Full Text Journal Articles by
Author Karuna Wongtangman

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Association Between Intraoperative Arterial Hypotension and Postoperative Delirium After Noncardiac Surgery: A Retrospective Multicenter Cohort Study.

Luca J Wachtendorf, Omid Azimaraghi, Peter Santer, Felix C Linhardt, Michael Blank, Aiman Suleiman, Curie Ahn, Ying H Low, Bijan Teja, Samir M Kendale, Maximilian S Schaefer, Timothy T Houle, Richard J Pollard, Balachundhar Subramaniam, Matthias Eikermann, Karuna Wongtangman,

<h4>Background</h4>It is unclear whether intraoperative arterial hypotension is associated with postoperative delirium. We hypothesized that intraoperative hypotension within a range frequently observed in clinical practice is associated with increased odds of delirium after surgery.<h4>Methods</h4>Adult noncardiac surgical patients undergoing general anesthesia at 2 academic medical centers between 2005 and 2017 were ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, :]

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The authors reply.

Karuna Wongtangman, Matthias Eikermann,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1188-e1189]

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Effect of Intraoperative Arterial Hypotension on the Risk of Perioperative Stroke After Noncardiac Surgery: A Retrospective Multicenter Cohort Study.

Karuna Wongtangman, Luca J Wachtendorf, Michael Blank, Stephanie D Grabitz, Felix C Linhardt, Omid Azimaraghi, Dana Raub, Stephanie Pham, Samir M Kendale, Ying H Low, Timothy T Houle, Matthias Eikermann, Richard J Pollard,

<h4>Background</h4>Intraoperative cerebral blood flow is mainly determined by cerebral perfusion pressure and cerebral autoregulation of vasomotor tone. About 1% of patients undergoing noncardiac surgery develop ischemic stroke. We hypothesized that intraoperative hypotension within a range frequently observed in clinical practice is associated with an increased risk of perioperative ischemic stroke ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 133(4):1000-1008]

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Psychometric properties of a Thai version of the Richards-Campbell sleep questionnaire.

Nuanprae Kitisin, Pawit Somnuke, Napat Thikom, Nattaya Raykateeraroj, Nisa Poontong, Chayanan Thanakiattiwibun, Karuna Wongtangman,

<h4>Background</h4>In critically ill patients, a poor sleep quality can escalate mortality and the length of hospital stays. Albeit being the gold standard for sleep assessment, polysomnography (PSG) is expensive and complicated. The Richards-Campbell sleep questionnaire (RCSQ) is another tool with proof of good correlation with PSG. RCSQ was translated into ... Read more >>

Nurs Crit Care (Nursing in critical care)
[2021, :]

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Association of Sedation, Coma, and In-Hospital Mortality in Mechanically Ventilated Patients With Coronavirus Disease 2019-Related Acute Respiratory Distress Syndrome: A Retrospective Cohort Study.

Karuna Wongtangman, Peter Santer, Luca J Wachtendorf, Omid Azimaraghi, Elias Baedorf Kassis, Bijan Teja, Kadhiresan R Murugappan, Shahla Siddiqui, Matthias Eikermann, ,

<h4>Objectives</h4>In patients with coronavirus disease 2019-associated acute respiratory distress syndrome, sedatives and opioids are commonly administered which may lead to increased vulnerability to neurologic dysfunction. We tested the hypothesis that patients with coronavirus disease 2019-associated acute respiratory distress syndrome are at higher risk of in-hospital mortality due to prolonged coma ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(9):1524-1534]

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The association of nitrous oxide on length of stay in the postanesthesia care unit: a retrospective observational study.

