Full Text Journal Articles by
Author Katharina Warncke

Advertisement

Find full text journal articles






Diabetic Ketoacidosis at Manifestation of Type 1 Diabetes in Childhood and Adolescence—Incidence and Risk Factors.

Hugo Segerer, Michael Wurm, Julia M Grimsmann, Beate Karges, Andreas Neu, Marina Sindichakis, Katharina Warncke, Axel Dost, Reinhard W Holl,

<h4>Background</h4>Diabetic ketoacidosis (DKA) is a potentially life-threatening metabolic disorder that can occur with manifestation of type 1 diabetes mellitus (T1D). The aim of this study was to analyze the incidence of DKA at the time of the diagnosis of T1D in childhood and adolescence, the risk factors, and regional approaches ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

Cited: 0 times

View full text PDF listing >>



Previous diabetic ketoacidosis as a risk factor for recurrence in a large prospective contemporary pediatric cohort: Results from the DPV initiative.

Johanna Hammersen, Sascha R Tittel, Katharina Warncke, Maria Fritsch, Kerstin Placzek, Danièle Pacaud, Beate Karges, Joachim Woelfle, Reinhard W Holl, ,

<h4>Objective</h4>To assess the role of previous episodes of diabetic ketoacidosis (DKA) and their time-lag as risk factors for recurring DKA in youth with type 1 diabetes (T1D).<h4>Research design and methods</h4>In a population-based analysis, data from 29,325 children and adolescents with T1D and at least 5 years of continuous follow-up were retrieved ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2021, 22(3):455-462]

Cited: 0 times

View full text PDF listing >>



Advertisement

An Age-Related Exponential Decline in the Risk of Multiple Islet Autoantibody Seroconversion During Childhood.

Ezio Bonifacio, Andreas Weiß, Christiane Winkler, Markus Hippich, Marian J Rewers, Jorma Toppari, Åke Lernmark, Jin-Xiong She, William A Hagopian, Jeffrey P Krischer, Kendra Vehik, Desmond A Schatz, Beena Akolkar, Anette-Gabriele Ziegler, ,

<h4>Objective</h4>Islet autoimmunity develops before clinical type 1 diabetes and includes multiple and single autoantibody phenotypes. The objective was to determine age-related risks of islet autoantibodies that reflect etiology and improve screening for presymptomatic type 1 diabetes.<h4>Research design and methods</h4>The Environmental Determinants of Diabetes in the Young study prospectively monitored 8,556 ... Read more >>

Diabetes Care (Diabetes care)
[2021, :]

Cited: 0 times

View full text PDF listing >>



[Is it possible to prevent diabetic ketoacidosis at diagnosis of pediatric type 1 diabetes? Lessons from the COVID-19 pandemic].

Kirsten Mönkemöller, Clemens Kamrath, Johanna Hammersen, Torben Biester, Katharina Warncke, Angeliki Pappa, Katharina Fink, Klemens Raile, Tilman R Rohrer, Reinhard W Holl, ,

<h4>Background</h4>Diabetic ketoacidosis (DKA) is a life-threatening emergency in children and adolescents with manifestation of type 1 diabetes mellitus (DM1) and often associated with delayed diagnosis or previous diagnostic errors. During the coronavirus disease 2019 (COVID-19) lockdown period in Germany, less patients presented at emergency departments and private practices<b>.</b><h4>Objective</h4>The aim of this study ... Read more >>

Monatsschr Kinderheilkd (Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde)
[2021, :1-8]

Cited: 0 times

View full text PDF listing >>



Thiamine-Responsive Megaloblastic Anemia-Related Diabetes: Long-Term Clinical Outcomes in 23 Pediatric Patients From the DPV and SWEET Registries.

