Full Text Journal Articles by
Author Kathleen M McKenzie


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Complete reaction cycle of a cocaine catalytic antibody at atomic resolution.

Xueyong Zhu, Tobin J Dickerson, Claude J Rogers, Gunnar F Kaufmann, Jenny M Mee, Kathleen M McKenzie, Kim D Janda, Ian A Wilson,

Antibody 7A1 hydrolyzes cocaine to produce nonpsychoactive metabolites ecgonine methyl ester and benzoic acid. Crystal structures of 7A1 Fab' and six complexes with substrate cocaine, the transition state analog, products ecgonine methyl ester and benzoic acid together and individually, as well as heptaethylene glycol have been analyzed at 1.5-2.3 angstroms ... Read more >>

Structure (Structure (London, England : 1993))
[2006, 14(2):205-216]

Cited: 16 times

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Quorum sensing in Vibrio harveyi: probing the specificity of the LuxP binding site.

Colin A Lowery, Kathleen M McKenzie, Longwu Qi, Michael M Meijler, Kim D Janda,

Quorum sensing activity was investigated in the bacterium Vibrio harveyi using a series of both natural and nonnatural analogs of DPD, the penultimate precursor to autoinducer AI-2. The progression of molecules that were both synthesized and investigated includes enantiomeric variants, carbon-chain extension, and hydroxyl-functional group addition/deletions of DPD. The compilation ... Read more >>

Bioorg. Med. Chem. Lett. (Bioorganic & Medicinal Chemistry Letters)
[2005, 15(9):2395-2398]

Cited: 25 times

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A furanosyl-carbonate autoinducer in cell-to-cell communication of V. harveyi.

Kathleen M McKenzie, Michael M Meijler, Colin A Lowery, Grant E Boldt, Kim D Janda,

An autoinducer arising from reaction of cyclized S-DPD and carbonate is shown to induce light in V. harveyi and thus may play a previously unknown role in quorum sensing. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2005, (38):4863-4865]

Cited: 7 times

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Simultaneous identification of multiple protein targets by using complementary-DNA phage display and a natural-product-mimetic probe.

Kathleen M McKenzie, Elizabeth J Videlock, Ute Splittgerber, David J Austin,

Angew. Chem. Int. Ed. Engl. (Angewandte Chemie (International ed. in English))
[2004, 43(31):4052-4055]

Cited: 9 times

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Synthesis and biological validation of a ubiquitous quorum-sensing molecule.

Michael M Meijler, Louis G Hom, Gunnar F Kaufmann, Kathleen M McKenzie, Chengzao Sun, Jason A Moss, Masayuki Matsushita, Kim D Janda,

Angew. Chem. Int. Ed. Engl. (Angewandte Chemie (International ed. in English))
[2004, 43(16):2106-2108]

Cited: 36 times

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