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COVID-19-Related Submission Priorities From the Journal of the Pediatric Infectious Diseases Society.

Michael Green, Felice C Adler-Shohet, Christopher C Blyth, Kathleen Chiotos, Jeffrey S Gerber, Ravi Jhaveri, Larry Kociolek, Rachel Martin-Blais, Debra Palazzi, Andi L Shane, Jennifer E Schuster, Stanford T Shulman, Gregory A Storch, Geoffrey A Weinberg, Theoklis Zaoutis,

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2021, :]

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Neonatal multidrug-resistant gram-negative infection: epidemiology, mechanisms of resistance, and management.

Dustin D Flannery, Kathleen Chiotos, Jeffrey S Gerber, Karen M Puopolo,

Infants admitted to the neonatal intensive care unit, particularly those born preterm, are at high risk for infection due to the combination of an immature immune system, prolonged hospitalization, and frequent use of invasive devices. Emerging evidence suggests that multidrug-resistant gram-negative (MDR-GN) infections are increasing in neonatal settings, which directly ... Read more >>

Pediatr Res (Pediatric research)
[2021, :]

Cited: 0 times

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Coronavirus disease 2019 in children.

Emily R Levy, Jennifer Blumenthal, Kathleen Chiotos,

<h4>Purpose of review</h4>Over the course of the coronavirus disease 2019 (COVID-19) pandemic, it has become clear that the clinical features, epidemiology, and outcomes of COVID-19 are distinct in children relative to adults. In this review, we will present recent pediatric studies informing our current understanding of COVID-19 in children, and ... Read more >>

Curr Opin Infect Dis (Current opinion in infectious diseases)
[2021, 34(5):500-509]

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A Stitch in Time: Optimizing Antibiotic Use From the Start.

Kathleen Chiotos, Scott L Weiss, Jeffrey S Gerber,

Crit Care Med (Critical care medicine)
[2021, 49(11):1993-1996]

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Criteria for Pediatric Sepsis-A Systematic Review and Meta-Analysis by the Pediatric Sepsis Definition Taskforce.

Kusum Menon, Luregn J Schlapbach, Samuel Akech, Andrew Argent, Paolo Biban, Enitan D Carrol, Kathleen Chiotos, Mohammod Jobayer Chisti, Idris V R Evans, David P Inwald, Paul Ishimine, Niranjan Kissoon, Rakesh Lodha, Simon Nadel, Cláudio Flauzino Oliveira, Mark Peters, Benham Sadeghirad, Halden F Scott, Daniela C de Souza, Pierre Tissieres, R Scott Watson, Matthew O Wiens, James L Wynn, Jerry J Zimmerman, Lauren R Sorce, ,

<h4>Objective</h4>To determine the associations of demographic, clinical, laboratory, organ dysfunction, and illness severity variable values with: 1) sepsis, severe sepsis, or septic shock in children with infection and 2) multiple organ dysfunction or death in children with sepsis, severe sepsis, or septic shock.<h4>Data sources</h4>MEDLINE, Embase, and the Cochrane Central Register ... Read more >>

Crit Care Med (Critical care medicine)
[2021, :]

Cited: 0 times

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Administration of a β-lactam Prior to Vancomycin as the First Dose of Antibiotic Therapy Improves Survival in Patients with Bloodstream Infections.

Joe Amoah, Eili Y Klein, Kathleen Chiotos, Sara E Cosgrove, Pranita D Tamma, ,

<h4>Objective</h4>Prompt initiation of antibiotic therapy improves the survival of patients with bloodstream infections (BSI). We sought to determine if the sequence of administration of the first dose of antibiotic therapy (i.e., β-lactam or vancomycin, if both cannot be administered simultaneously) impacts early mortality for patients with BSI.<h4>Methods</h4>We conducted a multicenter, ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, :]

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Characterization and Outcomes of Hospitalized Children With Coronavirus Disease 2019: A Report From a Multicenter, Viral Infection and Respiratory Illness Universal Study (Coronavirus Disease 2019) Registry.