Katharina Warncke, Nicole Prinz, Violeta Iotova, Desiree Dunstheimer, Nicolin Datz, Beate Karges, Mallikarjun V Jali, Dorothea Linsenmeyer, Birthe Susanne Olsen, Monika Seiwald, Priya Prahalad, Gideon de Sousa, Danièle Pacaud, ,

<h4>Objectives</h4>To describe clinical presentation and long-term outcomes in a large cohort of children diagnosed with thiamine-responsive megaloblastic anemia (TRMA)-related diabetes.<h4>Methods</h4>Data from the Diabetes Patienten Verlaufsdokumentation (DPV) and Better control in Pediatric and Adolescent diabeteS: Working to crEate CEnTers of Reference (SWEET) registries were used to identify cases. Complementary information was ... Read more >>

Can J Diabetes (Canadian journal of diabetes)
[2020, :]

Cited: 0 times

View full text PDF listing >>



[Type 1 diabetes in children and adolescents - a quick overview of the most relevant aspects for general practitioners].

Ruth Chmiel, David Flores Rodriguez, Katharina Warncke,

MMW Fortschr Med (MMW Fortschritte der Medizin)
[2020, 162(14):58-61]

Cited: 0 times

View full text PDF listing >>



Ketoacidosis in Children and Adolescents With Newly Diagnosed Type 1 Diabetes During the COVID-19 Pandemic in Germany.

Clemens Kamrath, Kirsten Mönkemöller, Torben Biester, Tilman R Rohrer, Katharina Warncke, Johanna Hammersen, Reinhard W Holl,

JAMA (JAMA)
[2020, 324(8):801-804]

Cited: 20 times

View full text PDF listing >>



Hierarchical Order of Distinct Autoantibody Spreading and Progression to Type 1 Diabetes in the TEDDY Study.

Kendra Vehik, Ezio Bonifacio, Åke Lernmark, Liping Yu, Alistair Williams, Desmond Schatz, Marian Rewers, Jin-Xiong She, Jorma Toppari, William Hagopian, Beena Akolkar, Anette G Ziegler, Jeffrey P Krischer, ,

<h4>Objective</h4>The first-appearing β-cell autoantibody has been shown to influence risk of type 1 diabetes (T1D). Here, we assessed the risk of autoantibody spreading to the second-appearing autoantibody and further progression to clinical disease in The Environmental Determinants of Diabetes in the Young (TEDDY) study.<h4>Research design and methods</h4>Eligible children with increased ... Read more >>

Diabetes Care (Diabetes care)
[2020, 43(9):2066-2073]

Cited: 1 time

View full text PDF listing >>



Diabetes management in Wolcott-Rallison syndrome: analysis from the German/Austrian DPV database.

Alena Welters, Thomas Meissner, Katja Konrad, Clemens Freiberg, Katharina Warncke, Sylvia Judmaier, Olga Kordonouri, Michael Wurm, Matthias Papsch, Gisela Fitzke, Silke Christina Schmidt, Sascha R Tittel, Reinhard W Holl,

<h4>Background</h4>Wolcott-Rallison syndrome (WRS) is characterized by permanent early-onset diabetes, skeletal dysplasia and several additional features, e.g. recurrent liver failure. This is the first multicentre approach that focuses on diabetes management in WRS. We searched the German/Austrian Diabetes-Patienten-Verlaufsdokumentation (DPV) registry and studied anthropometric characteristics, diabetes treatment, glycaemic control and occurrence of ... Read more >>

Orphanet J Rare Dis (Orphanet journal of rare diseases)
[2020, 15(1):100]

Cited: 1 time

View full text PDF listing >>



Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study.

Qian Li, Hemang Parikh, Martha D Butterworth, Åke Lernmark, William Hagopian, Marian Rewers, Jin-Xiong She, Jorma Toppari, Anette-G Ziegler, Beena Akolkar, Oliver Fiehn, Sili Fan, Jeffrey P Krischer, ,

Children at increased genetic risk for type 1 diabetes (T1D) after environmental exposures may develop pancreatic islet autoantibodies (IA) at a very young age. Metabolic profile changes over time may imply responses to exposures and signal development of the first IA. Our present research in The Environmental Determinants of Diabetes ... Read more >>

Diabetes (Diabetes)
[2020, 69(3):465-476]

Cited: 2 times

View full text PDF listing >>



Distinct Growth Phases in Early Life Associated With the Risk of Type 1 Diabetes: The TEDDY Study.

