinical oncology)
[2021, :]

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Development and validation of prognostic model for predicting mortality of COVID-19 patients in Wuhan, China.

Qi Mei, Amanda Y Wang, Amy Bryant, Yang Yang, Ming Li, Fei Wang, Jia Wei Zhao, Ke Ma, Liang Wu, Huawen Chen, Jinlong Luo, Shangming Du, Kathrin Halfter, Yong Li, Christian Kurts, Guangyuan Hu, Xianglin Yuan, Jian Li,

Novel coronavirus 2019 (COVID-19) infection is a global public health issue, that has now affected more than 200 countries worldwide and caused a second wave of pandemic. Severe adult respiratory syndrome-CoV-2 (SARS-CoV-2) pneumonia is associated with a high risk of mortality. However, prognostic factors predicting poor clinical outcomes of individual ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):22451]

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Oral insulin immunotherapy in children at risk for type 1 diabetes in a randomised controlled trial.

Robin Assfalg, Jan Knoop, Kristi L Hoffman, Markus Pfirrmann, Jose Maria Zapardiel-Gonzalo, Anna Hofelich, Anne Eugster, Marc Weigelt, Claudia Matzke, Julia Reinhardt, Yannick Fuchs, Melanie Bunk, Andreas Weiss, Markus Hippich, Kathrin Halfter, Stefanie M Hauck, Jörg Hasford, Joseph F Petrosino, Peter Achenbach, Ezio Bonifacio, Anette-Gabriele Ziegler,

<h4>Aims/hypothesis</h4>Oral administration of antigen can induce immunological tolerance. Insulin is a key autoantigen in childhood type 1 diabetes. Here, oral insulin was given as antigen-specific immunotherapy before the onset of autoimmunity in children from age 6 months to assess its safety and immune response actions on immunity and the gut microbiome.<h4>Methods</h4>A ... Read more >>

Diabetologia (Diabetologia)
[2021, 64(5):1079-1092]

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Breast cancer: Emerging principles of metastasis, adjuvant and neoadjuvant treatment from cancer registry data

Jutta Engel, Renate Eckel, Simone Schrodi, Kathrin Halfter, Gabriele Schubert-Fritschle, Dieter Hölzel,

<h4>Background</h4> A growing primary breast cancer (PT) can initiate local (LR), regional (pLN), and distant metastases (MET). Characteristics of these progressions such as initiation, frequency and duration of PT and MET growth describe principles of the MET process. They are bottlenecks through which molecular hypotheses and scientific terms for prediction ... Read more >>

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The human Descemet's membrane and lens capsule: Protein composition and biomechanical properties.

Willi Halfter, Suzette Moes, Kathrin Halfter, Monica S Schoenenberger, Christophe A Monnier, Joanna Kalita, Daphne Asgeirsson, Tatjana Binggeli, Paul Jenoe, Hendrik P N Scholl, Paul Bernhard Henrich,

The Descemet's membrane (DM) and the lens capsule (LC) are two ocular basement membranes (BMs) that are essential in maintaining stability and structure of the cornea and lens. In this study, we investigated the proteomes and biomechanical properties of these two materials to uncover common and unique properties. We also ... Read more >>

Exp Eye Res (Experimental eye research)
[2020, 201:108326]

Cited: 1 time

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Subclinical dysthyroid optic neuropathy: tritan deficiency as an early sign of dysthyroid optic neuropathy.

Aylin Garip-Kuebler, Kathrin Halfter, Lukas Reznicek, Annemarie Klingenstein, Siegfried Priglinger, Christoph R Hintschich,

<h4>Purpose</h4>The aim of this research was to investigate the subclinical findings of dysthyroid optic neuropathy (DON) and to look for early indicators for optic nerve compression in patients with Graves' orbitopathy.<h4>Patients and methods</h4>In this observational, retrospective study, the medical charts of 24 patients (32 eyes) with a diagnosis of DON ... Read more >>

Br J Ophthalmol (The British journal of ophthalmology)
[2020, :]

Cited: 1 time

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Correction: Evaluation of medical and surgical decompression in patients with dysthyroid optic neuropathy.