Salameh Sameh Obeidat, Karuna Wongtangman, Michael Blank, Luca J Wachtendorf, Maximilian Hammer, Maximilian S Schaefer, Peter Santer, Matthias Eikermann, Eswar Sundar,

<h4>Purpose</h4>To assess whether intraoperative use of nitrous oxide (N<sub>2</sub>O) as an adjunct to general anesthesia is associated with a shorter length of stay in the postanesthesia care unit (PACU).<h4>Methods</h4>We analyzed data from adult patients who underwent non-cardiothoracic surgery under general anesthesia between May 2008 and December 2018. We assessed the ... Read more >>

Can J Anaesth (Canadian journal of anaesthesia = Journal canadien d'anesthesie)
[2021, 68(11):1630-1640]

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Association of surgery type and duration of hospitalisation with the ability to live independently after surgery.

Felix C Linhardt, Luca J Wachtendorf, Karuna Wongtangman, Omid Azimaraghi, Maximilian S Schaefer, Matthias Eikermann, Samir Kendale,

Br J Anaesth (British journal of anaesthesia)
[2021, 127(3):e87-e90]

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Optimal Sedation in Patients Who Receive Neuromuscular Blocking Agent Infusions for Treatment of Acute Respiratory Distress Syndrome-A Retrospective Cohort Study From a New England Health Care Network.

Karuna Wongtangman, Stephanie D Grabitz, Maximilian Hammer, Luca J Wachtendorf, Xinling Xu, Maximilian S Schaefer, Philipp Fassbender, Peter Santer, Elias Baedorf Kassis, Daniel Talmor, Matthias Eikermann, ,

<h4>Objectives</h4>Two previously published trials (ARDS et Curarisation Systematique [ACURASYS] and Reevaluation of Systemic Early Neuromuscular Blockade [ROSE]) presented equivocal evidence on the effect of neuromuscular blocking agent infusions in patients with acute respiratory distress syndrome (acute respiratory distress syndrome). The sedation regimen differed between these trials and also within the ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(7):1137-1148]

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Goal-Directed Fluid Therapy Based on Pulse-Pressure Variation Compared with Standard Fluid Therapy in Patients Undergoing Complex Spine Surgery: A Randomized Controlled Trial.

Karuna Wongtangman, Sirichai Wilartratsami, Nattachai Hemtanon, Supinya Tiviraj, Manee Raksakietisak,

<h4>Study design</h4>Prospective, randomized, controlled study.<h4>Purpose</h4>To determine whether the use of goal-directed fluid therapy (GDT) guided by pulse-pressure variation (PPV) and fluid management protocol can reduce intraoperative hypotension, blood transfusion requirements, and postoperative complications in adults undergoing complex spine surgery.<h4>Overview of literature</h4>Complex spine surgeries involve a significant risk of blood loss ... Read more >>

Asian Spine J (Asian spine journal)
[2021, :]

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High-flow nasal oxygen for gastrointestinal endoscopy improves respiratory safety.

Peter Santer, Karuna Wongtangman, Mandeep S Sawhney, Matthias Eikermann,

Br J Anaesth (British journal of anaesthesia)
[2021, 127(1):7-11]

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Provider variability in the intraoperative use of neuromuscular blocking agents: a retrospective multicentre cohort study.

Friederike C Althoff, Xinling Xu, Luca J Wachtendorf, Denys Shay, Maria Patrocinio, Maximilian S Schaefer, Timothy T Houle, Philipp Fassbender, Matthias Eikermann, Karuna Wongtangman,

<h4>Objective</h4>To assess variability in the intraoperative use of non-depolarising neuromuscular blocking agents (NMBAs) across individual anaesthesia providers, surgeons and hospitals.<h4>Design</h4>Retrospective observational cohort study.<h4>Setting</h4>Two major tertiary referral centres, Boston, Massachusetts, USA.<h4>Participants</h4>265 537 adult participants undergoing non-cardiac surgery between October 2005 and September 2017.<h4>Main outcome measures</h4>We analysed the variances in NMBA use across ... Read more >>

BMJ Open (BMJ open)
[2021, 11(4):e048509]

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Discharge Prediction for Patients Undergoing Inpatient Surgery: Development and validation of the DEPENDENSE score.