Xiang Liu, Kendra Vehik, Yangxin Huang, Helena Elding Larsson, Jorma Toppari, Anette G Ziegler, Jin-Xiong She, Marian Rewers, William A Hagopian, Beena Akolkar, Jeffrey P Krischer, ,

<h4>Objective</h4>This study investigates two-phase growth patterns in early life and their association with development of islet autoimmunity (IA) and type 1 diabetes (T1D).<h4>Research design and methods</h4>The Environmental Determinants of Diabetes in the Young (TEDDY) study followed 7,522 genetically high-risk children in Sweden, Finland, Germany, and the U.S. from birth for ... Read more >>

Diabetes Care (Diabetes care)
[2020, 43(3):556-562]

Cited: 5 times

View full text PDF listing >>



Yield of a Public Health Screening of Children for Islet Autoantibodies in Bavaria, Germany.

Anette-Gabriele Ziegler, Kerstin Kick, Ezio Bonifacio, Florian Haupt, Markus Hippich, Desiree Dunstheimer, Martin Lang, Otto Laub, Katharina Warncke, Karin Lange, Robin Assfalg, Manja Jolink, Christiane Winkler, Peter Achenbach, ,

Importance:Public health screening for type 1 diabetes in its presymptomatic stages may reduce disease severity and burden on a population level. Objective:To determine the prevalence of presymptomatic type 1 diabetes in children participating in a public health screening program for islet autoantibodies and the risk for progression to clinical diabetes. ... Read more >>

JAMA (JAMA)
[2020, 323(4):339-351]

Cited: 7 times

View full text PDF listing >>



Maternal Type 1 Diabetes Reduces Autoantigen-Responsive CD4+ T Cells in Offspring.

Jan Knoop, Anne Eugster, Anita Gavrisan, Ramona Lickert, Eva-Maria Sedlmeier, Sevina Dietz, Annett Lindner, Katharina Warncke, Nadine Hummel, Anette-Gabriele Ziegler, Ezio Bonifacio,

Autoimmunity against pancreatic β-cell autoantigens is a characteristic of childhood type 1 diabetes (T1D). Autoimmunity usually appears in genetically susceptible children with the development of autoantibodies against (pro)insulin in early childhood. The offspring of mothers with T1D are protected from this process. The aim of this study was to determine ... Read more >>

Diabetes (Diabetes)
[2020, 69(4):661-669]

Cited: 1 time

View full text PDF listing >>



Metabolite-related dietary patterns and the development of islet autoimmunity.

Randi K Johnson, Lauren Vanderlinden, Brian C DeFelice, Katerina Kechris, Ulla Uusitalo, Oliver Fiehn, Marci Sontag, Tessa Crume, Andreas Beyerlein, Åke Lernmark, Jorma Toppari, Anette-G Ziegler, Jin-Xiong She, William Hagopian, Marian Rewers, Beena Akolkar, Jeffrey Krischer, Suvi M Virtanen, Jill M Norris, ,

The role of diet in type 1 diabetes development is poorly understood. Metabolites, which reflect dietary response, may help elucidate this role. We explored metabolomics and lipidomics differences between 352 cases of islet autoimmunity (IA) and controls in the TEDDY (The Environmental Determinants of Diabetes in the Young) study. We ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):14819]

Cited: 7 times

View full text PDF listing >>



Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: the TEDDY study.

Katri Lindfors, Jake Lin, Hye-Seung Lee, Heikki Hyöty, Matti Nykter, Kalle Kurppa, Edwin Liu, Sibylle Koletzko, Marian Rewers, William Hagopian, Jorma Toppari, Annette-Gabriele Ziegler, Beena Akolkar, Jeffrey P Krischer, Joseph F Petrosino, Richard E Lloyd, Daniel Agardh, ,

<h4>Objective</h4>Higher gluten intake, frequent gastrointestinal infections and adenovirus, enterovirus, rotavirus and reovirus have been proposed as environmental triggers for coeliac disease. However, it is not known whether an interaction exists between the ingested gluten amount and viral exposures in the development of coeliac disease. This study investigated whether distinct viral ... Read more >>

Gut (Gut)
[2020, 69(8):1416-1422]

Cited: 13 times

View full text PDF listing >>



The relationship between breastfeeding and reported respiratory and gastrointestinal infection rates in young children.