Utpal S Bhalala, Katja M Gist, Sandeep Tripathi, Karen Boman, Vishakha K Kumar, Lynn Retford, Kathleen Chiotos, Allison M Blatz, Heda Dapul, Sourabh Verma, Imran A Sayed, Varsha P Gharpure, Erica Bjornstad, Nancy Tofil, Katherine Irby, Ronald C Sanders, Julia A Heneghan, Melissa Thomas, Manoj K Gupta, Franscene E Oulds, Grace M Arteaga, Emily R Levy, Neha Gupta, Margit Kaufman, Amr Abdelaty, Mark Shlomovich, Shivanand S Medar, A M Iqbal O'Meara, Joshua Kuehne, Shina Menon, Paras B Khandhar, Aaron S Miller, Suzanne M Barry, Valerie C Danesh, Ashish K Khanna, Kimberly Zammit, Casey Stulce, Patrick W McGonagill, Asher Bercow, Ioana G Amzuta, Sandeep Gupta, Mohammed A Almazyad, Louisdon Pierre, Prithvi Sendi, Sidra Ishaque, Harry L Anderson, Pooja Nawathe, Murtaza Akhter, Patrick G Lyons, Catherine Chen, Allan J Walkey, Azra Bihorac, Imam Wada Bello, Judith Ben Ari, Tanja Kovacevic, Vikas Bansal, John T Brinton, Jerry J Zimmerman, Rahul Kashyap, ,

<h4>Objectives</h4>Multicenter data on the characteristics and outcomes of children hospitalized with coronavirus disease 2019 are limited. Our objective was to describe the characteristics, ICU admissions, and outcomes among children hospitalized with coronavirus disease 2019 using Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study: Coronavirus Disease ... Read more >>

Crit Care Med (Critical care medicine)
[2021, :]

Cited: 0 times

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Weighing the Risks of Perimyocarditis With the Benefits of SARS-CoV-2 mRNA Vaccination in Adolescents.

Ravi Jhaveri, Felice C Adler-Shohet, Christopher C Blyth, Kathleen Chiotos, Jeffrey S Gerber, Michael Green, Larry Kociolek, Rachel Martin-Blais, Debra Palazzi, Andi L Shane, Jennifer E Schuster, Stanford T Shulman, Gregory A Storch, Geoffrey A Weinberg, Theoklis Zaoutis,

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2021, :]

Cited: 0 times

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Case Report: Immune Dysregulation Due to Toxoplasma gondii Reactivation After Allogeneic Hematopoietic Cell Transplant.

Robert B Lindell, Michael S Wolf, Alicia M Alcamo, Michael A Silverman, Daniel E Dulek, William R Otto, Timothy S Olson, Carrie L Kitko, Paisit Paueksakon, Kathleen Chiotos,

Disseminated toxoplasmosis is an uncommon but highly lethal cause of hyperferritinemic sepsis after hematopoietic cell transplantation (HCT). We report two cases of disseminated toxoplasmosis from two centers in critically ill adolescents after HCT: a 19-year-old who developed fever and altered mental status on day +19 after HCT and a 20-year-old ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:719679]

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The Impact of Obesity on Disease Severity and Outcomes Among Hospitalized Children With COVID-19.