Maximilian Hammer, Friederike C Althoff, Katharina Platzbecker, Luca J Wachtendorf, Bijan Teja, Dana Raub, Maximilian S Schaefer, Karuna Wongtangman, Xinling Xu, Timothy T Houle, Matthias Eikermann, Kadhiresan R Murugappan,

<h4>Background</h4>A substantial proportion of patients undergoing inpatient surgery each year is at risk for postoperative institutionalization and loss of independence. Reliable individualized preoperative prediction of adverse discharge can facilitate advanced care planning and shared decision making.<h4>Methods</h4>Using hospital registry data from previously home-dwelling adults undergoing inpatient surgery, we retrospectively developed and ... Read more >>

Acta Anaesthesiol Scand (Acta anaesthesiologica Scandinavica)
[2021, 65(5):607-617]

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Effects of the Level and Duration of Mobilization Therapy in the Surgical ICU on the Loss of the Ability to Live Independently: An International Prospective Cohort Study.

Flora T Scheffenbichler, Bijan Teja, Karuna Wongtangman, Nicole Mazwi, Karen Waak, Stefan J Schaller, Xinling Xu, Silvia Barbieri, Nazzareno Fagoni, Jessica Cassavaugh, Manfred Blobner, Carol L Hodgson, Nicola Latronico, Matthias Eikermann,

<h4>Objectives</h4>It is unclear whether early mobilization in the surgical ICU helps improve patients' functional recovery to a level that enables independent living. We assessed dose of mobilization (level + duration). We tested the research hypotheses that dose of mobilization predicts adverse discharge and that both duration of mobilization and maximum ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(3):e247-e257]

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Effects of Volatile Anesthetics on Postoperative Ischemic Stroke Incidence.

Dana Raub, Katharina Platzbecker, Stephanie D Grabitz, Xinling Xu, Karuna Wongtangman, Stephanie B Pham, Kadhiresan R Murugappan, Khalid A Hanafy, Ala Nozari, Timothy T Houle, Samir M Kendale, Matthias Eikermann,

Background Preclinical studies suggest that volatile anesthetics decrease infarct volume and improve the outcome of ischemic stroke. This study aims to determine their effect during noncardiac surgery on postoperative ischemic stroke incidence. Methods and Results This was a retrospective cohort study of surgical patients undergoing general anesthesia at 2 tertiary ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, 10(5):e018952]

Cited: 2 times

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Influence of the acuity of patients' illness on effectiveness of early, goal-directed mobilization in the intensive care unit: a post hoc analysis.

Ludwig Scheffenbichler, Bijan Teja, Flora Scheffenbichler, Manfred Blobner, Timothy Houle, Matthias Eikermann, ,

Crit Care (Critical care (London, England))
[2020, 24(1):663]

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Supraglottic airway device versus tracheal intubation and the risk of emergent postoperative intubation after general anaesthesia in adults: a retrospective cohort study.

Maximilian Hammer, Peter Santer, Maximilian S Schaefer, Friederike C Althoff, Karuna Wongtangman, Ulrich H Frey, Xinling Xu, Matthias Eikermann, Philipp Fassbender,

<h4>Background</h4>We examined the association between emergent postoperative tracheal intubation and the use of supraglottic airway devices (SGAs) vs tracheal tubes.<h4>Methods</h4>We included data from adult noncardiac surgical cases under general anaesthesia between 2008 and 2018. We only included cases (n=59 991) in which both airways were deemed to be feasible options. ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2021, 126(3):738-745]

Cited: 2 times

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Incidence of Inadequate Pain Treatment among Ventilated, Critically Ill Surgical Patients in a Thai Population.