Nicole M Frank, Kristian F Lynch, Ulla Uusitalo, Jimin Yang, Maria Lönnrot, Suvi M Virtanen, Heikki Hyöty, Jill M Norris, ,

<h4>Background</h4>Although breastfeeding is touted as providing many health benefits to infants, some aspects of this relationship remain poorly understood.<h4>Methods</h4>The Environmental Determinants of Diabetes in the Young (TEDDY) is a prospective longitudinal study that follows children from birth through childhood, and collects data on illness events, breastfeeding duration, and time to ... Read more >>

BMC Pediatr (BMC pediatrics)
[2019, 19(1):339]

Cited: 2 times

View full text PDF listing >>



Predicting Islet Cell Autoimmunity and Type 1 Diabetes: An 8-Year TEDDY Study Progress Report.

Jeffrey P Krischer, Xiang Liu, Kendra Vehik, Beena Akolkar, William A Hagopian, Marian J Rewers, Jin-Xiong She, Jorma Toppari, Anette-G Ziegler, Åke Lernmark, ,

<h4>Objective</h4>Assessment of the predictive power of The Environmental Determinants of Diabetes in the Young (TEDDY)-identified risk factors for islet autoimmunity (IA), the type of autoantibody appearing first, and type 1 diabetes (T1D).<h4>Research design and methods</h4>A total of 7,777 children were followed from birth to a median of 9.1 years of ... Read more >>

Diabetes Care (Diabetes care)
[2019, 42(6):1051-1060]

Cited: 15 times

View full text PDF listing >>



Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families.

Markus Hippich, Andreas Beyerlein, William A Hagopian, Jeffrey P Krischer, Kendra Vehik, Jan Knoop, Christiane Winker, Jorma Toppari, Åke Lernmark, Marian J Rewers, Andrea K Steck, Jin-Xiong She, Beena Akolkar, Catherine C Robertson, Suna Onengut-Gumuscu, Stephen S Rich, Ezio Bonifacio, Anette-G Ziegler, , ,

The risk for autoimmunity and subsequently type 1 diabetes is 10-fold higher in children with a first-degree family history of type 1 diabetes (FDR children) than in children in the general population (GP children). We analyzed children with high-risk HLA genotypes (<i>n</i> = 4,573) in the longitudinal TEDDY birth cohort ... Read more >>

Diabetes (Diabetes)
[2019, 68(4):847-857]

Cited: 6 times

View full text PDF listing >>



Frequency and Characteristics of MODY 1 (HNF4A Mutation) and MODY 5 (HNF1B Mutation): Analysis From the DPV Database.

Katharina Warncke, Sebastian Kummer, Klemens Raile, Jürgen Grulich-Henn, Joachim Woelfle, Elisabeth Steichen, Nicole Prinz, Reinhard W Holl,

<h4>Objective</h4>To characterize the initial presentation and clinical course of patients with hepatocyte nuclear factor (HNF) 4A‒ and HNF1B‒MODY in a multinational registry.<h4>Design, setting, and participants</h4>Within the Diabetes Patienten Verlaufsdokumentation (DPV) registry, 44 patients with HNF4A- and 35 patients with HNF1B-MODY were characterized and compared with patients <20 years old with ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2019, 104(3):845-855]

Cited: 4 times

View full text PDF listing >>



Characterization of diabetes following pancreatic surgery in patients with congenital hyperinsulinism.

Alena Welters, Thomas Meissner, Jürgen Grulich-Henn, Elke Fröhlich-Reiterer, Katharina Warncke, Klaus Mohnike, Oliver Blankenstein, Ulrike Menzel, Nicolin Datz, Esther Bollow, Reinhard W Holl,

<h4>Background</h4>Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycaemia in infancy that leads to unfavourable neurological outcome if not treated adequately. In patients with severe diffuse CHI it remains under discussion whether pancreatic surgery should be performed or intensive medical treatment with the acceptance of recurrent episodes of ... Read more >>

Orphanet J Rare Dis (Orphanet journal of rare diseases)
[2018, 13(1):230]

Cited: 0 times

View full text PDF listing >>



The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update.