Sandeep Tripathi, Amy L Christison, Emily Levy, Jeremy McGravery, Aysun Tekin, Dawn Bolliger, Vishakha K Kumar, Vikas Bansal, Kathleen Chiotos, Katja M Gist, Heda R Dapul, Utpal S Bhalala, Varsha P Gharpure, Julia A Heneghan, Neha Gupta, Erica C Bjornstad, Vicki L Montgomery, Allan Walkey, Rahul Kashyap, Grace M Arteaga, ,

<h4>Objective</h4>To describe the impact of obesity on disease severity and outcomes of coronavirus disease 2019 (COVID-19) among hospitalized children.<h4>Methods</h4>This retrospective cohort study from the Society of Critical Care Medicine Viral Respiratory Illness Universal Study registry included all children hospitalized with COVID-19 from March 2020 to January 2021. Obesity was defined ... Read more >>

Hosp Pediatr (Hospital pediatrics)
[2021, :]

Cited: 0 times

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Coronavirus Disease 2019-Associated PICU Admissions: A Report From the Society of Critical Care Medicine Discovery Network Viral Infection and Respiratory Illness Universal Study Registry.

Sandeep Tripathi, Katja M Gist, Erica C Bjornstad, Rahul Kashyap, Karen Boman, Kathleen Chiotos, Varsha P Gharpure, Heda Dapul, Imran A Sayed, Joshua Kuehne, Julia A Heneghan, Manoj Gupta, Paras B Khandhar, Shina Menon, Neha Gupta, Vishakha K Kumar, Lynn Retford, Jerry Zimmerman, Utpal S Bhalala, ,

<h4>Objectives</h4>To compare clinical characteristics and outcomes of children admitted to the PICU for severe acute respiratory syndrome coronavirus 2-related illness with or without multisystem inflammatory syndrome in children. The secondary objective was to identify explanatory factors associated with outcome of critical illness defined by a composite index of in-hospital mortality ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(7):603-615]

Cited: 4 times

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The utility of paired upper and lower respiratory tract sampling for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing in patients with artificial airways.

Eimear M Kitt, Daniela H Davis, Caryn Kerman, Julia S Sammons, Lori K Handy, Elizabeth Gallagher, Kevin O'Callaghan, Rebecca M Harris, Susan E Coffin, Louis M Bell, Kathleen Chiotos,

Early in the coronavirus disease 2019 (COVID-19) pandemic, the CDC recommended collection of a lower respiratory tract (LRT) specimen for severe acute respiratory coronavirus virus 2 (SARS-CoV-2) testing in addition to the routinely recommended upper respiratory tract (URT) testing in mechanically ventilated patients. Significant operational challenges were noted at our ... Read more >>

Infect Control Hosp Epidemiol (Infection control and hospital epidemiology)
[2021, :1-3]

Cited: 0 times

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Initial Guidance on Use of Monoclonal Antibody Therapy for Treatment of Coronavirus Disease 2019 in Children and Adolescents.

Joshua Wolf, Mark J Abzug, Rachel L Wattier, Paul K Sue, Surabhi B Vora, Philip Zachariah, Daniel E Dulek, Alpana Waghmare, Rosemary Olivero, Kevin J Downes, Scott H James, Swetha G Pinninti, April Yarbrough, Margaret L Aldrich, Christine E MacBrayne, Vijaya L Soma, Steven P Grapentine, Carlos R Oliveira, Molly Hayes, David W Kimberlin, Sarah B Jones, Laura L Bio, Theodore H Morton, Jane S Hankins, Gabriela M Maron, Kathryn Timberlake, Jennifer L Young, Rachel C Orscheln, Hayden T Schwenk, David L Goldman, Helen E Groves, W Charles Huskins, Nipunie S Rajapakse, Gabriella S Lamb, Alison C Tribble, Elizabeth C Lloyd, Adam L Hersh, Emily A Thorell, Adam J Ratner, Kathleen Chiotos, Mari M Nakamura,

<h4>Background</h4>In November 2020, the US Food and Drug Administration (FDA) provided Emergency Use Authorizations (EUA) for 2 novel virus-neutralizing monoclonal antibody therapies, bamlanivimab and REGN-COV2 (casirivimab plus imdevimab), for the treatment of mild to moderate coronavirus disease 2019 (COVID-19) in adolescents and adults in specified high-risk groups. This has challenged ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2021, 10(5):629-634]

Cited: 9 times

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Outcomes of Patients With Coronavirus Disease 2019 Receiving Organ Support Therapies: The International Viral Infection and Respiratory Illness Universal Study Registry.