Napat Thikom, Ruangkhaw Thongsri, Piyawan Wongcharoenkit, Phannita Khruamingmongkhon, Karuna Wongtangman,

<h4>Background</h4>Inadequate pain treatment during intensive care unit stays causes many unfavorable outcomes. Pain assessment in mechanically ventilated patients is challenging because most cannot self-report pain. The incidence of pain among Thai surgical intensive care unit (SICU) patients has never been reported.<h4>Aims</h4>To determine the inadequate pain control incidence among ventilated, critically ... Read more >>

Pain Manag Nurs (Pain management nursing : official journal of the American Society of Pain Management Nurses)
[2021, 22(3):336-342]

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A Tool to Predict Readmission to the Intensive Care Unit in Surgical Critical Care Patients-The RISC Score.

Maximilian Hammer, Stephanie D Grabitz, Bijan Teja, Karuna Wongtangman, Marjorie Serrano, Sara Neves, Shahla Siddiqui, Xinling Xu, Matthias Eikermann,

<h4>Background</h4>Readmission to the Intensive Care Unit (ICU) is associated with a high risk of in-hospital mortality and higher health care costs. Previously published tools to predict ICU readmission in surgical ICU patients have important limitations that restrict their clinical implementation. We sought to develop a clinically intuitive score that can ... Read more >>

J Intensive Care Med (Journal of intensive care medicine)
[2021, 36(11):1296-1304]

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Study protocol for a randomised controlled trial evaluating the effects of the orexin receptor antagonist suvorexant on sleep architecture and delirium in the intensive care unit.

Omid Azimaraghi, Maximilian Hammer, Peter Santer, Katharina Platzbecker, Friederike C Althoff, Maria Patrocinio, Stephanie D Grabitz, Karuna Wongtangman, Sandra Rumyantsev, Xinling Xu, Maximilian S Schaefer, Patrick M Fuller, Balachundhar Subramaniam, Matthias Eikermann,

<h4>Introduction</h4>Insomnia frequently occurs in patients admitted to an intensive care unit (ICU). Sleep-promoting agents may reduce rapid eye movement sleep and have deliriogenic effects. Suvorexant (Belsomra) is an orexin receptor antagonist with Food and Drug Administration (FDA) approval for the treatment of adult insomnia, which improves sleep onset and maintenance ... Read more >>

BMJ Open (BMJ open)
[2020, 10(7):e038474]

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The effects of acetylcholinesterase inhibitors on morbidity after general anesthesia and surgery.

Denys Shaydenfish, Karuna Wongtangman, Matthias Eikermann, Maximilian S Schaefer,

Non-depolarizing neuromuscular blocking agents are used during general anesthesia to facilitate intubation and optimize surgical conditions. When patients leave the operating room after surgery, postoperative residual neuromuscular block occurs frequently, increasing vulnerability to respiratory complications such as hypoxemia and unplanned postoperative mechanical ventilation. To restore neuromuscular transmission and skeletal muscle ... Read more >>

Neuropharmacology (Neuropharmacology)
[2020, 173:108134]

Cited: 1 time

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Functional mobility recovery predicts readmission to the surgical intensive care unit.

Maximilian Hammer, Stephanie D Grabitz, Bijan Teja, Marjorie Serrano, Matthias Eikermann, ,

Intensive Care Med (Intensive care medicine)
[2020, 46(5):1054-1056]

Cited: 2 times

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A Randomized Placebo-Controlled Trial of Oral Ramosetron for Prevention of Post Operative Nausea and Vomiting after Intrathecal Morphine in Patients Undergoing Gynecological Surgery.

Suratsawadee Wangnamthip, Thitima Chinachoti, Somchai Amornyotin, Karuna Wongtangman, Numphung Sukantarat, Papiroon Noitasaeng,

<h4>Background</h4>The incidence of postoperative nausea and vomiting (PONV) after intrathecal morphine is high. Ramosetron is a 5-HT₃ antagonist that has been shown to reduce PONV in general anesthesia. The objective of this study was to evaluate the efficacy of Ramosetron in preventing PONV MATERIAL AND METHOD: 165 patients undergoing elective ... Read more >>

J Med Assoc Thai (Journal of the Medical Association of Thailand = Chotmaihet thangphaet)
[2016, 99(5):455-461]

Cited: 3 times

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