Marian Rewers, Heikki Hyöty, Åke Lernmark, William Hagopian, Jin-Xiong She, Desmond Schatz, Anette-G Ziegler, Jorma Toppari, Beena Akolkar, Jeffrey Krischer, ,

<h4>Purpose of review</h4>The environmental triggers of islet autoimmunity leading to type 1 diabetes (T1D) need to be elucidated to inform primary prevention. The Environmental Determinants of Diabetes in the Young (TEDDY) Study follows from birth 8676 children with T1D risk HLA-DR-DQ genotypes in the USA, Finland, Germany, and Sweden. Most ... Read more >>

Curr Diab Rep (Current diabetes reports)
[2018, 18(12):136]

Cited: 14 times

View full text PDF listing >>



Cardivascular Risk Profile in Patients with Diabetes and Acromegaly or Cushing's Disease - Analysis from the DPV Database.

Katharina Warncke, Sebastian Kummer, Peter Herbert Kann, Dominik Bergis, Esther Bollow, Michael Hummel, Flavius Zoicas, Sebastian Wernert, Reinhard W Holl,

<h4>Background</h4>Although diabetes is a common complication of acromegaly or Cushing´s disease, there are only few detailed studies with a focus on cardiovascular risk, metabolic control or diabetes therapy. Here, we provide a comprehensive characterization from the longitudinal DPV (Diabetes Patienten Verlaufsdokumentation) registry.<h4>Methods</h4>Patients from the registry≥18 years of age with diabetes ... Read more >>

Exp Clin Endocrinol Diabetes (Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association)
[2020, 128(2):104-110]

Cited: 1 time

View full text PDF listing >>



Time-Resolved Autoantibody Profiling Facilitates Stratification of Preclinical Type 1 Diabetes in Children.

David Endesfelder, Wolfgang Zu Castell, Ezio Bonifacio, Marian Rewers, William A Hagopian, Jin-Xiong She, Åke Lernmark, Jorma Toppari, Kendra Vehik, Alistair J K Williams, Liping Yu, Beena Akolkar, Jeffrey P Krischer, Anette-G Ziegler, Peter Achenbach, ,

Progression to clinical type 1 diabetes varies among children who develop β-cell autoantibodies. Differences in autoantibody patterns could relate to disease progression and etiology. Here we modeled complex longitudinal autoantibody profiles by using a novel wavelet-based algorithm. We identified clusters of similar profiles associated with various types of progression among ... Read more >>

Diabetes (Diabetes)
[2019, 68(1):119-130]

Cited: 10 times

View full text PDF listing >>



Fasting hypoglycemia is associated with disease progression in presymptomatic early stage type 1 diabetes.

Melanie Heinrich, Nicole Maison, Peter Achenbach, Robin Assfalg, Sonja Braig, Dominik Böcker, Desiree Dunstheimer, Uwe Ermer, Antonia Gavazzeni, Eva-Maria Gerstl, Sandra Hummel, Kerstin Kick, Herbert Müller, Nicole Nellen-Hellmuth, Christian Ockert, Marina Sindichakis, Stefanie Tretter, Katharina Warncke, Anette-Gabriele Ziegler, Andreas Beyerlein, ,

<h4>Objective</h4>In children with presymptomatic type 1 diabetes, intermittent hyperglycemia and rising hemoglobin A1c levels are a known signal of progression toward insulin-dependency. Episodes of hypoglycemia, however, have also been reported in one published case. We investigated the prevalence of hypoglycemia and its association with disease progression in children with presymptomatic ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2018, 19(7):1238-1242]

Cited: 0 times

View full text PDF listing >>



Reduction in White Blood Cell, Neutrophil, and Red Blood Cell Counts Related to Sex, HLA, and Islet Autoantibodies in Swedish TEDDY Children at Increased Risk for Type 1 Diabetes.

Falastin Salami, Hye-Seung Lee, Eva Freyhult, Helena Elding Larsson, Åke Lernmark, Carina Törn, ,

Islet autoantibodies (IAs) precede the clinical onset of type 1 diabetes (T1D); however, the knowledge is limited about whether the prodrome affects complete blood counts (CBCs) in 4- to 12-year-old children with increased genetic risk for T1D. This study tested whether CBCs were altered in 4- to 12-year-old children without ... Read more >>

Diabetes (Diabetes)
[2018, 67(11):2329-2336]

Cited: 1 time

View full text PDF listing >>



Advertisement

Disclaimer
2.5473 s