Aylin Garip Kuebler, Caroline Wiecha, Lukas Reznicek, Annemarie Klingenstein, Kathrin Halfter, Siegfried Priglinger, Christoph Hintschich,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Eye (Lond) (Eye (London, England))
[2020, 34(9):1716]

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Oral insulin immunotherapy in children at risk for type 1 diabetes in a randomized trial

Robin Assfalg, Jan Knoop, Kristi Hoffman, Markus Pfirrmann, Jose Maria Zapardiel-Gonzalo, Anna Hofelich, Anne Eugster, Marc Weigelt, Claudia Matzke, Julia Reinhardt, Yannick Fuchs, Melanie Bunk, Andreas Weiss, Markus Hippich, Kathrin Halfter, Stefanie Hauck, Jörg Hasford, Joseph Petrosino, Peter Achenbach, Ezio Bonifacio, Anette-Gabriele Ziegler,

<h4>Background</h4> Oral administration of antigen can induce immunological tolerance. Insulin is a key autoantigen in childhood type 1 diabetes with insulin autoimmunity often appearing in the first years of life. Here, oral insulin was given as antigen-specific immunotherapy before the onset of autoimmunity in children from age 6 months to ... Read more >>

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Prognostic Model for Mortality of Hospitalized Patients with COVID-19 Pneumonia in Wuhan, China: A Multi-center retrospective cohort study

Qi Mei, Amanda Wang, Yang Yang, Ming Li, Fei Wang, Zia Wei Zhao, Ke Ma, Liang Wu, Huawen Chen, Jinlong Luo, Shangming Du, Kathrin Halfter, Yong Li, Guangyuan Hu, Xianglin Yuan, Jian Li,

<h4>Background: </h4> Novel coronavirus (COVID-19) infection is a global public health issue and has now affected more than 70 countries worldwide. Severe adult respiratory syndrome-CoV-2 (SARS-CoV-2) pneumonia is associated with high risk of mortality. However, prognostic factors assessing poor clinical outcomes of individual patients with SARS-CoV-2 pneumonia remain unclear. <h4>Methods: ... Read more >>

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Evaluation of medical and surgical decompression in patients with dysthyroid optic neuropathy.

Aylin Garip Kuebler, Caroline Wiecha, Lukas Reznicek, Annemarie Klingenstein, Kathrin Halfter, Siegfried Priglinger, Christoph Hintschich,

<h4>Purpose</h4>To evaluate the effectiveness of steroid-pulse therapy and three-wall orbital decompression in patients with dysthyroid optic neuropathy (DON).<h4>Methods</h4>Twenty-five patients (46 eyes) with a diagnosis of DON between 2008 and 2015 were included in the study. The first group (7 patients, 16 eyes) consisted of patients with a steroid-pulse treatment only ... Read more >>

Eye (Lond) (Eye (London, England))
[2020, 34(9):1702-1709]

Cited: 2 times

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Genome-scale Pathway Flux Analysis Predicts Efficacy of anti-PD-1 Therapy in Melanoma

Qi Mei, Shangming Du, Kathrin Halfter, Xiaoyu Li, Guokun Zhang, Yingxia Li, Christian Saad, He Huang, Shankang Qi, Weiting Cheng, Guangyuan Hu, Ulrich Mansmann, Jian Li,

<h4>Background: </h4> Currently, predicting treatment efficacy to immunotherapy has been under extensive investigation. However, a putative biomarker for immunotherapy in melanoma remains to be found. <h4>Methods:</h4> Utilizing genetic data from two independent melanoma patient cohorts treated with anti-PD-1 therapy, the study described herein conducted a genome-scale pathway flux analysis (GPFA) ... Read more >>

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A systematic review of brief screeners for suicidal behaviour in primary care

Karoline Lukaschek, Milena Frank, Kathrin Halfter, Antonius Schneider, Jochen Gensichen,

The authors have requested that this preprint be removed from Research Square. ... Read more >>

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Comparison of different devices to measure the intraocular pressure in thyroid-associated orbitopathy.

Aylin Garip Kuebler, Caroline Wiecha, Lukas Reznicek, Annemarie Klingenstein, Kathrin Halfter, Siegfried Priglinger, Christoph Hintschich,

<h4>Purpose</h4>To evaluate the correlation of the intraocular pressure measurements (IOP) with non-contact tonometer Corvis Scheimpflug technology (Corvis ST), Goldmann applanation tonometry (GAT), ocular response analyzer (ORA), and iCARE rebound tonometer in patients with thyroid-associated orbitopathy (TAO) and eye-healthy subjects (control group).<h4>Methods</h4>Twenty-nine consecutive patients with TAO (79% female) and 30 eye-healthy ... Read more >>

Graefes Arch Clin Exp Ophthalmol (Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie)
[2019, 257(9):2025-2032]

Cited: 1 time

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Pain management in opioid maintenance treatment.

Gabi Koller, Andreas Schwarzer, Kathrin Halfter, Michael Soyka,

<b>Introduction</b>: Opioid addiction is a worldwide disease with a significant impact. A multitude of physical and mental comorbidities are associated with opioid addiction, pain being one of the most relevant. Insufficient pain management may lead to a disruption in medical treatment, self-medication, and subsequent harm to patients. <b>Areas covered</b>: In ... Read more >>

Expert Opin Pharmacother (Expert opinion on pharmacotherapy)
[2019, 20(16):1993-2005]

Cited: 1 time

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Computational analysis of receptor tyrosine kinase inhibitors and cancer metabolism: implications for treatment and discovery of potential therapeutic signatures.