Juan Pablo Domecq, Amos Lal, Christopher R Sheldrick, Vishakha K Kumar, Karen Boman, Scott Bolesta, Vikas Bansal, Michael O Harhay, Michael A Garcia, Margit Kaufman, Valerie Danesh, Sreekanth Cheruku, Valerie M Banner-Goodspeed, Harry L Anderson, Patrick S Milligan, Joshua L Denson, Catherine A St Hill, Kenneth W Dodd, Greg S Martin, Ognjen Gajic, Allan J Walkey, Rahul Kashyap, ,

<h4>Objectives</h4>To describe the outcomes of hospitalized patients in a multicenter, international coronavirus disease 2019 registry.<h4>Design</h4>Cross-sectional observational study including coronavirus disease 2019 patients hospitalized with laboratory-confirmed severe acute respiratory syndrome coronavirus-2 infection between February 15, 2020, and November 30, 2020, according to age and type of organ support therapies.<h4>Setting</h4>About 168 hospitals ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(3):437-448]

Cited: 5 times

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Intracranial Hypertension in Multisystem Inflammatory Syndrome in Children.

Andrew E Becker, Kathleen Chiotos, Jennifer L McGuire, Benjamin B Bruins, Alicia M Alcamo,

Multisystem inflammatory syndrome in children (MIS-C) is characterized by fever and multiorgan system dysfunction. Neurologic complications of MIS-C are not well described. We present 4 patients with MIS-C who had intracranial hypertension and discuss the unique management considerations when this occurs concurrently with significant myocardial dysfunction. ... Read more >>

J Pediatr (The Journal of pediatrics)
[2021, 233:263-267]

Cited: 0 times

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Cutaneous Findings in SARS-CoV-2-Associated Multisystem Inflammatory Disease in Children.

Allison M Blatz, Michelle Oboite, Kathleen Chiotos, Leslie Castelo-Soccio, Audrey R Odom John, ,

Rash is a common feature of multisystem inflammatory syndrome in children (MIS-C), a postinfectious hyperinflammatory disease associated with prior severe acute respiratory syndrome coronavirus 2 infection. Because the differential diagnosis of fever and rash in children is broad, understanding clinical characteristics of MIS-C may assist with diagnosis. Here we describe ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(3):ofab074]

Cited: 1 time

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A Wrinkle in Time to Antibiotics in Sepsis: When Should ONE Hour Be the Goal?

Kathleen Chiotos, Scott L Weiss,

J Pediatr (The Journal of pediatrics)
[2021, 233:13-15]

Cited: 0 times

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Multicenter Interim Guidance on Use of Antivirals for Children With Coronavirus Disease 2019/Severe Acute Respiratory Syndrome Coronavirus 2.

Kathleen Chiotos, Molly Hayes, David W Kimberlin, Sarah B Jones, Scott H James, Swetha G Pinninti, April Yarbrough, Mark J Abzug, Christine E MacBrayne, Vijaya L Soma, Daniel E Dulek, Surabhi B Vora, Alpana Waghmare, Joshua Wolf, Rosemary Olivero, Steven Grapentine, Rachel L Wattier, Laura Bio, Shane J Cross, Nicholas O Dillman, Kevin J Downes, Carlos R Oliveira, Kathryn Timberlake, Jennifer Young, Rachel C Orscheln, Pranita D Tamma, Hayden T Schwenk, Philip Zachariah, Margaret L Aldrich, David L Goldman, Helen E Groves, Nipunie S Rajapakse, Gabriella S Lamb, Alison C Tribble, Adam L Hersh, Emily A Thorell, Mark R Denison, Adam J Ratner, Jason G Newland, Mari M Nakamura,

<h4>Background</h4>Although coronavirus disease 2019 (COVID-19) is a mild infection in most children, a small proportion develop severe or critical illness. Data describing agents with potential antiviral activity continue to expand such that updated guidance is needed regarding use of these agents in children.<h4>Methods</h4>A panel of pediatric infectious diseases physicians and ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2021, 10(1):34-48]

Cited: 11 times

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Infectious Diseases Society of America Position Paper: Recommended Revisions to the National Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) Sepsis Quality Measure.