Jian Li, Kathrin Halfter, Mengying Zhang, Christian Saad, Kai Xu, Bernhard Bauer, Yijiang Huang, Lei Shi, Ulrich R Mansmann,

<h4>Background</h4>Receptor tyrosine kinase (RTK) inhibitors are frequently used to treat cancers and the results have been mixed, some of these small molecule drugs are highly successful while others show a more modest response. A high number of studies have been conducted to investigate the signaling mechanisms and corresponding therapeutic influence ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):600]

Cited: 1 time

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Correction: Diabetes-related changes in the protein composition and the biomechanical properties of human retinal vascular basement membranes.

Willi Halfter, Suzette Moes, Daphne O Asgeirsson, Kathrin Halfter, Philipp Oertle, Esther Melo Herraiz, Marija Plodinec, Paul Jenoe, Paul Bernhard Henrich,

[This corrects the article DOI: 10.1371/journal.pone.0189857.]. ... Read more >>

PLoS One (PloS one)
[2018, 13(4):e0195772]

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Computational modeling of methionine cycle-based metabolism and DNA methylation and the implications for anti-cancer drug response prediction.

Mengying Zhang, Christian Saad, Lien Le, Kathrin Halfter, Bernhard Bauer, Ulrich R Mansmann, Jian Li,

The relationship between metabolism and methylation is considered to be an important aspect of cancer development and drug efficacy. However, it remains poorly defined how to apply this aspect to improve preclinical disease characterization and clinical treatment outcome. Using available molecular information from Kyoto Encyclopedia of Genes and Genomes (KEGG) ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(32):22546-22558]

Cited: 3 times

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PTPRG and PTPRC modulate nilotinib response in chronic myeloid leukemia cells.

Julia Drube, Thomas Ernst, Markus Pfirrmann, Benadict Vincent Albert, Sebastian Drube, Daniela Reich, Anne Kresinsky, Kathrin Halfter, Claudio Sorio, Christian Fabisch, Andreas Hochhaus, Frank-D Böhmer,

The introduction of second-generation tyrosine kinase inhibitors (TKIs) targeting the protein-tyrosine kinase (PTK) BCR-ABL1 has improved treatment response in chronic myeloid leukemia (CML). However, in some patients response still remains suboptimal. Protein-tyrosine phosphatases (PTPs) are natural counter-actors of PTK activity and can affect TKI sensitivity, but the impact of PTPs ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(10):9442-9455]

Cited: 2 times

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Bringing 3D tumor models to the clinic - predictive value for personalized medicine.

Kathrin Halfter, Barbara Mayer,

Current decision-guiding algorithms in cancer drug treatment are based on decades of research and numerous clinical trials. For the majority of patients, this data is successfully applied for a systemic disease management. For a number of patients however, treatment stratification according to clinically based risk criteria will not be sufficient. ... Read more >>

Biotechnol J (Biotechnology journal)
[2017, 12(2):]

Cited: 15 times

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Testing chemotherapy efficacy in HER2 negative breast cancer using patient-derived spheroids.

Kathrin Halfter, Oliver Hoffmann, Nina Ditsch, Mareike Ahne, Frank Arnold, Stefan Paepke, Dieter Grab, Ingo Bauerfeind, Barbara Mayer,

<h4>Background</h4>Targeted anti-HER2 therapy has greatly improved the prognosis for many breast cancer patients. However, treatment for HER2 negative disease is currently still selected from a multitude of untargeted chemotherapeutic treatment options. A predictive test was developed using patient-derived spheroids to identify the most effective therapy for patients with HER2 negative ... Read more >>

J Transl Med (Journal of translational medicine)
[2016, 14(1):112]

Cited: 12 times

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Prospective cohort study using the breast cancer spheroid model as a predictor for response to neoadjuvant therapy--the SpheroNEO study.

Kathrin Halfter, Nina Ditsch, Hans-Christian Kolberg, Holger Fischer, Tanja Hauzenberger, Franz Edler von Koch, Ingo Bauerfeind, Gunter von Minckwitz, Ilona Funke, Alexander Crispin, Barbara Mayer, ,

<h4>Background</h4>Aim of this prospective study was to predict response to neoadjuvant therapy in breast cancer patients using an in vitro breast cancer spheroid model.<h4>Methods</h4>Three-dimensional spheroids were directly generated from fresh breast tumor biopsies of 78 patients eligible for neoadjuvant therapy. Cell survival was measured after in vitro exposure to the ... Read more >>

BMC Cancer (BMC cancer)
[2015, 15:519]

Cited: 8 times

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