Chanu Rhee, Kathleen Chiotos, Sara E Cosgrove, Emily L Heil, Sameer S Kadri, Andre C Kalil, David N Gilbert, Henry Masur, Edward J Septimus, Daniel A Sweeney, Jeffrey R Strich, Dean L Winslow, Michael Klompas,

The Centers for Medicare & Medicaid Services' Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) measure has appropriately established sepsis as a national priority. However, the Infectious Diseases Society of America (IDSA and five additional endorsing societies) is concerned about SEP-1's potential to drive antibiotic overuse because it does ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, 72(4):541-552]

Cited: 19 times

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Evidence of Microangiopathy in Children with Sars-Cov-2 Regardless of Clinical Presentation

Caroline Diorio, Kevin O McNerney, Michele P. Lambert, Michele Paessler, Julie Chase, Kandace Gollomp, Benjamin L Laskin, Laura A Vella, Sarah E Henrickson, Emily Liebling, Chakkapong Burudpakdee, Jessica Lee, Fran Balamuth, Allison M Blatz, Kathleen Chiotos, Julie C Fitzgerald, Therese Giglia, Audrey R Odom John, Whitney Petrosa, Kathleen Sullivan, Char M Witmer, Hamid Bassiri, Edward M Behrens, David T. Teachey,

Introduction: During the Coronavirus Disease 2019 (COVID-19) pandemic caused by Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2), 3 distinct phenotypes have emerged in children. The majority of children have mild or no symptoms. Similar to adults, a minority of children can be severely affected with respiratory distress requiring intensive ... Read more >>

Blood (Blood)
[2020, 136(20):28-29]

Cited: 0 times

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Multicenter Initial Guidance on Use of Antivirals for Children With Coronavirus Disease 2019/Severe Acute Respiratory Syndrome Coronavirus 2.

Kathleen Chiotos, Molly Hayes, David W Kimberlin, Sarah B Jones, Scott H James, Swetha G Pinninti, April Yarbrough, Mark J Abzug, Christine E MacBrayne, Vijaya L Soma, Daniel E Dulek, Surabhi B Vora, Alpana Waghmare, Joshua Wolf, Rosemary Olivero, Steven Grapentine, Rachel L Wattier, Laura Bio, Shane J Cross, Nicholas O Dillman, Kevin J Downes, Kathryn Timberlake, Jennifer Young, Rachel C Orscheln, Pranita D Tamma, Hayden T Schwenk, Philip Zachariah, Margaret Aldrich, David L Goldman, Helen E Groves, Gabriella S Lamb, Alison C Tribble, Adam L Hersh, Emily A Thorell, Mark R Denison, Adam J Ratner, Jason G Newland, Mari M Nakamura,

<h4>Background</h4>Although coronavirus disease 2019 (COVID-19) is mild in nearly all children, a small proportion of pediatric patients develop severe or critical illness. Guidance is therefore needed regarding use of agents with potential activity against severe acute respiratory syndrome coronavirus 2 in pediatrics.<h4>Methods</h4>A panel of pediatric infectious diseases physicians and pharmacists ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2020, 9(6):701-715]

Cited: 42 times

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Distinguishing Multisystem Inflammatory Syndrome in Children From Kawasaki Disease and Benign Inflammatory Illnesses in the SARS-CoV-2 Pandemic.

Daniel J Corwin, Laura F Sartori, Kathleen Chiotos, Audrey R Odom John, Keri Cohn, Hamid Bassiri, Edward M Behrens, David T Teachey, Sarah E Henrickson, Caroline J Diorio, Joseph J Zorc, Fran Balamuth,

<h4>Objective</h4>The aim of the study was to compare presenting clinical and laboratory features among children meeting the surveillance definition for multisystem inflammatory syndrome in children (MIS-C) across a range of illness severities.<h4>Methods</h4>This is a retrospective single-center study of patients younger than 21 years presenting between March 1 and May 15, ... Read more >>

Pediatr Emerg Care (Pediatric emergency care)
[2020, 36(11):554-558]

Cited: 6 times

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Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS-CoV-2.

Caroline Diorio, Sarah E Henrickson, Laura A Vella, Kevin O McNerney, Julie Chase, Chakkapong Burudpakdee, Jessica H Lee, Cristina Jasen, Fran Balamuth, David M Barrett, Brenda L Banwell, Kathrin M Bernt, Allison M Blatz, Kathleen Chiotos, Brian T Fisher, Julie C Fitzgerald, Jeffrey S Gerber, Kandace Gollomp, Christopher Gray, Stephan A Grupp, Rebecca M Harris, Todd J Kilbaugh, Audrey R Odom John, Michele Lambert, Emily J Liebling, Michele E Paessler, Whitney Petrosa, Charles Phillips, Anne F Reilly, Neil D Romberg, Alix Seif, Deborah A Sesok-Pizzini, Kathleen E Sullivan, Julie Vardaro, Edward M Behrens, David T Teachey, Hamid Bassiri,

BACKGROUNDInitial reports from the severe acute respiratory coronavirus 2 (SARS-CoV-2) pandemic described children as being less susceptible to coronavirus disease 2019 (COVID-19) than adults. Subsequently, a severe and novel pediatric disorder termed multisystem inflammatory syndrome in children (MIS-C) emerged. We report on unique hematologic and immunologic parameters that distinguish between ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2020, 130(11):5967-5975]

Cited: 93 times

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425. The Utility of Paired Upper and Lower COVID-19 Sampling in Patients with Artificial Airways

Eimear Kitt, Julia S Sammons, Kathleen Chiotos, Susan E Coffin, Susan E Coffin, Allison Ballantine, Elizabeth Gallagher, Coralee DelValle Mojica, Kevin P O’Callaghan, Caryn Kerman, Rebecca Harris, Louis Bell, Daniela Davis, Ellen Nord,

Abstract <h4>Background</h4> The Centers for Disease Control and Prevention (CDC) recommends upper respiratory tract (URT) polymerase chain reaction (PCR) testing as the initial diagnostic test for Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Lower respiratory tract (LRT) testing for patients requiring mechanical ventilation is also recommended. The goal of this study ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(Suppl 1):S279-S279]

Cited: 0 times

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Convalescent plasma for pediatric patients with SARS-CoV-2-associated acute respiratory distress syndrome.

Caroline Diorio, Elizabeth M Anderson, Kevin O McNerney, Eileen C Goodwin, Julie C Chase, Marcus J Bolton, Claudia P Arevalo, Madison E Weirick, Sigrid Gouma, Laura A Vella, Sarah E Henrickson, Kathleen Chiotos, Julie C Fitzgerald, Todd J Kilbaugh, Audrey R Odom John, Allison M Blatz, Michele P Lambert, Kathleen E Sullivan, Margaret R Tartaglione, Danielle Zambrano, Meghan Martin, Jessica H Lee, Pampee Young, David Friedman, Deborah A Sesok-Pizzini, Scott E Hensley, Edward M Behrens, Hamid Bassiri, David T Teachey,

There are no proven safe and effective therapies for children who develop life-threatening complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Convalescent plasma (CP) has demonstrated potential benefit in adults with SARS-CoV-2, but has theoretical risks.We present the first report of CP in children with life-threatening coronavirus disease 2019 ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2020, 67(11):e28693]

Cited: 18 times

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